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Master Thesis

Le rôle de l'intégrité du faisceau cortico-réticulo-spinal dans récupération des fonctions motrices et de la marche après un AVC ischémique, une étude longitudinale en imagerie en tenseur de diffusion et tractographie

Abstract : Stroke is the leading cause of acquired disability in adults in France. The diffusion tensor imaging (DTI) showed interest in the study of the integrity of corticospinal tract (CST) as a prognostic marker for functional recovery, but the corticoreticulospinal tract (CRT), could play a key role in the recovery of walking. Our main objective was to determine whether there was a significant correlation between the structural integrity of CRT and motor and functional recovery, and walking in patients with ischemic stroke and moderate to severe lesion of the CST. We used data from 26 patients with carotid ischemic stroke and 14 controls aged 18-70 years. The clinical evaluation and imaging of DTI and tractography was performed at 1 and 6 months post stroke. Our study is innovative in several respects: it shows that the analysis of the integrity of the motor tracts is the most relevant in sub-acute phase (one month) after stroke; it excludes participation contralesional CST by its direct fiber in the recovery of walking; finally, it shows the role of ipsilesionnal CRT in the recovery of walking: the most relevant biomarker for predicting recovery of walking being the combined analysis of the FA CST and CRT.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01215665
Contributor : Jean-Hugues Morneau <>
Submitted on : Wednesday, October 14, 2015 - 4:25:00 PM
Last modification on : Wednesday, July 15, 2020 - 8:58:04 AM
Long-term archiving on: : Thursday, April 27, 2017 - 4:44:35 AM

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  • HAL Id : dumas-01215665, version 1

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Coline Huber. Le rôle de l'intégrité du faisceau cortico-réticulo-spinal dans récupération des fonctions motrices et de la marche après un AVC ischémique, une étude longitudinale en imagerie en tenseur de diffusion et tractographie. Médecine humaine et pathologie. 2015. ⟨dumas-01215665⟩

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