J. Alonso, M. C. Angermeyer, S. Bernert, R. Bruffaerts, T. S. Brugha et al., Psychotropic drug utilization in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project, Acta Psychiatr Scand, issue.420, 2002.

S. Ansaloni, B. P. Leung, N. P. Sebastian, R. Samudralwar, M. Gadaleta et al., TrkB Isoforms Differentially Affect AICD Production through Their Intracellular Functional Domains, International Journal of Alzheimer's Disease, vol.22, issue.7, pp.729382-729392, 2011.
DOI : 10.1016/j.mcn.2010.01.007

V. Avdoshina, I. Mocchetti, C. Liu, M. A. Young, K. Anastos et al., Single-Nucleotide Polymorphisms in TrkB and Risk for Depression, JAIDS Journal of Acquired Immune Deficiency Syndromes, vol.64, issue.2, pp.138-141, 2013.
DOI : 10.1097/QAI.0b013e3182a468e9

C. Barthel, N. Yeremenko, R. Jacobs, R. E. Schmidt, M. Bernateck et al., Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis, Arthritis Research & Therapy, vol.11, issue.3, 2009.
DOI : 10.1186/ar2716

L. Becquemont, A. Alfirevic, U. Amstutz, H. Brauch, E. Jacqz-aigrain et al., Practical recommendations for pharmacogenomics-based prescription: 2010 ESF???UB Conference on Pharmacogenetics and Pharmacogenomics, Pharmacogenomics, vol.12, issue.1, pp.113-124, 2011.
DOI : 10.2217/pgs.10.147

J. M. Bostwick and V. S. Pankratz, Affective Disorders and Suicide Risk: A Reexamination, American Journal of Psychiatry, vol.157, issue.12, pp.1925-1932, 2000.
DOI : 10.1176/appi.ajp.157.12.1925

E. Castren and T. Rantamaki, The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity, Developmental Neurobiology, vol.8, issue.5, pp.289-297, 2010.
DOI : 10.1002/dneu.20758

R. Colle, F. Gressier, C. Verstuyft, E. Deflesselle, J. P. Lepine et al., Brain-derived neurotrophic factor Val66Met polymorphism and 6-month antidepressant remission in depressed Caucasian patients, Journal of Affective Disorders, vol.175, pp.233-240, 2015.
DOI : 10.1016/j.jad.2015.01.013

A. Cozza, E. Melissari, P. Iacopetti, V. Mariotti, A. Tedde et al., SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population, J Alzheimers Dis, vol.15, issue.1, pp.61-70, 2008.

K. Demyttenaere, A. Bonnewyn, R. Bruffaerts, G. De-girolamo, I. Gasquet et al., Clinical factors influencing the prescription of antidepressants and benzodiazepines:, Journal of Affective Disorders, vol.110, issue.1-2, pp.84-93, 2008.
DOI : 10.1016/j.jad.2008.01.011

C. Dong, M. L. Wong, and J. Licinio, Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans, Molecular Psychiatry, vol.57, issue.12, pp.1105-111892, 2009.
DOI : 10.1016/j.jad.2007.02.017

S. G. Dorsey, C. L. Renn, L. Carim-todd, C. A. Barrick, L. Bambrick et al., In Vivo Restoration of Physiological Levels of Truncated TrkB.T1 Receptor Rescues Neuronal Cell Death in a Trisomic Mouse Model, Neuron, vol.51, issue.1, 2006.
DOI : 10.1016/j.neuron.2006.06.009

S. Douma, T. Van-laar, J. Zevenhoven, R. Meuwissen, E. Van-garderen et al., Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB, Nature, vol.6, issue.7003, pp.430-1034, 1038.
DOI : 10.1084/jem.183.4.1533

C. T. Drake, T. A. Milner, and S. L. Patterson, Ultrastructural localization of full-length trkB immunoreactivity in rat hippocampus suggests multiple roles in modulating activity-dependent synaptic plasticity, J Neurosci, issue.18, pp.19-8009, 1999.

J. S. Dunham, J. F. Deakin, F. Miyajima, A. Payton, and C. T. Toro, Expression of hippocampal brain-derived neurotrophic factor and its receptors in Stanley consortium brains, Journal of Psychiatric Research, vol.43, issue.14, pp.1175-1184, 2009.
DOI : 10.1016/j.jpsychires.2009.03.008

D. L. Foley, M. C. Neale, and K. S. Kendler, Reliability of a lifetime history of major depression: implications for heritability and co-morbidity, Psychological Medicine, vol.28, issue.4, pp.857-870, 1998.
DOI : 10.1017/S0033291798006977

F. Gressier, E. Bouaziz, C. Verstuyft, P. Hardy, L. Becquemont et al., 5-HTTLPR modulates antidepressant efficacy in depressed women, Psychiatric Genetics, vol.19, issue.4, pp.195-200, 2009.
DOI : 10.1097/YPG.0b013e32832cef0d

W. H. Hahn, J. S. Suh, B. S. Cho, M. A. Kohli, D. Czamara et al., Linkage and Association Study of Neurotrophins and Their Receptors as Novel Susceptibility Genes for Childhood IgA Nephropathy, Pediatric Research, vol.629, issue.4, pp.299-305, 2011.
DOI : 10.1203/PDR.0b013e31820b9365

E. J. Huang and L. F. Reichardt, : Roles in Neuronal Development and Function, Annual Review of Neuroscience, vol.24, issue.1, pp.677-736, 2001.
DOI : 10.1146/annurev.neuro.24.1.677

M. J. Kempton, Z. Salvador, M. R. Munafo, J. R. Geddes, A. Simmons et al., Structural Neuroimaging Studies in Major Depressive Disorder, Archives of General Psychiatry, vol.68, issue.7, pp.675-69060, 2011.
DOI : 10.1001/archgenpsychiatry.2011.60

J. P. Lepine, M. Gastpar, J. Mendlewicz, and A. Tylee, Depression in the community, International Clinical Psychopharmacology, vol.12, issue.1, pp.19-29, 1997.
DOI : 10.1097/00004850-199701000-00003

Y. Li, B. W. Luikart, S. Birnbaum, J. Chen, C. H. Kwon et al., TrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment, Neuron, vol.59, issue.3, pp.399-412, 2008.
DOI : 10.1016/j.neuron.2008.06.023

Z. Li, Y. Zhang, Z. Wang, J. Chen, J. Fan et al., The role of BDNF, NTRK2 gene and their interaction in development of treatment-resistant depression: Data from multicenter, prospective, longitudinal clinic practice, Journal of Psychiatric Research, vol.47, issue.1, pp.8-14, 2013.
DOI : 10.1016/j.jpsychires.2012.10.003

J. Licinio, C. Dong, and M. L. Wong, Novel Sequence Variations in the Brain-Derived Neurotrophic Factor Gene and Association With Major Depression and Antidepressant Treatment Response, Archives of General Psychiatry, vol.66, issue.5, pp.488-49738, 2009.
DOI : 10.1001/archgenpsychiatry.2009.38

. Gene-gene, of the brain-derived neurotrophic-factor and neurotrophic tyrosine kinase receptor 2 genes in geriatric depression, Rejuvenation Res, vol.12, issue.6

X. Liu, C. B. Chan, Q. Qi, G. Xiao, H. R. Luo et al., Optimization of a Small Tropomyosin-Related Kinase B (TrkB) Agonist 7,8-Dihydroxyflavone Active in Mouse Models of Depression, Journal of Medicinal Chemistry, vol.55, issue.19, pp.55-8524, 1021.
DOI : 10.1021/jm301099x

A. D. Lopez and C. C. Murray, The global burden of disease, 1990???2020, Nature Medicine, vol.72, issue.11, pp.1241-1243, 1038.
DOI : 10.1016/S0140-6736(97)03360-6

K. Luberg, J. Wong, C. S. Weickert, and T. Timmusk, Human TrkB gene: novel alternative transcripts, protein isoforms and expression pattern in the prefrontal cerebral cortex during postnatal development, Journal of Neurochemistry, vol.99, issue.4, pp.952-964, 2010.
DOI : 10.1111/j.1471-4159.2010.06662.x

G. S. Malhi, D. Adams, R. Porter, A. Wignall, L. Lampe et al., Clinical practice recommendations for depression, Acta Psychiatrica Scandinavica, vol.12, issue.suppl. 8, pp.8-26, 2009.
DOI : 10.1111/j.1600-0447.2009.01382.x

B. R. Miller and R. Hen, The current state of the neurogenic theory of depression and anxiety, Current Opinion in Neurobiology, vol.30, 2015.
DOI : 10.1016/j.conb.2014.08.012

A. Nakagawara, Trk receptor tyrosine kinases: A bridge between cancer and neural development, Cancer Letters, vol.169, issue.2, pp.107-114, 2001.
DOI : 10.1016/S0304-3835(01)00530-4

A. Nakagawara, X. G. Liu, N. Ikegaki, P. S. White, D. J. Yamashiro et al., Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2), Genomics, vol.25, issue.2, pp.25-538, 1995.
DOI : 10.1016/0888-7543(95)80055-Q

M. K. Nock, I. Hwang, N. A. Sampson, and R. C. Kessler, Mental disorders, comorbidity and suicidal behavior: Results from the National Comorbidity Survey Replication, Molecular Psychiatry, vol.156, issue.8, pp.868-87629, 2009.
DOI : 10.1111/j.1749-6632.2001.tb05800.x

M. M. Ohayon and M. H. Lader, Use of Psychotropic Medication in the General Population of France, Germany, Italy, and the United Kingdom, The Journal of Clinical Psychiatry, vol.63, issue.9, pp.817-825, 2002.
DOI : 10.4088/JCP.v63n0912

N. Perroud, K. J. Aitchison, R. Uher, R. Smith, P. Huezo-diaz et al., Genetic Predictors of Increase in Suicidal Ideation During Antidepressant Treatment in the GENDEP Project, Neuropsychopharmacology, vol.150, issue.12, pp.34-2517, 2009.
DOI : 10.1111/j.1399-5618.2008.00603.x

F. Rage, M. Silhol, F. Biname, S. Arancibia, and L. Tapia-arancibia, Effect of aging on the expression of BDNF and TrkB isoforms in rat pituitary, Neurobiology of Aging, vol.28, issue.7, pp.1088-1098, 2007.
DOI : 10.1016/j.neurobiolaging.2006.05.013

T. Rantamaki, L. Vesa, H. Antila, D. Lieto, A. Tammela et al., Antidepressant Drugs Transactivate TrkB Neurotrophin Receptors in the Adult Rodent Brain Independently of BDNF and Monoamine Transporter Blockade, PLoS ONE, vol.50, issue.6, 2011.
DOI : 10.1371/journal.pone.0020567.s004

M. Rihl, E. Kruithof, C. Barthel, F. De-keyser, E. M. Veys et al., Involvement of neurotrophins and their receptors in spondyloarthritis synovitis: relation to inflammation and response to treatment, Annals of the Rheumatic Diseases, vol.64, issue.11, pp.1542-1549032599, 2004.
DOI : 10.1136/ard.2004.032599

X. Ruan, H. Liu, L. Boardman, and J. P. Kocher, Genome-Wide Analysis of Loss of Heterozygosity in Breast Infiltrating Ductal Carcinoma Distant Normal Tissue Highlights Arm Specific Enrichment and Expansion across Tumor Stages, PLoS ONE, vol.21, issue.4, 2014.
DOI : 10.1371/journal.pone.0095783.s009

S. Sakuragi, K. Tominaga-yoshino, and A. Ogura, Involvement of TrkB-and p75(NTR)-signaling pathways in two contrasting forms of long-lasting synaptic plasticity, Sci Rep, vol.3, pp.3185-3195, 1038.

D. V. Sheehan, Y. Lecrubier, K. H. Sheehan, P. Amorim, J. Janavs et al., The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM- IV and ICD-10, J Clin Psychiatry, vol.59, issue.20, pp.22-33, 1998.

K. L. Spalding, O. Bergmann, K. Alkass, S. Bernard, M. Salehpour et al., Dynamics of Hippocampal Neurogenesis in Adult Humans, Cell, vol.153, issue.6, pp.1219-1227, 2013.
DOI : 10.1016/j.cell.2013.05.002

URL : https://hal.archives-ouvertes.fr/hal-00839513

P. F. Sullivan, M. C. Neale, and K. S. Kendler, Genetic Epidemiology of Major Depression: Review and Meta-Analysis, American Journal of Psychiatry, vol.157, issue.10, pp.157-1552, 2000.
DOI : 10.1176/appi.ajp.157.10.1552

A. Szczepankiewicz, P. Sobkowiak, M. Rachel, A. Breborowicz, N. Schoneich et al., Multilocus Analysis of Candidate Genes Involved in Neurogenic Inflammation in Pediatric Asthma and Related Phenotypes: A Case???Control Study, Journal of Asthma, vol.24, issue.2, pp.329-335, 2012.
DOI : 10.1002/(SICI)1521-4141(199810)28:10<3240::AID-IMMU3240>3.0.CO;2-U

M. H. Trivedi, A. J. Rush, S. R. Wisniewski, A. A. Nierenberg, D. Warden et al., Evaluation of Outcomes With Citalopram for Depression Using Measurement-Based Care in STAR*D: Implications for Clinical Practice, American Journal of Psychiatry, vol.163, issue.1, pp.28-40, 2006.
DOI : 10.1176/appi.ajp.163.1.28

Y. Zhang, Y. Fujiwara, Y. Doki, S. Takiguchi, T. Yasuda et al., Overexpression of Tyrosine Kinase B Protein as a Predictor for Distant Metastases and Prognosis in Gastric Carcinoma, Oncology, vol.75, issue.1-2, pp.17-26, 1159.
DOI : 10.1159/000151615