Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke, New England Journal of Medicine, vol.359, issue.13, pp.1317-1346, 2008. ,
DOI : 10.1056/NEJMoa0804656
A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke, New England Journal of Medicine, vol.372, issue.1, pp.11-20, 2015. ,
DOI : 10.1056/NEJMoa1411587
Facilities available in French hospitals treating acute stroke patients: comparison with 24 other European countries, Journal of Neurology, vol.159, issue.6, pp.867-73, 2009. ,
DOI : 10.1007/s00415-009-5029-2
Transient Ischemic Attack ??? Proposal for a New Definition, New England Journal of Medicine, vol.347, issue.21, pp.1713-1719, 2002. ,
DOI : 10.1056/NEJMsb020987
Les chiffres clés de l'AVC [Internet] Available from, 2013. ,
Prévalence des accidents vasculaires cérébraux et de leurs séquelles et impact sur les activités de la vie quotidienne: apports des enquêtes déclaratives Handicap-?santé-?ménages et Handicap-?santé-?institution ,
Available from, 2012. ,
Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment, Stroke, vol.24, issue.1, pp.35-41, 1993. ,
DOI : 10.1161/01.STR.24.1.35
Recombinant tissue plasminogen activator in acute thrombotic and embolic stroke, Annals of Neurology, vol.39, issue.1, pp.78-86, 1992. ,
DOI : 10.1002/ana.410320113
Arterial status after intravenous TPA therapy for ischaemic stroke. A need for further interventions, Int Angiol J Int Union Angiol, 2001. ,
Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection, New England Journal of Medicine, vol.372, issue.11, pp.1009-1027, 2015. ,
DOI : 10.1056/NEJMoa1414792
Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke, New England Journal of Medicine, vol.372, issue.11, pp.1019-1049, 2015. ,
DOI : 10.1056/NEJMoa1414905
Stent-Retriever Thrombectomy after Intravenous t-PA vs. t-PA Alone in Stroke, New England Journal of Medicine, vol.372, issue.24, pp.2285-95, 2015. ,
DOI : 10.1056/NEJMoa1415061
Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy. The Lancet, pp.1670-1674, 2000. ,
Indications for Early Aspirin Use in Acute Ischemic Stroke : A Combined Analysis of 40 000 Randomized Patients From the Chinese Acute Stroke Trial and the International Stroke Trial, Stroke, vol.31, issue.6, pp.1240-1249, 2000. ,
DOI : 10.1161/01.STR.31.6.1240
Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia. Stroke, pp.51-58, 1977. ,
Thresholds in cerebral ischemia - the ischemic penumbra, Stroke, vol.12, issue.6, pp.723-728, 1981. ,
DOI : 10.1161/01.STR.12.6.723
Regional cerebral blood flow thresholds during cerebral ischemia. Fed Proc, pp.2493-2497, 1979. ,
Reversal of focal " misery-? perfusion syndrome " by extra-?intracranial arterial bypass in hemodynamic cerebral ischemia. A case study with 15O positron emission tomography. Stroke, pp.454-463, 1981. ,
Available from: http://www.em-?consulte.com/article/103738/alertePM 24. le point sur? -? Imagerie de perfusion : principes et applications cliniques, 2015. ,
Geography, Structure, and Evolution of Diffusion and Perfusion Lesions in Diffusion and Perfusion Imaging Evaluation For Understanding Stroke Evolution (DEFUSE), Stroke, vol.40, issue.10, pp.3245-51, 2009. ,
DOI : 10.1161/STROKEAHA.109.558635
Infarction of 'non-core-non-penumbral' tissue after stroke: multivariate modelling of clinical impact, Brain, vol.134, issue.6, pp.1765-76, 2011. ,
DOI : 10.1093/brain/awr100
Beyond Mismatch Evolving Paradigms in Imaging the Ischemic Penumbra With Multimodal Magnetic Resonance Imaging. Stroke, pp.2729-2764, 2003. ,
Prolonged Persistence of Substantial Volumes of Potentially Viable Brain Tissue After Stroke : A Correlative PET-CT Study With Voxel-Based Data Analysis, Stroke, vol.27, issue.4, pp.599-606, 1996. ,
DOI : 10.1161/01.STR.27.4.599
Comparison of Ischemic Lesion Evolution in Embolic Versus Mechanical Middle Cerebral Artery Occlusion in Sprague Dawley Rats Using Diffusion and Perfusion Imaging. Stroke, pp.1283-1290, 2006. ,
Time Is Penumbra: Imaging, Selection and Outcome, Cerebrovascular Diseases, vol.38, issue.1, pp.59-72, 2014. ,
DOI : 10.1159/000365503
Imagerie par résonance magnétique de diffusion de l'encéphale chez l'adulte: technique, résultats normaux et pathologiques. EMC -? Radiol Imag Médicale -? Musculosquelettique -? Neurol -? Maxillofac, pp.1-20, 2014. ,
Improving detection of ischemic lesions at 3Tesla with optimized diffusion-weighted magnetic resonance imaging, Journal of Neuroradiology, vol.41, issue.1, pp.45-51, 2014. ,
DOI : 10.1016/j.neurad.2013.04.003
URL : https://hal.archives-ouvertes.fr/inserm-00845255
Sequence-specific MR Imaging Findings That Are Useful in Dating Ischemic Stroke, RadioGraphics, vol.32, issue.5, pp.1285-97, 2012. ,
DOI : 10.1148/rg.325115760
Intravenous Thrombolysis Based on Diffusion-Weighted Imaging and Fluid-Attenuated Inversion Recovery Mismatch in Acute Stroke Patients with Unknown Onset Time, Cerebrovascular Diseases, vol.31, issue.5, pp.435-476, 2011. ,
DOI : 10.1159/000323850
DWI-FLAIR mismatch for the identification of patients with acute ischaemic stroke within 4??5 h of symptom onset (PRE-FLAIR): a multicentre observational study, The Lancet Neurology, vol.10, issue.11, pp.978-86, 2011. ,
DOI : 10.1016/S1474-4422(11)70192-2
DWI prediction of symptomatic hemorrhagic transformation in acute MCA infarct, J Neuroradiol J Neuroradiol, vol.29, issue.1, pp.6-13, 2002. ,
MR screening of candidates for thrombolysis: How to identify stroke mimics?, Journal of Neuroradiology, vol.41, issue.5, 2014. ,
DOI : 10.1016/j.neurad.2014.05.008
Imageries de diffusion et de perfusion en IRM à la phase hyperaiguë de l'accident vasculaire cérébral ischémique, J Radiol, issue.81, pp.858-69, 2000. ,
T2-?*weighted perfusion MRI. Diagn Interv Imaging, pp.1205-1214, 2013. ,
Comparaison des méthodes de quantification du volume des lésions ischémiques par imagerie de diffusion / perfusion à la phase aiguë de l'infarctus cérébral ,
The Physiological Significance of the Time-?to-?Maximum (Tmax) Parameter in Perfusion MRI. Stroke, pp.1169-74, 2010. ,
Visual Assessment of Perfusion-Diffusion Mismatch Is Inadequate to Select Patients for Thrombolysis, Cerebrovascular Diseases, vol.29, issue.6, pp.592-598, 2010. ,
DOI : 10.1159/000311080
Perfusion-?Weighted Magnetic Resonance Imaging Thresholds Identifying Core, Irreversibly Infarcted Tissue. Stroke, pp.1425-1455, 2003. ,
Optimal Definition for PWI/DWI Mismatch in Acute Ischemic Stroke Patients, Journal of Cerebral Blood Flow & Metabolism, vol.35, issue.5, pp.887-91, 2008. ,
DOI : 10.1038/sj.jcbfm.9600604
Diffusion- and Perfusion-Weighted MRI : The DWI/PWI Mismatch Region in Acute Stroke, Stroke, vol.30, issue.8, 1999. ,
DOI : 10.1161/01.STR.30.8.1591
Magnetic resonance perfusion diffusion mismatch and thrombolysis in acute ischaemic stroke: a systematic review of the evidence to date, Journal of Neurology, Neurosurgery & Psychiatry, vol.78, issue.5, pp.485-91, 2007. ,
DOI : 10.1136/jnnp.2006.100347
Which MR-derived Perfusion Parameters are the Best Predictors of Infarct Growth in Hyperacute Stroke? Comparative Study between Relative and Quantitative Measurements, Radiology, vol.223, issue.2, pp.361-70, 2002. ,
DOI : 10.1148/radiol.2232010673
Viability Thresholds of Ischemic Penumbra of Hyperacute Stroke Defined by Perfusion-Weighted MRI and Apparent Diffusion Coefficient, Stroke, vol.32, issue.5, pp.1140-1146, 2001. ,
DOI : 10.1161/01.STR.32.5.1140
Optimal Tmax Threshold for Predicting Penumbral Tissue in Acute Stroke, Stroke, vol.40, issue.2, 2009. ,
DOI : 10.1161/STROKEAHA.108.526954
Multiattribute Selection of Acute Stroke Imaging Software Platform for Extending the Time for Thrombolysis in Emergency Neurological Deficits (EXTEND) Clinical Trial, International Journal of Stroke, vol.32, issue.3, p.2013 ,
DOI : 10.1016/S1474-4422(08)70044-9
Refining the Perfusion?Diffusion Mismatch Hypothesis. Stroke, pp.1153-1162, 2005. ,
Comparison of Computed Tomographic and Magnetic Resonance Perfusion Measurements in Acute Ischemic Stroke: Back-to-Back Quantitative Analysis, Stroke, vol.45, issue.6, pp.1727-1759, 2014. ,
DOI : 10.1161/STROKEAHA.114.005419
Early Diffusion-Weighted Imaging and Perfusion-Weighted Imaging Lesion Volumes Forecast Final Infarct Size in DEFUSE 2, Stroke, vol.44, issue.3, pp.681-686, 2013. ,
DOI : 10.1161/STROKEAHA.111.000135
Maps of Time to Maximum and Time to Peak for Mismatch Definition in Clinical Stroke Studies Validated With Positron Emission Tomography, Stroke, vol.41, issue.12, pp.2817-2838, 2010. ,
DOI : 10.1161/STROKEAHA.110.594432
Imaging of acute stroke, The Lancet Neurology, vol.5, issue.9, pp.755-68, 2006. ,
DOI : 10.1016/S1474-4422(06)70545-2
Moving Beyond a Single Perfusion Threshold to Define Penumbra A Novel Probabilistic Mismatch Definition. Stroke, pp.1548-55, 2012. ,
Relationships Between Cerebral Perfusion and Reversibility of Acute Diffusion Lesions in DEFUSE Insights from RADAR. Stroke, pp.1692-1699, 2009. ,
How Sustained Is 24-Hour Diffusion-Weighted Imaging Lesion Reversal?, Stroke, vol.46, issue.3, pp.704-714, 2015. ,
DOI : 10.1161/STROKEAHA.114.008322
The Ischemic Penumbra: Correlates in Imaging and Implications for Treatment of Ischemic Stroke, Cerebrovascular Diseases, vol.32, issue.4, pp.307-327, 2011. ,
DOI : 10.1159/000330462
The resistance to ischemia of white and gray matter after stroke, Annals of Neurology, vol.9, issue.5, pp.695-701, 2004. ,
DOI : 10.1002/ana.20265
Fragmentation of the Classical Magnetic Resonance Mismatch "Penumbral" Pattern With Time, Stroke, vol.40, issue.12, pp.3752-3759, 2009. ,
DOI : 10.1161/STROKEAHA.109.555011
Mechanisms of Unexplained Neurological Deterioration After Intravenous Thrombolysis, Stroke, vol.45, issue.12, p.114, 2014. ,
DOI : 10.1161/STROKEAHA.114.006745
Magnetic resonance imaging profiles predict clinical response to early reperfusion: The diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study, Annals of Neurology, vol.292, issue.5, pp.508-525, 2006. ,
DOI : 10.1002/ana.20976
RAPID Automated Patient Selection for Reperfusion Therapy: A Pooled Analysis of the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET) and the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution (DEFUSE) Study, Stroke, vol.42, issue.6, pp.1608-1622, 2011. ,
DOI : 10.1161/STROKEAHA.110.609008
MRI profile and response to endovascular reperfusion after stroke (DEFUSE 2): a prospective cohort study, The Lancet Neurology, vol.11, issue.10, pp.860-867 ,
DOI : 10.1016/S1474-4422(12)70203-X
Refining the Definition of the Malignant Profile Insights From the DEFUSE-?EPITHET Pooled Data Set. Stroke, pp.1270-1275, 2011. ,
Real-?time Diffusion-?Perfusion Mismatch Analysis ,
Identifying and utilizing the ischemic penumbra, Neurology, vol.79, issue.Issue 13, Supplement 1, pp.79-85, 2012. ,
DOI : 10.1212/WNL.0b013e3182695814
Monitoring Intravenous Recombinant Tissue Plasminogen Activator Thrombolysis for Acute Ischemic Stroke With Diffusion and Perfusion MRI, Stroke, vol.31, issue.6, pp.1318-1346, 2000. ,
DOI : 10.1161/01.STR.31.6.1318
Evaluation of early reperfusion and IV tPA therapy using diffusion- and perfusion-weighted MRI, Neurology, vol.52, issue.9, pp.1792-1800, 1999. ,
DOI : 10.1212/WNL.52.9.1792
Diffusion- and perfusion-weighted MRI response to thrombolysis in stroke, Annals of Neurology, vol.282, issue.1, pp.28-37, 2002. ,
DOI : 10.1002/ana.10067
Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial, The Lancet Neurology, vol.7, issue.4, pp.299-309, 2008. ,
DOI : 10.1016/S1474-4422(08)70044-9
How Reliable Is Perfusion MR in Acute Stroke?: Validation and Determination of the Penumbra Threshold Against Quantitative PET, Stroke, vol.39, issue.3, pp.870-877, 2008. ,
DOI : 10.1161/STROKEAHA.107.500090
Dose Escalation of Desmoteplase for Acute Ischemic Stroke (DEDAS): Evidence of Safety and Efficacy 3 to 9 Hours After Stroke Onset, Stroke, vol.37, issue.5, pp.1227-1258, 2006. ,
DOI : 10.1161/01.STR.0000217403.66996.6d
Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion???diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study, The Lancet Neurology, vol.8, issue.2, pp.141-50, 2009. ,
DOI : 10.1016/S1474-4422(08)70267-9
Mismatch-Based Delayed Thrombolysis: A Meta-Analysis, Stroke, vol.41, issue.1, pp.25-33, 2010. ,
DOI : 10.1161/STROKEAHA.109.566869
Salvage of the PWI/DWI Mismatch up to 48 h from Stroke Onset Leads to Favorable Clinical Outcome, International Journal of Stroke, vol.30, issue.4, pp.565-70, 2015. ,
DOI : 10.1161/STROKEAHA.110.582874
Evaluation of risk of hemorrhagic transformation in local intra- arterial thrombolysis in acute ischemic stroke by initial SPECT, Stroke, vol.25, issue.2, pp.298-303, 1994. ,
DOI : 10.1161/01.STR.25.2.298
Optimal Magnetic Resonance Perfusion Thresholds Identifying Ischemic Penumbra and Infarct Core: A Chinese Population-based Study, CNS Neuroscience & Therapeutics, vol.35, issue.3, 2014. ,
DOI : 10.1111/cns.12367
Tissue at Risk Is Overestimated in Perfusion-?Weighted Imaging: MR Imaging in Acute Stroke Patients without Vessel Recanalization, Am J Neuroradiol, vol.26, issue.4, pp.815-824, 2005. ,
Factors that determine penumbral tissue loss in acute ischaemic stroke, Brain, vol.136, issue.12, pp.3554-60, 2013. ,
DOI : 10.1093/brain/awt246
Influence of Admission Body Temperature on Stroke Mortality, Stroke, vol.31, issue.2, pp.404-413, 2000. ,
DOI : 10.1161/01.STR.31.2.404
The Association of Blood Pressure and Collateral Circulation in Hyperacute Ischemic Stroke Patients Treated with Intravenous Thrombolysis, Cerebrovascular Diseases, pp.130-137, 2015. ,
DOI : 10.1159/000371339
Acute hyperglycemia adversely affects stroke outcome: A magnetic resonance imaging and spectroscopy study, Annals of Neurology, vol.30, issue.1, pp.20-28, 2002. ,
DOI : 10.1002/ana.10241
Recommendations on Angiographic Revascularization Grading Standards for Acute Ischemic Stroke: A Consensus Statement, Stroke, vol.44, issue.9, pp.2650-63, 2013. ,
DOI : 10.1161/STROKEAHA.113.001972
Clinical and Magnetic Resonance Imaging Predictors of Very Early Neurological Response to Intravenous Thrombolysis in Patients With Middle Cerebral Artery Occlusion Available from, J Am Heart Assoc Cardiovasc Cerebrovasc Dis, vol.2, issue.6, 2013. ,
Association of Early National Institutes of Health Stroke Scale Improvement With Vessel Recanalization and Functional Outcome After Intravenous Thrombolysis in Ischemic Stroke, Stroke, vol.42, issue.6, pp.1638-1681, 2011. ,
DOI : 10.1161/STROKEAHA.110.606194
Incidence of New Diffusion-Weighted Imaging Lesions Outside the Area of Initial Hypoperfusion Within 1 Week After Acute Ischemic Stroke, Stroke, vol.43, issue.10, pp.2654-2662, 2012. ,
DOI : 10.1161/STROKEAHA.112.655993
Hemodynamic Factors and Perfusion Abnormalities in Early Neurological Deterioration, Stroke, vol.40, issue.6, pp.443-50, 2009. ,
DOI : 10.1161/STROKEAHA.108.532465
Effect of blood pressure and diabetes on stroke in progression. The Lancet, Jul, vol.16344, issue.8916, pp.156-165, 1994. ,
Impact of collateral flow on tissue fate in acute ischaemic stroke, Journal of Neurology, Neurosurgery & Psychiatry, vol.79, issue.6, 2008. ,
DOI : 10.1136/jnnp.2007.132100
Reperfusion Within 6 Hours Outperforms Recanalization in Predicting Penumbra Salvage, Lesion Growth, Final Infarct, and Clinical Outcome, Stroke, vol.46, issue.6, pp.1582-1591 ,
DOI : 10.1161/STROKEAHA.114.007964
Reperfusion Is a Stronger Predictor of Good Clinical Outcome than Recanalization in Ischemic Stroke, Radiology, vol.269, issue.1, pp.240-248, 2013. ,
DOI : 10.1148/radiol.13122327
Recovery of motor function after stroke, Stroke, vol.19, issue.12, pp.1497-500, 1988. ,
DOI : 10.1161/01.STR.19.12.1497
Intravenous Alteplase for Stroke: Beyond the Guidelines and in Particular Clinical Situations, Stroke, vol.38, issue.9, pp.2612-2620, 2007. ,
DOI : 10.1161/STROKEAHA.106.480566