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Phe diminuent rapidement de l'année 0 à l'année 1 d'un facteur de 1,5. Puis, à partir de la 3 ème année (année 2), les taux ne cessent d'augmenter pour atteindre 50% d'échec entre l'année 6 et 7 (soit 1 prélèvement sur 2 supérieur aux normes) De plus, il est important de noter qu'un taux très élevé de 64, 19% de concentrations en Phe supérieures à 5 mg/dl est observé lors de la dernière année ,
Sur les 10 patients atteints d'HMP, aucun n'est encore assez âgé pour pouvoir inclure la 10 ème année (année 9) dans l'étude ,
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