. Dans-le-groupe, haptoglobine est significativement plus élevée que dans le groupe des AJG C4d-(0,1 g/L versus 1, pp.45-52

J. Moake, Thrombotic Microangiopathies, New England Journal of Medicine, vol.347, issue.8, pp.589-600, 2002.
DOI : 10.1056/NEJMra020528

M. Rosove, Thrombotic microangiopathies, Seminars in Arthritis and Rheumatism, vol.43, issue.6, pp.797-805, 2014.
DOI : 10.1016/j.semarthrit.2013.11.004

J. George and C. Nester, Syndromes of Thrombotic Microangiopathy, New England Journal of Medicine, vol.371, issue.7, pp.1847-1895, 2014.
DOI : 10.1056/NEJMra1312353

J. Sarma and P. Ward, The complement system, Cell and Tissue Research, vol.44, issue.16, pp.227-262, 2011.
DOI : 10.1007/s00441-010-1034-0

R. Caires, I. Marques, L. Repizo, V. Sato, L. Carmo et al., De Novo Thrombotic Microangiopathy After Kidney Transplantation: Clinical Features, Treatment, and Long-Term Patient and Graft Survival, Transplantation Proceedings, vol.44, issue.8, pp.2388-90, 2012.
DOI : 10.1016/j.transproceed.2012.07.039

N. Laure-hélène, Atlas de pathologie rénale, Ed Médecine Sciences Flammarion, pp.427-62, 2008.

J. Dunkelberger and W. Song, Complement and its role in innate and adaptive immune responses, Cell Research, vol.71, issue.1, pp.34-50, 2010.
DOI : 10.1146/annurev.immunol.15.1.649

M. Walport and . Complement, First of two parts, N Engl J Med, vol.5344, issue.14, pp.1058-66, 2001.

M. Walport and . Complement, Second of two parts, N Engl J Med, vol.12344, issue.15, pp.1140-1184, 2001.

D. Cohen, R. Colvin, M. Daha, C. Drachenberg, M. Haas et al., Pros and cons for C4d as a biomarker, Kidney International, vol.81, issue.7, pp.628-667, 2012.
DOI : 10.1038/ki.2011.497

S. Nilsson, R. Sim, S. Lea, V. Fremeaux-bacchi, and A. Blom, Complement factor I in health and disease, Molecular Immunology, vol.48, issue.14, pp.1611-1631, 2011.
DOI : 10.1016/j.molimm.2011.04.004

K. Murata and W. Baldwin, Mechanisms of complement activation, C4d deposition, and their contribution to the pathogenesis of antibody-mediated rejection, Transplantation Reviews, vol.23, issue.3
DOI : 10.1016/j.trre.2009.02.005

R. Corrêa, J. Machado, M. Da-silva, F. Helmo, C. Guimarães et al., The Importance of C4d in Biopsies of Kidney Transplant Recipients, Clinical and Developmental Immunology, vol.12, issue.3, p.678180, 2013.
DOI : 10.1111/j.1600-6143.2011.03757.x

D. Ricklin, G. Hajishengallis, K. Yang, and J. Lambris, Complement: a key system for immune surveillance and homeostasis, Nature Immunology, vol.632, issue.9, pp.785-97, 2011.
DOI : 10.1038/nature07205

A. Roos, M. Daha, J. Van-pelt, and S. Berger, Mannose-binding lectin and the kidney, Nephrology Dialysis Transplantation, vol.22, issue.12, pp.3370-77, 2007.
DOI : 10.1093/ndt/gfm524

S. Berger, A. Roos, and M. Daha, Complement and the kidney: What the nephrologist needs to know in 2006?, Nephrology Dialysis Transplantation, vol.20, issue.12, pp.2613-2632, 2005.
DOI : 10.1093/ndt/gfi166

V. Nickeleit and M. Mihatsch, Kidney transplants, antibodies and rejection: is C4d a magic marker?, Nephrology Dialysis Transplantation, vol.18, issue.11, pp.2232-2271, 2003.
DOI : 10.1093/ndt/gfg304

A. Djamali, D. Kaufman, T. Ellis, W. Zhong, A. Matas et al., Diagnosis and Management of Antibody-Mediated Rejection: Current Status and Novel Approaches, American Journal of Transplantation, vol.2012, issue.5 Pt 1, pp.255-71, 2014.
DOI : 10.1111/ajt.12589

H. Regele, G. Böhmig, A. Habicht, D. Gollowitzer, and M. Schillinger, Capillary Deposition of Complement Split Product C4d in Renal Allografts is Associated with Basement Membrane Injury in Peritubular and Glomerular Capillaries: A Contribution of Humoral Immunity to Chronic Allograft Rejection, Journal of the American Society of Nephrology, vol.13, issue.9, pp.2371-80, 2002.
DOI : 10.1097/01.ASN.0000025780.03790.0F

M. Haas, B. Sis, L. Racusen, K. Solez, D. Glotz et al., Banff 2013 Meeting Report: Inclusion of C4d-Negative Antibody-Mediated Rejection and Antibody-Associated Arterial Lesions, American Journal of Transplantation, vol.17, issue.2, pp.272-83, 2014.
DOI : 10.1111/ajt.12590

C. Seemayer, A. Gaspert, V. Nickeleit, and M. Mihatsch, C4d staining of renal allograft biopsies: a comparative analysis of different staining techniques, Nephrology Dialysis Transplantation, vol.22, issue.2, pp.568-76, 2007.
DOI : 10.1093/ndt/gfl594

K. Solez, R. Colvin, L. Racusen, M. Haas, B. Sis et al., Banff 07 Classification of Renal Allograft Pathology: Updates and Future Directions, American Journal of Transplantation, vol.23, issue.4
DOI : 10.1046/j.1523-1755.1999.00299.x

H. Ludovico-martins, C. Silva, W. Teodoro, M. Filho, D. Noronha et al., Analysis of Different Staining Techniques for C4d Detection in Renal Allograft Biopsies, Transplantation Proceedings, vol.41, issue.3
DOI : 10.1016/j.transproceed.2009.01.073

K. Solez, R. Colvin, L. Racusen, M. Haas, B. Sis et al., Banff 07 Classification of Renal Allograft Pathology: Updates and Future Directions, American Journal of Transplantation, vol.23, issue.4
DOI : 10.1046/j.1523-1755.1999.00299.x

H. Regele, M. Exner, B. Watschinger, C. Wenter, M. Wahrmann et al., Endothelial C4d deposition is associated with inferior kidney allograft outcome independently of cellular rejection, Nephrology Dialysis Transplantation, vol.16, issue.10, pp.2058-66, 2001.
DOI : 10.1093/ndt/16.10.2058

J. Zwirner, E. Felber, V. Herzog, G. Riethmüller, and H. Feucht, Classical pathway of complement activation in normal and diseased human glomeruli, Kidney International, vol.36, issue.6, pp.1069-77, 1989.
DOI : 10.1038/ki.1989.302

Y. Shen, X. Chen, C. Sun, M. Dai, Y. Yan et al., Association between anti-beta2 glycoprotein I antibodies and renal glomerular C4d deposition in lupus nephritis patients with glomerular microthrombosis: a prospective study of 155 cases

M. Noris, F. Mescia, and G. Remuzzi, STEC-HUS, atypical HUS and TTP are all diseases of complement activation, Nature Reviews Nephrology, vol.46, issue.11, pp.622-655, 2012.
DOI : 10.1038/nrneph.2012.195

J. Chapin, B. Weksler, C. Magro, and J. Laurence, Eculizumab in the treatment of refractory idiopathic thrombotic thrombocytopenic purpura, British Journal of Haematology, vol.26, issue.6, pp.772-74, 2012.
DOI : 10.1111/j.1365-2141.2012.09084.x

D. Cohen, M. Koopmans, K. Hovinga, I. Berger, S. et al., Potential for glomerular C4d as an indicator of thrombotic microangiopathy in lupus nephritis, Arthritis & Rheumatism, vol.114, issue.8, pp.2460-69, 2008.
DOI : 10.1002/art.23662

S. Kim and H. Jeong, Glomerular C4d Deposition Indicates in situ Classic Complement Pathway Activation, but is not a Marker for Lupus Nephritis Activity, Yonsei Medical Journal, vol.44, issue.1
DOI : 10.3349/ymj.2003.44.1.75

M. Noris and G. Remuzzi, Thrombotic Microangiopathy After Kidney Transplantation, American Journal of Transplantation, vol.9, issue.7
DOI : 10.1111/j.1600-6143.2010.03156.x

E. Wagner and M. Frank, Therapeutic potential of complement modulation, Nature Reviews Drug Discovery, vol.59, issue.1, pp.43-56, 2010.
DOI : 10.1038/nrd3011

C. Parker, Eculizumab for paroxysmal nocturnal haemoglobinuria, The Lancet, vol.373, issue.9665, pp.759-67, 2009.
DOI : 10.1016/S0140-6736(09)60001-5

J. Schmidtko, S. Peine, Y. El-housseini, M. Pascual, and P. Meier, Treatment of Atypical Hemolytic Uremic Syndrome and Thrombotic Microangiopathies: A Focus on Eculizumab, American Journal of Kidney Diseases, vol.61, issue.2, pp.289-99, 2013.
DOI : 10.1053/j.ajkd.2012.07.028

G. Keating, Eculizumab: A Review of Its Use in Atypical Haemolytic Uraemic Syndrome, Drugs, vol.26, issue.8, pp.2053-66, 2013.
DOI : 10.1007/s40265-013-0147-7

J. Chua, H. Baelde, M. Zandbergen, S. Wilhelmus, L. Van-es et al., Complement Factor C4d Is a Common Denominator in Thrombotic Microangiopathy, Journal of the American Society of Nephrology, vol.26, issue.9, pp.2239-2286, 2015.
DOI : 10.1681/ASN.2014050429

C. Debiais, Etude de la fixation glomérulaire de l'anticorps anti-C4d en pathologie du greffon rénal, Thèse de doctorat en médecine, sous la direction du Pr Guy Touchard, pp.27-2014

K. Lechner and H. Obermeier, Cancer-Related Microangiopathic Hemolytic Anemia, Medicine, vol.91, issue.4, pp.195-205, 2012.
DOI : 10.1097/MD.0b013e3182603598

H. Izzedine and M. Perazella, Thrombotic Microangiopathy, Cancer, and Cancer Drugs, American Journal of Kidney Diseases, vol.66, issue.5, pp.272-6386, 2015.
DOI : 10.1053/j.ajkd.2015.02.340

P. Mannucci, M. Karimi, A. Mosalaei, M. Canciani, and F. Peyvandi, Patients with localized and disseminated tumors have reduced but measurable levels of ADAMTS- 13 (von Willebrand factor cleaving protease, Haematologica, vol.88, issue.4, pp.454-58, 2003.

D. Charba, J. Moake, M. Harris, and J. Hester, Abnormalities of von willebrand factor multimers in drug-associated thrombotic microangiopathies, American Journal of Hematology, vol.74, issue.3, pp.268-77, 1993.
DOI : 10.1002/ajh.2830420306

F. Castagna, J. Wang, M. Emit, G. Wang, S. Jelic et al., 9A.09, Journal of Hypertension, vol.33, issue.1, p.119, 2015.
DOI : 10.1097/01.hjh.0000467672.93812.38

M. Markiewski, B. Nilsson, K. Ekdahl, T. Mollnes, and J. Lambris, Complement and coagulation: strangers or partners in crime? Trends Immunol, pp.184-92, 2007.

K. Ritis, M. Doumas, D. Mastellos, A. Micheli, and S. Giaglis, A novel C5a receptortissue factor cross-talk in neutrophils links innate immunity to coagulation pathways

A. Krarup, R. Wallis, J. Presanis, P. Gál, and R. Sim, Simultaneous Activation of Complement and Coagulation by MBL-Associated Serine Protease 2, PLoS ONE, vol.C, issue.7, p.623, 2007.
DOI : 10.1371/journal.pone.0000623.g005

J. Patzelt, A. Verschoor, and H. Langer, Platelets and the complement cascade in atherosclerosis, Frontiers in Physiology, vol.21, issue.294, p.49, 2015.
DOI : 10.1161/hq0701.092160

J. Navratil, S. Manzi, A. Kao, S. Krishnaswami, C. Liu et al., Platelet C4d is highly specific for systemic lupus erythematosus, Arthritis & Rheumatism, vol.10, issue.2, pp.670-74, 2006.
DOI : 10.1002/art.21627

H. Ota, K. Fox-talbot, W. Hu, Z. Qian, F. Sanfilippo et al., Terminal Complement Components Mediate Release of von Willebrand Factor and Adhesion of Platelets in Arteries of Allografts, Transplantation, vol.79, issue.3, pp.276-81, 2005.
DOI : 10.1097/01.TP.0000146195.76904.D3