application recherche le pixel dont le renforcement est le plus élevé à l'intérieur de la zone d'intérêt, et le marque d'une mire de couleur ,
Decrease in the Stroke Case Fatality Rates in a French Population-Based Twenty-Year Study, Cerebrovascular Diseases, vol.24, issue.5, pp.439-483, 2007. ,
DOI : 10.1159/000108434
A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke, New England Journal of Medicine, vol.372, issue.1, pp.11-20, 2015. ,
DOI : 10.1056/NEJMoa1411587
Accuracy of dynamic perfusion CT with deconvolution in detecting acute hemispheric stroke, Am J Neuroradiol, vol.26, pp.104-116, 2005. ,
Comparison of perfusion computed tomography and computed tomography angiography source images with perfusionweighted imaging and diffusion-weighted imaging in patients with acute stroke of < 6 hours' duration, Stroke, vol.34, pp.1539-1585, 2003. ,
Les apports du registre dijonnais des accidents vasculaires c??r??braux en 20 ans d???activit??, Revue Neurologique, vol.164, issue.2, pp.138-185, 2008. ,
DOI : 10.1016/j.neurol.2007.06.003
Preventing stroke: saving lives around the world, The Lancet Neurology, vol.6, issue.2, pp.182-189, 2007. ,
DOI : 10.1016/S1474-4422(07)70031-5
Pathophysiology of Stroke Rehabilitation: Temporal Aspects of Neurofunctional Recovery, Cerebrovascular Diseases, vol.21, issue.1-2, pp.6-17, 2006. ,
DOI : 10.1159/000089588
Molecular mechanisms of ischemic neuronal injury, Annals of Emergency Medicine, vol.36, issue.5, pp.483-506, 2000. ,
DOI : 10.1016/S0196-0644(00)82028-4
Thresholds in cerebral ischemia - the ischemic penumbra, Stroke, vol.12, issue.6, pp.723-728, 1981. ,
DOI : 10.1161/01.STR.12.6.723
Functional recovery of cortical neurons as related to degree and duration of ischemia, Annals of Neurology, vol.220, issue.3, pp.294-301, 1983. ,
DOI : 10.1002/ana.410140307
Blood-brain barrier, reperfusion injury, and hemorrhagic transformation in acute ischemic stroke, Neurology, vol.79, issue.Issue 13, Supplement 1, pp.52-57, 2012. ,
DOI : 10.1212/WNL.0b013e3182697e70
Advances in the Vascular Pathophysiology of Ischemic Stroke, Thrombosis Research, vol.98, issue.3, pp.73-81, 2000. ,
DOI : 10.1016/S0049-3848(00)00218-8
The neurovascular unit, matrix proteases, and innate inflammation ,
Regulation of cerebral vasculature in normal and ischemic brain, Neuropharmacology, vol.55, issue.3, pp.281-288, 2008. ,
DOI : 10.1016/j.neuropharm.2008.04.017
Benign focal ischemic preconditioning induces neuronal Hsp70 and prolonged astrogliosis with expression of Hsp27, Brain Research, vol.863, issue.1-2, pp.169-81, 2000. ,
DOI : 10.1016/S0006-8993(00)02133-8
Neurogliovascular unit after cerebral ischemia: Is the vascular wall a pharmacological target, Psychoneuroendocrinology, vol.32, 2007. ,
DOI : 10.1016/j.psyneuen.2007.03.015
Background Review and Current Concepts of Reperfusion Injury, Archives of Neurology, vol.47, issue.11, pp.1245-1254, 1990. ,
DOI : 10.1001/archneur.1990.00530110107027
Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke, New England Journal of Medicine, vol.359, issue.13, pp.1317-1340, 2008. ,
DOI : 10.1056/NEJMoa0804656
and the IST-3 collaborative group. The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST- 3]): a randomised controlled trial, Lancet, vol.379, pp.2352-63, 2012. ,
Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials, The Lancet, vol.384, issue.9958, pp.1929-1964, 2014. ,
DOI : 10.1016/S0140-6736(14)60584-5
Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke, New England Journal of Medicine, vol.372, issue.11, pp.1019-1049, 2015. ,
DOI : 10.1056/NEJMoa1414905
Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection, New England Journal of Medicine, vol.372, issue.11, pp.1009-1027, 2015. ,
DOI : 10.1056/NEJMoa1414792
The contribution of intra-arterial thrombectomy in acute ischemic stroke in patients treated with intravenous thrombolysis, European Stroke Organization Conference, 2015. ,
Thrombectomy within 8 Hours after Symptom Onset in Ischemic Stroke, New England Journal of Medicine, vol.372, issue.24, pp.2296-306, 2015. ,
DOI : 10.1056/NEJMoa1503780
Stent-Retriever Thrombectomy after Intravenous t-PA vs. t-PA Alone in Stroke, New England Journal of Medicine, vol.372, issue.24, 2015. ,
DOI : 10.1056/NEJMoa1415061
URL : http://dx.doi.org/10.7892/boris.69540
Post ischemic attenuation of cerebral artery reactivity is increased in the presence of tissue plasminogen activator, Stroke, 2000. ,
Effects of Recombinant Tissue Plasminogen Activator After Intraluminal Thread Occlusion in Mice: Role of Hemodynamic Alterations, Stroke, vol.32, issue.11, pp.2641-2648, 2001. ,
DOI : 10.1161/hs1101.097381
Reliability of the ECASS Radiological Classification of Postthrombolysis Brain Haemorrhage: A Comparison of CT and Three MRI Sequences, Cerebrovascular Diseases, vol.29, issue.6, pp.597-604, 2010. ,
DOI : 10.1159/000312867
URL : https://hal.archives-ouvertes.fr/hal-00795775
Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II), The Lancet, vol.352, issue.9136, pp.1245-1251, 1998. ,
DOI : 10.1016/S0140-6736(98)08020-9
Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study, The Lancet, vol.369, issue.9558, pp.275-282, 2007. ,
DOI : 10.1016/S0140-6736(07)60149-4
Symptomatic Intracranial Hemorrhage following Intravenous Thrombolysis for Acute Ischemic Stroke: A Critical Review of Case Definitions, Cerebrovasc Dis, vol.34, pp.106-114, 2012. ,
Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS), JAMA: The Journal of the American Medical Association, vol.274, issue.13, pp.1017-1025, 1995. ,
DOI : 10.1001/jama.274.13.1017
Magnetic resonance imaging profiles predict clinical response to early reperfusion: The diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study, Annals of Neurology, vol.292, issue.5, pp.508-517, 2006. ,
DOI : 10.1002/ana.20976
Thrombolysis with alteplase 3???4??5 h after acute ischaemic stroke (SITS-ISTR): an observational study, The Lancet, vol.372, issue.9646, pp.1303-1309, 2008. ,
DOI : 10.1016/S0140-6736(08)61339-2
Implementation and outcome of thrombolysis with alteplase 3???4??5 h after an acute stroke: an updated analysis from SITS-ISTR, The Lancet Neurology, vol.9, issue.9, pp.866-874, 2010. ,
DOI : 10.1016/S1474-4422(10)70165-4
Thrombolysis for acute ischemic stroke: results of the Canadian Alteplase for Stroke Effectiveness Study, Canadian Medical Association Journal, vol.172, issue.10, pp.1307-1312, 2005. ,
DOI : 10.1503/cmaj.1041561
Subtherapeutic Warfarin Is Not Associated With Increased Hemorrhage Rates in Ischemic Strokes Treated With Tissue Plasminogen Activator, Stroke, vol.42, issue.4, 2011. ,
DOI : 10.1161/STROKEAHA.110.599183
Predictors of Hemorrhagic Transformation in Patients Receiving Intra-Arterial Thrombolysis * Editorial Comment, Stroke, vol.33, issue.3, pp.717-741, 2002. ,
DOI : 10.1161/hs0302.104110
Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials, Lancet, vol.363, pp.768-774, 2004. ,
Intravenous thrombolysis in stroke patients of >=80 versus <80 years of age--a systematic review across cohort studies, Age and Ageing, vol.35, issue.6, pp.572-580, 2006. ,
DOI : 10.1093/ageing/afl104
Baseline Blood Pressure but Not Early Computed Tomography Changes Predicts Major Hemorrhage After Streptokinase in Acute Ischemic Stroke, Stroke, vol.33, issue.9, pp.2236-2242, 2002. ,
DOI : 10.1161/01.STR.0000027859.59415.66
Symptomatic Hemorrhagic Transformation and Its Predictors in Acute Ischemic Stroke with Atrial Fibrillation, European Neurology, vol.64, issue.4, pp.193-200, 2010. ,
DOI : 10.1159/000319048
Frequency and predictors of spontaneous hemorrhagic transformation in ischemic stroke and its association with prognosis, Journal of Neurology, vol.88, issue.12, pp.905-917, 2014. ,
DOI : 10.1007/s00415-014-7297-8
Interventions in the Management of Serum Lipids for Preventing Stroke Recurrence:, Stroke, vol.40, issue.11, p.2091, 2009. ,
DOI : 10.1161/STROKEAHA.109.561860
Statin Therapy and the Risk of Intracerebral Hemorrhage: A Meta-Analysis of 31 Randomized Controlled Trials, Stroke, vol.43, issue.8, 2012. ,
DOI : 10.1161/STROKEAHA.112.655894
Use of selective serotonin reuptake inhibitors and risk of stroke: a systematic review and meta-analysis, Journal of Neurology, vol.124, issue.4, 2014. ,
DOI : 10.1007/s00415-014-7251-9
Cerebral hemorrhage after intra-arterial thrombolysis for ischemic stroke: The PROACT II trial, Neurology, vol.57, issue.9, pp.1603-1610, 2001. ,
DOI : 10.1212/WNL.57.9.1603
Markers of Increased Risk of Intracerebral Hemorrhage After Intravenous Recombinant Tissue Plasminogen Activator Therapy for Acute Ischemic Stroke in Clinical Practice: The Multicenter rt-PA Acute Stroke Survey, Circulation, vol.105, issue.14, pp.1679-1685, 2002. ,
DOI : 10.1161/01.CIR.0000012747.53592.6A
Cholesterol Levels and Risk of Hemorrhagic Stroke: A Systematic Review and Meta-Analysis, Stroke, vol.44, issue.7 ,
DOI : 10.1161/STROKEAHA.113.001326
Influence of Lipid Profiles on the Risk of Hemorrhagic Transformation after Ischemic Stroke: Systematic Review, Cerebrovascular Diseases Extra, vol.1, issue.1, pp.130-141, 2011. ,
DOI : 10.1159/000335014
Admission Fibrinolytic Profile Is Associated With Symptomatic Hemorrhagic Transformation in Stroke Patients Treated With Tissue Plasminogen Activator, Stroke, vol.35, issue.9, pp.2123-2127, 2004. ,
DOI : 10.1161/01.STR.0000137608.73660.4c
Matrix Metalloproteinase-9 Pretreatment Level Predicts Intracranial Hemorrhagic Complications After Thrombolysis in Human Stroke, Circulation, vol.107, issue.4, pp.598-603, 2003. ,
DOI : 10.1161/01.CIR.0000046451.38849.90
Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy, The Lancet, vol.355, issue.9216, pp.1670-1674, 2000. ,
DOI : 10.1016/S0140-6736(00)02237-6
Extent of Early Ischemic Changes on Computed Tomography (CT) Before Thrombolysis: Prognostic Value of the Alberta Stroke Program Early CT Score in ECASS II, Stroke, vol.37, issue.4, pp.973-978, 2006. ,
DOI : 10.1161/01.STR.0000206215.62441.56
Collateral Flow Averts Hemorrhagic Transformation After Endovascular Therapy for Acute Ischemic Stroke, Stroke, vol.42, issue.8, pp.2235-2244, 2011. ,
DOI : 10.1161/STROKEAHA.110.604603
Symptomatic Intracerebral Hemorrhage following Thrombolytic Therapy for Acute Ischemic Stroke: A Review of the Risk Factors, Cerebrovasc Dis, vol.24, pp.1-10, 2007. ,
Niaz Ahmed, for the SITS Investigators. Safe Implementation of Treatments in Stroke (SITS) Symptomatic Intracerebral Hemorrhage Risk Score. Predicting the Risk of Symptomatic Intracerebral Hemorrhage in Ischemic Stroke Treated With Intravenous Alteplase, Stroke, 2012. ,
The HAT Score: A simple grading scale for predicting hemorrhage after thrombolysis, Neurology, vol.71, issue.18, pp.1417-1423, 2008. ,
DOI : 10.1212/01.wnl.0000330297.58334.dd
Validation Assessment of Risk Scores to Predict Postthrombolysis Intracerebral Haemorrhage, International Journal of Stroke, vol.35, issue.2, pp.109-111, 2011. ,
DOI : 10.1111/j.1747-4949.2010.00556.x
Quantitative Assessment of Cerebral Hemodynamics Using CT: Stability, Accuracy, and Precision Studies in Dogs, Journal of Computer Assisted Tomography, vol.23, issue.4, pp.506-521, 1999. ,
DOI : 10.1097/00004728-199907000-00003
Simultaneous measurement of regional cerebral blood flow by perfusion CT and stable xenon CT: a validation study, Am J Neuroradiol, vol.22, pp.905-919, 2001. ,
Correlation of early dynamic CT perfusion imaging with whole-brain MR diffusion and perfusion imaging in acute hemispheric stroke, Am J Neuroradiol, 2003. ,
Bayesian Hemodynamic Parameter Estimation by Bolus Tracking Perfusion Weighted Imaging, IEEE Transactions on Medical Imaging, vol.31, issue.7, pp.1381-95, 2012. ,
DOI : 10.1109/TMI.2012.2189890
Bayesian estimation of cerebral perfusion using a physiological model of microvasculature, NeuroImage, vol.33, issue.2, pp.570-579, 2006. ,
DOI : 10.1016/j.neuroimage.2006.06.015
Assessment of the accuracy of a Bayesian estimation algorithm for perfusion CT by using a digital phantom, Neuroradiology, vol.41, issue.10, pp.1197-203, 2013. ,
DOI : 10.1007/s00234-013-1237-7
Bayesian Analysis of Perfusion-weighted Imaging to Predict Infarct Volume: Comparison with Singular Value Decomposition, Magnetic Resonance in Medical Sciences, vol.13, issue.1, pp.45-50, 2014. ,
DOI : 10.2463/mrms.2013-0085
Signal-to-Noise Ratio and acquisition duration explain erroneous Mean transit Time in acute stroke CT perfusion imaging, Stroke, vol.43, p.2251, 2012. ,
Bayesian Estimation of Cerebral Perfusion Using Reduced-Contrast-Dose Dynamic Susceptibility Contrast Perfusion at 3T, American Journal of Neuroradiology, vol.36, issue.4, pp.710-718, 2015. ,
DOI : 10.3174/ajnr.A4184
MRI perfusion measurements calculated using advanced deconvolution techniques predict survival in recurrent glioblastoma treated with bevacizumab, Journal of Neuro-Oncology, vol.14, issue.Suppl 5, pp.497-505, 2015. ,
DOI : 10.1007/s11060-015-1755-8
Comparison of perfusion computed tomography and computed tomography angiography source images with perfusionweighted imaging and diffusion-weighted imaging in patients with acute stroke of < 6 hours duration, Stroke, vol.34, pp.1539-1585, 2003. ,
Accuracy of dynamic perfusion CT with deconvolution in detecting acute hemispheric stroke, Am J Neuroradiol, vol.26, pp.104-116, 2005. ,
Differences in CT Perfusion Maps Generated by Different Commercial Software: Quantitative Analysis by Using Identical Source Data of Acute Stroke Patients, Radiology, vol.254, issue.1, pp.200-209, 2010. ,
DOI : 10.1148/radiol.254082000
The Cortical Ischemic Core and Not the Consistently Present Penumbra Is a Determinant of Clinical Outcome in Acute Middle Cerebral Artery Occlusion, Stroke, vol.34, issue.10, pp.2426-2461, 2003. ,
DOI : 10.1161/01.STR.0000091232.81947.C9
Perfusion-CT Assessment of Infarct Core and Penumbra: Receiver Operating Characteristic Curve Analysis in 130 Patients Suspected of Acute Hemispheric Stroke, Stroke, vol.37, issue.4, pp.979-85, 2006. ,
DOI : 10.1161/01.STR.0000209238.61459.39
Perfusion CT in Acute Stroke: A Comprehensive Analysis of Infarct and Penumbra, Radiology, vol.267, issue.2, pp.543-50, 2013. ,
DOI : 10.1148/radiol.12120971
Determination of CT Perfusion Thresholds for the Evaluation of Acute Ischemic Core and Penumbra Utilizing Bayesian Deconvolution Method. Abstract No:1510 Submission Number:1510 Institutions ,
Accident vasculaire cérébral : prise en charge précoce (alerte, phase pré-hospitalière, phase hospitalière initiale, indications de la thrombolyse) Recommandations Mai Disponible sur : http://www.has-sante.fr/portail/jcms/c_830203/fr/accident-vasculaire-cerebral- prise-en-charge-precoce-alerte-phase-prehospitaliere-phase, 2009. ,
A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke, New England Journal of Medicine, vol.372, issue.1, pp.11-20, 2015. ,
DOI : 10.1056/NEJMoa1411587
Mismatch-Based Delayed Thrombolysis: A Meta-Analysis, Stroke, vol.41, issue.1, pp.25-33, 2010. ,
DOI : 10.1161/STROKEAHA.109.566869
Perfusion computed tomography to assist decision making for stroke thrombolysis, Brain, vol.138, issue.7, p.71, 2015. ,
DOI : 10.1093/brain/awv071
Initial ??TTP Map-Defect?? of Computed Tomography Perfusion as a Predictor of Hemorrhagic Transformation of Acute Ischemic Stroke, Cerebrovascular Diseases Extra, vol.3, issue.1, pp.14-25, 2013. ,
DOI : 10.1159/000346113
Prediction of Poststroke Hemorrhagic Transformation Using Computed Tomography Perfusion, Stroke, vol.44, issue.11, pp.0-00, 2013. ,
DOI : 10.1161/STROKEAHA.113.002396
Association of CT Perfusion Parameters with Hemorrhagic Transformation in Acute Ischemic Stroke, Am J Neuroradiol, vol.34, issue.10, pp.1895-900, 2013. ,
Risk Assessment of Hemorrhagic Transformation of Acute Middle Cerebral Artery Stroke Using Multimodal CT, Journal of Neuroimaging, vol.30, issue.2, 2012. ,
DOI : 10.1111/j.1552-6569.2010.00562.x
Admission CT Perfusion Is an Independent Predictor of Hemorrhagic Transformation in Acute Stroke with Similar Accuracy to DWI, Cerebrovasc Dis, vol.33, pp.8-15, 2012. ,
Improving inter-observer agreement about brain microbleeds: development of the Brain Observer MicroBleed Scale (BOMBS), Stroke, 2009. ,
Influence of partial volume on venous output and arterial input function, Am J Neuroradiol, 2006. ,
Imaging selection in ischemic stroke: feasibility of automated CT-perfusion analysis, Research, vol.10, 2015. ,
une transformation hémorragique est une complication potentiellement grave d'un infarctus cérébral, pouvant être aggravée par la thrombolyse. De nombreux facteurs de risque de transformation hémorragique ont été rapportés dans la littérature, mais l'apport de méthodes d'imagerie avancées fréquemment utilisée à la phase aigüe d'un infarctus cérébral ,
Déterminer l'apport du scanner de perfusion dans la prédiction précoce du risque de transformation hémorragique en phase aigüe d'un infarctus cérébral ,