.. Données-sur-la-méthylation-de-l-'adn, 55 a/ Niveau de méthylation global entre exposés et non-exposés, p.56

A. Vested, Associations of in utero Exposure to Perfluorinated Alkyl Acids with Human Semen Quality and Reproductive Hormones in Adult Men, Environmental Health Perspectives, vol.121, pp.453-458, 2013.
DOI : 10.1289/ehp.1205118

M. Cocuzza and S. C. Esteves, Shedding Light on the Controversy Surrounding the Temporal Decline in Human Sperm Counts: A Systematic Review, The Scientific World Journal, vol.17, issue.2, p.365691, 2014.
DOI : 10.1002/ijc.20088

J. D. Meeker, Semen quality and sperm DNA damage in relation to urinary bisphenol A among men from an infertility clinic?????????, Reproductive Toxicology, vol.30, issue.4, pp.532-539, 2010.
DOI : 10.1016/j.reprotox.2010.07.005

N. Tumba-byn and T. , Differential Effects of Bisphenol A and Diethylstilbestrol on Human, Rat and Mouse Fetal Leydig Cell Function, PLoS ONE, vol.31, issue.12, p.51579, 2012.
DOI : 10.1371/journal.pone.0051579.g007

D. A. Crain, Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing, Fertility and Sterility, vol.90, issue.4, pp.911-940, 2008.
DOI : 10.1016/j.fertnstert.2008.08.067

M. Denham, Relationship of Lead, Mercury, Mirex, Dichlorodiphenyldichloroethylene, Hexachlorobenzene, and Polychlorinated Biphenyls to Timing of Menarche Among Akwesasne Mohawk Girls, PEDIATRICS, vol.115, issue.2, pp.127-134, 2005.
DOI : 10.1542/peds.2004-1161

M. A. Ottinger, An Overview of Dioxin-Like Compounds, PCB, and Pesticide Exposures Associated with Sexual Differentiation of Neuroendocrine Systems, Fluctuating Asymmetry, and Behavioral Effects in Birds, Journal of Environmental Science and Health, Part C, vol.39, issue.2, pp.286-300, 2009.
DOI : 10.1080/10590500903310229

L. Fusani, D. Seta, D. Dessì-fulgheri, F. Farabollini, and F. , Altered reproductive success in rat pairs after environmental-like exposure to xenoestrogen, Proceedings of the Royal Society B: Biological Sciences, vol.24, issue.9, pp.1631-1636, 2007.
DOI : 10.1191/0960327105ht551oa

N. J. Cabaton, Effects of Low Doses of Bisphenol A on the Metabolome of Perinatally Exposed CD-1 Mice, Environmental Health Perspectives, vol.121, pp.586-593, 2013.
DOI : 10.1289/ehp.1205588

H. Mackay, Organizational Effects of Perinatal Exposure to Bisphenol-A and Diethylstilbestrol on Arcuate Nucleus Circuitry Controlling Food Intake and Energy Expenditure in Male and Female CD-1 Mice, Endocrinology, vol.154, issue.4, pp.1465-1475, 2013.
DOI : 10.1210/en.2012-2044

J. A. Rogers, L. Metz, and V. W. Yong, Review: Endocrine disrupting chemicals and immune responses: A focus on bisphenol-A and its potential mechanisms, Molecular Immunology, vol.53, issue.4, pp.421-430, 2013.
DOI : 10.1016/j.molimm.2012.09.013

A. V. Rubtsov, K. Rubtsova, J. W. Kappler, and P. Marrack, Genetic and hormonal factors in female-biased autoimmunity, Autoimmunity Reviews, vol.9, issue.7, pp.494-498, 2010.
DOI : 10.1016/j.autrev.2010.02.008

K. L. Phiel, R. A. Henderson, S. J. Adelman, and M. M. Elloso, Differential estrogen receptor gene expression in human peripheral blood mononuclear cell populations, Immunology Letters, vol.97, issue.1
DOI : 10.1016/j.imlet.2004.10.007

M. Cunningham and G. Gilkeson, Estrogen Receptors in Immunity and Autoimmunity, Clinical Reviews in Allergy & Immunology, vol.35, issue.5
DOI : 10.1007/s12016-010-8203-5

M. Frericks, M. Meissner, and C. Esser, 16 Microarray analysis of the AHR system: tissue-specific flexibility in signal and target genes Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells, Clin. Rev. Allergy Immunol. Toxicol. Appl. Pharmacol. Nat. Rev. Immunol, vol.40, issue.10, pp.66-73, 2007.

J. L. Hugla and J. P. Thomé, Effects of Polychlorinated Biphenyls on Liver Ultrastructure, Hepatic Monooxygenases, and Reproductive Success in the Barbel, Ecotoxicology and Environmental Safety, vol.42, issue.3
DOI : 10.1006/eesa.1998.1761

. Saf, 19. Diethylstilboestrol and diethylstilboestrol dipropionate 20. Smith, O. W. Diethylstilbestrol in the prevention and treatment of complications of pregnancy S. The influence of diethylstilbestrol on the progress and outcome of pregnancy as based on a comparison of treated with untreated primigravidas, IARC Monogr. Eval. Carcinog . Risk Chem. Hum. Am. J. Obstet. Gynecol. Am, vol.42, issue.56, pp.265-273, 1948.

J. J. Bittner, Possible Relationship of the Estrogenic Hormones, Genetic Susceptibility , and Milk Influence in the Production of Mammary Cancer in Mice, Cancer Res, vol.2, pp.710-721, 1942.

W. J. Dieckmann, M. E. Davis, L. M. Rynkiewicz, and R. E. Pottinger, Does the Administration of Diethylstilbestrol during Pregnancy have Therapeutic Value?*???, American Journal of Obstetrics and Gynecology, vol.66, issue.5, pp.1062-1081, 1953.
DOI : 10.1016/S0002-9378(16)38617-3

A. Spira, Administration of diethylstilbestrol during pregnancy, a public health problem]. Rev, pp.249-272, 1983.

A. L. Herbst, H. Ulfelder, and D. C. Poskanzer, Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women, American Journal of Obstetrics and Gynecology, vol.181, issue.6
DOI : 10.1016/S0002-9378(99)70411-4

R. N. Hoover, Adverse Health Outcomes in Women Exposed In Utero to Diethylstilbestrol, New England Journal of Medicine, vol.365, issue.14, pp.1304-1314, 2011.
DOI : 10.1056/NEJMoa1013961

M. P. Vessey, D. V. Fairweather, B. Norman-smith, and J. Buckley, A randomized double-blind controlled trial of the value of stilboestrol therapy in pregnancy: long-term follow-up of mothers and their offspring, BJOG: An International Journal of Obstetrics and Gynaecology, vol.28, issue.11, pp.1007-1017, 1983.
DOI : 10.1016/S0140-6736(78)92237-7

H. F. Meyer-bahlburg, Depression in adults with a history of prenatal DES exposure, Psychopharmacol. Bull, vol.21, pp.686-689, 1985.

A. A. Ehrhardt, Psychopathology in prenatally DES-exposed females: current and lifetime adjustment., Psychosomatic Medicine, vol.49, issue.2, pp.183-196, 1987.
DOI : 10.1097/00006842-198703000-00008

R. C. Pillard, Psychopathology and social functioning in men prenatally exposed to diethylstilbestrol (DES)., Psychosomatic Medicine, vol.55, issue.6, pp.485-491, 1987.
DOI : 10.1097/00006842-199311000-00003

C. R. Gustavson, Increased risk of profound weight loss among women exposed to diethylstilbestrol in utero, Behavioral and Neural Biology, vol.55, issue.3, pp.307-312, 1991.
DOI : 10.1016/0163-1047(91)90645-7

L. Titus-ernstoff, Psychosexual Characteristics of Men and Women Exposed Prenatally to Diethylstilbestrol, Epidemiology, vol.14, issue.2, pp.155-160, 2003.
DOI : 10.1097/01.EDE.0000039059.38824.B2

O. Reilly, E. J. Mirzaei, F. Forman, M. R. Ascherio, and A. , Diethylstilbestrol Exposure in Utero and Depression in Women, American Journal of Epidemiology, vol.171, issue.8, pp.876-882, 2010.
DOI : 10.1093/aje/kwq023

D. L. Katz, F. R. Frankenburg, L. I. Benowitz, and J. M. Gilbert, BRIEF COMMUNICATION, The Journal of Nervous and Mental Disease, vol.175, issue.5, pp.306-308, 1987.
DOI : 10.1097/00005053-198705000-00011

M. T. Tsuang, G. Winokur, and R. R. Crowe, Morbidity risks of schizophrenia and affective disorders among first degree relatives of patients with schizophrenia, mania, depression and surgical conditions, The British Journal of Psychiatry, vol.137, issue.6, pp.497-504, 1980.
DOI : 10.1192/bjp.137.6.497

L. M. Morimoto, E. White, and P. A. Newcomb, Selection Bias in the Assessment of Gene-Environment Interaction in Case-Control Studies, American Journal of Epidemiology, vol.158, issue.3, pp.259-263, 2003.
DOI : 10.1093/aje/kwg147

D. R. Grayson, Y. Chen, E. Dong, M. Kundakovic, and A. Guidotti, From trans-methylation to cytosine methylation: Evolution of the methylation hypothesis of schizophrenia, Epigenetics, vol.4, issue.3, pp.144-149, 2009.
DOI : 10.4161/epi.4.3.8534

M. Toledo-rodriguez, Maternal smoking during pregnancy is associated with epigenetic modifications of the brain-derived neurotrophic factor-6 exon in adolescent offspring, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol.33, issue.5
DOI : 10.1002/ajmg.b.31109

. Genet and E. E. Hatch, 41 Cancer risk in women exposed to diethylstilbestrol in utero, JAMA J. Am. Med. Assoc, vol.280, pp.1350-1354, 1998.

W. C. Strohsnitter, Cancer Risk in Men Exposed In Utero to Diethylstilbestrol, JNCI Journal of the National Cancer Institute, vol.93, issue.7
DOI : 10.1093/jnci/93.7.545

. Natl, Cancer Inst, pp.545-551, 2001.

J. R. Palmer, Prenatal Diethylstilbestrol Exposure and Risk of Breast Cancer, Cancer Epidemiology Biomarkers & Prevention, vol.15, issue.8
DOI : 10.1158/1055-9965.EPI-06-0109

K. Warita, Microarray and gene ontology analyses reveal downregulation of DNA repair and apoptotic pathways in diethylstilbestrol-exposed testicular Leydig cells, The Journal of Toxicological Sciences, vol.37, issue.2, pp.287-295, 2012.
DOI : 10.2131/jts.37.287

S. A. Rowas, Effect of in utero exposure to diethylstilbestrol on lumbar and femoral bone, articular cartilage, and the intervertebral disc in male and female adult mice progeny with and without swimming exercise, Arthritis Research & Therapy, vol.14, issue.1, p.17, 2012.
DOI : 10.1186/ar3696

R. Haddad, A. Kasneci, K. Mepham, I. A. Sebag, and L. Chalifour, Gestational exposure to diethylstilbestrol alters cardiac structure/function, protein expression and DNA methylation in adult male mice progeny, Toxicology and Applied Pharmacology, vol.266, issue.1, pp.27-37, 2013.
DOI : 10.1016/j.taap.2012.10.018

Y. Yin, Neonatal diethylstilbestrol exposure alters the metabolic profile of uterine epithelial cells, Disease Models & Mechanisms, vol.5, issue.6, pp.870-880, 2012.
DOI : 10.1242/dmm.009076

W. C. Strohsnitter, Autoimmune Disease Incidence Among Women Prenatally Exposed to Diethylstilbestrol, The Journal of Rheumatology, vol.37, issue.10, pp.2167-2173, 2010.
DOI : 10.3899/jrheum.091092

A. I. Saeed, TM4: a free, open-source system for microarray data management and analysis 50. Petronis, A. Epigenetics and twins: three variations on the theme, BioTechniques Trends Genet. TIG, vol.34, issue.22, pp.374-378, 2003.

T. A. Slotkin and F. J. Seidler, Comparative developmental neurotoxicity of organophosphates in vivo: Transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems, Brain Research Bulletin, vol.72, issue.4-6, pp.232-274, 2007.
DOI : 10.1016/j.brainresbull.2007.01.005

S. K. Tiwari, S. Agarwal, L. K. Chauhan, V. N. Mishra, and R. K. Chaturvedi, Bisphenol-A Impairs Myelination Potential During Development in the Hippocampus of the Rat Brain, Molecular Neurobiology, vol.44, issue.1, pp.10-1007, 2014.
DOI : 10.1007/s12035-014-8817-3

Y. L. Guo, T. J. Lai, S. J. Chen, and C. C. Hsu, Gender-related decrease in Raven's progressive matrices scores in children prenatally exposed to polychlorinated biphenyls and related contaminants, Bulletin of Environmental Contamination and Toxicology, vol.12, issue.1, pp.8-13, 1995.
DOI : 10.1007/BF00212382

S. L. Schantz and J. J. Widholm, Cognitive Effects of Endocrine-Disrupting Chemicals in Animals, Environmental Health Perspectives, vol.109, issue.12, pp.1197-1206, 2001.
DOI : 10.1289/ehp.011091197

L. Corrieri, D. Seta, D. Canoine, V. Fusani, and L. , Developmental exposure to xenoestrogen enhances spatial learning in male rats, Hormones and Behavior, vol.51, issue.5, pp.620-625, 2007.
DOI : 10.1016/j.yhbeh.2007.03.002

R. N. Sadowski, Effects of perinatal bisphenol A exposure during early development on radial arm maze behavior in adult male and female rats, Neurotoxicology and Teratology, vol.42, pp.17-24, 2014.
DOI : 10.1016/j.ntt.2014.01.002

L. Ricceri, Developmental exposure to chlorpyrifos alters reactivity to environmental and social cues in adolescent mice, Toxicology and Applied Pharmacology, vol.191, issue.3, pp.189-201, 2003.
DOI : 10.1016/S0041-008X(03)00229-1

L. Ricceri, Developmental Neurotoxicity of Organophosphorous Pesticides: Fetal and Neonatal Exposure to Chlorpyrifos Alters Sex-Specific Behaviors at Adulthood in Mice, Toxicological Sciences, vol.93, issue.1, pp.105-113, 2006.
DOI : 10.1093/toxsci/kfl032

A. Venerosi, Neonatal exposure to chlorpyrifos affects maternal responses and maternal aggression of female mice in adulthood, Neurotoxicology and Teratology, vol.30, issue.6, pp.468-474, 2008.
DOI : 10.1016/j.ntt.2008.07.002

A. Venerosi, G. Calamandrei, and L. Ricceri, A social recognition test for female mice reveals behavioral effects of developmental chlorpyrifos exposure, Neurotoxicology and Teratology, vol.28, issue.4, pp.466-471, 2006.
DOI : 10.1016/j.ntt.2006.05.003

P. Palanza, S. Parmigiani, H. Liu, and F. S. Vom-saal, Prenatal Exposure to Low Doses of the Estrogenic Chemicals Diethylstilbestrol and o,p???-DDT Alters Aggressive Behavior of Male and Female House Mice, Pharmacology Biochemistry and Behavior, vol.64, issue.4, pp.665-672, 1999.
DOI : 10.1016/S0091-3057(99)00151-3

M. Tanaka, R. Ohtani-kaneko, M. Yokosuka, and C. Watanabe, Low-dose perinatal diethylstilbestrol exposure affected behaviors and hypothalamic estrogen receptor-??-positive cells in the mouse, Neurotoxicology and Teratology, vol.26, issue.2, pp.261-269, 2004.
DOI : 10.1016/j.ntt.2003.11.003

M. Ishido, J. Yonemoto, and M. Morita, Mesencephalic neurodegeneration in the orally administered bisphenol A-caused hyperactive rats, Toxicology Letters, vol.173, issue.1, pp.66-72, 2007.
DOI : 10.1016/j.toxlet.2007.06.014

L. Gioiosa, E. Fissore, G. Ghirardelli, S. Parmigiani, and P. Palanza, Developmental exposure to low-dose estrogenic endocrine disruptors alters sex differences in exploration and emotional responses in mice, Hormones and Behavior, vol.52, issue.3, pp.307-316, 2007.
DOI : 10.1016/j.yhbeh.2007.05.006

H. Ogi, K. Itoh, and S. Fushiki, Social behavior is perturbed in mice after exposure to bisphenol A: a novel assessment employing an IntelliCage, Brain and Behavior, vol.31, issue.3, pp.223-228, 2013.
DOI : 10.1002/brb3.130

X. Xu, D. Tian, X. Hong, L. Chen, and L. Xie, Sex-specific influence of exposure to bisphenol-A between adolescence and young adulthood on mouse behaviors, Neuropharmacology, vol.61, issue.4, pp.565-573, 2011.
DOI : 10.1016/j.neuropharm.2011.04.027

X. Xu, Sex-specific effects of long-term exposure to bisphenol-A on anxiety- and depression-like behaviors in adult mice, Chemosphere, vol.120, pp.258-266, 2014.
DOI : 10.1016/j.chemosphere.2014.07.021

D. J. Hoffman, C. A. Eagles-smith, J. T. Ackerman, T. L. Adelsbach, and K. R. Stebbins, Oxidative stress response of Forster's terns (Sterna forsteri) and Caspian terns (Hydroprogne caspia) to mercury and selenium bioaccumulation in liver, kidney, and brain, Environmental Toxicology and Chemistry, vol.58, issue.4
DOI : 10.1002/etc.459

J. Stein, T. Schettler, D. Wallinga, and M. Valenti, In Harm???s Way: Toxic Threats to Child Development, Journal of Developmental and Behavioral Pediatrics, vol.23, issue.Supplement, pp.13-22, 2002.
DOI : 10.1097/00004703-200202001-00004

G. Winneke, Developmental aspects of environmental neurotoxicology: Lessons from lead and polychlorinated biphenyls, Journal of the Neurological Sciences, vol.308, issue.1-2, pp.9-15, 2011.
DOI : 10.1016/j.jns.2011.05.020

M. M. Martel, K. Klump, J. T. Nigg, S. M. Breedlove, and C. L. Sisk, Potential hormonal mechanisms of Attention-Deficit/Hyperactivity Disorder and Major Depressive Disorder: A new perspective, Hormones and Behavior, vol.55, issue.4, pp.465-479, 2009.
DOI : 10.1016/j.yhbeh.2009.02.004

L. Hwang, Environmental Stressors and Violence: Lead and Polychlorinated Biphenyls, Reviews on Environmental Health, vol.22, issue.4
DOI : 10.1515/REVEH.2007.22.4.313

J. M. Braun, Prenatal Bisphenol A Exposure and Early Childhood Behavior, Environmental Health Perspectives, vol.117, issue.12, pp.1945-1952, 2009.
DOI : 10.1289/ehp.0900979

Z. Liew, Prenatal Exposure to Perfluoroalkyl Substances and the Risk of Congenital Cerebral Palsy in Children doi:10.1093/aje/kwu179 75. Hong, S.-B. et al. Bisphenol A in relation to behavior and learning of school-age children, Am. J. Epidemiol. J. Child Psychol. Psychiatry, vol.54, pp.890-899, 2013.

T. Parrón, M. Requena, A. F. Hernández, and R. Alarcón, Association between environmental exposure to pesticides and neurodegenerative diseases, Toxicology and Applied Pharmacology, vol.256, issue.3, pp.379-385, 2011.
DOI : 10.1016/j.taap.2011.05.006

V. M. Darras, Endocrine disrupting polyhalogenated organic pollutants

M. E. Gilbert, J. Rovet, Z. Chen, and N. Koibuchi, Developmental thyroid hormone disruption: Prevalence, environmental contaminants and neurodevelopmental consequences, NeuroToxicology, vol.33, issue.4, pp.842-852, 2012.
DOI : 10.1016/j.neuro.2011.11.005

F. Chen, L. Zhou, Y. Bai, R. Zhou, and L. Chen, Sex differences in the adult HPA axis and affective behaviors are altered by perinatal exposure to a low dose of bisphenol A, Brain Research, vol.1571
DOI : 10.1016/j.brainres.2014.05.010

T. Suzuki, Prenatal and neonatal exposure to bisphenol-a enhances the central dopamine d1 receptor-mediated action in mice: enhancement of the methamphetamine-induced abuse state, Neuroscience, vol.117, issue.3, pp.639-644, 2003.
DOI : 10.1016/S0306-4522(02)00935-1

W. Chen, Repeated exposure to chlorpyrifos alters the performance of adolescent male rats in animal models of depression and anxiety, NeuroToxicology, vol.32, issue.4, pp.355-361, 2011.
DOI : 10.1016/j.neuro.2011.03.008

A. H. Veenema and I. D. Neumann, Central vasopressin and oxytocin release: regulation of complex social behaviours, Prog. Brain Res, vol.170, pp.261-276, 2008.
DOI : 10.1016/S0079-6123(08)00422-6

D. Vries, G. J. Buijs, R. M. Sluiter, and A. A. , Gonadal hormone actions on the morphology of the vasopressinergic innervation of the adult rat brain, Brain Research, vol.298, issue.1, pp.141-145, 1984.
DOI : 10.1016/0006-8993(84)91157-0

T. M. Han and G. J. De-vries, Organizational effects of testosterone, estradiol, and dihydrotestosterone on vasopressin mRNA expression in the bed nucleus of the stria terminalis, Journal of Neurobiology, vol.389, issue.3
DOI : 10.1002/neu.10157

P. R. Kodavanti and M. C. Curras-collazo, Neuroendocrine actions of organohalogens: Thyroid hormones, arginine vasopressin, and neuroplasticity, Frontiers in Neuroendocrinology, vol.31, issue.4, pp.479-496, 2010.
DOI : 10.1016/j.yfrne.2010.06.005

B. N. Roy, R. L. Reid, and D. A. Van-vugt, The Effects of Estrogen and Progesterone on Corticotropin-Releasing Hormone and Arginine Vasopressin Messenger Ribonucleic Acid Levels in the Paraventricular Nucleus and Supraoptic Nucleus of the Rhesus Monkey, Endocrinology, vol.140, issue.5, pp.2191-2198, 1999.
DOI : 10.1210/endo.140.5.6684

A. C. Scallet, M. Wofford, J. C. Meredith, W. T. Allaben, and S. A. Ferguson, Dietary Exposure to Genistein Increases Vasopressin but Does Not Alter beta-Endorphin in the Rat Hypothalamus, Toxicological Sciences, vol.72, issue.2, pp.296-300, 2003.
DOI : 10.1093/toxsci/kfg029

J. N. Ferguson, L. J. Young, and T. R. Insel, The Neuroendocrine Basis of Social Recognition, Frontiers in Neuroendocrinology, vol.23, issue.2, pp.200-224, 2002.
DOI : 10.1006/frne.2002.0229

T. L. Bale and D. M. Dorsa, Sex differences in and effects of estrogen on oxytocin receptor messenger ribonucleic acid expression in the ventromedial hypothalamus, Endocrinology, vol.136, pp.27-32, 1995.

A. W. Sullivan, ), Endocrinology, vol.155, issue.10, pp.102014-1379, 1210.
DOI : 10.1210/en.2014-1379

T. Kumamoto and S. Oshio, Effect of fetal exposure to bisphenol A on brain mediated by X-chromosome inactivation, The Journal of Toxicological Sciences, vol.38, issue.3, pp.485-494, 2013.
DOI : 10.2131/jts.38.485

D. Santos, M. Matos, and A. M. Coimbra, Developmental toxicity of endocrine disruptors in early life stages of zebrafish, a genetic and embryogenesis study, Neurotoxicology and Teratology, vol.46, pp.18-25, 2014.
DOI : 10.1016/j.ntt.2014.08.002

X. Xu, Bisphenol A promotes dendritic morphogenesis of hippocampal neurons through estrogen receptor-mediated ERK1/2 signal pathway, Chemosphere, vol.96, pp.129-137, 2014.
DOI : 10.1016/j.chemosphere.2013.09.063

M. E. Rebuli, Investigation of the Effects of Subchronic Low Dose Oral Exposure to Bisphenol A (BPA) and Ethinyl Estradiol (EE) on Estrogen Receptor Expression in the Juvenile and Adult Female Rat Hypothalamus, Toxicological Sciences, vol.140, issue.1, pp.190-203, 2014.
DOI : 10.1093/toxsci/kfu074

P. Mahawong, Comparative effects of neonatal diethylstilbestrol on external genitalia development in adult males of two mouse strains with differential estrogen sensitivity, Differentiation, vol.88, issue.2-3, pp.70-83, 2006.
DOI : 10.1016/j.diff.2014.09.004

G. C. Panzica, Neuropeptides and Enzymes are Targets for the Action of Endocrine Disrupting Chemicals in the Vertebrate Brain, Journal of Toxicology and Environmental Health, Part B, vol.41, issue.5-7, pp.449-472, 2011.
DOI : 10.1007/s00441-008-0606-8

C. E. Marx and J. A. Lieberman, PSYCHONEUROENDOCRINOLOGY OF SCHIZOPHRENIA, Psychiatric Clinics of North America, vol.21, issue.2, pp.413-434, 1998.
DOI : 10.1016/S0193-953X(05)70013-7

J. R. Stevens, Schizophrenia: Reproductive Hormones and the Brain, American Journal of Psychiatry, vol.159, issue.5, pp.713-719, 2002.
DOI : 10.1176/appi.ajp.159.5.713

J. I. Koenig, Prenatal exposure to a repeated variable stress paradigm elicits behavioral and neuroendocrinological changes in the adult offspring: potential relevance to schizophrenia, Behavioural Brain Research, vol.156, issue.2, pp.251-261, 2005.
DOI : 10.1016/j.bbr.2004.05.030

J. M. Goldstein, Sex, hormones and affective arousal circuitry dysfunction in schizophrenia, Hormones and Behavior, vol.50, issue.4, pp.612-622, 2006.
DOI : 10.1016/j.yhbeh.2006.06.029

K. North and J. Golding, A maternal vegetarian diet in pregnancy is associated with hypospadias, BJU International, vol.54, issue.1, pp.107-113, 2000.
DOI : 10.1046/j.1464-410x.2000.00436.x

A. S. Brown, Serologic Evidence of Prenatal Influenza in the Etiology of Schizophrenia, Archives of General Psychiatry, vol.61, issue.8, pp.774-780, 2004.
DOI : 10.1001/archpsyc.61.8.774

M. Segal, Prolactin and estradiol serum levels in unmedicated male paranoid schizophrenia patients, Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol.31, issue.2, pp.378-382, 2007.
DOI : 10.1016/j.pnpbp.2006.09.016

A. L. Hoff, Association of Estrogen Levels With Neuropsychological Performance in Women With Schizophrenia, American Journal of Psychiatry, vol.158, issue.7, pp.1134-1139, 2001.
DOI : 10.1176/appi.ajp.158.7.1134

R. K. Salokangas, T. Honkonen, and S. Saarinen, Women have later onset than men in schizophrenia???but only in its paranoid form. Results of the DSP project, European Psychiatry, vol.18, issue.6
DOI : 10.1016/j.eurpsy.2003.03.001

C. D. Conrad, Chronic Glucocorticoids Increase Hippocampal Vulnerability to Neurotoxicity under Conditions That Produce CA3 Dendritic Retraction But Fail to Impair Spatial Recognition Memory, Journal of Neuroscience, vol.27, issue.31, pp.8278-8285, 2007.
DOI : 10.1523/JNEUROSCI.2121-07.2007

J. J. Cerqueira, Morphological Correlates of Corticosteroid-Induced Changes in Prefrontal Cortex-Dependent Behaviors, Journal of Neuroscience, vol.25, issue.34, pp.7792-7800, 2005.
DOI : 10.1523/JNEUROSCI.1598-05.2005

N. Ingram, Interaction of corticosterone and nicotine in regulation of prepulse inhibition in mice, Neuropharmacology, vol.48, issue.1, pp.80-92, 2005.
DOI : 10.1016/j.neuropharm.2004.08.015

A. M. Hosie, M. E. Wilkins, H. M. Da-silva, and T. G. Smart, Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites, Nature, vol.23, issue.7118, pp.486-489, 2006.
DOI : 10.1093/nar/gkg520

C. E. Marx, Neuroactive Steroids are Altered in Schizophrenia and Bipolar Disorder: Relevance to Pathophysiology and Therapeutics, Neuropsychopharmacology, vol.157
DOI : 10.1038/sj.npp.1300952

C. A. Frye and M. E. Rhodes, Estrogen-priming can enhance progesterone's anti-seizure effects in part by increasing hippocampal levels of allopregnanolone, Pharmacology Biochemistry and Behavior, vol.81, issue.4, pp.907-916, 2005.
DOI : 10.1016/j.pbb.2005.06.016

F. Bernardi, Progesterone and Medroxyprogesterone Acetate Effects on Central and Peripheral Allopregnanolone and Beta-Endorphin Levels, Neuroendocrinology, vol.83, issue.5-6, pp.348-359, 2006.
DOI : 10.1159/000095400

H. Picard, I. Amado, S. Mouchet-mages, J. Olié, and M. Krebs, The Role of the Cerebellum in Schizophrenia: an Update of Clinical, Cognitive, and Functional Evidences, Schizophrenia Bulletin, vol.34, issue.1, pp.155-172, 2008.
DOI : 10.1093/schbul/sbm049

Z. J. Daskalakis, B. K. Christensen, P. B. Fitzgerald, S. I. Fountain, and R. Chen, Reduced Cerebellar Inhibition in Schizophrenia: A Preliminary Study, American Journal of Psychiatry, vol.162, issue.6, pp.1203-1205, 2005.
DOI : 10.1176/appi.ajp.162.6.1203

S. L. Eastwood, A. J. Law, I. P. Everall, and P. J. Harrison, The axonal chemorepellant semaphorin 3A is increased in the cerebellum in schizophrenia and may contribute to its synaptic pathology, Molecular Psychiatry, vol.8, issue.2, pp.148-155, 2003.
DOI : 10.1038/sj.mp.4001233

A. Reif, Neural stem cell proliferation is decreased in schizophrenia, but not in depression, Molecular Psychiatry, vol.84, issue.5, pp.514-522, 2006.
DOI : 10.1038/sj.mp.4001791

K. Kim, Suppressive Effects of Bisphenol A on the Proliferation of Neural Progenitor Cells, Journal of Toxicology and Environmental Health, Part A, vol.9, issue.15-16, pp.1288-1295, 2007.
DOI : 10.1210/en.2005-0565

W. M. Humphrey, H. Dong, C. A. Csernansky, and J. G. Csernansky, Immediate and delayed hippocampal neuronal loss induced by kainic acid during early postnatal development in the rat, Developmental Brain Research, vol.137, issue.1, pp.1-12, 2002.
DOI : 10.1016/S0165-3806(02)00344-9

S. V. Kyosseva, Mitogen-activated protein kinases in schizophrenia, Biological Psychiatry, vol.46, issue.5, pp.689-696, 1999.
DOI : 10.1016/S0006-3223(99)00104-3

N. J. Maclusky, T. Hajszan, and C. Leranth, The Environmental Estrogen Bisphenol A Inhibits Estradiol-Induced Hippocampal Synaptogenesis, Environmental Health Perspectives, vol.113, issue.6, pp.675-679, 2005.
DOI : 10.1289/ehp.7633

G. Chana, S. Landau, C. Beasley, I. P. Everall, and D. Cotter, Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: evidence for decreased neuronal somal size and increased neuronal density, Biological Psychiatry, vol.53, issue.12, pp.1086-1098, 2003.
DOI : 10.1016/S0006-3223(03)00114-8

K. Nakamura, K. Itoh, T. Sugimoto, and S. Fushiki, Prenatal exposure to bisphenol A affects adult murine neocortical structure, Neuroscience Letters, vol.420, issue.2, pp.100-105, 2007.
DOI : 10.1016/j.neulet.2007.02.093

V. Haroutunian and K. L. Davis, Introduction to the Special Section: Myelin and oligodendrocyte abnormalities in schizophrenia, The International Journal of Neuropsychopharmacology, vol.10, issue.04
DOI : 10.1017/S1461145706007449

C. Seiwa, Bisphenol A Exerts Thyroid-Hormone-Like Effects on Mouse Oligodendrocyte Precursor Cells, Neuroendocrinology, vol.80, issue.1, pp.21-30, 2004.
DOI : 10.1159/000080663

W. R. Perlman, Alteration in Estrogen Receptor ?? mRNA Levels in Frontal Cortex and Hippocampus of Patients with Major Mental Illness, Biological Psychiatry, vol.58, issue.10, pp.812-824, 2005.
DOI : 10.1016/j.biopsych.2005.04.047

L. Monje, J. Varayoud, E. H. Luque, and J. G. Ramos, Neonatal exposure to bisphenol A modifies the abundance of estrogen receptor ?? transcripts with alternative 5'-untranslated regions in the female rat preoptic area, Journal of Endocrinology, vol.194, issue.1, pp.201-212, 2007.
DOI : 10.1677/JOE-07-0014

I. N. Ferrier, E. C. Johnstone, T. J. Crow, and I. Rincon-rodriguez, Anterior Pituitary Hormone Secretion in Chronic Schizophrenics, Archives of General Psychiatry, vol.40, issue.7, pp.755-761, 1983.
DOI : 10.1001/archpsyc.1983.01790060053007

B. T. Akingbemi, C. M. Sottas, A. I. Koulova, G. R. Klinefelter, and M. P. Hardy, Inhibition of Testicular Steroidogenesis by the Xenoestrogen Bisphenol A Is Associated with Reduced Pituitary Luteinizing Hormone Secretion and Decreased Steroidogenic Enzyme Gene Expression in Rat Leydig Cells, Endocrinology, vol.145, issue.2, pp.592-603, 2004.
DOI : 10.1210/en.2003-1174

S. Miyamoto, R. B. Mailman, J. A. Lieberman, and G. Duncan, Blunted brain metabolic response to ketamine in mice lacking D1A dopamine receptors, Brain Research, vol.894, issue.2, pp.167-180, 2001.
DOI : 10.1016/S0006-8993(01)01991-6

M. Ishido, M. Morita, S. Oka, and Y. Masuo, Alteration of gene expression of G protein-coupled receptors in endocrine disruptors-caused hyperactive rats, Regulatory Peptides, vol.126, issue.1-2, pp.145-153, 2005.
DOI : 10.1016/j.regpep.2004.08.035

H. T. Mueller, V. Haroutunian, K. L. Davis, and J. H. Meador-woodruff, Expression of the ionotropic glutamate receptor subunits and NMDA receptor-associated intracellular proteins in the substantia nigra in schizophrenia, Molecular Brain Research, vol.121, issue.1-2, pp.60-69, 2004.
DOI : 10.1016/j.molbrainres.2003.11.004

I. Klejbor, Fibroblast growth factor receptor signaling affects development and function of dopamine neurons - inhibition results in a schizophrenia-like syndrome in transgenic mice, Journal of Neurochemistry, vol.41, issue.5, pp.1243-1258, 2006.
DOI : 10.1159/000082136

B. S. Rubin, Evidence of Altered Brain Sexual Differentiation in Mice Exposed Perinatally to Low, Environmentally Relevant Levels of Bisphenol A, Endocrinology, vol.147, issue.8, pp.3681-3691, 2006.
DOI : 10.1210/en.2006-0189

S. Tando, Effects of pre- and neonatal exposure to bisphenol A on murine brain development, Brain and Development, vol.29, issue.6, pp.352-356, 2007.
DOI : 10.1016/j.braindev.2006.10.003

D. Mancama, I. Mata, R. W. Kerwin, and M. J. Arranz, Choline acetyltransferase variants and their influence in schizophrenia and olanzapine response, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol.18, issue.7, pp.849-853, 2007.
DOI : 10.1002/ajmg.b.30468

K. Miyagawa, M. Narita, M. Narita, H. Akama, and T. Suzuki, Memory impairment associated with a dysfunction of the hippocampal cholinergic system induced by prenatal and neonatal exposures to bisphenol-A, Neuroscience Letters, vol.418, issue.3, pp.236-241, 2007.
DOI : 10.1016/j.neulet.2007.01.088

D. Arsi?, S. W. Beasley, and M. J. Sullivan, Switched-on Sonic hedgehog: A gene whose activity extends beyond fetal development ? to oncogenesis, Journal of Paediatrics and Child Health, vol.2, issue.6, pp.421-423, 2007.
DOI : 10.1101/gad.1025302

H. Ogura, J. Aruga, and K. Mikoshiba, Behavioral abnormalities of Zic1 and Zic2 mutant mice: implications as models for human neurological disorders, Behavior Genetics, vol.31, issue.3, pp.317-324, 2001.
DOI : 10.1023/A:1012235510600

K. Miyagawa, Changes in central dopaminergic systems with the expression of Shh or GDNF in mice perinatally exposed to bisphenol-A, Nihon Shinkei Seishin Yakurigaku Zasshi, vol.27, pp.69-75, 2007.

A. Michelato, 3??? UTR (AGG)n repeat of glial cell line-derived neurotrophic factor (GDNF) gene polymorphism in schizophrenia, Neuroscience Letters, vol.357, issue.3, pp.235-237, 2004.
DOI : 10.1016/j.neulet.2003.12.089

J. Kehr, Galanin Is a Potent In Vivo Modulator of Mesencephalic Serotonergic Neurotransmission, Neuropsychopharmacology, vol.27, issue.3, pp.341-356, 2002.
DOI : 10.1016/S0893-133X(02)00309-3

E. Ericson and S. Ahlenius, Suggestive evidence for inhibitory effects of galanin on mesolimbic dopaminergic neurotransmission, Brain Research, vol.822, issue.1-2, pp.200-209, 1999.
DOI : 10.1016/S0006-8993(99)01144-0

J. R. Mccarrey, The epigenome as a target for heritable environmental disruptions of cellular function, Molecular and Cellular Endocrinology, vol.354, issue.1-2, pp.9-15, 2012.
DOI : 10.1016/j.mce.2011.09.014

S. V. Fernandez, Expression and DNA methylation changes in human breast epithelial cells after bisphenol A exposure, International Journal of Oncology, vol.41, pp.369-377, 2012.
DOI : 10.3892/ijo.2012.1444

J. G. Bromer, Y. Zhou, M. B. Taylor, L. Doherty, and H. S. Taylor, Bisphenol-A exposure in utero leads to epigenetic alterations in the developmental programming of uterine estrogen response, The FASEB Journal, vol.24, issue.7, pp.2273-2280, 2010.
DOI : 10.1096/fj.09-140533

T. Doshi, C. Souza, V. Dighe, and G. Vanage, Effect of neonatal exposure on male rats to bisphenol a on the expression of DNA methylation machinery in the postimplantation embryo, Journal of Biochemical and Molecular Toxicology, vol.32, issue.137, pp.337-343, 2012.
DOI : 10.1002/jbt.21425

T. Yaoi, Genome-wide analysis of epigenomic alterations in fetal mouse forebrain after exposure to low doses of bisphenol A, Biochemical and Biophysical Research Communications, vol.376, issue.3, pp.563-567, 2008.
DOI : 10.1016/j.bbrc.2008.09.028

J. H. Kim, Perinatal bisphenol A exposure promotes dose-dependent alterations of the mouse methylome, BMC Genomics, vol.15, issue.1, p.30, 2014.
DOI : 10.1038/ng.471

Y. Li, Diethylstilbestrol (DES)-Stimulated Hormonal Toxicity is Mediated by ER?? Alteration of Target Gene Methylation Patterns and Epigenetic Modifiers (DNMT3A, MBD2, and HDAC2) in the Mouse Seminal Vesicle, Environmental Health Perspectives, vol.122, pp.262-268, 2014.
DOI : 10.1289/ehp.1307351

J. G. Bromer, J. Wu, Y. Zhou, and H. S. Taylor, Diethylstilbestrol Exposure: An Epigenetic Mechanism for Altered Developmental Programming, Endocrinology, vol.150, issue.7, pp.3376-3382, 2009.
DOI : 10.1210/en.2009-0071

K. Sato, Neonatal Exposure to Diethylstilbestrol Alters the Expression of DNA Methyltransferases and Methylation of Genomic DNA in the Epididymis of Mice, Endocrine Journal, vol.53, issue.3, pp.331-337, 2006.
DOI : 10.1507/endocrj.K06-009

W. Tang, 1 in Mouse Uteri Neonatally Exposed to Diethylstilbestrol or Genistein, Endocrinology, vol.149, issue.12, pp.5922-5931, 2008.
DOI : 10.1210/en.2008-0682

K. Sato, Neonatal Exposure to Diethylstilbestrol Alters Expression of DNA Methyltransferases and Methylation of Genomic DNA in the Mouse Uterus, Endocrine Journal, vol.56, issue.1, pp.131-139, 2009.
DOI : 10.1507/endocrj.K08E-239

S. Li, Neonatal diethylstilbestrol exposure induces persistent elevation of c-fos expression and hypomethylation in its exon-4 in mouse uterus, Molecular Carcinogenesis, vol.4, issue.2, pp.78-84, 2003.
DOI : 10.1002/mc.10147

A. Park, Regulation of dendritic arborization by BCR Rac1 GTPase-activating protein, a substrate of PTPRT, Journal of Cell Science, vol.125, issue.19, pp.4518-4531, 2012.
DOI : 10.1242/jcs.105502

S. Li, K. Haigh, J. J. Haigh, and A. Vasudevan, Endothelial VEGF Sculpts Cortical Cytoarchitecture, Journal of Neuroscience, vol.33, issue.37, pp.14809-14815, 2013.
DOI : 10.1523/JNEUROSCI.1368-13.2013

M. Brini, T. Calì, D. Ottolini, and E. Carafoli, Neuronal calcium signaling: function and dysfunction, Cellular and Molecular Life Sciences, vol.105, issue.28, 2014.
DOI : 10.1007/s00018-013-1550-7

E. Masliah, W. Dumaop, D. Galasko, and P. Desplats, Distinctive patterns of DNA methylation associated with Parkinson disease, Epigenetics, vol.57, issue.10, pp.1030-1038, 2013.
DOI : 10.2307/3001534

Z. Kaminsky, A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorder, Molecular Psychiatry, vol.38, issue.7, pp.728-740, 2012.
DOI : 10.1038/mp.2011.64

E. L. Dempster, Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder, Human Molecular Genetics, vol.20, issue.24, pp.4786-4796, 2011.
DOI : 10.1093/hmg/ddr416

S. Li, Developmental exposure to diethylstilbestrol elicits demethylation of estrogen-responsive lactoferrin gene in mouse uterus, Cancer Res, vol.57, pp.4356-4359, 1997.

A. Bhan, Histone Methyltransferase EZH2 Is Transcriptionally Induced by Estradiol as Well as Estrogenic Endocrine Disruptors Bisphenol-A and Diethylstilbestrol, Journal of Molecular Biology, vol.426, issue.20, pp.3426-3441, 2014.
DOI : 10.1016/j.jmb.2014.07.025

L. A. Hilakivi-clarke, Elevated in utero estrogenic environment may increase later breast cancer risk by down-regulating miRNAs, Abstract Cancer Res, vol.835, issue.71, pp.835-835, 2011.

B. Weber, C. Stresemann, B. Brueckner, and F. Lyko, Methylation of Human MicroRNA Genes in Normal and Neoplastic Cells, Cell Cycle, vol.6, issue.9, pp.1001-1005, 2007.
DOI : 10.4161/cc.6.9.4209

A. Lujambio, A microRNA DNA methylation signature for human cancer metastasis, Proceedings of the National Academy of Sciences, vol.105, issue.36, pp.13556-13561, 2008.
DOI : 10.1073/pnas.0803055105

Q. Cao, Coordinated Regulation of Polycomb Group Complexes through microRNAs in Cancer, Cancer Cell, vol.20, issue.2, pp.187-199, 2011.
DOI : 10.1016/j.ccr.2011.06.016

B. E. Walker, Tumors of female offspring of mice exposed prenatally to diethylstilbestrol, J. Natl. Cancer Inst, vol.73, pp.133-140, 1984.

V. S. Turusov, L. S. Trukhanova, P. Yud, and L. Tomatis, Occurrence of tumours in the descendants of CBA male mice prenatally treated with diethylstilbestrol, International Journal of Cancer, vol.73, issue.1
DOI : 10.1002/ijc.2910500126

R. R. Newbold, Increased tumors but uncompromised fertility in the female descendants of mice exposed developmentally to diethylstilbestrol, Carcinogenesis, vol.19, issue.9, pp.1655-1663, 1998.
DOI : 10.1093/carcin/19.9.1655

R. R. Newbold, Proliferative lesions and reproductive tract tumors in male descendants of mice exposed developmentally to diethylstilbestrol, Carcinogenesis, vol.21, issue.7, pp.1355-1363, 2000.
DOI : 10.1093/carcin/21.5.355

P. Mahawong, Prenatal diethylstilbestrol induces malformation of the external genitalia of male and female mice and persistent second-generation developmental abnormalities of the external genitalia in two mouse strains, Differentiation, vol.88, issue.2-3, pp.51-69, 2014.
DOI : 10.1016/j.diff.2014.09.005

H. Klip, Hypospadias in sons of women exposed to diethylstilbestrol in utero: a cohort study, The Lancet, vol.359, issue.9312, pp.1102-1107, 2002.
DOI : 10.1016/S0140-6736(02)08152-7

M. M. Brouwers, Hypospadias: a transgenerational effect of diethylstilbestrol?, Human Reproduction, vol.21, issue.3, pp.666-669, 2006.
DOI : 10.1093/humrep/dei398

L. Titus-ernstoff, Birth defects in the sons and daughters of women who were exposed in utero to diethylstilbestrol (DES), International Journal of Andrology, vol.166, issue.2, pp.377-384, 2010.
DOI : 10.1111/j.1365-2605.2009.01010.x

L. Titus-ernstoff, Offspring of Women Exposed In Utero to Diethylstilbestrol (DES), Epidemiology, vol.19, issue.2, pp.251-257, 2008.
DOI : 10.1097/EDE.0b013e318163152a

M. K. Skinner, Endocrine disruptor induction of epigenetic transgenerational inheritance of disease, Molecular and Cellular Endocrinology, vol.398, issue.1-2, 2014.
DOI : 10.1016/j.mce.2014.07.019

J. A. Hackett, Germline DNA Demethylation Dynamics and Imprint Erasure Through 5-Hydroxymethylcytosine, Science, vol.339, issue.6118, pp.448-452, 2013.
DOI : 10.1126/science.1229277

C. Guerrero-bosagna, M. Settles, B. Lucker, and M. K. Skinner, Epigenetic Transgenerational Actions of Vinclozolin on Promoter Regions of the Sperm Epigenome, PLoS ONE, vol.5, issue.9, 2010.
DOI : 10.1371/journal.pone.0013100.s005

E. Heard and R. A. Martienssen, Transgenerational Epigenetic Inheritance: Myths and Mechanisms, Cell, vol.157, issue.1, pp.95-109, 2014.
DOI : 10.1016/j.cell.2014.02.045

D. Crews and A. C. Gore, Life Imprints: Living in a Contaminated World, Environmental Health Perspectives, vol.119, issue.9, pp.1208-1210, 2011.
DOI : 10.1289/ehp.1103451

P. Marx-stoelting, Assessment of three approaches for regulatory decision making on pesticides with endocrine disrupting properties, Regulatory Toxicology and Pharmacology, vol.70, issue.3, 2014.
DOI : 10.1016/j.yrtph.2014.09.001