45 3.2.1. Biopsies, p.45 ,
61 6.1.1, p.64 ,
plusieurs études cliniques sont en cours (PANACHE-01 et ESPAC-5) Ces études ont pour but d'évaluer de façon prospective et en intention de traiter, l'efficacité de différents traitements néoadjuvants chez les patients résécables d'emblée et borderline, p.90 ,
Reprint of: Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012, European Journal of Cancer, vol.51, issue.9, pp.1201-1203, 1990. ,
DOI : 10.1016/j.ejca.2015.05.004
Curative resection is the single most important factor determining outcome in patients with pancreatic adenocarcinoma, British Journal of Surgery, vol.91, issue.5 ,
DOI : 10.1002/bjs.4484
Cancer statistics, CA Cancer J Clin. 2015 Feb, vol.65, issue.1, pp.5-29, 2015. ,
DOI : 10.3322/caac.21208
Adjuvant Chemotherapy With Gemcitabine vs Observation in Patients Undergoing Curative-Intent Resection of Pancreatic Cancer, JAMA, vol.297, issue.3, pp.267-77, 2007. ,
DOI : 10.1001/jama.297.3.267
Adjuvant Chemotherapy With Fluorouracil Plus Folinic Acid vs Gemcitabine Following Pancreatic Cancer Resection, JAMA, vol.304, issue.10, pp.1073-81, 2010. ,
DOI : 10.1001/jama.2010.1275
Adjuvant chemoradiotherapy and chemotherapy in resectable pancreatic cancer: a randomised controlled trial, The Lancet, vol.358, issue.9293, pp.1576-85, 2001. ,
DOI : 10.1016/S0140-6736(01)06651-X
Preoperative/Neoadjuvant Therapy in Pancreatic Cancer: A Systematic Review and Meta-analysis of Response and Resection Percentages, PLoS Medicine, vol.23, issue.4, 2010. ,
DOI : 10.1371/journal.pmed.1000267.s005
Neoadjuvant therapy in pancreatic adenocarcinoma: A meta-analysis of phase II trials, Surgery, vol.150, issue.3, pp.466-73, 2011. ,
DOI : 10.1016/j.surg.2011.07.006
Neoadjuvant chemoradiation and pancreaticoduodenectomy for initially locally advanced head pancreatic adenocarcinoma, European Journal of Surgical Oncology (EJSO), vol.35, issue.12, pp.1306-1317, 2009. ,
DOI : 10.1016/j.ejso.2009.06.005
URL : https://hal.archives-ouvertes.fr/hal-00556315
Pancreaticoduodenectomy following chemoradiotherapy for locally advanced adenocarcinoma of the pancreatic head, HPB, vol.15, issue.9, pp.716-739, 2013. ,
DOI : 10.1111/hpb.12039
Gemcitabine in the chemoradiotherapy for locally advanced pancreatic cancer: A meta-analysis, Radiotherapy and Oncology, vol.99, issue.2, pp.108-121, 2011. ,
DOI : 10.1016/j.radonc.2011.04.001
A phase II single institutional experience with preoperative radiochemotherapy in pancreatic adenocarcinoma, European Journal of Surgical Oncology (EJSO), vol.28, issue.5, 2002. ,
DOI : 10.1053/ejso.2002.1293
A Randomized Phase 2 Trial of Neoadjuvant Chemotherapy in Resectable Pancreatic Cancer: Gemcitabine Alone Versus Gemcitabine Combined with Cisplatin, Annals of Surgical Oncology, vol.223, issue.11, pp.2088-96, 2007. ,
DOI : 10.1245/s10434-007-9384-x
Fluorouracil vs Gemcitabine Chemotherapy Before and After Fluorouracil-Based Chemoradiation Following Resection of Pancreatic Adenocarcinoma, JAMA, vol.299, issue.9, pp.1019-1045, 2008. ,
DOI : 10.1001/jama.299.9.1019
Cancers with increasing incidence trends in the United States: 1999 through 2008, CA: A Cancer Journal for Clinicians, vol.37, issue.RR-16, pp.118-146, 2008. ,
DOI : 10.3322/caac.20141
Survival among patients with adenocarcinoma of the pancreas: a population-based study (United States). Cancer Causes Control CCC, 2006. ,
1423 Pancreaticoduodenectomies for Pancreatic Cancer: A Single-Institution Experience???, Journal of Gastrointestinal Surgery, vol.10, issue.9, pp.1199-210, 2006. ,
DOI : 10.1016/j.gassur.2006.08.018
Pancreatic adenocarcinoma in a young patient population--12-year experience at Memorial Sloan ,
Sixty-One Years of Pancreatic Cancer in Denmark From 1943 to 2003, Pancreas, vol.38, issue.4, pp.374-382, 2009. ,
DOI : 10.1097/MPA.0b013e31819b71ae
Monographs on the evaluation of carcinogenic risks to Humans Tobacco smoke and involuntary smoking, IARC, vol.83, 2004. ,
Tobacco and the risk of pancreatic cancer: a review and meta-analysis. Langenbecks Arch Surg Dtsch Ges Für Chir, pp.535-580, 2008. ,
Body Mass Index and Risk, Age of Onset, and Survival in Patients With Pancreatic Cancer, JAMA, vol.301, issue.24, pp.2553-62, 2009. ,
DOI : 10.1001/jama.2009.886
Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies, British Journal of Cancer, vol.95, issue.11, pp.2076-83, 2005. ,
DOI : 10.1093/jnci/89.18.1360
Antidiabetic Therapies Affect Risk of Pancreatic Cancer, Gastroenterology, vol.137, issue.2, pp.482-490, 2009. ,
DOI : 10.1053/j.gastro.2009.04.013
Past Medical History and Pancreatic Cancer Risk: Results From a Multicenter Case-Control Study, Annals of Epidemiology, vol.20, issue.2, pp.92-100, 2010. ,
DOI : 10.1016/j.annepidem.2009.11.010
URL : https://hal.archives-ouvertes.fr/hal-01260406
Familial pancreatic cancer, Arch Pathol Lab Med, vol.133, issue.3, pp.365-74, 2009. ,
Identification and screening of individuals at increased risk for pancreatic cancer with emphasis on known environmental and genetic factors and hereditary syndromes, JOP J Pancreas, vol.11, issue.3, pp.203-215, 2010. ,
Advances in counselling and surveillance of patients at risk for pancreatic cancer, Gut, vol.56, issue.10, 2007. ,
DOI : 10.1136/gut.2006.108456
Genetic alterations in precancerous pancreatic lesions and their clinical implications, Gastroent??rologie Clinique et Biologique, vol.33, issue.10-11, pp.10-111028, 2009. ,
DOI : 10.1016/j.gcb.2009.08.007
Influence of Resection Margins on Survival for Patients With Pancreatic Cancer Treated by Adjuvant Chemoradiation and/or Chemotherapy in the ESPAC-1 Randomized Controlled Trial, Annals of Surgery, vol.234, issue.6, pp.758-68, 2001. ,
DOI : 10.1097/00000658-200112000-00007
Classification of R1 resections for pancreatic cancer: the prognostic relevance of tumour involvement within 1???mm of a resection margin, Histopathology, vol.27, issue.18 suppl (abstr, pp.277-83, 2009. ,
DOI : 10.1111/j.1365-2559.2009.03376.x
The retroperitoneal resection margin and vessel involvement are important factors determining survival after pancreaticoduodenectomy for ductal adenocarcinoma of the head of the pancreas, Virchows Archiv, vol.433, issue.3, pp.237-279, 1998. ,
DOI : 10.1007/s004280050242
Monographie de l'Association française de chirurgie. Cancer du pancréas, 2010. ,
Pancreatic carcinoma: the role of high-resolution multislice spiral CT in the diagnosis and assessment of resectability, Eur Radiol, vol.13, issue.1, pp.149-56, 2003. ,
Pancreatic adenocarcinoma: diagnosis and staging using multidetector-row computed tomography (MDCT) and magnetic resonance imaging (MRI), Cancer Imaging, vol.7, issue.Special Issue A, 2007. ,
DOI : 10.1102/1470-7330.2007.9010
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727968
Pancreatic tumors: comparison of dual-phase helical CT and endoscopic sonography., American Journal of Roentgenology, vol.170, issue.5, pp.1315-1337, 1998. ,
DOI : 10.2214/ajr.170.5.9574609
Preoperative tissue diagnosis for tumours of the pancreas, British Journal of Surgery, vol.36, issue.1, pp.5-20, 2009. ,
DOI : 10.1002/bjs.6407
Review of endoscopic ultrasound-guided fine-needle aspiration cytology, Diagnostic Cytopathology, vol.31, issue.2, pp.140-75, 2006. ,
DOI : 10.1002/dc.20300
Diagnostic challenge in autoimmune pancreatitis: beware of shipwreck!, Gut, vol.57, issue.12, pp.1646-1653, 2008. ,
DOI : 10.1136/gut.2008.158972
Diagnosis of autoimmune pancreatitis by core needle biopsy: application of six microscopic criteria, Virchows Archiv, vol.15, issue.Suppl 1, 2009. ,
DOI : 10.1007/s00428-009-0747-5
Pancreatic Adenocarcinoma, Version 2.2014, J Natl Compr Canc Netw, vol.12, issue.8, pp.1083-93, 2014. ,
org -Société savante médicale française d'hépatogastroentérologie et d'oncologie digestive [Internet], 2015. ,
Duodénopancréatectomie céphalique. EMC -Tech Chir -Appar Dig, 2011. ,
Pancreatic Adenocarcinoma with Venous Involvement: Is Up-Front Synchronous Portal-Superior Mesenteric Vein Resection Still Justified? A Survey of the Association Fran??aise de Chirurgie, Annals of Surgical Oncology, vol.19, issue.suppl 3, pp.1874-83 ,
DOI : 10.1245/s10434-014-4304-3
Should the Portal Vein Be Routinely Resected During Pancreaticoduodenectomy For Adenocarcinoma?, Annals of Surgery, vol.257, issue.4, 2013. ,
DOI : 10.1097/SLA.0b013e318269d23c
Indications and Techniques of Extended Resection for Pancreatic Cancer, World Journal of Surgery, vol.28, issue.6, pp.976-82, 2006. ,
DOI : 10.1007/s00268-005-0438-6
Is pancreatectomy with arterial reconstruction a safe and useful procedure for locally advanced pancreatic cancer?, Journal of Hepato-Biliary-Pancreatic Surgery, vol.13, issue.6, pp.850-857, 2009. ,
DOI : 10.1007/s00534-009-0190-7
Concomitant Benefit of Preoperative Irradiation in Preventing Pancreas Fistula Formation After Pancreatoduodenectomy, Archives of Surgery, vol.126, issue.7, pp.885-894, 1960. ,
DOI : 10.1001/archsurg.1991.01410310095014
Hemorrhage after Duodenopancreatectomy: Impact of Neoadjuvant Radiochemotherapy and Experience with Sentinel Bleeding, World Journal of Surgery, vol.133, issue.2, pp.212-218, 2005. ,
DOI : 10.1007/s00268-004-7557-3
Neoadjuvant therapy for Non-metastatic Pancreatic Ductal Adenocarcinoma, Seminars in Oncology, vol.42, issue.1, pp.86-97 ,
DOI : 10.1053/j.seminoncol.2014.12.008
Neoadjuvant therapy in resectable pancreatic cancer: A critical review, Cancer Treatment Reviews, vol.39, issue.5, pp.518-542, 2013. ,
DOI : 10.1016/j.ctrv.2012.09.008
Neoadjuvant 5 Fluorouracil-Cisplatin Chemoradiation Effect on Survival in Patients with Resectable Pancreatic Head Adenocarcinoma: A Ten-Year Single Institution Experience, Oncology, vol.76, issue.6, pp.413-422, 2009. ,
DOI : 10.1159/000215928
Optimal Duration and Timing of Adjuvant Chemotherapy After Definitive Surgery for Ductal Adenocarcinoma of the Pancreas: Ongoing Lessons From the ESPAC-3 Study, Journal of Clinical Oncology, vol.32, issue.6, pp.504-516, 2014. ,
DOI : 10.1200/JCO.2013.50.7657
Pancreaticoduodenectomy After Placement of Endobiliary Metal Stents, Journal of Gastrointestinal Surgery, vol.9, issue.8, pp.1094-104, 2005. ,
DOI : 10.1016/j.gassur.2005.08.006
Feasibility of preoperative combined radiation therapy and chemotherapy with 5-fluorouracil and cisplatin in potentially resectable pancreatic adenocarcinoma: The French SFRO-FFCD 97-04 Phase II trial, International Journal of Radiation Oncology*Biology*Physics, vol.65, issue.5, pp.1471-1479, 2006. ,
DOI : 10.1016/j.ijrobp.2006.02.054
URL : https://hal.archives-ouvertes.fr/hal-00428006
Neoadjuvant Chemoradiation for Localized Adenocarcinoma of the Pancreas, Annals of Surgical Oncology, vol.18, issue.10:, 2001. ,
DOI : 10.1007/s10434-001-0758-1
Preoperative Gemcitabine-Based Chemoradiation for Patients With Resectable Adenocarcinoma of the Pancreatic Head, Journal of Clinical Oncology, vol.26, issue.21, pp.3496-502, 2008. ,
DOI : 10.1200/JCO.2007.15.8634
Neoadjuvant Chemotherapy Generates a Significant Tumor Response in Resectable Pancreatic Cancer Without Increasing Morbidity, Annals of Surgery, vol.248, issue.6, pp.1014-1036, 2008. ,
DOI : 10.1097/SLA.0b013e318190a6da
Neoadjuvante Radiochemotherapie mit Gemcitabin/Cisplatin gefolgt von Resektion versus prim??rer Resektion bei resektablem Pankreaskopfkarzinom, Strahlentherapie und Onkologie, vol.189, issue.5, pp.7-16, 2015. ,
DOI : 10.1007/s00066-014-0737-7
Gemcitabine in Combination With Oxaliplatin Compared With Gemcitabine Alone in Locally Advanced or Metastatic Pancreatic Cancer: Results of a GERCOR and GISCAD Phase III Trial, Journal of Clinical Oncology, vol.23, issue.15, pp.3509-3525, 2005. ,
DOI : 10.1200/JCO.2005.06.023
Induction gemcitabine and oxaliplatin therapy followed by a twice-weekly infusion of gemcitabine and concurrent external-beam radiation for neoadjuvant treatment of locally advanced pancreatic cancer, Cancer, vol.138, issue.2, pp.277-84, 2013. ,
DOI : 10.1002/cncr.27736
A Multi- Institutional Phase II Study of Neoadjuvant Gemcitabine and Oxaliplatin with Radiation Therapy in Patients with Pancreatic Cancer. Cancer, pp.2692-700, 2013. ,
Neoadjuvant docetaxel-based chemoradiation for resectable adenocarcinoma of the pancreas: New neoadjuvant regimen was safe and provided an interesting pathologic response, European Journal of Surgical Oncology (EJSO), vol.36, issue.10, pp.987-92, 2010. ,
DOI : 10.1016/j.ejso.2010.07.003
Neoadjuvant gemcitabine, docetaxel, and capecitabine followed by gemcitabine and capecitabine/radiation therapy and surgery in locally advanced, unresectable pancreatic adenocarcinoma. Cancer, pp.673-80, 2015. ,
FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer, New England Journal of Medicine, vol.364, issue.19, pp.1817-1842, 2011. ,
DOI : 10.1056/NEJMoa1011923
URL : https://hal.archives-ouvertes.fr/hal-00598658
5-Fluorouracil/Leucovorin Combined with Irinotecan and Oxaliplatin (FOLFIRINOX) as Second-Line Chemotherapy in Patients with Advanced Pancreatic Cancer Who Have Progressed on Gemcitabine-Based Therapy, Chemotherapy, vol.59, issue.4, pp.273-282, 2013. ,
DOI : 10.1159/000356158
Neoadjuvant FOLFIRINOX for Borderline Resectable Pancreas Cancer: A New Treatment Paradigm?, The Oncologist, vol.19, issue.3, pp.266-74, 2014. ,
DOI : 10.1634/theoncologist.2013-0273
FOLFIRINOX for Locally Advanced Pancreatic Adenocarcinoma: Results of an AGEO Multicenter Prospective Observational Cohort, Annals of Surgical Oncology, vol.17, issue.11, pp.295-301 ,
DOI : 10.1245/s10434-014-3898-9
FOLFIRINOX in Locally Advanced Pancreatic Cancer: The Massachusetts General Hospital Cancer Center Experience, The Oncologist, vol.18, issue.5, pp.543-551, 2013. ,
DOI : 10.1634/theoncologist.2012-0435
Locally Advanced Pancreatic Adenocarcinoma: Reassessment of Response with CT after Neoadjuvant Chemotherapy and Radiation Therapy, Radiology, vol.273, issue.1, pp.108-124, 2014. ,
DOI : 10.1148/radiol.14132914
Classification of Surgical Complications, Annals of Surgery, vol.240, issue.2, pp.205-218, 2004. ,
DOI : 10.1097/01.sla.0000133083.54934.ae
Postoperative pancreatic fistula: An international study group (ISGPF) definition, Surgery, vol.138, issue.1, pp.8-13, 2005. ,
DOI : 10.1016/j.surg.2005.05.001
The Comprehensive Complication Index, Annals of Surgery, vol.258, issue.1, p.2013 ,
DOI : 10.1097/SLA.0b013e318296c732
Cancer du pancréas [Internet]. Thésaurus national de cancérologie digestive, 2015. ,
Frequency of major complications after EUS-guided FNA of solid pancreatic masses: a prospective evaluation, Gastrointestinal Endoscopy, vol.63, issue.4, pp.622-631, 2006. ,
DOI : 10.1016/j.gie.2005.05.024
EUS-guided fine-needle aspiration of the pancreas: Evaluation of pancreatitis as a complication, Gastrointestinal Endoscopy, vol.56, issue.6, pp.864-871, 2002. ,
DOI : 10.1016/S0016-5107(02)70361-1
Assessment of complications of EUS-guided fine-needle aspiration, Gastrointestinal Endoscopy, vol.53, issue.4, pp.470-474, 2001. ,
DOI : 10.1067/mge.2001.112839
Preoperative Biliary Drainage for Cancer of the Head of the Pancreas, New England Journal of Medicine, vol.362, issue.2, pp.129-166, 2010. ,
DOI : 10.1056/NEJMoa0903230
Pre-operative biliary drainage for obstructive jaundice, Cochrane Database Syst Rev, vol.336, issue.3, p.5444, 2012. ,
DOI : 10.1002/14651858.CD005444.pub3
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164472
Radiological and Surgical Implications of Neoadjuvant Treatment With FOLFIRINOX for Locally Advanced and Borderline Resectable Pancreatic Cancer, Annals of Surgery, vol.261, issue.1, pp.12-19, 2015. ,
DOI : 10.1097/SLA.0000000000000867
Effect of chemoradiotherapy and neoadjuvant chemoradiotherapy in resectable pancreatic cancer: a systematic review and meta-analysis, Journal of Cancer Research and Clinical Oncology, vol.225, issue.4, pp.549-59 ,
DOI : 10.1007/s00432-013-1572-4
A Systematic Review of Resectability and Survival After Concurrent Chemoradiation in Primarily Unresectable Pancreatic Cancer, Annals of Surgical Oncology, vol.240, issue.Suppl 3, pp.194-205, 2010. ,
DOI : 10.1245/s10434-009-0762-4
Pancreaticoduodenectomy for Pancreatic Adenocarcinoma: Postoperative Adjuvant Chemoradiation Improves Survival, Annals of Surgery, vol.225, issue.5, 1997. ,
DOI : 10.1097/00000658-199705000-00018
Adjuvant Radiotherapy and 5-Fluorouracil After Curative Resection of Cancer of the Pancreas and Periampullary Region, Annals of Surgery, vol.230, issue.6, p.776, 1999. ,
DOI : 10.1097/00000658-199912000-00006
Preoperative chemoradiation in potentially resectable pancreatic adenocarcinoma: feasibility, treatment effect evaluation and prognostic factors, analysis of the SFRO-FFCD 9704 trial and literature review, Annals of Oncology, vol.20, issue.8 ,
DOI : 10.1093/annonc/mdp015
Long term morbidity of neoadjuvant chemoradiation for pancreatic head adenocarcinoma, European Journal of Surgical Oncology (EJSO), vol.32, issue.1, pp.77-86, 2006. ,
DOI : 10.1016/j.ejso.2005.10.004
Resection of Borderline Resectable and Locally Advanced Pancreatic Adenocarcinomas after Neoadjuvant Chemotherapy. Oncology, 2015. ,
Available from, 2015. ,