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Master Thesis

Les champignons endophytes : impact sur les écosystèmes et production de molécules d'intérêt thérapeutique

Abstract : Fungal endophytes are a diverse polyphyletic group, mainly composed of species from Ascomycetes. Their way of life is characterized by an endophytic phase : they colonize host plants asymptomatically, for at least one part of their life cycle. All plants in natural ecosystems interact with endophytic fungi. For fifty years, there has been a growing interest in their study following the discovery of their involvement in many toxicosis observed in cattle and also their capacity to produce an anticancer drug, paclitaxel, the active ingredient of Taxol®, a blockbuster drug in pharmaceutical industry. This work aims at achieving a state of the art on endophytic fungi and especially their impact on the ecosystems and their ability to produce therapeutic substances. We have described the impact of endophytes on host phenotypes, on the surrounding plants (allelopathy), but also on animals and microorganisms interacting with colonized plants. We also studied the bioactive molecules produced by these fungi by describing four therapeutic substances with high added value. Finally, we discussed the biotechnological aspects describing the different strategies for optimizing the production of these molecules.
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Master Thesis
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Submitted on : Monday, June 20, 2016 - 8:55:17 AM
Last modification on : Tuesday, May 11, 2021 - 11:36:18 AM
Long-term archiving on: : Friday, September 23, 2016 - 12:07:11 AM


  • HAL Id : dumas-01266084, version 1


Andéol Sénéquier-Crozet, Benjamin Canard. Les champignons endophytes : impact sur les écosystèmes et production de molécules d'intérêt thérapeutique. Sciences pharmaceutiques. 2016. ⟨dumas-01266084⟩



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