P. Sauder, M. Andreoletti, G. Cambonie, G. Capellier, M. Feissel et al., Sedation and analgesia in intensive care (with the exception of new-born babies) French Society of Anesthesia and Resuscitation. French-speaking Resuscitation Society], Ann Fr Anesthèsie Rèanimation. août, vol.27, pp.7-8541, 2008.

C. Arbour, M. Choinière, J. Topolovec-vranic, C. Loiselle, K. Puntillo et al., Detecting Pain in Traumatic Brain-injured Patients With Different Levels of Consciousness During Common Procedures in the ICU, The Clinical Journal of Pain, vol.30, issue.11, pp.960-969, 2014.
DOI : 10.1097/AJP.0000000000000061

M. Roulin and A. Ramelet, Behavioral changes in brain-injured critical care adults with different levels of consciousness during nociceptive stimulation: an observational study, Intensive Care Medicine, vol.17, issue.12, pp.1115-1138, 2014.
DOI : 10.1007/s00134-014-3380-y

S. Zafar and J. Suarez, Automated pupillometer for monitoring the critically ill patient: A critical appraisal, Journal of Critical Care, vol.29, issue.4, pp.599-603, 2014.
DOI : 10.1016/j.jcrc.2014.01.012

M. Larson, D. Sessler, D. Washington, B. Merrifield, J. Hynson et al., Pupillary Response to Noxious Stimulation During Isoflurane and Propofol Anesthesia, Anesthesia & Analgesia, vol.76, issue.5, pp.1072-1080, 1993.
DOI : 10.1213/00000539-199305000-00028

M. Larson, F. Tayefeh, D. Sessler, M. Daniel, and M. Noorani, Sympathetic Nervous System Does Not Mediate Reflex Pupillary Dilation during Desflurane Anesthesia, Anesthesiology, vol.85, issue.4, pp.748-54, 1996.
DOI : 10.1097/00000542-199610000-00009

L. Barvais, E. Engelman, J. Eba, E. Coussaert, F. Cantraine et al., Effect site concentrations of remifentanil and pupil response to noxious stimulation, British Journal of Anaesthesia, vol.91, issue.3, pp.347-52, 2003.
DOI : 10.1093/bja/aeg178

J. Paulus, A. Roquilly, H. Beloeil, J. Théraud, K. Asehnoune et al., Pupillary reflex measurement predicts insufficient analgesia before endotracheal suctioning in critically ill patients, Critical Care, vol.17, issue.4, p.161, 2013.
DOI : 10.1097/00000542-199710000-00019

URL : https://hal.archives-ouvertes.fr/inserm-00870106

S. Isnardon, M. Vinclair, C. Genty, A. Hebrard, P. Albaladejo et al., Pupillometry to detect pain response during general anaesthesia following unilateral popliteal sciatic nerve block, European Journal of Anaesthesiology, vol.30, issue.7, pp.429-463, 2013.
DOI : 10.1097/EJA.0b013e32835f0030

T. Bouillon, J. Bruhn, L. Radulescu, C. Andresen, T. Shafer et al., Pharmacodynamic Interaction between Propofol and Remifentanil Regarding Hypnosis, Tolerance of Laryngoscopy, Bispectral Index, and Electroencephalographic Approximate Entropy, Anesthesiology, vol.100, issue.6, pp.1353-72, 2004.
DOI : 10.1097/00000542-200406000-00006

M. Mertens, E. Olofsen, F. Engbers, A. Burm, J. Bovill et al., Propofol Reduces Perioperative Remifentanil Requirements in a Synergistic Manner, Anesthesiology, vol.99, issue.2, pp.347-59, 2003.
DOI : 10.1097/00000542-200308000-00016

S. Kern, G. Xie, J. White, and T. Egan, A Response Surface Analysis of Propofol???Remifentanil Pharmacodynamic Interaction in Volunteers, Anesthesiology, vol.100, issue.6, pp.1373-81, 2004.
DOI : 10.1097/00000542-200406000-00007

M. Larson, D. Sessler, M. Ozaki, J. Mcguire, and M. Schroeder, Pupillary Assessment of Sensory Block Level during Combined Epidural/General Anesthesia, Anesthesiology, vol.79, issue.1, pp.42-50, 1993.
DOI : 10.1097/00000542-199307000-00009

A. Lukaszewicz, D. Dereu, E. Gayat, and D. Payen, The Relevance of Pupillometry for Evaluation of Analgesia Before Noxious Procedures in the Intensive Care Unit, Anesthesia & Analgesia, vol.120, issue.6, pp.1297-300, 2015.
DOI : 10.1213/ANE.0000000000000609

C. Réanimation and . Grenoble, Le Comité de Protection des Personnes Sud Est II a donné un avis favorable en date du, 2014.