E. Andres and K. Serraj, Optimal management of pernicious anemia, Journal of Blood Medicine, vol.3, pp.97-103, 2012.
DOI : 10.2147/JBM.S25620

B. Toh, Diagnosis and classification of autoimmune gastritis, Autoimmunity Reviews, vol.13, issue.4-5, pp.4-5459, 2014.
DOI : 10.1016/j.autrev.2014.01.048

L. Vannella, E. Lahner, J. Osborn, and B. Annibale, Systematic review: gastric cancer incidence in pernicious anaemia, Alimentary Pharmacology & Therapeutics, vol.101, issue.4, pp.375-82, 2013.
DOI : 10.1111/apt.12177

L. Arnaud, J. Fagot, A. Mathian, M. Paita, A. Fagot-campagna et al., Prevalence and incidence of systemic lupus erythematosus in France: A 2010 nation-wide population-based study, Autoimmunity Reviews, vol.13, issue.11, pp.1082-1091, 2014.
DOI : 10.1016/j.autrev.2014.08.034

D. Block, C. , D. Leeuw, I. , V. Gaal et al., Autoimmune Gastritis in Type 1 Diabetes: A Clinically Oriented Review, The Journal of Clinical Endocrinology & Metabolism, vol.93, issue.2, pp.363-71, 2008.
DOI : 10.1210/jc.2007-2134

J. Anaya, The diagnosis and clinical significance of polyautoimmunity, Autoimmunity Reviews, vol.13, issue.4-5, pp.4-5423, 2014.
DOI : 10.1016/j.autrev.2014.01.049

B. Toh, I. Van-driel, and P. Gleeson, Pernicious Anemia, N Engl J Med, vol.337, issue.20, pp.1441-1449, 1997.

D. Elios, M. Appelmelk, B. Amedei, A. Bergman, M. Prete et al., Gastric autoimmunity: the role of Helicobacter pylori and molecular mimicry, Trends in Molecular Medicine, vol.10, issue.7, pp.316-339, 2004.
DOI : 10.1016/j.molmed.2004.06.001

B. Appelmelk, G. Faller, D. Claeys, T. Kirchner, and C. Vandenbroucke-grauls, Bugs on trial: the case of Helicobacter pylori and autoimmunity, Immunology Today, vol.19, issue.7, pp.296-305, 1998.
DOI : 10.1016/S0167-5699(98)01281-X

D. Claeys, G. Faller, B. Appelmelk, R. Negrini, and T. Kirchner, The gastric H+,K+-ATPase is a major autoantigen in chronic Helicobacter pylori gastritis with body mucosa atrophy, Gastroenterology, vol.115, issue.2
DOI : 10.1016/S0016-5085(98)70200-8

M. Saito, M. Morioka, K. Wakasa, K. Izumiyama, A. Mori et al., In Japanese patients with type A gastritis with pernicious anemia the condition is very poorly associated with Helicobacter pylori infection, Journal of Infection and Chemotherapy, vol.19, issue.2, pp.208-218, 2012.
DOI : 10.1007/s10156-012-0476-6

G. Sébahoun, Hématologie clinique et biologique Wolters Kluwer France, 2005.

C. Snow, Laboratory Diagnosis of Vitamin B12 and Folate Deficiency, Archives of Internal Medicine, vol.159, issue.12, pp.1289-98, 1999.
DOI : 10.1001/archinte.159.12.1289

L. Parnetti, V. Caso, A. Santucci, F. Corea, A. Lanari et al., Mild hyperhomocysteinemia is a risk-factor in all etiological subtypes of stroke, Neurological Sciences, vol.25, issue.1, pp.13-20, 2004.
DOI : 10.1007/s10072-004-0219-5

A. Caldera, J. Mora, M. Kotler, and G. Eiger, Pulmonary Embolism in a Patient with Pernicious Anemia and Hyperhomocysteinemia, Chest, vol.122, issue.4, pp.1487-1495, 2002.
DOI : 10.1378/chest.122.4.1487

A. Kharchafi, Z. Oualim, T. Amezyane, F. Mahassin, D. Ghafir et al., Maladie de Biermer et thrombose veineuse. ?? propos de deux observations, La Revue de M??decine Interne, vol.23, issue.6, pp.563-569, 2002.
DOI : 10.1016/S0248-8663(02)00613-6

A. Bougteba, A. Basir, and N. Kissani, Infarctus c??r??bral r??cidivant r??v??lant une maladie de Biermer, Revue Neurologique, vol.165, issue.12, pp.1099-102, 2009.
DOI : 10.1016/j.neurol.2009.01.051

E. Lahner, Pernicious anemia: New insights from a gastroenterological point of view, World Journal of Gastroenterology, vol.15, issue.41, p.5121, 2009.
DOI : 10.3748/wjg.15.5121

E. Andrès, S. Affenberger, S. Vinzio, E. Noel, G. Kaltenbach et al., Carences en vitamine B12 chez l'adulte??: ??tiologies, manifestations cliniques et traitement, La Revue de M??decine Interne, vol.26, issue.12, pp.938-984, 2005.
DOI : 10.1016/j.revmed.2005.04.036

M. Samuels, the neurology of anaemia, Practical Neurology, vol.3, issue.3, pp.132-173, 2003.
DOI : 10.1046/j.1474-7766.2003.02129.x

T. Vogel, G. Kaltenbach, B. Geny, and E. Andrès, Vitamine B9, vitamine B12, homocyst??ine, et fonctions cognitives, NPG Neurologie - Psychiatrie - G??riatrie, vol.13, issue.76, pp.225-256, 2013.
DOI : 10.1016/j.npg.2013.01.005

D. Cattan, Pernicious anemia: What are the actual diagnosis criteria?, World Journal of Gastroenterology, vol.17, issue.4, p.543, 2011.
DOI : 10.3748/wjg.v17.i4.543

A. Kuzminski, E. Giacco, R. Allen, S. Stabler, and J. Lindenbaum, Effective Treatment of Cobalamin Deficiency With Oral Cobalamin, Blood. 15 août, vol.92, issue.4, pp.1191-1199, 1998.

A. Spoelstra-de-man, S. Wagenaar, . Van-der-sluys, A. Veer, and C. Brouwer, Relationship between pernicious anaemia and gastric neuroendocrine cell disorders, The Netherlands Journal of Medicine, vol.56, issue.2, pp.56-62, 2000.
DOI : 10.1016/S0300-2977(99)00117-5

G. Rindi, C. Bordi, S. Rappel, S. Rosa, M. Stolte et al., Gastric Carcinoids and Neuroendocrine Carcinomas: Pathogenesis, Pathology, and Behavior, World Journal of Surgery, vol.20, issue.2, pp.168-72, 1996.
DOI : 10.1007/s002689900026

N. Loukili, E. Noel, G. Blaison, B. Goichot, G. Kaltenbach et al., Donn??es actuelles sur la maladie de Biermer. ?? propos d'une ??tude r??trospective de 49??observations, La Revue de M??decine Interne, vol.25, issue.8, pp.556-61, 2004.
DOI : 10.1016/j.revmed.2004.03.008

I. Song, H. Lee, H. Kim, S. Bae, K. Lee et al., A Multicenter Retrospective Analysis of the Clinical Features of Pernicious Anemia in a Korean Population, Journal of Korean Medical Science, vol.28, issue.2, p.200, 2013.
DOI : 10.3346/jkms.2013.28.2.200

. Homocystéine, vitamine B12 et acide folique dans le déclin cognitif chez les personnes âgées, Pathol Biol. oct, vol.61, issue.5, pp.184-92, 2013.

D. Lamarque, Place de l'endoscopie dans le dépistage du cancer gastrique des pathologies néoplasiques ou prénéoplasiques de l'estomac. Hépato-Gastro Oncol Dig. 1 janv, pp.47-52, 2009.

L. Vannella, E. Lahner, J. Osborn, C. Bordi, M. Miglione et al., Risk factors for progression to gastric neoplastic lesions in patients with atrophic gastritis, Alimentary Pharmacology & Therapeutics, vol.31, issue.9, pp.1042-50, 2010.
DOI : 10.1111/j.1365-2036.2010.04268.x

URL : https://hal.archives-ouvertes.fr/hal-00552530

A. Familiaux, autre maladie auto-immune/néoplasie/autre/non disponible ET lien familial père/mère/fratrie/autre 11) Antécédents personnels : aucun/anémie/maladie de Biermer/ dysthyroïdie autoimmune/diabète de type 1/ diabète de type 2/AVC/maladie thromob-embolique/troubles neuropsychiatriques

. Mode-d-'entrée, Mauvaise tolérance : non/syndrome confusionnel/hypotension artérielle/tachycardie/désaturation/polypnée/douleur thoracique/non disponible 17)Signes d'anémie :non/pâleur cutanéomuqueuse/asthénie/dyspnée/palpitations/vertiges/non disponible 18) Signes digestifs : non/affections buccales-glossite/ dyspepsie-épigastralgiesdysphagie

B. Vitamine, 34-17.56/>17.56/non disponible ET valeur absolue 32) Fer sérique

C. Ac-anti, positif/négatif/non disponible 38) Myélogramme compatible : non/oui

. Dosage-homocystéine-ou-acide-méthylmalonique, CRP (mg/L) :<5/>5/non disponible ET valeur absolue si >5 41) Glycémie à jeûn

. Statut-lipidique, Bilan thyroïdien : normal/diminué

. Histologie, Biermer 49) Traitemen : oui/non aux items transfusion