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Master Thesis

Évaluation du rôle de la radiothérapie dans la prise en charge multimodale des tumeurs desmoplastiques : étude rétrospective multicentrique de 107 patients

Abstract : Purpose: Evaluate the prognosis impact of adjuvant abdominal radiotherapy in multimodal treatment of Desmoplastic small round cell tumor (DSRCT). Materials and methods: Retrospective study including all patients treated for primary abdominal DSRCT in 8 French hospitals from 1991 to 2014. Patients were divided into three groups: group A treated with adjuvant radiotherapy (RT) after surgery, group B without RT after surgery and group C treated exclusively with chemotherapy. Peritoneal progression-free survival (PPFS), progression-free survival (PFS) and overall survival (OS) were evaluated. We also performed a comparison between group A and B to evaluate RT after surgery and according to the quality of the surgery: complete cytoreductive surgery (CCS) or incomplete cytoreductive surgery (ICS). Results: Thirty-seven patients were included in group A (35.9%), thirty-six (34.9%) in group B and thirty (28.0%) in group C. Three-year OS was 61.2% [41.0-76.0], 37.6% [22.0-53.1], and 17.3% [6.3-32.8] for group A, B and C, respectively. OS, PPFS and PFS differed significantly between the three groups (p<0.001). OS and PPFS were higher in group A compared to group B (p=0.045 and p=0.006, respectively). Three-year PPFS was 23.8% [10.3-40.4] for group A and 12.51% [4.0-26.2] for group B. After CCS, RT improved PPFS (p=0.024) but differences in OS and PFS were not significant (p=0.40 and p=0.30, respectively). After ICS, RT improved OS (p=0.044) and a tendency to increase was observed for PPFS and PFS but the difference was not statistically significant (p=0.073 and p=0.076). Conclusion: Our study showed the significant impact of adjuvant abdominal radiotherapy in multimodal treatment of abdominal DSRCT.
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Master Thesis
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Vincent Atallah. Évaluation du rôle de la radiothérapie dans la prise en charge multimodale des tumeurs desmoplastiques : étude rétrospective multicentrique de 107 patients. Cancer. 2015. ⟨dumas-01234220⟩

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