R. Coleman and R. Rubens, The clinical course of bone metastases from breast cancer, British Journal of Cancer, vol.55, issue.1, pp.61-67, 1987.
DOI : 10.1038/bjc.1987.13

T. Plunkett, P. Smith, and R. Rubens, Risk of complications from bone metastases in breast cancer, European Journal of Cancer, vol.36, issue.4, pp.476-82, 2000.
DOI : 10.1016/S0959-8049(99)00331-7

B. Kuru, M. Camlibel, S. Dinc, M. Gulcelik, D. Gonullu et al., Prognostic factors for survival in breast cancer patients who developed distant metastasis subsequent to definitive surgery, Singapore Med J, vol.49, pp.904-915, 2008.

N. Kinnane, Burden of bone disease, European Journal of Oncology Nursing, vol.11, pp.28-31, 2007.
DOI : 10.1016/j.ejon.2007.07.002

H. Brown and J. Healey, Metastatic cancer to the bone. Cancer: Principles and practice of oncology, pp.1986-97, 2001.

R. Coleman, Metastatic bone disease: clinical features, pathophysiology and treatment strategies, Cancer Treatment Reviews, vol.27, issue.3, pp.165-76, 2001.
DOI : 10.1053/ctrv.2000.0210

K. Weilbaecher, T. Guise, and L. Mccauley, Cancer to bone: a fatal attraction, Nature Reviews Cancer, vol.71, issue.6, pp.411-436, 2011.
DOI : 10.1038/nrc3055

A. Lipton, Pathophysiology of bone metastases: How this knowledge may lead to therapeutic intervention, J Support Oncol, vol.2, pp.205-225, 2004.

R. Coleman, Clinical Features of Metastatic Bone Disease and Risk of Skeletal Morbidity, Clinical Cancer Research, vol.12, issue.20
DOI : 10.1158/1078-0432.CCR-06-0931

B. Berrettoni and J. Carter, Mechanisms of cancer metastasis to bone., The Journal of Bone & Joint Surgery, vol.68, issue.2, pp.308-320, 1986.
DOI : 10.2106/00004623-198668020-00021

H. Abrams, Skeletal Metastases in Carcinoma, Radiology, vol.55, issue.4, pp.534-542, 1950.
DOI : 10.1148/55.4.534

H. Tongaonkar, J. Kulkarni, and M. Kamat, Solitary metastases from renal cell carcinoma: A review, Journal of Surgical Oncology, vol.207, issue.1, pp.45-53, 1992.
DOI : 10.1002/jso.2930490111

J. Holland, D. Trenkner, T. Wasserman, and F. B. Plasmacytoma, Plasmacytoma. Treatment results and conversion to myeloma, Cancer, vol.13, issue.6, pp.1513-1520, 1992.
DOI : 10.1002/1097-0142(19920315)69:6<1513::AID-CNCR2820690633>3.0.CO;2-X

H. Katagiri, M. Takahashi, J. Inagaki, H. Sugiura, S. Ito et al., Determining the site of the primary cancer in patients with skeletal metastasis of unknown origin, Cancer, vol.223, issue.3, pp.533-540, 1999.
DOI : 10.1002/(SICI)1097-0142(19990801)86:3<533::AID-CNCR24>3.0.CO;2-1

M. Tubiana-hulin, J. Laredo, J. Lagrange, and J. Body, Enquête sur la prise en charge des métastases osseuses en Europe francophone, par le GEMO : réponse des oncologues médicaux, Bull Cancer, vol.92, p.191, 2005.

M. Tubiana-hulin, D. Maulmont, C. Guinebretière, and J. , Strat??gie de prise en charge des m??tastases osseuses r??v??latrices, Revue du Rhumatisme, vol.75, issue.4, pp.332-340, 2008.
DOI : 10.1016/j.rhum.2008.01.002

B. Rougraff, J. Kneisl, and M. Simon, Skeletal metastases of unknown origin. A prospective study of a diagnostic strategy., The Journal of Bone & Joint Surgery, vol.75, issue.9, pp.1276-81, 1993.
DOI : 10.2106/00004623-199309000-00003

M. Vieillard, N. Boutry, P. Chastanet, B. Duquesnoy, A. Cotten et al., Contribution of percutaneous biopsy to the definite diagnosis in patients with suspected bone tumor, Joint Bone Spine, vol.72, issue.1, pp.53-60, 2005.
DOI : 10.1016/j.jbspin.2004.03.008

L. Chevalier, T. Cvitkovic, E. Caille, P. Harvey, J. Contesso et al., Early metastatic cancer of unknown primary origin at presentation. A clinical study of 302

L. Rest, C. Bizais, and Y. , Positron emission tomography:how useful is this new functional imaging tool in rheumatology?, Joint Bone Spine, vol.67, issue.6, pp.588-93, 2000.
DOI : 10.1016/S1297-319X(00)00208-6

O. Warburg, The metabolism of tumors, Br J Surg, vol.19, p.168, 1931.

P. Rigo and P. Paulus, Oncologic applications of positron emission tomography with fluorine- 18 fluorodeoxyglucose, Eur J Nucl Med, vol.82, pp.1160-1166, 1996.

H. Demir, F. Berk, M. Raderer, P. Plowman, U. Lassen et al., The role of nuclear medicine in the diagnosis of cancer of unknown origin, Q J Nucl Med Mol Imaging, vol.48, pp.164-73, 2004.

P. Fencl, O. Belohlavek, M. Skopalova, M. Jaruskova, I. Kantorova et al., Prognostic and diagnostic accuracy of [18F]FDG-PET/CT in 190 patients with carcinoma of unknown primary, European Journal of Nuclear Medicine and Molecular Imaging, vol.38, issue.11, pp.1783-92, 2007.
DOI : 10.1007/s00259-007-0456-8

J. Alberini, T. Belhocine, R. Hustinx, F. Daenen, and P. Rigo, Whole-body positron emission tomography using fluorodeoxyglucose in patients with metastases of unknown primary tumours (CUP syndrome), Nuclear Medicine Communications, vol.24, issue.10, pp.1081-1087, 2003.
DOI : 10.1097/00006231-200310000-00008

M. Warski, L. Stanc, E. Gontier, E. Vilain, D. Banal et al., In search of an unknown primary tumour presenting with cervical metastases: Performance of hybrid FDG-PET???CT, Nuclear Medicine Communications, vol.28, issue.5, pp.365-71, 2007.
DOI : 10.1097/MNM.0b013e3280708edf

D. Lardinois, W. Weder, T. Hany, E. Kamel, S. Korom et al., Staging of Non???Small-Cell Lung Cancer with Integrated Positron-Emission Tomography and Computed Tomography, New England Journal of Medicine, vol.348, issue.25, pp.2500-2507, 2003.
DOI : 10.1056/NEJMoa022136

P. Bourguet, S. Groupe-de-travail, and . Tep-fdg-recommandations, Standards options et recommandations pour l'utilisation de la tomographie par émission de positons au 18-FDG en cancérologie, Bull Cancer, vol.90, pp.67-79, 2003.

. Recommandations-pour-la-pratique-clinique, utilisation de la TEP-FDG dans les cancers de l'oesophage, de l'estomac, du colon et du rectum, du canal anal, de l'intestin grêle, du pancréas et des voies biliaires, du foie et les tumeurs endocrines (système digestif), Bull Cancer, vol.94, pp.212-220, 2007.

F. Moog, J. Kotzerke, and S. Reske, FDG PET can replace bone scintigraphy in primary staging of malignant lymphoma, J Nucl Med, vol.40, pp.1407-1420, 1999.

D. Groheux, E. Hindie, M. Espié, M. Toubert, J. Misset et al., Intérêts et perspectives de la TEP-TDM en sénologie : revue de la littérature, Bull Cancer, vol.94, pp.658-68, 2007.

S. Mahner, S. Schirrmacher, W. Brenner, L. Jenicke, C. Habermann et al., Comparison between positron emission tomography using 2-[fluorine-18]fluoro-2-deoxy-D-glucose, conventional imaging and computed tomography for staging of breast cancer, Annals of Oncology, vol.19, issue.7, pp.1249-54, 2008.
DOI : 10.1093/annonc/mdn057

K. Spaepen, S. Stroobants, P. Dupont, S. Van-steenweghen, J. Thomas et al., Prognostic value of positron emission tomography (PET) with fluorine-18

A. Kole, O. Nieweg, J. Pruim, H. Hoekstra, H. Koops et al., Detection of unknown occult primary tumors using positron emission tomography, Cancer, vol.36, issue.6, pp.1160-1166, 1998.
DOI : 10.1002/(SICI)1097-0142(19980315)82:6<1160::AID-CNCR22>3.0.CO;2-3

U. Lassen, G. Daugaard, A. Eigtved, K. Damgaard, and L. Friberg, 18F-FDG whole body positron emission tomography (PET) in patients with unknown primary tumours (UPT), European Journal of Cancer, vol.35, issue.7, pp.1076-82, 1999.
DOI : 10.1016/S0959-8049(99)00077-5

D. Rades, G. Kuhnel, I. Wildfang, A. Borner, H. Schmoll et al., Localised disease in cancer of unknown primary (CUP): the value of positron emission tomography (PET) for individual therapeutic management, Annals of Oncology, vol.12, issue.11, pp.1605-1614, 2001.
DOI : 10.1023/A:1013107732572

U. Joshi, J. Van-der-hoeven, E. Comans, G. Herder, G. Teule et al., In search of an unknown primary tumour presenting with extracervical metastases: the diagnostic performance of FDG-PET, The British Journal of Radiology, vol.77, issue.924, pp.1000-1006, 2004.
DOI : 10.1259/bjr/69059431

R. Delgado-bolton, C. Fernandez-perez, A. Gonzalez-mate, and J. Carreras, Meta-analysis of the performance of 18F-FDG PET in primary tumor detection in unknown primary tumors

. Fluoro-d-, Glucose positron emission tomography in disseminated carcinoma of unknown primary site, Cancer, vol.109, pp.292-301, 2007.

M. Duet, J. Pouchot, F. Lioté, and M. Faraggi, Role for positron emission tomography in skeletal diseases, Joint Bone Spine, vol.74, issue.1, pp.14-23, 2007.
DOI : 10.1016/j.jbspin.2006.04.007

P. Rigo, Tomographie à émission de positons en pathologie ostéo-articulaire et en rhumatologie, Médecine nucléaire, vol.27, pp.630-635, 2003.

T. Yanagawa, T. Shinozaki, Y. Iizuka, K. Takagishi, and H. Watanabe, Role of

. Metastatic-bone-tumors, Analysis of factors affecting prognosis and efficacy of CT and 18 F- FDG PET-CT in identifying primary lesions, Mol Clin Oncol, vol.2, pp.875-81, 2014.

V. Kakhki, K. Anvari, R. Sadeghi, A. Mahmoudian, and M. Torabian-kakhki, Pattern and distribution of bone metastases in common malignant tumors, Nuclear Medicine Review, vol.16, issue.2, pp.66-75, 2013.
DOI : 10.5603/NMR.2013.0037

T. Ozülker, K. Uzun, A. Ozülker, F. Ozpaçaci, and T. , Comparison of 18 F-FDG-PET/CT with 99m Tc-MDP bone scintigraphy for the detection of bone metastases in cancer patients

I. Fogelman, G. Cook, and O. Israel, Positron emission tomography and bone metastases, Seminars in Nuclear Medicine, vol.35, issue.2, pp.135-177, 2005.
DOI : 10.1053/j.semnuclmed.2004.11.005

M. Malvezzi, P. Bertuccio, F. Levi, L. Vecchia, C. Negri et al., European cancer mortality predictions for the year 2014, Annals of Oncology, vol.25, issue.8, pp.1650-1656, 2014.
DOI : 10.1093/annonc/mdu138

L. Chatenoud, P. Bertuccio, C. Bosetti, M. Malvezzi, F. Levi et al., Trends in mortality from major cancers in the Americas: 1980-2010, Annals of Oncology, vol.25, issue.9, pp.1843-53, 2014.
DOI : 10.1093/annonc/mdu206

D. Angelis, R. Sant, M. Coleman, M. Francisci, S. Baili et al., Cancer survival in Europe 1999???2007 by country and age: results of EUROCARE-5???a population-based study, The Lancet Oncology, vol.15, issue.1, pp.23-34, 2014.
DOI : 10.1016/S1470-2045(13)70546-1

G. Cook, S. Houston, R. Rubens, M. Maisey, and I. Fogelman, Detection of bone metastases in breast cancer by 18FDG PET: differing metabolic activity in osteoblastic and osteolytic lesions., Journal of Clinical Oncology, vol.16, issue.10, pp.3375-3384, 1998.
DOI : 10.1200/JCO.1998.16.10.3375

M. Hetzel, C. Arslandemir, H. König, A. Buck, K. Nüssle et al., F-18 NaF PET for Detection of Bone Metastases in Lung Cancer: Accuracy, Cost-Effectiveness, and Impact on Patient Management, Journal of Bone and Mineral Research, vol.16, issue.12, pp.2206-2220, 2003.
DOI : 10.1359/jbmr.2003.18.12.2206

R. Fujimoto, T. Higashi, Y. Nakamoto, T. Hara, A. Lyshchik et al., Diagnostic accuracy of bone metastases detection in cancer patients: Comparison between bone scintigraphy and whole-body FDG-PET, Annals of Nuclear Medicine, vol.121, issue.31 Suppl, pp.399-408, 2006.
DOI : 10.1007/BF03027375

P. Shie, R. Cardarelli, D. Brandon, W. Erdman, and N. Abdulrahim, Meta-analysis: Comparison of F-18 Fluorodeoxyglucose-Positron Emission Tomography and Bone Scintigraphy in the Detection of Bone Metastases in Patients With Breast Cancer, Clinical Nuclear Medicine, vol.33, issue.2, pp.97-101, 2008.
DOI : 10.1097/RLU.0b013e31815f23b7

C. Caldarella, G. Treglia, A. Giordano, and L. Giovanella, When to perform positron emission tomography/computed tomography or radionuclide bone scan in patients with recently diagnosed prostate cancer, Cancer Manag Res, vol.5, pp.123-154, 2013.

M. Umbehr, M. Müntener, T. Hany, T. Sulser, and L. Bachmann, The Role of 11C-Choline and 18F-Fluorocholine Positron Emission Tomography (PET) and PET/CT in Prostate Cancer: A Systematic Review and Meta-analysis, European Urology, vol.64, issue.1, pp.106-123, 2013.
DOI : 10.1016/j.eururo.2013.04.019

H. Schirrmeister, M. Bommer, A. Buck, S. Müller, P. Messer et al., Initial results in the assessment of multiple myeloma using 18F-FDG PET, European Journal of Nuclear Medicine and Molecular Imaging, vol.29, issue.3, pp.361-367, 2002.
DOI : 10.1007/s00259-001-0711-3

B. Durie, A. Waxman, D. Agnolo, A. Williams, and C. , Whole-body (18)F-FDG PET identifies high-risk myeloma, J Nucl Med, vol.43, pp.1457-63, 2002.

T. Bartel, J. Haessler, T. Brown, J. Shaughnessy, F. Van-rhee et al., F18-fluorodeoxyglucose positron emission tomography in the context of other imaging techniques and prognostic factors in multiple myeloma, Blood, vol.114, issue.10, pp.2068-76, 2009.
DOI : 10.1182/blood-2009-03-213280

S. Cappabianca, A. Porto, M. Petrillo, B. Greco, A. Reginelli et al., Preliminary study on the correlation between grading and histology of solitary pulmonary nodules and contrast enhancement and [18F]fluorodeoxyglucose standardised uptake value after evaluation by dynamic multiphase CT and PET/CT, Journal of Clinical Pathology, vol.64, issue.2, pp.114-123, 2011.
DOI : 10.1136/jcp.2010.076562

O. Kandemir, K. Karakus, O. Katrancioglu, and A. Sarikaya, Semi-quantitative investigation of primary tumor and bone metastasis in lung cancer patients using the PET-CT approach, Int J Clin exp Med, vol.7, pp.2624-2655, 2014.

D. Koksal, F. Demirag, H. Bayiz, O. Ozmen, E. Tatci et al., The correlation of SUVmax with pathological characteristics of primary tumor and the value of Tumor/ Lymph node SUVmax ratio for predicting metastasis to lymph nodes in resected NSCLC patients, Journal of Cardiothoracic Surgery, vol.83, issue.1, p.63, 2013.
DOI : 10.1016/j.athoracsur.2006.12.034

J. Maillefert, C. Tavernier, and J. Tebib, Determining the site of the primary cancer in patients with skeletal metastasis of unknown origin, Cancer, vol.69, issue.7, pp.1759-60, 2000.
DOI : 10.1002/(SICI)1097-0142(20000401)88:7<1759::AID-CNCR33>3.0.CO;2-I

M. Werner, P. Aschoff, M. Reimold, C. Pfannenberg, and . Fdg-pet, FDG-PET/CT-guided biopsy of bone metastases sets a new course in patient management after extensive imaging and multiple futile biopsies, The British Journal of Radiology, vol.84, issue.999, pp.65-72, 2011.
DOI : 10.1259/bjr/26998246

B. Klaeser, M. Mueller, R. Schmid, C. Guevara, T. Krause et al., PET-CT-guided interventions in the management of FDG-positive lesions in patients suffering from solid malignancies: initial experiences, European Radiology, vol.12, issue.7, pp.1780-1785, 2009.
DOI : 10.1007/s00330-009-1338-1

J. Maillefert, J. Tebib, M. Huguenin, B. Chauffert, F. Pascaud et al., Les métastases osseuses révélatrices : recherche du cancer primitif. Etude d'une série de cent quinze cas, Sem Hop Paris, vol.69, pp.372-380, 1993.

N. Pavlidis and K. Fizazi, Cancer of unknown primary (CUP), Critical Reviews in Oncology/Hematology, vol.54, issue.3, pp.243-50, 2005.
DOI : 10.1016/j.critrevonc.2004.10.002

P. Mantaka, R. Baum, A. Hertel, S. Adams, A. Niessen et al., PET with 2-[F- 18]-fluoro-2-deoxy-D-glucose (FDG) in patients with cancer of unknown primary (CUP)

C. Decroisette, I. Monnet, H. Berard, G. Quere, L. Caer et al., Epidemiology and Treatment Costs of Bone Metastases from Lung Cancer: A French Prospective, Observational, Multicenter Study (GFPC 0601), Journal of Thoracic Oncology, vol.6, issue.3, pp.576-82, 2011.
DOI : 10.1097/JTO.0b013e318206a1e3

URL : https://hal.archives-ouvertes.fr/hal-00596800

H. Katagiri, M. Takahashi, K. Wakai, H. Sugiura, T. Kataoka et al., Prognostic factors and a scoring system for patients with skeletal metastasis, Journal of Bone and Joint Surgery - British Volume, vol.87, issue.5, pp.698-703, 2005.
DOI : 10.1302/0301-620X.87B5.15185

Z. Horne, D. Clump, J. Vargo, S. Shah, S. Beriwal et al., Pretreatment SUVmax predicts progression-free survival in early-stage non-small cell lung cancer treated with stereotactic body radiation therapy, Radiation Oncology, vol.9, issue.1, p.41, 2014.
DOI : 10.1016/j.lungcan.2012.08.016