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Master Thesis

Facteurs pronostiques de survie dans les cholangiocarcinomes intrahépatiques

Abstract : Incidence rates of intrahepatic cholangiocarcinoma have recently increased in Western Countries. These cancers have a particularly bad prognosis and guidelines weren’t published until recently due to a lack of randomized data. The aim of our retrospective study was to assess clinical and biological features, treatment modalities and outcome of patients diagnosed with intrahepatic cholangiocarcinoma. We also aimed to identify prognostic factors in these tumors. METHODS : Patients whom had histological diagnosis of intrahepatic cholangiocarcinoma in our center between 2009 and 2013 were included. Clinicopathological parameters, and imaging data were retrospectively analyzed to identify prognosis factors, using different statistic models. RESULTS : The median survival of the 115 patients enrolled was 9,6 months [IC95 = 5,4-13,7]. On multivariate analysis, albumin levels (p=0,002), CRP concentration (p<0,001), Glasgow Prognostic Score (p<0,001), Platelet to Lymphocyte ratio (p=0,005) and Lymphocyte to Neutrophil ratio (p<0,001), tumor’s size (p=0,001) and tumor’s stage (p=0,015) were associated with overall survival independently of the initial treatment given. CONCLUSION : Our study identified inflammation-based score as prognostic factors in intrahepatic cholangiocarcinoma. These data suggests the role of systemic inflammatory response in the carcinogenesis of these tumors, which is one of the background of some actual studies evaluating targeted therapies. Future similar results might lead to a more personalized treatment, based on the specific risk of each patient.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01250335
Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Friday, March 25, 2016 - 11:53:30 AM
Last modification on : Wednesday, August 23, 2017 - 4:28:57 PM
Long-term archiving on: : Sunday, June 26, 2016 - 10:10:12 AM

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Adèle Robert. Facteurs pronostiques de survie dans les cholangiocarcinomes intrahépatiques. Médecine humaine et pathologie. 2015. ⟨dumas-01250335⟩

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