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Master Thesis

Les tumeurs vulvo-vaginales mésenchymateuses : une série de 255 cas

Abstract : Introduction: The vulvovaginal mesenchymal tumors (VVT) are rare and their diagnostics may be difficult. Methods: This study reports 255 cases reviewed in two readings; 188 cases were from Bergonié Institute, a tumor expert center and 67 were from the Bordeaux University Hospital (UH) (general center). Some cases required further analysis (immunohistochemistry and molecular biology) to correct many diagnoses. Results: The final results describe the population and histological subtypes in the two institutions, as well as diagnostic tools. A total of 53 histological types were reported; benign tumors were most common (76.1% of cases) and corresponded mainly (65.5%) to tumors specific of that location. This work highlights the concordance / discordance diagnostic for cases communicated for advice. Finally, this work focus on specific site benign tumors, representing 127 cases (49.8%), in purpose to better describe and summarize diagnostic issues. These tumors are usually classified in the right category, but their accurate typing is sometimes a problem, remaining without consequence for most cases. The main risk is to ignore the deep angiomyxoma (DAM) with local recurrence potential; our study shows that AMP is well recognized by pathologists with diagnosis precisely proposed in 72.7% of cases and over-diagnosed in 66.7%, while corresponding to another benign tumor (type "benign genital stromal tumor" in 73.3%) in 93.8% of the cases. Conclusion: This wide range of VVT shows, despite their rarity, a great variety and reflects histological diagnostic issues.
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Master Thesis
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Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Wednesday, December 16, 2015 - 6:27:43 PM
Last modification on : Wednesday, August 23, 2017 - 4:30:57 PM
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  • HAL Id : dumas-01245167, version 1



Marie Dilly-Feldis. Les tumeurs vulvo-vaginales mésenchymateuses : une série de 255 cas. Médecine humaine et pathologie. 2015. ⟨dumas-01245167⟩



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