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Master Thesis

Caractérisation des patients ayant des métastases opérées d’adénocarcinome de l’intestin grêle

Abstract : Introduction: Small bowel adenocarcinoma (SBA) is an uncommon tumor and the therapeutic management is not well established. The curative treatment for resectable tumor and its metastases is carcinological surgery. Unfortunately, the most common treatment performed for metastatic tumor is palliative chemotherapy (CT). Results: This retrospective study assessed clinical, paraclinical, overall survival (OS) and progression-free survival (PFS) in 34 patients with resected metastasis mainly coming from NADEGE’s cohort. Patients had synchronous metastases (25) or metachronous metastases (9). Ileal primitive localization was twice as common compared with patients in NADEGE’s cohort. Adjuvant CT was given to 29/34 patients after metastatic surgery and among them 25 had oxaliplatin. The OS for patients treated with surgery +/- CT was 25.1 months. The PFS was 13.6 months and increased to 21.2 months for patients with healthy resection margins. In univariate analyses, factors associated with a decrease of OS were adjuvant CT without oxaliplatin (p=0.034), a poorly differentiated histology (p=0.0037) and an invaded resection margin (p=0.014). Conclusion: AIG’s with resected metastases provides an increase of OS compared with those reported in the literature without surgery. Nevertheless, this OS remains lesser than the OS for colorectal cancer with resected metastases. Adjuvant CT with oxaliplatin and carcinological surgery are major prognostic factors.
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Master Thesis
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Submitted on : Thursday, January 7, 2016 - 5:57:32 PM
Last modification on : Friday, October 23, 2020 - 4:42:52 PM
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  • HAL Id : dumas-01252608, version 1


Pierre Rompteaux. Caractérisation des patients ayant des métastases opérées d’adénocarcinome de l’intestin grêle. Médecine humaine et pathologie. 2015. ⟨dumas-01252608⟩



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