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Master Thesis

Analyse des toxicités aigües digestives hautes recensées dans le PHRC TOMOREP

Abstract : Background and purpose: Soft-tissue sarcomas of the retroperitoneum (RPS) are rare tumors whose prognosis is locoregional. Neoadjuvant radiation therapy (NRT) has several theoretical benefits. The purpose of this abstract was to evaluate the acute duodenal and jejuno-ileal toxicity associated with NRT and "en bloc" surgery for RPS through TOMOREP’s population. Material and Methods: TOMOREP was a national phase 2 trial including 48 patients. NRT was realized by Helical Tomotherapy radiotherapy. A dose of 54 Gy was delivered in daily fractions 6 to 8 weeks before surgery. Toxicity was assessed using the NCI Common Terminology Criteria for adverse Events through follow up consultation at two and six months after surgery. Results: Two of the 48 patients were not analyzed, one of which was due to a metastatic evolution during radiotherapy; the other was lost of view. Five patients died including three during the six months following surgery. After two months, two patients presented a duodenal toxicity of at least grade three. One of them was due to a grade three duodenal stenosis. The other one was a grade five linked to a duodenal fistula due to a partial resection. Three patients presented jejuno-ileal toxicity superior or equal to grade three including one grade four linked to a jejuno-ileal fistula. At six months no toxicity above grade 3 was found. Conclusion: Combination of Helical Tomotherapy Radiotherapy (54Gy) followed by en bloc surgery for RPS is feasible with acceptable toxicity.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01217397
Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Monday, October 19, 2015 - 3:19:04 PM
Last modification on : Wednesday, August 23, 2017 - 4:40:12 PM
Long-term archiving on: : Thursday, April 27, 2017 - 6:39:26 AM

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Clément Kintzinger. Analyse des toxicités aigües digestives hautes recensées dans le PHRC TOMOREP. Médecine humaine et pathologie. 2015. ⟨dumas-01217397⟩

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