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Master Thesis

Impact du bevacizumab adjuvant sur les lymphocèles dans les tumeurs épithéliales malignes de l’ovaire de stade avancé

Abstract : The objective of the study was to describe the effect of adjuvant bevacizumab on symptomatic lymphoceles in advanced ovarian cancer after optimal surgery. The effect of bevacizumab on survival was also studied in this cohort. This retrospective study included patients with advanced ovarian cancer (International Federation of Gynecology and Obstetrics FIGO 1988 stages IIIB, IIIC, IV) and who had cytoreductive surgery with pelvic and lombo-aortic lymphadenectomy in Gustave Roussy Institute from 2005 to 2014. 255 patients were included. The rate of symptomatic lymphocele was 33.6% (85 out of 253). 61 patients (24.5%) received adjuvant bevacizumab. In multivariate analysis, bevacizumab wasn’t associated with the risk of symptomatic lymphocele wtih hazard ratio at 1.62 (IC95%= 0.87-3.01, p=0.12). The bevacizumab had an impact on disease free survival (DFS) with hazard ratio at 0.6 (IC95%= 0.41-0.91, p=0.01) and the median DFS was 31.7 months in bevacizumab group and 23 months in the control group. In conclusion, bevacizumab wasn’t associated with the risk of symptomatic lymphocele in our study but it had an impact on DFS in patients and prolonged the median DFS by about 9 months in patients with advanced ovarian cancer and complete surgery. Further studies are needed to confirm this result.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01231069
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Submitted on : Thursday, November 19, 2015 - 3:02:07 PM
Last modification on : Monday, October 19, 2020 - 11:06:27 AM
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  • HAL Id : dumas-01231069, version 1

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Morgane Perrin. Impact du bevacizumab adjuvant sur les lymphocèles dans les tumeurs épithéliales malignes de l’ovaire de stade avancé. Médecine humaine et pathologie. 2015. ⟨dumas-01231069⟩

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