Skip to Main content Skip to Navigation
Master Thesis

Évaluation du mésusage des benzodiazépines en France entre 2007 et 2012, données de l'assurance maladie

Abstract : Background: Benzodiazepines (BZD) are commonly used in France and they are associated with risks such as falls, bone fractures, dementia, road traffic accidents and work injuries. The main goal was to estimate the frequency of benzodiazepine misuse in France between 2007 and 2012 using a French insurance claims database (EGB, Echantillon Généraliste de Bénéficiaires). Methods: In this time, every subject with a first BZD dispensation (hypnotics including zopiclone, zolpidem, and anxiolytics), was included in the study. Three misuse criteria were defined: i/ frequency of concomitant dispensations of two BZD of the same type within 30 days following the index dispensation; ii/ frequency of index dispensations covering more than 4 weeks of treatment for hypnotics and more than 12 weeks for anxiolytics; iii/ frequency of at least one new dispensation of a hypnotic or anxiolytic over the 2 months following the end of the treatment coverage period. Results: About 10 000 hypnotics and 18 000 anxiolytics users were identified each year as new users of BZD. According to the year of BZD initiation, 27% to 30% of hypnotic users and 17% to 20% of anxiolytic users had at least one misuse criterion. The most frequent misuse criterion was renewal of the first dispensation over the 2 months following the end of the treatment coverage period, which varied between 2007 and 2012 from 19 to 22% for hypnotics and 10 to 12% for anxiolytics. Misuse by a treatment covering more than 4 weeks for hypnotics varied from 14 to 16%, and more than 12 weeks for anxiolytics from 11 and 13%. Misuse by concomitance varied from 4 to 6% for both hypnotics and anxiolytics. Discussion/Conclusion: According to the considered criteria, one forth of hypnotic users and one fifth of anxiolytic users in France presented with misuse of BZD. These results confirm that actions to improve good prescription and use of BZD are still needed in France.
Document type :
Master Thesis
Complete list of metadata

Cited literature [7 references]  Display  Hide  Download

https://dumas.ccsd.cnrs.fr/dumas-01258478
Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Tuesday, January 19, 2016 - 10:34:13 AM
Last modification on : Wednesday, August 23, 2017 - 4:29:39 PM
Long-term archiving on: : Wednesday, April 20, 2016 - 11:00:38 AM

Identifiers

  • HAL Id : dumas-01258478, version 1

Collections

Citation

Arnaud Panes. Évaluation du mésusage des benzodiazépines en France entre 2007 et 2012, données de l'assurance maladie. Sciences pharmaceutiques. 2015. ⟨dumas-01258478⟩

Share

Metrics

Record views

162

Files downloads

326