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Master Thesis

Étude retrospective de l'efficacité du tacrolimus dans les langues géographiques algiques

Abstract : INTRODUCTION: Geographic tongue is usually an asymptomatic disorder. There is no symptomatic treatment evaluated with clinical trials. Our objective was to evaluate the efficiency of Tacrolimus in painful Geographic Tongue (GT). METHODS: A retrospective descriptive cohort study was performed in the Odontology Department PQR at the CHU in Bordeaux from January 2012 to May 2015. Patients with painful GT were treated by 0.1% Tacrolimus topically twice a day during one month. The primary endpoint was the evaluation of pain with a numerical pain scale (NPS) from 0 to 10 the first day and one month later. The secondary endpoints were the improvement of the quality of life and of the alimentation. RESULTS: Thirty one patients with GT consulted during the period studied. Seventeen were burned tongue, five patients presented primitive glossodynia and twelve had a painful GT. Ten patients were treated by Tacrolimus topically. There was an a! verage of 6 (+/- 1,7) of the NPS at the first consultation. The GT lesions were present in all cases. Feeding difficulties or burns were described by patient. The evaluation one month after the prescription of Protopic showed a significant improvement of the NPS with an average of 2 (+/-1,6) . An improvement of the quality of life was noted for all patients. No serious adverse events have been reported except an esophagus pain for three patients. CONCLUSIONS: The utilization of topical Tacrolimus seems to be efficient and well tolerated in painful GT. Otherwise, randomized trials versus placebo is necessary to conclude with certitude.
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Master Thesis
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Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Friday, December 18, 2015 - 10:47:12 AM
Last modification on : Wednesday, August 23, 2017 - 4:29:27 PM
Long-term archiving on: : Saturday, April 29, 2017 - 9:00:27 PM


  • HAL Id : dumas-01246164, version 1



Stéphanie Haddad. Étude retrospective de l'efficacité du tacrolimus dans les langues géographiques algiques. Médecine humaine et pathologie. 2015. ⟨dumas-01246164⟩



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