A. A. Zink-s, L. N. Von, and A. , Comparative assessment of virulence traits in Legionella spp, Microbiology, vol.149, pp.631-672, 2003.

A. H. , E. J. Forey-f, R. M. Girardo-p, and . Farge-p, Legionella pneumophila serogroup 1 strain Paris: endemic distribution throughout France, J Clin Microbiol, issue.7, pp.41-3320, 2003.

A. H. Farge-p, M. H. Gouy-m, and L. G. Forey-f, Clinical and environmental isolates of Legionella pneumophila serogroup 1 cannot be distinguished by sequence analysis of two surface protein genes and three housekeeping genes, Appl Environ Microbiol, vol.71, issue.1, pp.282-291, 2005.

B. M. , S. M. Anson, . P. Bandyopadhyay, C. Y. Byrne-b, and S. S. Swanson-m, Genetie evidence that Legionella pneumophila RpoS modulates expression of the transmission phenotype in both the exponential phase and the stationary phaseLegionella pneumophila catalase-peroxidases are required for proper trafficking and growth in primary macrophages, Infect Immun Infect Immun, vol.72, issue.5 68, pp.2468-76, 2003.

B. J. Brown-m and G. J. Collier-p, Relationship between Legionella pneumophila and Acanthamoeba polyphaga: physiological status and susceptibility to chemical inactivation, Appl Environ Microbiol, issue.8, pp.58-2420, 1992.

B. C. Wahara and H. M. , Complement component C3 fixes selectively to the major outer membrane protein (MOMP) of Legionella pneumophila and mediates phagocytosis of liposome-MOMP complexes by human monocytes, J Exp Med, vol.172, issue.4, pp.1201-1211, 1990.

O. R. Bens and F. B. , Classification of the genus Legionella, Sernin Respir Infect, vol.13, issue.2, pp.90-99, 1998.

B. R. Thacker-w, A. M. Daneshv, and B. D. , Legionella waltersii sp. nov. and an unnamed Legionella genomospecies isolated from water in Australia, Int J Syst Bacteriol, vol.46, issue.3, pp.631-635, 1996.

B. G. Fernandez-r, H. D. , B. S. , and M. , Virulence of patient and water isolates of Legionella pneumophila in guinea pigs and mouse L929 cells varies with bacterial genotype, Can J Microbiol, issue.6, pp.40-426, 1994.

B. H. , N. S. , V. H. An, S. J. Den, and B. J. Peeters-m, Subclinical Legionella infection in workers near the source of a large outbreak of Legionnaires disease, J Infect Dis, vol.184, issue.4, pp.515-523, 2001.

B. D. Steigerwalt-a, . Epple-p, . F. Bibb-w, . M. Mckinney-r, and . W. Starnes-r, Legionella pneumophila serogroup Lansing 3 isolated from a patient with fatal pneumonia, and descriptions of L. pneumophila subsp. pneumophila subsp. nov., L. pneumophila subsp. fraseri subsp. nov., and L. pneumophila subsp. pascullei subsp. nov, J Clin Microbiol, vol.26, issue.9, pp.1695-703, 1988.

B. J. , F. P. Kunkel-r, C. C. , H. M. , and F. J. , Replicative Legionella pneumophila lung infection in intratracheally inoculated A/J mice. A murine model of human Legionnaires' disease, Am J Pathol, issue.6, pp.145-1537, 1994.

B. J. , F. J. , R. D. Legendre-m, and E. N. Mcclain-m, The role of Legionella pneumophila-infected Hartmannella vermiformis as an infectious particle in a murine model of Legionnaire's disease, Infect Immun, issue.12, pp.65-5330, 1997.

B. A. Vickers-r, L. M. Elder-e, and G. G. , Plasmid and surface antigen markers of endemic and epidemic Legionella pneumophila strains, J Clin Microbiol, vol.16, issue.2, pp.230-235, 1982.

B. A. Mcgraw-b, P. K. Selander-r, and W. T. , Sequence polymorphism of dotA and mip alleles mediating invasion and intracellular replication of Legionella pneumophila, Curr Microbiol, vol.44, issue.5, pp.314-336, 2002.

C. C. , J. S. Bitar-d, and C. D. Maine-c, Les légionelloses survenues en France en, BEH, vol.26, pp.129-132, 2004.

C. J. Gudiol-f, D. J. Pallares-r, and A. J. Verdaguer-r, Risk factors for nosocomial Legionella pneumophila pneumonia, Am J Respir Crit Care Med, vol.1493, issue.1, pp.625-634, 1994.

C. C. , R. C. Bruggemann-h, M. A. Zidane-n, and M. L. , Evidence in the Legionella pneumophila genome for exploitation of host cell fonctions and high genome plasticity, Nat Genet, issue.11, pp.36-1165, 2004.

C. R. Suga, . Koike-t, . Lopez-r, and H. J. Gibson-t, Multiple sequence alignment with the Clustal series of programs, Nucleic Acids Res, issue.13, pp.31-3497, 2003.

C. M. Morozov, . Shi-s, C. J. Sheng-h, and . M. Gomez-s, The genomic sequence of the accidentai pathogen Legionella pneumophila, Science, issue.5692, pp.305-1966, 2004.

C. J. , C. S. , Y. L. Bermudez-l, F. S. , and T. L. , Intracellular growth in Acanthamoeba castellanii affects monocyte entry mechanisms and enhances virulence of Legionella pneumophila, Infect Immun, vol.67, issue.9, pp.4427-4461, 1999.

C. S. Bermudez-l, . H. El-etr-s, and C. E. Duhamel-g, Legionella pneurnophila entry gene rtxA is involved in virulence, Infect Immun, vol.69, issue.1, pp.508-525, 2001.

C. G. Vogel-j and I. R. , The Legionella pneurnophila LidA protein: a translocated substrate of the Dot/lem system associated with maintenance of bacterial integrity, Mol Microbiol, vol.48, issue.2, pp.305-326, 2003.

T. F. Rozen-d and L. R. , Parallel changes in gene expression after 20,000 generations of evolution in Escherichiacoli, Proc Natl Acad Sei US A, pp.1072-1079, 2003.

D. P. Brenner-d, W. L. Thacker-w, . Vesey-g, and . Steigerw-alt-ag, Five new Legionella species isolated from water, Int J Syst Bacteriol, vol.43, issue.2, pp.329-366, 1993.

D. C. Heuner-k, H. C. Brand-b, and S. , Flagellum of Legionella pneumophila positively affects the early phase of infection of eukaryotic host cells, Infect Immun, vol.69, issue.4, pp.2116-2138, 2001.

D. A. , A. H. , R. M. , L. G. , F. J. et al., Clinical and environmental distributions of Legionella strains in France are different, J Clin Microbiol, vol.42, issue.1, pp.458-60, 2004.

E. P. Beer-k and D. E. , Influence of growth temperature on virulence of Legionella pneurnophila, Infect Immun, vol.55, issue.11, pp.2701-2706, 1987.

F. B. , B. R. , B. R. Fields-b, J. B. Shotts-e, . C. Feeley-j et al., Legionella and Legionnaires' disease: 25 years of investigationProliferation of Legionella pneumophila as an intracellular parasite of the ciliated protozoan Tetrahymena pyriformis, Clin Microbiol Rev. Appl Environ Microbiol, vol.15, issue.433, pp.506-532, 1984.

F. G. Bang-h, L. B. Mann-k, and H. , Mip protein of Legionella pneumophila exhibits peptidyl-prolyl-cis/trans isomerase (PPlase) activity, Mol Microbiol, vol.6, issue.10, pp.1375-83, 1992.

F. A. , G. S. Faigle-m, C. N. Stevanovic-s, and N. , Novel lysophospholipase A secreted by Legionella pneumophila, J Bacteriol, vol.183, issue.6, pp.2121-2125, 2001.

F. C. , C. W. Orrison-l, S. S. , T. D. , and P. D. , Ecological distribution of Legionella pneumophila, Appl Environ Microbiol, vol.41, issue.1, pp.9-16, 1981.

F. N. Alexiou-daniel, B. J. Bernander-s, and E. M. Castellani, A multicenter evaluation of genotypic methods for the epidemiologic typing of Legionella pneumophila serogroup 1: results of a pan-European study, Clin Microbiol Infect, vol.5, issue.8, pp.462-477, 1999.

N. K. Warwick-s, S. N. , and E. T. , The use of 16S ribosomal RNA analyses to investigate the phylogeny of the family Legionellaceae, J Gen Microbiol, vol.137, issue.5, pp.1215-1237, 1991.

G. V. Fry-n, A. B. Luck-p, M. H. , and E. J. , Consensus sequence-based scheme for epidemiological typing of clinical and environmental isolates of Legionella pneumophila, J Clin Microbiol, vol.43, issue.5, pp.2047-52, 2005.

G. V. Fry-n, H. T. , and P. , Sequence-based typing of Legionella pneumophila serogroup 1 offers the potential for true portability in legionellosis outbreak investigation, J Clin Microbiol, issue.7, pp.41-2932, 2003.

G. D. Hernandez-v, . H. Nguyen-l, and C. B. Jensen-d, Synthesis of the stationary-phase sigma factor sigmas is positively regulated by ppGpp, J Bacteriol, issue.24, pp.175-7982, 1993.

G. H. , H. S. Enright-m, W. C. Tamia, and . J. Feil-e, Determining the genetic structure of the natural population of Staphylococcus aureus: a comparison of multilocus sequence typing with pulsed-field gel electrophoresis, randomly amplified polymorphie DNA analysis, and phage typing, J Clin Microbiol, issue.12, pp.40-4544, 2002.

O. S. and A. Kwaik-y, Identification of the aspartate-beta-semialdehyde dehydrogenase gene of Legionella pneumophila and characterization of a null mutant, Infect Immun, vol.66, issue.5, pp.1898-903, 1998.

H. O. Gao-l and A. Kwaik-y, From protozoa to mammalian cells: a new paradigm in the life cycle of intracellular bacterial pathogens, Environ Microbiol, vol.2, issue.3, pp.251-65, 2000.

H. R. Roller-c, S. R. , and G. K. , Effect of sait concentration and temperature on survival of Legionella pneumophila, Lett Appl Microbiol, vol.26, issue.1, pp.64-72, 1998.

H. K. Bender-beck, . C. Brand-b, . C. Luck-p, . H. Mann-k, and . Marre-r, Cloning and genetic characterization of the flagellum subunit gene (jlaA) of Legionella pneumophila serogroup 1, Infect Immun, issue.7, pp.63-2499, 1995.

J. M. Kvint-k and N. Shingler-v, Regulation of sigma factor competition by the alarmone ppGpp, Genes Dev, vol.16, issue.10, pp.1260-70, 2002.

K. C. Fields-b, J. B. Shotts-e, and W. E. , Effects of cytochalasin D and methylamine on intracellular growth of Legionella pneumophila in amoebae and human monocyte-like cells, Infect Immun, vol.59, issue.3, pp.758-63, 1991.

K. S. , L. H. , P. M. , L. K. , and Y. Y. Woo-s, Application of RNA polymerase beta-subunit gene (rpoB) sequences for the molecular differentiation of Legionella species, J Clin Microbiol, issue.7, pp.40-2653, 2002.

K. R. , F. J. Konig-b, F. M. Luneberg-e, and R. J. , Biochemical and functional analyses of the Mip protein: influence of the N-terminal half and of peptidylprolyl isomerase activity on the virulence of Legionella pneumophila, Infect Immun, issue.8, pp.71-4389, 2003.

K. H. , T. H. Yamamoto-h, K. K. , and S. , Evaluation of the activity of antimicrobial agents against Legionella pneumophila multiplying in a human monocytic cell line, THP-1, and an alveolar epithelial cell line, A549, J Infect Chemother, vol.6, issue.4, pp.206-216, 2000.

L. T. Vickers-r, Y. V. , W. , and G. M. , Growth of 28 Legionella species on selective culture media: a comparative study, J Clin Microbiol, issue.10, pp.31-2764, 1993.

M. R. Scheel-t and C. N. , Discovery of a nonclassical siderophore, legiobactin, produced by strains of Legionella pneumophila, J Bacteriol, vol.182, issue.3, pp.749-57, 2000.

M. R. Viswanathan-v and C. N. , Identification and temperature regulation of Legionella pneumophila genes involved in type IV pilus biogenesis and type II protein secretion, Infect Immun, vol.66, issue.4, pp.1776-82, 1998.

P. F. , R. S. , M. H. , R. M. Lasne-y, and G. P. , Legionella gresilensis sp. nov. and Legionella beliardensis sp. nov., isolated from water in France, Int J Syst Evol Microbiol, pp.51-1949, 2001.

L. E. , M. B. Dary, . Kooistra-o, . Zahringer-u, and . Rohde-m, Chromosomal insertion and excision of a 30 kb unstable genetic element is responsible for phase variation of lipopolysaccharide and other virulence determinants in Legionella pneumophila, Mol Microbiol, vol.39, issue.5, pp.1259-71, 2001.

L. E. Zahringer-u, K. Y. Steinmann-d, . Hartmann-m, and . Steinmetz-i, Phase-variable expression of lipopolysaccharide contributes to the virulence of Legionella pneumophila, J Exp Med, vol.188, issue.1, pp.49-60, 1998.

L. D. Fieser-n, . Gloggler-k, and M. Forsbach-birk-v, The response regulator LetA regulates the stationary-phase stress response in Legionella pneumophila and is required for efficient infection of Acanthamoeba castellanii, FEMS Microbiol Lett, vol.219, issue.2, pp.241-249, 2003.

M. J. Mathur-r and I. R. Maxfield-boumil-r, Analysis of the Legionella pneumophila flil gene: intracellular growth of a defined mutant defective for flagellum biosynthesis, Infect Immun, issue.6, pp.65-2497, 1997.

M. P. , H. S. , C. D. , C. C. Guitard-c, and . Brigaud-t, Epidémie communautaire de légionellose, Pas-de, BEH, pp.36-37, 2003.

M. A. and S. M. Anson, Legionella pneumophila CsrA is a pivotai repressor of transmission traits and activator of replication, Mol Microbiol, vol.50, issue.2, pp.445-61, 2003.

M. A. , S. Ans, and O. M. , Differentiate to thrive: lessons from the Legionella pneumophila life cycle, Mol Microbiol, vol.53, issue.1, pp.29-40, 2004.

M. R. , F. T. Brown-e, P. J. Fields-b, and D. R. , Role of biofilms in the survival of Legionella pneumophila in a model potable-water system, Microbiology, pp.147-3121, 2001.

N. H. , K. J. Zhu-x, and R. A. Kahn-r, A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes, Science, issue.5555, pp.295-679, 2002.

O. M. Messner-p, H. J. , M. R. , and H. , Temperature-dependent expression of flagella in Legionella, J Gen Microbiol, vol.137, issue.8, pp.1955-61, 1991.

M. Y. Ko-k, L. H. , P. M. , and K. Y. , Legionella busanensis sp. nov., isolated from cooling tower water in Korea, Int J Syst Evol Microbiol, pp.53-77, 2003.

P. J. , M. L. , B. R. , G. C. , and C. P. Breiman-r, Comparison of Legionella pneumophila isolates by -arbitrarily primed PCR and pulsed-field gel electrophoresis: analysis from seven epidemic investigations, J Clin Microbiol, issue.11, pp.33-2872, 1995.

R. S. , R. P. , H. R. , P. M. Wenzel-r, and . M. Helms-c, Persistence of Legionella pneumophila in a hospital's water system: a 13-year survey, Infect Control Hosp Epidemiol, vol.20, issue.12, pp.793-800, 1999.

-. A. Riboldl, J. S. Konig-b, R. S. Weiss-m, and . Hacker-j, Crystal structure of Mip, a prolylisomerase from Legionella pneumophila, Nat Struct Biol, vol.8, issue.9, pp.779-83, 2001.

J. M. Mallet-m and R. E. Fournier-p, Real-time PCR for universal antibiotic susceptibility testing, J Antimicrob Chemother, vol.54, issue.2, pp.538-579, 2004.

S. M. , C. S. , R. D. Bermudez-l, and C. J. , Genetie and phenotypic differences between Legionella pneumophila strains, J Clin Microbiol, vol.40, issue.4, pp.1352-62, 2002.

S. K. , M. A. Kukarin-a, . Muzzin-o, and D. S. Bass-i, Structural modules of the large subunits of RNA polymerase. Introducing archaebacterial and chloroplast split sites in the beta and beta' subunits of Escherichia coli RNA polymerase, J Biol Chem, issue.44, pp.271-27969, 1996.

S. B. and A. Kwaik-y, Expression of multiple pili by Legionella pneumophila: identification and characterization of a type IV pilin gene and its role in adherence to marnrnalian and protozoan cells, Infect Immun, vol.66, issue.4, pp.1768-75, 1998.

J. E. , Y. V. Studemann, . Noirclerc-sa, . M. Voye, . Klauck-e et al., LegionellosisSequential recognition of two distinct sites in sigma(S) by the proteolytic targeting factor RssB and ClpX, N Engl J Med Embo J, vol.337, issue.1016, pp.682-689, 1997.

T. S. , Y. M. , Y. Y. Kobayashi-y, and T. Konno-t, Establishment and characterization of a human acute monocytic leukemia cell line (THP-1), Int J Cancer, vol.26, issue.2, pp.171-177, 1980.

V. V. Edelstein-p and C. D. Pope-c, The Legionella pneumophila iraAB locus is required for iron assimilation, intracellular infection, and virulence, Infect Immun, vol.68, issue.3, pp.1069-79, 2000.

W. N. Frost, C. , and M. , Detection of Legionellae in hospital water samples by quantitative real-time LightCycler PCR, Appl Environ Microbiol, vol.67, issue.9, pp.3985-93, 2001.