. Cependant, les signes stomatologiques, lorsqu'ils sont recherchés, sont très fortement présents, jusqu'à 100 % des cas dans la cohorte de Oguike

. Dans-notre-Étude, l'état bucco-dentaire est renseigné dans 68 % des cas comme mauvais, à l'exception d'un patient

J. Delanghe, M. Langlois, D. Buyzere, M. Torck, and M. , Vitamin C Deficiency and Scurvy Are Not Only a Dietary Problem but Are Codetermined by the Haptoglobin Polymorphism, Clinical Chemistry, vol.53, issue.8, p.1397400, 2007.
DOI : 10.1373/clinchem.2007.088658

J. Delanghe, D. Buyzere, M. Speeckaert, M. Langlois, and M. , Genetic Aspects of Scurvy and the European Famine of 1845???1848, Nutrients, vol.5, issue.9, p.35828, 2013.
DOI : 10.3390/nu5093582

C. Apport-recommandés-en-vitamine and . Internet, Disponible sur: https

. Berger, Apport d'antioxydants en réanimation : pourquoi, lesquels, avec quels objectifs [Internet]. [cité 29 sept 2015] Disponible sur: http://www.srlf.org/rc, pp.20110808-095626, 2011.

F. Guittard, Carence en vitamine C, un diagnostic toujours d'actualité en médecine générale ?: enquête téléphonique, 2011.

C. Porquet, Etude des hypovitaminoses C sévères chez les patients hospitalisés au CHU de Toulouse: à propos de 74 dossiers de scorbut biologique dépistés au CHU sur une année et de 10 observations de scorbut clinique diagnostiqué en médecine interne [Thèse d'exercice Faculté des sciences médicales Rangueil, 2009.

F. Godard, Evaluation des cas de déficit en vitamine c et de scorbut dans des service de médecine de l'est de la réunion [Thèse d'exercice], 2014.

M. Bernard, Les nouveaux visages du scorbut en 2010: étude rétrospective du statut en vitamine C de patients hospitalisés dans les services de post-urgences médicales de l'hôpital Purpan durant l'année 2010 [Thèse d'exercice Faculté des sciences médicales Rangueil, 2011.

M. Oguike, . Scorbut, and . Précarité, prévalence d'une maladie oubliée en médecine générale [Thèse d'exercice]. [France]: Université de Montpellier I. Faculté de médecine; 2014. 11. Trébern-Launay K. Hypovitaminose C et précarité: étude prospective à la Permanence d'Accès aux

S. Blateau, . Scorbut, C. Déficit-en-vitamine, B. Waszkiewicz-robak, and E. Piekot, étude rétrospective à propos de 164 cas [Thèse d'exercice]. [France]: Université de Reims Champagne-Ardenne Evaluation of vitamins A, C and E content in diets of adolescents living in Warsaw, p.215, 2005.

G. Handelman, Vitamin C deficiency in dialysis patients--are we perceiving the tip of an iceberg? Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc -Eur Ren Assoc, févr, vol.22, issue.2, p.32831, 2007.

H. Biesalski, P. Tveden-nyborg, and J. Lykkesfeldt, Parenteral ascorbic acid in haemodialysis patients):7416. 16. Hodges. Experimental Scurvy in Man, Curr Opin Clin Nutr Metab Care. nov, vol.115, issue.68, p.286079, 2008.

J. Moores, Vitamin C: a wound healing perspective, British Journal of Community Nursing, vol.18, issue.Sup12, 2013.
DOI : 10.12968/bjcn.2013.18.Sup12.S6

S. Boulinguez, M. Bouyssou-gauthier, D. Vençay, P. Bedane, C. Bonnetblanc et al., Scurvy presenting with ecchymotic purpura and hemorrhagic ulcers of the lower limbs], Ann Dermatol Vénéréologie. mai, vol.127, issue.20, p.5102, 2000.

I. De-oliveira, V. De-souza, V. Motta, and S. Da-silva, collagen accumulation in cartilage-like MSC sheet Effects of Oral Vitamin C Supplementation on Anxiety in Students: A Double-Blind, Randomized, Placebo- Controlled Trial, Cytotechnology. 16 nov Pak J Biol Sci PJBS. janv, vol.2118, issue.1, p.118, 2015.

Y. Li and H. Schellhorn, New developments and novel therapeutic perspectives for vitamin C, J Nutr. oct, vol.137, issue.10, p.217184, 2007.

J. Lykkesfeldt, A. Michels, B. Frei, C. Vitamin, K. Khaw et al., Relation between plasma ascorbic acid and mortality in men and women in EPIC- Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition Jungert A, Neuhäuser-Berthold M. The lower vitamin C plasma concentrations in elderly men compared with elderly women can partly be attributed to a volumetric dilution effect due to differences in fat-free mass, Adv Nutr. 4 janv Lancet. 3 mars Br J Nutr, vol.5357113, issue.145, pp.168-2485964, 2001.

J. Lykkesfeldt, H. Poulsen, R. Uchio, Y. Hirose, S. Murosaki et al., Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials High dietary intake of vitamin C suppresses age-related thymic atrophy and contributes to the maintenance of immune cells in vitamin C-deficient senescence marker protein- 30 knockout mice Vitamin C for preventing and treating the common cold, Br J Nutr. mai Br J Nutr. 28 févr Cochrane Database Syst Rev, vol.103113, issue.283, pp.12519-276039, 2007.

C. Johnston, G. Barkyoumb, and S. Schumacher, Vitamin C Supplementation Slightly Improves Physical Activity Levels and Reduces Cold Incidence in Men with Marginal Vitamin C Status: A Randomized Controlled Trial, Nutrients, vol.6, issue.7, p.257283, 2014.
DOI : 10.3390/nu6072572

M. Langlois, J. Delanghe, M. Buyzere, D. Bernard, J. Ouyang et al., Effect of haptoglobin on the metabolism of vitamin C Vitamin C in plasma is inversely related to blood pressure and change in blood pressure during the previous year in young Black and White women Ascorbic acid prevents VEGFinduced increases in endothelial barrier permeability, 2011: the scurvy Odyssey. BMJ Case Rep [Internet]. 17 sept, pp.60610-60641, 1997.

O. Disponible-sur-dolberg, A. Elis, M. Lishner, C. Piéto-le-corvaisier, C. Cadiou et al., Scurvy in the 21st century, Rev Médecine Interne Fondée Par Société Natl Francaise Médecine Interne, pp.12258-3610034, 2000.

W. Mak and T. Thirumoorthy, A case of scurvy in Singapore in the year, 2006.

G. Beaune, C. Martin, D. Martin, J. Deplante, F. Heluwaert et al., Vitamin C measurements in vulnerable populations: 4 cases of scurvy] A rare presentation of an ancient disease: scurvy presenting as orthostatic hypotension Do you remember scurvy? Clin Ter, Ann Biol Clin BMJ Case Rep, vol.65165, issue.15, pp.659-392536, 2007.

N. Ma, C. Thompson, W. S. Pailhous, S. Lamoureux, S. Caietta et al., Brief Report: Scurvy as a Manifestation of Food Selectivity in Children with AutismScurvy, an old disease still in the news: two case reports]. Arch Pédiatrie Organe Off Sociéte Fr Pédiatrie, J Autism Dev Disord. 21 nov janv, vol.4222, issue.1, p.635, 2015.

A. Kitcharoensakkul, M. Schulz, C. Kassel, R. Khanna, G. Liang et al., Disponible sur: http://www.ncbi.nlm.nih.gov/pubmed/26063195 44 Scurvy revealed by difficulty walking: three cases in young children Ratanachu-Ek. Scurvy in pediatric patients: a review of 28 cases, 14700174 46. Najera-Martinez. [Scurvy. A study of 13 cases]. -PubMed -NCBI [Internet], p.2248, 2014.

V. Canadananovi?, S. Latinovi?, S. Bari?i?, N. Babi?, and S. Jovanovi?, Age-related changes of vitamin C levels in aqueous humour, Military Medical and Pharmaceutical Journal of Serbia, vol.72, issue.9, p.8236, 2015.
DOI : 10.2298/VSP131212063C

E. Cheung, R. Mutahar, F. Assefa, M. Ververs, S. Nasiri et al., An Epidemic of Scurvy in Afghanistan: Assessment and Response, Food and Nutrition Bulletin, vol.24, issue.3, p.24755, 2003.
DOI : 10.1177/156482650302400302

M. Vece, C. Agnoli, S. Grioni, S. Sieri, V. Pala et al., Dietary Total Antioxidant Capacity and Colorectal Cancer in the Italian EPIC Cohort Ascorbic acid and ascorbate-2- phosphate decrease HIF activity and malignant properties of human melanoma cells, PloS One. BMC Cancer, vol.1015, issue.111, p.867, 2015.

K. Li, J. Wang, M. Shi, J. Li, L. Yan et al., Prescription consisting of Vitamin C and Baicalin inhibits tumor growth by enhancing the antioxidant capacity in vivo, J BUON Off J Balk Union Oncol. oct, vol.20, issue.5, pp.136872-53, 2015.

J. Kaiser and . Oncology, Vitamin C could target some common cancers, Science, vol.350, issue.6261
DOI : 10.1126/science.350.6261.619

J. Yun, E. Mullarky, C. Lu, K. Bosch, A. Kavalier et al., Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH, Science, vol.350, issue.6266, 2015.
DOI : 10.1126/science.aaa5004

S. Vannier, Le déficit en vitamine C est-il un facteur de risque d'hémorragie intracérébrale spontanée ? [Thèse d'exercice, 2013.

L. Bermond and . Le, Scorbut en gériatrie: à propos d'un cas et revue de la littérature [Thèse d'exercice], 2010.

S. Gariballa, Poor Vitamin C Status is Associated with Increased Depression Symptoms Following Acute Illness in Older People, International Journal for Vitamin and Nutrition Research, vol.84, issue.1-2, p.127, 2014.
DOI : 10.1024/0300-9831/a000188

L. Bris and T. , Quel est l'intérêt de l'ascorbémie dans le diagnostic et le traitement du scorbut ? [Thèse d'exercice]. [France]: Université de Caen UFR de médecine; 2012. 61. Raynaud-Simon. Scurvy in hospitalized elderly patients, 20617280.

L. Malmauret, J. Leblanc, I. Cuvelier, and P. Verger, Dietary intakes and vitamin status of a sample of homeless people in Paris, European Journal of Clinical Nutrition, vol.56, issue.4, p.31320, 2002.
DOI : 10.1038/sj.ejcn.1601312

M. Szczuko, T. Seidler, E. Stachowska, K. Safranow, M. Olszewska et al., Influence of daily diet on ascorbic acid supply to students, ):21320. 65. Wrieden W, Hannah M, 2014.

H. Pedoe, J. Simon, E. Hudes, J. Tice, J. Simon et al., Plasma vitamin C and food choice in the third Glasgow MONICA population survey Relation of serum ascorbic acid to mortality among US adults Relation of Ascorbic Acid to Coronary Artery Calcium The Coronary Artery Risk Development in Young Adults Study, J Epidemiol Community Health. mai J Am Coll Nutr. juin Am J Epidemiol. 15 mars, vol.5420159, issue.536, pp.35560-6625563, 2000.

G. Schectman, J. Byrd, H. Gruchow, J. Hampl, C. Taylor et al., The influence of smoking on vitamin C status in adults Vitamin C Deficiency and Depletion in the United States: The Third National Health and Nutrition Examination Survey Are lifestyle factors good predictors of retinol and vitamin C deficiency in apparently healthy adults?, Am J Public Health. févr Am J Public Health. mai Eur J Clin Nutr. févr, vol.7994870556, issue.702, pp.15862-6996104, 1988.

T. Matilainen, E. Vartiainen, P. Puska, G. Alfthan, S. Pokusajeva et al., Plasma ascorbic acid concentrations in the Republic of Karelia, Russia and in North Karelia, Finland Bachelot-Narquin R, Institut national de prévention et d'éducation pour la santé. Baromètre santé nutrition, Eur J Clin Nutr. févr, vol.50, issue.72, p.11520, 1996.

N. Na, J. Delanghe, Y. Taes, M. Torck, W. Baeyens et al., Serum vitamin C concentration is influenced by haptoglobin polymorphism and iron status in Chinese Cahill LE, El-Sohemy A. Haptoglobin genotype modifies the association between dietary vitamin C and serum ascorbic acid deficiency, nov Clin Chim Acta Int J Clin Chem. mars Am J Clin Nutr. 1 déc, vol.2636592, issue.116, pp.885-90, 2005.

M. Langlois, D. Buyzere, M. Delanghe, and J. , PLASMA VITAMIN C FOR PREDICTING CARDIOVASCULAR DISEASE: MORE THAN A NUTRITIONAL BIOMARKER, Acta Clinica Belgica, vol.137, issue.4, pp.341-344, 2009.
DOI : 10.1161/ATVBAHA.107.153965

X. Li, X. Wang, J. Wei, and Y. T. , Relationship between dietary vitamin C and Type 2 diabetes], 28 oct, vol.40, issue.10, pp.1109-1123, 2015.

L. Touyz, Oral scurvy and periodontal disease, J Can Dent Assoc. déc, vol.63, issue.11, pp.837-882, 1997.

T. Blee, T. Cogbill, and P. Lambert, Hemorrhage associated with vitamin C deficiency in surgical patients, Surgery, vol.131, issue.4, p.408, 2002.
DOI : 10.1067/msy.2002.122373

O. Fain, Musculoskeletal manifestations of scurvy, PubMed -NCBI [Internet]
DOI : 10.1016/j.jbspin.2004.01.007

A. Amaliya, M. Laine, B. Loos, U. Van-der-velden, A. Kessels et al., Java project on periodontal diseases: effect of vitamin C/calcium threonate/citrus flavonoids supplementation on periodontal pathogens, CRP and HbA1c La demande de vitamines en médecine générale : ressenti et réponses du médecin. Enquête qualitative auprès de médecins généralistes -document [Internet]. [cité 29 sept 2015]. Disponible sur: https Randomized clinical trial of ascorbic acid in the treatment of pressure ulcers, Disponible sur, pp.1453-60, 1995.

R. Asleh and A. Levy, -Tocopherol and Vitamin C on the Generation of Dysfunctional HDL Associated with Diabetes and the Hp 2-2 Genotype, Antioxidants & Redox Signaling, vol.12, issue.2, pp.209-226, 2010.
DOI : 10.1089/ars.2009.2829

J. Yun, C. Rago, I. Cheong, R. Pagliarini, P. Angenendt et al., Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells, Science, vol.325, issue.5947, pp.1555-1564, 2009.
DOI : 10.1126/science.1174229