il faut 6-12 mois de supplémentation pour retrouver les taux physiologiques de DHEA observés chez un individu jeune [25], il paraît logique que le temps de latence des effets soit supérieur à 3 mois chez 60 ,
Les résultats de notre étude ne confirment pas l'amélioration de la prise de DHEA sur la masse musculaire ,
Les résultats obtenus laissent penser que la DHEA aurait des propriétés bénéfiques sur la cognition, 60 % des individus parlent d'une efficacité moyenne à très importante contrebalançant le manque de preuves de la littérature à ce sujet ,
les différentes publications se contredisent sur la question ,
on peut citer le cas d'une patiente, souffrant de cystites à répétition attribuées à la sécheresse de la muqueuse vaginale, qui suite à la prise de DHEA n'a ,
-Neuroactive neurosteroids : DHEA and DHEA-sulfate -Acta, Paediatr, vol.433, pp.78-80, 1999. ,
URL : https://hal.archives-ouvertes.fr/hal-00555453
-Etude de l'administration de déhydroépiandrostérone chez le sujet de 60 à 79 ans ou protocole DHEAge, 2004. ,
URL : https://hal.archives-ouvertes.fr/hal-00555453
-Relationships of dehydroepiandrosterone sulfate in the ederly with functional, psychological, and mental status, and short-term mortality : a french community-based study, Proc. Natl. Acad. Sei, pp.13410-13415, 1996. ,
URL : https://hal.archives-ouvertes.fr/inserm-00319551
-DHEA et intracrinologie de jouvence pour la peau? Entre raison et inagie -Rev, Med. Liege, vol.57, issue.7, pp.438-442, 2002. ,
URL : https://hal.archives-ouvertes.fr/hal-00807891
??ber Androsteron, ein krystallisiertes m??nnliches Sexualhormon. I. Isolierung und Reindarstellung aus M??nnerharn., Hoppe-Seyler??s Zeitschrift f??r physiologische Chemie, vol.229, issue.4-6, pp.167-84, 1934. ,
DOI : 10.1515/bchm2.1934.229.4-6.167
-Immunological characterization ofDHEA sulfotransferase :from human liver and adrenals, Mol. Pharmacol, vol.41, pp.645-651, 1992. ,
URL : https://hal.archives-ouvertes.fr/hal-00656345
Characterization and measurement of dehydroepiandrosterone sulfate in rat brain., Proc. Natl. Acad. Sei, pp.4704-4707, 1981. ,
DOI : 10.1073/pnas.78.8.4704
Pattern of Plasma Dehydroepiandrosterone Sulfate Levels in Humans from Birth to Adulthood: Evidence for Testicular Production*, The Journal of Clinical Endocrinology & Metabolism, vol.47, issue.3, pp.572-577, 1978. ,
DOI : 10.1210/jcem-47-3-572
Physiological importance of dehydroepiandrosterone, The Lancet, vol.343, issue.8911, pp.1479-1481, 1994. ,
DOI : 10.1016/S0140-6736(94)92587-9
The zona reticularis is the site of biosynthesis of dehydroepiandrostérone and dehydroepiandrosterone sulfate in the adult human adrenal cortex resulting :from its low expression of3B-hydroxysteroïd deshydrogenase, J. Clin. Endocrinol. Metab, vol.81, issue.10, pp.3558-3565, 1996. ,
Sharpe Timms-Dehydroepiandrosterone replacement in aging humans, J. Clin. Endocrinol. 1vletab, vol.84, issue.5, pp.1527-1533, 1999. ,
Physiologie humaine -2e Ed. -Pradel, Paris-1996 ,
Reduction of atherosclerosis by administration of dehydroepiandrosterone. A study in the hypercholesterolemic New Zealand white rabbit with aortic intimal injury., Journal of Clinical Investigation, vol.82, issue.2, pp.712-720, 1998. ,
DOI : 10.1172/JCI113652
Changes in Bone Turnover Markers and Menstrual Function After Short-term Oral DHEA in Young Women with Anorexia Nervosa, Journal of Bone and Mineral Research, vol.8, issue.1 ,
DOI : 10.1359/jbmr.1999.14.1.136
Effects of Age on Serum Dehydroepiandrosterone Sulfate, IGF-I, and IL-6 Levels in Women, Calcified Tissue International, vol.66, issue.6, pp.414-422, 2000. ,
DOI : 10.1007/s002230010084
-The age of dehydroepiandrosterone -Lancet, pp.1193-1194, 1995. ,
URL : https://hal.archives-ouvertes.fr/hal-00460959
-Dehydroepiandrosterone (DHEA) supplementation for cognition and well-being-Cochrane Database Syst, Rev, vol.2, p.304, 2000. ,
URL : https://hal.archives-ouvertes.fr/hal-01156596
-The biologie role of dehydroépiandrosterone (DHEA) ,
-DHEA sulfotransferase localization in hum.an adrenal glands : a light and electron microscopie study, J. Clin. Endocrinol ,
-Replacement ofDHEA in aging men and women. Potential remedial e:ffects -Ann, NY. Acad. Sei, vol.774, pp.128-142, 1995. ,
URL : https://hal.archives-ouvertes.fr/hal-01005949
DHEA, Current Opinion in Obstetrics and Gynecology, vol.8, issue.5 ,
DOI : 10.1097/00001703-199610000-00006
DHEA antagonizes the neurotoxic effect of cortisterone and translocation of stress-actived protein kinase 3 in hippocampal primary cultures - Neuroscience-1999, pp.429-436 ,
DHEA and Peripheral Androgen and Estrogen Formation: Intracrinology, Annals of the New York Academy of Sciences, vol.12, issue.1 Dehydroepiand, pp.16-28, 1995. ,
DOI : 10.1016/0303-7207(85)90138-8
DHEA and the Intracrine Formation of Androgens and Estrogens in Peripheral Target Tissues: Its Role during Aging, Steroids, vol.63, issue.5-6, pp.5-6, 1998. ,
DOI : 10.1016/S0039-128X(98)00007-5
Effects of dehydroepiandrosterone on collagen and collagenase gene expression by skin fibroblasts in culture, Journal of Dermatological Science, vol.23, issue.2, pp.103-113, 2000. ,
DOI : 10.1016/S0923-1811(99)00094-8
et al -Dehydroepiandrosterone replacement administration : pharmacokinetic and pharmacodynamie studies in healthy elderly subjects, J. Clin. Endocrinol. Metab, vol.8, issue.9, pp.3208-3225, 2000. ,
-Marked attenuation ofultradian and circadian rhythms ofDHEA in postmenopausal women: evidence for reduced, pp.17-20 ,
URL : https://hal.archives-ouvertes.fr/tel-00259428
-DHEA and its transformation into androgens and estrogens in peripherical target tissues: intracrinology-Front Neuroendocrinol, pp.185-212, 2001. ,
URL : https://hal.archives-ouvertes.fr/hal-01129713
Serum DHEAS levels correlate with platelet cGMP in normal women, Journal of Endocrinological Investigation, vol.74, issue.Suppl.A, pp.28-30, 2001. ,
DOI : 10.1007/BF03343922
Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: Relationship to gender, subjective health, smoking habits, and 10-year mortality, Proceedings of the National Academy of Sciences, vol.98, issue.14, pp.8145-8150, 2001. ,
DOI : 10.1073/pnas.121177998
-Identification and isolation of dehydroepiandrosterone from peripheral plasma, J. Biol. Chem, vol.209, pp.767-72, 1954. ,
URL : https://hal.archives-ouvertes.fr/hal-00408923
-Effect ofreplacement dose ofDHEA in men and women of advancing age, J. Clin. Endocrinol. Metab, vol.78, pp.1360-1367, 1994. ,
URL : https://hal.archives-ouvertes.fr/hal-00506698
The Effects of Oral Dehydroepiandrosterone on Endocrine-Metabolic Parameters in Postmenopausal Women*, The Journal of Clinical Endocrinology & Metabolism, vol.71, issue.3, pp.696-704, 1990. ,
DOI : 10.1210/jcem-71-3-696
-Regulation ofhuman dehydroepiandrosterone metabolism by ,
URL : https://hal.archives-ouvertes.fr/hal-00143244
-Is there a case for DHEA replacement?-Clin ,
Age Changes and Sex Differences in Serum Dehydroepiandrosterone Sulfate Concentrations throughout Adulthood, The Journal of Clinical Endocrinology & Metabolism, vol.59, issue.3, pp.551-555, 1984. ,
DOI : 10.1210/jcem-59-3-551
-A long-term longitudinal measurement of plasma DHEA-S in normal men, J. Clin. Metab, vol.75, issue.4, pp.1002-1004, 1992. ,
Dehydroepiandrosterone in the treatment of erectile dysfunction: a prospective, double-blind, randomised, placebo-controlled study-Urology-1999, pp.590-590 ,
Interne-2001-152, suppl. n°3, pp.1-43 ,
Dehydroisoandrosterone Is Secreted Episodically and Synchronously with Cortisol by Normal Man, The Journal of Clinical Endocrinology & Metabolism, vol.33, issue.1, p.87, 1971. ,
DOI : 10.1210/jcem-33-1-87
A genetic component to the variation of dehydroepiandrosterone sulfate, Metabolism, vol.34, issue.8, pp.731-736, 1985. ,
DOI : 10.1016/0026-0495(85)90023-X
-Relationship ofHDL cholesterol to testosterone, estradio l and sex-hormone binding glo bulin levels in men and women -Metabo lism - 1983, pp.428-460 ,
URL : https://hal.archives-ouvertes.fr/hal-01292489
EFFECT OF EXOGENOUS CORTICOTROPIN ON THE HISTOCHEMICAL PATTERN OF THE HUMAN ADRENAL CORTEX AND A COMPARISON WITH THE CHANGES DURING STRESS, The Journal of Clinical Endocrinology & Metabolism, vol.16, issue.5, p.580, 1956. ,
DOI : 10.1210/jcem-16-5-580
-Dehydroepiandrosterone for the treatment of systemic lupus erythematosus-Exp, Pharmacother, vol.3, issue.1, pp.23-31, 2002. ,
-The role of dehydroepiandrosterone in diabetes mellitus -Pharmacotherapy-1999, pp.582-591 ,
URL : https://hal.archives-ouvertes.fr/insu-00381794
-Effects of dehydroepiandrosterone replacement in ederly men: event-related potentials, memory, and well-being, J. Geront. Bio. Med. Sei, vol.53, issue.5, pp.385-390, 1998. ,
URL : https://hal.archives-ouvertes.fr/hal-01158033
-Double-blind treatment of major depression with dehydroepiandrosterone -Am, J. Psychiatry, vol.156, issue.4, pp.646-649, 1999. ,
-Effects ofreplacement dose of dehydroepiandrosterone in men and women of advancing age, J. Clin. Endocrinol. Metab, vol.78, issue.6, pp.1360-1367, 1994. ,
URL : https://hal.archives-ouvertes.fr/hal-00506698
-DHEA: pilule de jouvence ou simple précurseur des stéroïdes sexuels -Med, Ther. Endocr, vol.37, pp.133-175, 2001. ,
URL : https://hal.archives-ouvertes.fr/hal-00109100
Sex Difference in the Metabolism of Dehydroisoandrosterone Sulfate*, The Journal of Clinical Endocrinology & Metabolism, vol.51, issue.2, p.334, 1980. ,
DOI : 10.1210/jcem-51-2-334
Dehydroepiandrosterone and cardiac arrythmia ,
stéroïde le plus abondant de l'organisme dont le taux sanguin régresse avec l'âge, est présentée par les médias comme une« hormone miracle» bien que son activité pharmacologique exacte reste mystérieuse et inconnue ,
quel doit être le rôle du professionnel de santé? Mots clés ,