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Master Thesis

L'origine du spermatozoïde influence-t-elle les résultats de l'ICSI et le déroulement de la grossesse ?‎ Analyse comparative de 150 cycles avec recours de spermatozoïdes testiculaires d'hommes atteints d'azoospermie non-obstructive ou de spermatozoïdes éjaculés d'hommes atteints d'oligo-asthéno-tératospermie externe

Abstract : Background : The aim of the study was to compare the clinical and biological outcome of attempts at ICSI and obstetric and perinatal outcomes of pregnancies according to the origin of the injected sperm (ejaculated or testicular) in severe damages of spermatogenesis. Method : Comparative study, retrospective, single-center observational and over 150 ICSI cycles carried out between January 2005 and December 2013 at Rouen University Hospital. Comparing a group of 50 first ICSI cycles of patients with non-obstructive azoospermia (using testicular sperm) and a group of first 100 ICSI cycles patient suffering from extreme oligo-astheno-teratozoospermia (using sperm ejaculated). Results : The fertilization rate was significantly higher in the group with use of sperm ejaculated. Similarly, embryo OATS patients seem to be better qualifies that ANO patients. However, we do not find significant difference in the rate of implantation, clinical pregnancy, evolutive pregnancy and birth between the two groups. About 47 pregnancies initiated and newborns 40 designed, we find no significant difference in the rate of obstetric complications and congenitals malformations. Conclusion : Overall, the study did not reveal any significant difference in the outcome of ICSI cycles, the pregnancies outcomes and health status of newborns according to the origin of the sperm used.
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https://dumas.ccsd.cnrs.fr/dumas-01246463
Contributor : Bibliothèque Santé <>
Submitted on : Friday, December 18, 2015 - 3:38:25 PM
Last modification on : Monday, December 2, 2019 - 10:24:01 AM
Long-term archiving on: : Saturday, March 19, 2016 - 2:10:52 PM

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  • HAL Id : dumas-01246463, version 1

Citation

Raphaël Cusumano. L'origine du spermatozoïde influence-t-elle les résultats de l'ICSI et le déroulement de la grossesse ?‎ Analyse comparative de 150 cycles avec recours de spermatozoïdes testiculaires d'hommes atteints d'azoospermie non-obstructive ou de spermatozoïdes éjaculés d'hommes atteints d'oligo-asthéno-tératospermie externe. Gynécologie et obstétrique. 2015. ⟨dumas-01246463⟩

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