H. P. Adams, B. H. Bendixen, L. J. Kappelle, J. Biller, B. B. Love et al., Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment, Stroke, vol.24, issue.1, pp.35-41, 1993.
DOI : 10.1161/01.STR.24.1.35

P. Amarenco, J. Bogousslavsky, L. R. Caplan, G. A. Donnan, and M. G. Hennerici, New Approach to Stroke Subtyping: The A-S-C-O (Phenotypic) Classification of Stroke, Cerebrovascular Diseases, vol.27, issue.5, pp.502-508, 2009.
DOI : 10.1159/000210433

P. Amarenco, J. Bogousslavsky, L. R. Caplan, G. A. Donnan, M. E. Wolf et al., The ASCOD Phenotyping of Ischemic Stroke (Updated ASCO Phenotyping), Cerebrovascular Diseases, vol.36, issue.1, pp.1-5, 2013.
DOI : 10.1159/000352050

C. Marini, D. Santis, F. Sacco, S. Russo, T. Olivieri et al., Contribution of Atrial Fibrillation to Incidence and Outcome of Ischemic Stroke: Results From a Population-Based Study, Stroke, vol.36, issue.6, pp.1115-1119, 2005.
DOI : 10.1161/01.STR.0000166053.83476.4a

H. Lin, P. Wolf, M. Kelly-hayes, A. Beiser, C. Kase et al., Stroke Severity in Atrial Fibrillation: The Framingham Study, Stroke, vol.27, issue.10, pp.1760-1764, 1996.
DOI : 10.1161/01.STR.27.10.1760

B. Gage, A. Waterman, W. Shannon, M. Boechler, M. Rich et al., Validation of Clinical Classification Schemes for Predicting Stroke, JAMA, vol.285, issue.22, 2001.
DOI : 10.1001/jama.285.22.2864

G. Lip, R. Nieuwlaat, R. Pister, D. Lane, and H. Crijns, Refining Clinical Risk Stratification for Predicting Stroke and Thromboembolism in Atrial Fibrillation Using a Novel Risk Factor-Based Approach, Chest, vol.137, issue.2, pp.263-72, 2010.
DOI : 10.1378/chest.09-1584

M. Alberts, J. Eikelboom, and G. Haukey, Antithrombotic therapy for stroke prevention in non valvular atrial fibrillation. The Lancet Neurology. Decembre 2012, p.10661081

A. Investigators, Effetc of clopidogrel added to aspirin in patients with atrial fibrillation, N.Engl.J.Med, vol.360, pp.2066-2078, 2009.

R. Hart, L. Pearce, and M. Aguilar, Meta-analysis: Antithrombotic Therapy to Prevent Stroke in Patients Who Have Nonvalvular Atrial Fibrillation, Annals of Internal Medicine, vol.146, issue.12, pp.857-67, 2007.
DOI : 10.7326/0003-4819-146-12-200706190-00007

D. Singer, Y. Chang, M. Fang, L. Borowsky, N. Pomernacki et al., The Net Clinical Benefit of Warfarin Anticoagulation in Atrial Fibrillation, Annals of Internal Medicine, vol.151, issue.5, pp.297-305, 2009.
DOI : 10.7326/0003-4819-151-5-200909010-00003

A. Go, E. Hylek, K. Phillips, Y. Chang, L. Henault et al., Prevalence of Diagnosed Atrial Fibrillation in Adults, JAMA, vol.285, issue.18, pp.2370-2375, 2001.
DOI : 10.1001/jama.285.18.2370

R. Pisters, D. Lane, R. Nieuwlaat, C. De-vos, H. Crijns et al., A Novel User-Friendly Score (HAS-BLED) To Assess 1-Year Risk of Major Bleeding in Patients With Atrial Fibrillation, Chest, vol.138, issue.5, pp.1093-100, 2010.
DOI : 10.1378/chest.10-0134

C. Coordination and . Bordeaux, EMIR : Effets indésirables des Médicaments : Incidence et Risque, sur les hospitalisations liées à un effet indésirable médicamenteux. Décembre, 2007.

D. Gladstone, E. Bui, J. Fang, A. Laupacis, M. Lindsay et al., Potentially Preventable Strokes in High-Risk Patients With Atrial Fibrillation Who Are Not Adequately Anticoagulated, Stroke, vol.40, issue.1, pp.235-240, 2009.
DOI : 10.1161/STROKEAHA.108.516344

G. Agnelli, H. Buller, A. Cohen, M. Curto, A. Gallus et al., Apixaban for Extended Treatment of Venous Thromboembolism, New England Journal of Medicine, vol.368, issue.8, pp.699-708, 2013.
DOI : 10.1056/NEJMoa1207541

URL : https://hal.archives-ouvertes.fr/hal-00771313

E. Romualdi, M. Donaldini, and W. Ageno, Oral rivaroxaban after symptomatic venous thromboembolism: the continued treatment study (EINSTEIN-Extension study), Expert Review of Cardiovascular Therapy, vol.9, issue.7
DOI : 10.1586/erc.11.62

S. Connolly, M. Ezekowitz, S. Yusuf, J. Eikelboom, J. Oldgren et al., Dabigatran versus Warfarin in Patients with Atrial Fibrillation, Wallentin L; RE-LY Steering Committee and Investigators. Dabigatran versus warfarin in patients with atrial fibrillation, pp.1139-1151, 2009.
DOI : 10.1056/NEJMoa0905561

W. Baker and O. Phung, Systematic Review and Adjusted Indirect Comparison Meta-Analysis of Oral Anticoagulants in Atrial Fibrillation, Circulation: Cardiovascular Quality and Outcomes, vol.5, issue.5, pp.711-719, 2012.
DOI : 10.1161/CIRCOUTCOMES.112.966572

J. Eikelboom, S. Connolly, M. Brueckmann, C. Granger, A. Kappetein et al., Dabigatran versus Warfarin in Patients with Mechanical Heart Valves, New England Journal of Medicine, vol.369, issue.13, pp.1206-1220, 2013.
DOI : 10.1056/NEJMoa1300615

P. Chevalier, Aperçu des principales études concernant les NAO (Nouveaux Anticoagulants oraux) Minerva : Revue d'Evidence-Based Medecine, Mise à jour, pp.31-34

G. Ernst, C. Stöllberger, F. Abzieher, W. Veit-dirscherl, E. Bonner et al., Morphology of the left atrial appendage, The Anatomical Record, vol.312, issue.4, pp.553-61, 1995.
DOI : 10.1002/ar.1092420411

H. Nakajima, Y. Seo, T. Ishizu, M. Yamamoto, T. Machino et al., Analysis of the left atrial appendage by three-dimensional transoesophageal echocardiography

P. Su, K. Mccarthy, and S. Ho, Occluding the left atrial appendage: anatomical considerations, Heart, vol.94, issue.9, pp.1166-70, 2008.
DOI : 10.1136/hrt.2006.111989

D. Biase, L. Santangeli, P. Anselmino, M. Mohanty, P. Salvetti et al., Does the Left Atrial Appendage Morphology Correlate With the Risk of Stroke in Patients With Atrial Fibrillation?, Journal of the American College of Cardiology, vol.60, issue.6, pp.531-539, 2012.
DOI : 10.1016/j.jacc.2012.04.032

V. Fuster, Top 10 cardiovascular therapies and interventions for the next decade, Nature Reviews Cardiology, vol.61, issue.11, pp.671-683, 2014.
DOI : 10.1016/S0140-6736(12)60075-0

A. Dawson, S. Asopa, and J. Dunning, Should patients undergoing cardiac surgery with atrial fibrillation have left atrial appendage exclusion? Interact Cardiovasc Thorac Surg, pp.306-311

H. Sievert, M. Lesh, T. Trepels, H. Omran, A. Bartorelli et al., Percutaneous Left Atrial Appendage Transcatheter Occlusion to Prevent Stroke in High-Risk Patients With Atrial Fibrillation: Early Clinical Experience, Circulation, vol.105, issue.16, pp.1887-1896, 2002.
DOI : 10.1161/01.CIR.0000015698.54752.6D

A. Jain and S. Gallagher, National Institute for Health and Clinical Excellence (NICE)

A. Kanderian, A. Gillinov, G. Pettersson, E. Blackstone, and A. Klein, Success of Surgical Left Atrial Appendage Closure, Journal of the American College of Cardiology, vol.52, issue.11, pp.924-933, 2008.
DOI : 10.1016/j.jacc.2008.03.067

A. Vahanian, O. Alfieri, F. Andreotti, M. Antunes, G. Baron-esquivias et al., Guidelines for the management of valvular heart disease (version 2012), Eur Heart J, vol.33, pp.2451-96, 2012.

P. Aubry, *. , J. Juliard, E. Brochet, D. Himbert et al., Left atrial appendage percutaneous exclusion: Perspectives, Annales de Cardiologie et, pp.61-423, 2012.

P. Renou1, . Nicot1, . Iriart2, . Debruxelles1, and . Poli1, Thambo2: Percutaneous left atrial appendage closure for stroke patients with nonvalvular atrial fibrillation and contraindication for oral anticoagulation

M. Urena, J. Rodés-cabau, and X. Freixa, Percutaneous Left Atrial Appendage Closure With the AMPLATZER Cardiac Plug Device in Patients With Nonvalvular Atrial Fibrillation and Contraindications to Anticoagulation Therapy, Journal of the American College of Cardiology, vol.62, issue.2, 2013.
DOI : 10.1016/j.jacc.2013.02.089

P. Block, S. Burstein, P. Casale, P. Kramer, P. Teirstein et al., Percutaneous Left Atrial Appendage Occlusion for Patients in Atrial Fibrillation Suboptimal for Warfarin Therapy, JACC: Cardiovascular Interventions, vol.2, issue.7, pp.594-600, 2009.
DOI : 10.1016/j.jcin.2009.05.005

R. Schwartz, D. Holmes, V. Tassel, R. Hauser, R. Henry et al., Left atrial appendage obliteration. Mechanisms of healing and intracardiac integration

T. Nakai, M. Lesh, E. Gerstenfeld, R. Virmani, R. Jones et al., Percutaneous Left Atrial Appendage Occlusion (PLAATO) for Preventing Cardioembolism: First Experience in Canine Model, Circulation, vol.105, issue.18, pp.2217-2239, 2002.
DOI : 10.1161/01.CIR.0000015605.30810.51

S. Ostermayer, M. Reisman, P. Kramer, R. Matthews, W. Gray et al., Percutaneous Left Atrial Appendage Transcatheter Occlusion (PLAATO System) to Prevent Stroke in High-Risk Patients With Non-Rheumatic Atrial Fibrillation, Journal of the American College of Cardiology, vol.46, issue.1, pp.9-14, 2005.
DOI : 10.1016/j.jacc.2005.03.042

J. Park, A. Bethencourt, H. Sievert, G. Santoro, B. Meier et al., Left atrial appendage closure with amplatzer cardiac plug in atrial fibrillation: Initial European experience, Catheterization and Cardiovascular Interventions, vol.84, issue.6, pp.700-706
DOI : 10.1002/ccd.25619

Y. Lam, G. Yip, C. Yu, W. Chan, B. Cheng et al., Left atrial appendage closure with Amplatzer cardiac plug for stroke prevention in atrial fibrillation: Initial Asia-Pacific experience, Catheterization and Cardiovascular Interventions, vol.123, issue.5, pp.794-800
DOI : 10.1002/ccd.23136

A. Tzikas, S. Shakir, S. Gafoor, H. Omran, S. Berti et al., Left atrial appendage occlusion for stroke prevention in atrial

D. Holmes, V. Reddy, Z. Turi, S. Doshi, H. Sievert et al., Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial, The Lancet, vol.374, issue.9689, pp.534-576, 2009.
DOI : 10.1016/S0140-6736(09)61343-X

V. Reddy, D. Holmes, S. Doshi, P. Neuzil, and S. Kar, Safety of Percutaneous Left Atrial Appendage Closure: Results From the Watchman Left Atrial Appendage System for Embolic Protection in Patients With AF (PROTECT AF) Clinical Trial and the Continued Access Registry, Circulation, vol.123, issue.4, pp.417-441, 2011.
DOI : 10.1161/CIRCULATIONAHA.110.976449

V. Reddy, S. Möbius-winkler, and M. Miller, Left Atrial Appendage Closure With the Watchman Device in Patients With a Contraindication for Oral Anticoagulation, Journal of the American College of Cardiology, vol.61, issue.25, pp.2551-2556, 2013.
DOI : 10.1016/j.jacc.2013.03.035

. Boston-scientific-corporation and M. Elletson, Prospective randomized evaluation of the WATCHMAN LAA closure device in patients with atrial fibrillation versus long term warfarin therapy (PREVAIL), 2013.

H. Sanchez, M. Sievert, . Valderrabano, Y. Vivek, and . Reddy, Left Atrial Appendage Closure as an Alternative to Warfarin for Stroke Prevention in Atrial Fibrillation. A Patient-Level Meta-Analysis, Journal Of The American College Of Cardiology, vol.65, issue.24, 2015.

A. Has, Recommandations de Bonne Pratique. Bon usage des agents plaquettaires : argumentaire, 2012.

K. Knudsen, J. Rosand, D. Karluk, and S. Greenberg, Clinical diagnosis of cerebral amyloid angiopathy: Validation of the Boston Criteria, Neurology, vol.56, issue.4, pp.537-546, 2001.
DOI : 10.1212/WNL.56.4.537

J. Ruiz-garcia and R. Moreno, Percutaneous closure of left atrial appendage: device-indicated antiplatelet therapy may also lead to fatal bleeding. A call for evidence-based antiplatelet regimen, Journal of Thrombosis and Thrombolysis, vol.367, issue.3, pp.359-361, 2014.
DOI : 10.1007/s11239-013-0992-y

L. Uull, V. Martin, B. Vidal, and A. Cervera, Intracranial hemorrhage during dual antiplatelet therapy after percutaneous left atrial appendage closure, Cerebrovasc. Dis. Basel Switz, vol.38, pp.73-74, 2014.

A. Biffi, A. Halpin, A. Towfighi, A. Gilson, K. Busl et al., Aspirin and recurrent intracerebral hemorrhage in cerebral amyloid angiopathy, Neurology, vol.75, issue.8, pp.693-698, 2010.
DOI : 10.1212/WNL.0b013e3181eee40f

S. Bert, U. Paradossi, F. Meucci, G. Trianni, A. Tzikas et al., Periprocedural Intracardiac Echocardiography for Left Atrial Appendage Closure, JACC: Cardiovascular Interventions, vol.7, issue.9, 2014.
DOI : 10.1016/j.jcin.2014.04.014

H. Omran, W. Jung, and R. Rabahieh, Imaging of thrombi and assessment of left atrial appendage function: a prospective study comparing transthoracic and transoesophageal echocardiography, Heart, vol.81, issue.2, pp.192-198, 1999.
DOI : 10.1136/hrt.81.2.192

J. N. Dacher, C. Sanair, and J. Caudron, Recherche de thrombus dans l'auricule gauche en scanner cardiaque: alternative à l'ETO ? réalités Cardiologiques No. 288

J. Hur, Y. Kim, and H. Lee, Left Atrial Appendage Thrombi in Stroke Patients: Detection with Two-Phase Cardiac CT Angiography versus Transesophageal Echocardiography, Radiology, vol.251, issue.3, pp.683-690, 2009.
DOI : 10.1148/radiol.2513090794

S. Wassertheil-smoller, . Md, F. Phd, N. Tanya, M. Turan et al., MSN, RN; on behalf of the American Heart Association Stroke Council, Council on Cardiovascular Nursing, Council on Clinical Cardiology, and Interdisciplinary Council on Quality of Care and Outcomes Research. Guidelines for the Prevention of Stroke in Patients With Stroke or Transient Ischemic Attack. A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association, Stroke, vol.42, pp.227-276, 2011.

M. Schwamm, F. John, and A. Wilson, MD; on behalf of the American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and Council on Peripheral Vascular Disease. Guidelines for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack. A Guideline for Healthcare Professionals From the American Heart

J. and C. Hemphill, Guidelines for the Management of Spontaneous Intracerebral Hemorrhage. Stroke, 2015.

T. Phan, M. Koh, and E. Wijdicks, Safety of Discontinuation of Anticoagulation in Patients With Intracranial Hemorrhage at High Thromboembolic Risk, Archives of Neurology, vol.57, issue.12, pp.1710-1713, 2000.
DOI : 10.1001/archneur.57.12.1710

H. Hanger, T. Wilkinson, N. Fayez-iskander, and R. Sainsbury, The risk of recurrent stroke after intracerebral haemorrhage, Journal of Neurology, Neurosurgery & Psychiatry, vol.78, issue.8, pp.836-840, 2007.
DOI : 10.1136/jnnp.2006.106500

B. A. Steinberg, Contreindications to Anticoagulation Therapy and Eligibility for Novel Anticoagulation in Older Patients with Atrial Fibrillation, Cardiovasc. Ther, vol.33, pp.77-183, 2015.

R. D. Bailey, H. R. Benavente, O. Pearce, and L. , Recurrent brain hemorrhage is more frequent than ischemic stroke after intracranial hemorrhage, Neurology, vol.56, issue.6, pp.773-777, 2001.
DOI : 10.1212/WNL.56.6.773

C. Weimar, Recurrent Stroke after Lobar and Deep Intracerebral Hemorrhage: A Hospital-Based Cohort Study, Cerebrovascular Diseases, vol.32, issue.3, pp.283-288, 2011.
DOI : 10.1159/000330643

S. Vermeer, A. Algra, C. Franck, P. Koudstaal, and G. Rinkel, Long-term prognosis after recovery from primary intracerebral hemorrhage, Neurology, vol.59, issue.2, pp.205-209, 2002.
DOI : 10.1212/WNL.59.2.205

F. Dentali, Efficacy and Safety of the Novel Oral Anticoagulants in Atrial Fibrillation: A Systematic Review and Meta-Analysis of the Literature, Circulation, vol.126, issue.20, pp.2381-2391, 2012.
DOI : 10.1161/CIRCULATIONAHA.112.115410

L. Morgenstern, Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association, Stroke, vol.41, issue.9, pp.2018-2129, 2010.
DOI : 10.1161/STR.0b013e3181ec611b

M. Pasquini, Variation in Restarting Antithrombotic Drugs at Hospital Discharge After Intracerebral Hemorrhage, Stroke, vol.45, issue.9, pp.2643-2648, 2014.
DOI : 10.1161/STROKEAHA.114.006202

R. Hart, H. Diener, S. Yang, S. Connolly, L. Wallentin et al., Intracranial Hemorrhage in Atrial Fibrillation Patients During Anticoagulation With Warfarin or Dabigatran: The RE-LY Trial, Stroke, vol.43, issue.6, pp.1511-1517, 2012.
DOI : 10.1161/STROKEAHA.112.650614

L. Pantoni, Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges, The Lancet Neurology, vol.9, issue.7, pp.689-701, 2010.
DOI : 10.1016/S1474-4422(10)70104-6

J. A. Nicoll, C. Burnett, S. Love, D. I. Gra-ham, D. Dewar et al., High frequency of apolipoprotein E ?2 Allele in hemorrhage due to cerebral amyloid angiopathy, Annals of Neurology, vol.8, issue.6, pp.716-721, 1997.
DOI : 10.1002/ana.410410607

M. Eckman, J. Rosand, K. Knudsen, D. Singer, and S. Greenberg, Can Patients Be Anticoagulated After Intracerebral Hemorrhage?: A Decision Analysis, Stroke, vol.34, issue.7, pp.1710-1716, 2003.
DOI : 10.1161/01.STR.0000078311.18928.16

A. Charidimou, C. Shakeshaft, and D. Werring, Cerebral Microbleeds on Magnetic Resonance Imaging and Anticoagulant-Associated Intracerebral Hemorrhage Risk, Frontiers in Neurology, vol.3, 2012.
DOI : 10.3389/fneur.2012.00133

M. L. Flaherty, B. Kissela, D. Woo, D. Kleindorfer, K. Alwell et al., The increasing incidence of anticoagulant-associated intracerebral hemorrhage, Neurology, vol.68, issue.2, pp.116-121, 2007.
DOI : 10.1212/01.wnl.0000250340.05202.8b

K. Kim, J. R. Macfall, and M. E. Payne, Classification of White Matter Lesions on Magnetic Resonance Imaging in Elderly Persons, Biological Psychiatry, vol.64, issue.4, pp.273-280, 2008.
DOI : 10.1016/j.biopsych.2008.03.024

E. Smith, J. Rosand, K. Knudsen, E. Hylek, and S. Greenberg, Leukoaraiosis is associated with warfarin-related hemorrhage following ischemic stroke, Neurology, vol.59, issue.2, pp.193-197, 2002.
DOI : 10.1212/WNL.59.2.193

F. Fazekas, R. Kleinert, G. Roob, G. Klein-ert, P. Kapeller et al., Histopathologic analysis of fociof signal loss on gradient-echoT2_- weighted MR images in patients with spontaneous intracerebral hemorrhage :evidence of microangiopathy-relatedmicrobleeds, AJNR Am.J.Neuroradiol, vol.20, pp.637-642, 1999.

A. Shoamanesh, C. S. Kwok, and O. Benavente, Cerebral microbleeds: histopathological correlation of neuroimaging. Cere-brovasc.Dis, pp.528-534, 2011.

D. Werring, K. A. Knudsen, J. Rosand, D. Karluk, and S. M. Greenberg, Cerebral Microbleeds: Pathophysiologyto Clinical PracticeClinical diagnosis of cerebralamyloid angiopathy: validation of the Boston criteria, Neurology, vol.100, issue.56, pp.537-539, 2001.
DOI : 10.1017/CBO9780511974892

H. Ueno, H. Naka, T. Ohshita, K. Kondo, E. Nomura et al., Association between Cerebral Microbleeds on T2*-Weighted MR Images and Recurrent Hemorrhagic Stroke in Patients Treated with Warfarin following Ischemic Stroke, American Journal of Neuroradiology, vol.29, issue.8, pp.1483-1486, 2008.
DOI : 10.3174/ajnr.A1120

C. Cordonnier, A. Salman, R. Wardlaw, J. Sveinbjornsdottir, S. Sigurdsson et al., Spontaneous brainmicrobleeds: systematic review, subgroup analyses and standards for study design and reporting. Brain Cerebral microbleeds in the population based AGES- Reykjavik study: prevalence and location, J. Neurol.Neurosurg Psychiatr, vol.130, issue.79, pp.1002-1006, 1988.

M. M. Poels, M. W. Vernooij, M. A. Ikram, A. Hofman, G. P. Krestin et al., Prevalenceandriskfactors of cerebral microbleeds: anupdate of the Rotterdam scan study. Stroke, pp.103-106, 2010.

Y. Fan, L. Zhang, W. Lam, V. Mok, and K. Wong, Cerebral Microbleeds as a Risk Factor for Subsequent Intracerebral Hemorrhages Among Patients With Acute Ischemic Stroke, Stroke, vol.34, issue.10, pp.2459-2462, 2003.
DOI : 10.1161/01.STR.0000090841.90286.81

R. Salman, S. Warach, L. J. Launer, M. A. Vanbuchem, and M. M. Breteler, Cerebral microbleeds: aguide to detection and interpretation. LancetNeurol, pp.165-174, 2009.

A. Charidimou and D. J. , Cerebral microbleeds: detection, mechanisms and clinical challenges, Future Neurology, vol.6, issue.5, pp.587-611, 2011.
DOI : 10.2217/fnl.11.42

H. Vinters, Cerebral amyloid angiopathy. A critical review, Stroke, vol.18, issue.2, pp.311-324, 1987.
DOI : 10.1161/01.STR.18.2.311

S. Passero, L. Burgalassi, P. D-'andrea, and N. Battistini, Recurrence of Bleeding in Patients With Primary Intracerebral Hemorrhage, Stroke, vol.26, issue.7, pp.1189-1192, 1995.
DOI : 10.1161/01.STR.26.7.1189

R. G. Hart, B. S. Boop, A. , and D. C. , Oral Anticoagulants and Intracranial Hemorrhage : Facts and Hypotheses, Stroke, vol.26, issue.8, pp.1471-1477, 1995.
DOI : 10.1161/01.STR.26.8.1471

H. Schneble, Antithrombotic Therapy and Bleeding Risk in a Prospective Cohort Study of Patients With Cerebral Cavernous Malformations, Stroke, vol.43, issue.12, 2012.
DOI : 10.1161/STROKEAHA.112.668533

P. Labauge, C. Denier, F. Bergametti, and E. Tournier-lasserve, Genetics of cavernous angiomas, The Lancet Neurology, vol.6, issue.3, pp.237-244, 2007.
DOI : 10.1016/S1474-4422(07)70053-4

J. Zabramski, T. Wascher, and R. Spetzler, The natural history of familial cavernous malformations: results of an ongoing study, Journal of Neurosurgery, vol.80, issue.3, pp.422-432, 1994.
DOI : 10.3171/jns.1994.80.3.0422

J. Robinson, I. Awad, and J. Little, Natural history of the cavernous angioma, Journal of Neurosurgery, vol.75, issue.5, pp.709-723, 1991.
DOI : 10.3171/jns.1991.75.5.0709

J. L. Moriarity, R. E. Clatterbuck, and D. Rigamonti, The natural history of cavernous malformations, Neurosurg. Clin. N. Am, vol.10, pp.411-417, 1999.

D. Kondziolka, L. Lunsford, and J. Kestle, The natural history of cerebral cavernous malformations, Journal of Neurosurgery, vol.83, issue.5, pp.820-824, 1995.
DOI : 10.3171/jns.1995.83.5.0820

P. Porter, R. Willinsky, W. Harper, and M. Wallace, Cerebral cavernous malformations: natural history and prognosis after clinical deterioration with or without hemorrhage, Journal of Neurosurgery, vol.87, issue.2, pp.190-197, 1997.
DOI : 10.3171/jns.1997.87.2.0190

P. Labauge, L. Brunereau, S. Laberge, and J. Houtteville, Prospective follow-up of 33 asymptomatic patients with familial cerebral cavernous malformations, Neurology, vol.57, issue.10
DOI : 10.1212/WNL.57.10.1825

W. , V. Kummer, and R. , Hemorrhagic transformation of ischemic brain tissue: asymptomatic or symptomatic?, Stroke, vol.32, pp.1330-1335, 2001.

A. Ringleb, S. Lorenzano, C. Manelfe, and L. Bozzao, Hemorrhagic transformation within 36 hours of a cerebral infarct: relationships with early clinical deterioration and 3- month outcome in the European. Cooperative Acute Stroke Study I (ECASS I) cohort

M. Pessin, C. Estol, F. Lafranchise, and L. Caplan, Safety of anticoagulation after hemorrhagic infarction 125. Marsh EB et al. Hemorragic Transformation in Patients with Acute Ischemic Stroke and Indication for Anticoagulation, Neurology. Ev J.Neurol, vol.43, pp.1298-1303, 1993.

V. Reddy, The clinical impact of incomplete left atrial appendage closure with the Watchman Device in patients with atrial fibrillation: a PROTECT AF (Percutaneous Closure of the Left Atrial Appendage Versus Warfarin Therapy for Prevention of Stroke in Patients With Atrial Fibrillation) substudy, J Am Coll Cardiol, vol.59, issue.10, pp.923-932, 2012.

N. Echelle, National Institute of Health Stroke Scale) traduite et modifiée d'après l'étude NINDS

M. D. Reichart, Score de Rankin Modifié, Med. Hyg, vol.58, p.33, 2000.

A. Tunstall-pedoe, H. Tverdal, P. Wedel, L. Whincup, I. M. Wilhelmsen et al., on behalf of the SCORE project group. (ESC) Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project, European Heart Journa, vol.24, pp.987-1003, 2003.