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Master Thesis

Relaxométrie par résonance magnétique dans les maladies hépatiques chroniques : comparaison de la cartographie T1, T2 et de l’imagerie de diffusion pour le diagnostic et l’évaluation de la sévérité de la cirrhose

Abstract : Background: MR relaxometry has been extensively studied in the field of cardiac diseases, but its contribution to liver imaging is unclear. We aimed to compare liver and spleen T1 mapping, T2 mapping, and diffusion-weighted MR imaging (DWI) for assessing the diagnosis and severity of cirrhosis. Methods: We prospectively included 129 patients with normal (n=40) and cirrhotic livers (n=89) from May to September 2014. Non-enhanced liver T1 mapping, splenic T2 mapping, and liver and splenic DWI were measured and compared for assessing cirrhosis severity using Child-Pugh score, MELD score, and presence or not of large esophageal varices (EVs) and liver stiffness measurements using Fibroscan(®) as reference. Results: Liver T1 mapping was the only variable demonstrating significant differences between normal patients (500±79ms), Child-Pugh A patients (574±84ms) and Child-Pugh B/C patients (690±147ms; all p-values <0.00001). Liver T1 mapping had a significant correlation with Child-Pugh score (Pearson's correlation coefficient of 0.46), MEDL score (0.30), and liver stiffness measurement (0.52). Areas under the receiver operating characteristic curves of liver T1 mapping for the diagnosis of cirrhosis (O.85; 95% confidence intervals (CI), 0.77-0.91), Child-Pugh B/C cirrhosis (0.87; 95%CI, 0.76-0.93), and large EVs (0.75; 95%CI, 0.63-0.83) were greater than that of spleen T2 mapping, liver and spleen DWI (all p-values<0.01). Conclusion: Liver T1 mapping is a promising new diagnostic tool for assessing cirrhosis diagnosis and severity, showing higher diagnostic accuracy than liver and spleen DWI, while T2 mapping is not reliable.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01216657
Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Friday, October 16, 2015 - 3:56:06 PM
Last modification on : Wednesday, August 23, 2017 - 4:33:32 PM
Long-term archiving on: : Monday, January 18, 2016 - 6:05:31 AM

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Matthieu Feldis. Relaxométrie par résonance magnétique dans les maladies hépatiques chroniques : comparaison de la cartographie T1, T2 et de l’imagerie de diffusion pour le diagnostic et l’évaluation de la sévérité de la cirrhose. Médecine humaine et pathologie. 2015. ⟨dumas-01216657⟩

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