L. Lowe, A. Custovic, and A. Woodcock, Childhood asthma, Current Allergy and Asthma Reports, vol.158, issue.2, pp.159-65, 2004.
DOI : 10.1007/s11882-004-0062-9

F. Martinez, A. Wright, L. Taussig, C. Holberg, M. Halonen et al., Asthma and Wheezing in the First Six Years of Life, New England Journal of Medicine, vol.332, issue.3, pp.133-141, 1995.
DOI : 10.1056/NEJM199501193320301

R. Zeiger, C. Dawson, and S. Weiss, Relationships between duration of asthma and asthma severity among children in the Childhood Asthma Management Program (CAMP), Journal of Allergy and Clinical Immunology, vol.103, issue.3, pp.376-87, 1999.
DOI : 10.1016/S0091-6749(99)70460-4

A. Simpson, V. Tan, J. Winn, M. Svensén, C. Bishop et al., Beyond Atopy, American Journal of Respiratory and Critical Care Medicine, vol.181, issue.11, pp.1200-1206, 2010.
DOI : 10.1164/rccm.200907-1101OC

J. Just, S. Pierre, P. Amat, F. Gouvis-echraghi, R. Lambert-guillemot et al., What lessons can be learned about asthma phenotypes in children from cohort studies? Pediatr Allergy Immunol Off Publ Eur Soc Pediatr Allergy Immunol, juin, vol.26, issue.4, pp.300-305, 2015.

J. Just, R. Gouvis-echraghi, R. Couderc, N. Guillemot-lambert, and P. Saint-pierre, Novel severe wheezy young children phenotypes: Boys atopic multiple-trigger and girls nonatopic uncontrolled wheeze, Journal of Allergy and Clinical Immunology, vol.130, issue.1, pp.103-113, 2012.
DOI : 10.1016/j.jaci.2012.02.041

J. Antó, M. Pinart, M. Akdis, C. Auffray, C. Bachert et al., Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) Seminar, Journal of Allergy and Clinical Immunology, vol.129, issue.4, pp.943-54, 2012.
DOI : 10.1016/j.jaci.2012.01.047

A. Simpson, L. Soderstrom, S. Ahlstedt, C. Murray, A. Woodcock et al., IgE antibody quantification and the probability of wheeze in preschool children, Journal of Allergy and Clinical Immunology, vol.116, issue.4, pp.744-753, 2005.
DOI : 10.1016/j.jaci.2005.06.032

J. Bousquet, P. Jeffery, W. Busse, M. Johnson, and A. Vignola, Asthma, American Journal of Respiratory and Critical Care Medicine, vol.161, issue.5, pp.1720-1765, 2000.
DOI : 10.1164/ajrccm.161.5.9903102

URL : https://hal.archives-ouvertes.fr/inserm-00422525

L. Cohn, J. Elias, and G. Chupp, : Mechanisms of Disease Persistence and Progression, Annual Review of Immunology, vol.22, issue.1, pp.789-815, 2004.
DOI : 10.1146/annurev.immunol.22.012703.104716

C. Ober and T. Yao, The genetics of asthma and allergic disease: a 21st century perspective, Immunological Reviews, vol.127, issue.Suppl, pp.10-30, 2011.
DOI : 10.1111/j.1600-065X.2011.01029.x

M. Cal??kan, Y. Bochkov, E. Kreiner-møller, K. Bønnelykke, M. Stein et al., Rhinovirus Wheezing Illness and Genetic Risk of Childhood-Onset Asthma, New England Journal of Medicine, vol.368, issue.15, pp.1398-407, 2013.
DOI : 10.1056/NEJMoa1211592

K. Bønnelykke, P. Sleiman, K. Nielsen, E. Kreiner-møller, J. Mercader et al., A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations, Nature Genetics, vol.1, issue.1, pp.51-56, 2014.
DOI : 10.1093/nar/gki408

Y. Liu, Z. Wang, W. Zhen, S. Lu, Z. Liu et al., Association between genetic polymorphisms in the ADAM33 gene and asthma risk: a meta-analysis, DNA Cell Biol. nov, vol.33, issue.11, pp.793-801, 2014.

U. Sahiner, A. Semic-jusufagic, J. Curtin, E. Birben, D. Belgrave et al., IgE synthesis and replication in a birth cohort, Allergy, vol.147, issue.Suppl 15, pp.1648-58, 2014.
DOI : 10.1111/all.12504

M. Schieck, V. Sharma, S. Michel, A. Toncheva, L. Worth et al., 2 locus control region is associated with changes in DNA methylation and gene expression, Allergy, vol.27, issue.9, pp.1171-80, 2014.
DOI : 10.1111/all.12450

A. Lluis, N. Ballenberger, S. Illi, M. Schieck, M. Kabesch et al., Regulation of TH17 markers early in life through maternal farm exposure, Journal of Allergy and Clinical Immunology, vol.133, issue.3, pp.864-71, 2014.
DOI : 10.1016/j.jaci.2013.09.030

M. Herr, J. Just, L. Nikasinovic, C. Foucault, L. Marec et al., Risk factors and characteristics of respiratory and allergic phenotypes in early childhood, Journal of Allergy and Clinical Immunology, vol.130, issue.2, pp.389-96, 2012.
DOI : 10.1016/j.jaci.2012.05.054

I. Annesi-maesano, A. Didier, M. Klossek, I. Chanal, D. Moreau et al., The score for allergic rhinitis (SFAR): a simple and valid assessment method in population studies, Allergy, vol.57, issue.2, pp.107-121, 2002.
DOI : 10.1034/j.1398-9995.2002.1o3170.x

URL : https://hal.archives-ouvertes.fr/hal-00595555

H. Recommandations, Asthme de l'enfant de moins de 36 mois: diagnostic, prise en charge et

L. Kaufman and P. Rousseeuw, Finding Groups in Data: An Introduction to Cluster Analysis. 1 edition, 2005.
DOI : 10.1002/9780470316801

C. Gelmetti and C. Colonna, The value of SCORAD and beyond. Towards a standardized evaluation of severity?, Allergy, vol.14, issue.s78, pp.61-66, 2004.
DOI : 10.1067/mjd.2002.122187

J. Skripak, E. Matsui, K. Mudd, and R. Wood, The natural history of IgE-mediated cow's milk allergy, Journal of Allergy and Clinical Immunology, vol.120, issue.5, pp.1172-1179, 2007.
DOI : 10.1016/j.jaci.2007.08.023

J. Just, E. Deslandes-boutmy, F. Amat, K. Desseaux, A. Nemni et al., Natural history of allergic sensitization in infants with early-onset atopic dermatitis: results from ORCA Study. Pediatr Allergy Immunol Off Publ Eur Soc Pediatr Allergy Immunol, nov, vol.25, issue.7, pp.668-73, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01103219

J. Just, N. Nicoloyanis, M. Chauvin, C. Pribil, A. Grimfeld et al., Lack of eosinophilia can predict remission in wheezy infants?, Clinical & Experimental Allergy, vol.162, issue.5, pp.767-73, 2008.
DOI : 10.1016/j.jaci.2004.09.022

Y. Liu, A. Zhuo, W. Liu, S. Xu, and S. Li, The -33C/T polymorphism in the interleukin 4 gene is associated with asthma risk: a meta-analysis, J Investig Allergol Clin Immunol, vol.24, issue.2, pp.114-135, 2014.

L. Breiman, J. Friedman, C. Stone, and R. Olshen, Classification and Regression Trees. 1 re éd. Chapman and Hall, 1984.

L. Breiman, Random Forests, Machine Learning, vol.45, issue.1, pp.5-32, 2001.
DOI : 10.1023/A:1010933404324

J. Just, R. Gouvis-echraghi, S. Rouve, S. Wanin, and D. Moreau, Two novel, severe asthma phenotypes identified during childhood using a clustering approach, European Respiratory Journal, vol.40, issue.1, pp.55-60, 2012.
DOI : 10.1183/09031936.00123411

R. Kurukulaaratchy, W. Karmaus, A. Raza, S. Matthews, G. Roberts et al., The influence of gender and atopy on the natural history of rhinitis in the first 18 years of life, Clinical & Experimental Allergy, vol.118, issue.Part 2, pp.851-860, 2011.
DOI : 10.1111/j.1365-2222.2011.03765.x

I. Marenholz, T. Kerscher, A. Bauerfeind, J. Esparza-gordillo, R. Nickel et al., An interaction between filaggrin mutations and early food sensitization improves the prediction of childhood asthma, Journal of Allergy and Clinical Immunology, vol.123, issue.4, pp.911-917, 2009.
DOI : 10.1016/j.jaci.2009.01.051

M. Herr, C. B. Nikasinovic, L. Foucault, C. , L. Marec et al., Does allergic rhinitis exist in infancy? Findings from the PARIS birth cohort, Allergy, vol.36, issue.Suppl 1, pp.214-235, 2011.
DOI : 10.1111/j.1398-9995.2010.02467.x

M. Rochat, S. Illi, M. Ege, S. Lau, T. Keil et al., Allergic rhinitis as a predictor for wheezing onset in school-aged children, Journal of Allergy and Clinical Immunology, vol.126, issue.6, pp.1170-1175, 2010.
DOI : 10.1016/j.jaci.2010.09.008

G. Roberts, N. Patel, F. Levi-schaffer, P. Habibi, and G. Lack, Food allergy as a risk factor for life-threatening asthma in childhood: A case-controlled study, Journal of Allergy and Clinical Immunology, vol.112, issue.1, pp.168-74, 2003.
DOI : 10.1067/mai.2003.1569

N. Vogel, H. Katz, R. Lopez, and D. Lang, Food Allergy Is Associated With Potentially Fatal Childhood Asthma, Journal of Asthma, vol.78, issue.10, pp.862-868, 2008.
DOI : 10.1159/000097676

D. Mudarri and W. Fisk, Public health and economic impact of dampness and mold, Indoor Air, vol.54, issue.10, pp.226-261, 2007.
DOI : 10.1067/mai.2001.112262

S. Cho, T. Reponen, G. Lemasters, L. Levin, J. Huang et al., Mold damage in homes and wheezing in infants, Annals of Allergy, Asthma & Immunology, vol.97, issue.4, pp.539-584, 2006.
DOI : 10.1016/S1081-1206(10)60947-7

Y. Iossifova, T. Reponen, P. Ryan, L. Levin, D. Bernstein et al., Mold exposure during infancy as a predictor of potential asthma development, Annals of Allergy, Asthma & Immunology, vol.102, issue.2, pp.131-138, 2009.
DOI : 10.1016/S1081-1206(10)60243-8

M. Sears, J. Greene, A. Willan, D. Taylor, E. Flannery et al., Long-term relation between breastfeeding and development of atopy and asthma in children and young adults: a longitudinal study, The Lancet, vol.360, issue.9337, pp.901-908, 2002.
DOI : 10.1016/S0140-6736(02)11025-7

S. Kuyucu, Y. Saraçlar, A. Tuncer, C. Saçkesen, G. Adalioglu et al., Determinants of atopic sensitization in Turkish school children: effects of pre-and post-natal events and maternal atopy. Pediatr Allergy Immunol Off Publ Eur Soc Pediatr Allergy Immunol, févr, vol.15, issue.1, pp.62-71, 2004.

Y. Huang, C. Nelson, E. Brodie, T. Desantis, M. Baek et al., Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma, Journal of Allergy and Clinical Immunology, vol.127, issue.2, pp.372-81, 2011.
DOI : 10.1016/j.jaci.2010.10.048

E. Sutherland, T. King, N. Icitovic, B. Ameredes, E. Bleecker et al., A trial of clarithromycin for the treatment of suboptimally controlled asthma, Journal of Allergy and Clinical Immunology, vol.126, issue.4, pp.747-53, 2010.
DOI : 10.1016/j.jaci.2010.07.024

N. Zhu, Y. Gong, X. Chen, J. Zhang, F. Long et al., Association between the polymorphisms of interleukin-4, the interleukin-4 receptor gene and asthma, Chin Med J (Engl), vol.126, issue.15, pp.2943-51, 2013.

Y. Li, B. Guo, L. Zhang, J. Han, B. Wu et al., Association between C-589T polymorphisms of interleukin-4 gene promoter and asthma: A meta-analysis, Respiratory Medicine, vol.102, issue.7, pp.984-92, 2008.
DOI : 10.1016/j.rmed.2008.02.008

M. Basehore, T. Howard, L. Lange, W. Moore, G. Hawkins et al., A comprehensive evaluation of IL4 variants in ethnically diverse populations: association of total serum IgE levels and asthma in white subjects, Journal of Allergy and Clinical Immunology, vol.114, issue.1, pp.80-87, 2004.
DOI : 10.1016/j.jaci.2004.05.035

M. Smolnikova, S. Smirnova, M. Freidin, and O. Tyutina, ) in severe bronchial asthma in children from the Krasnoyarsk region, West Siberia, International Journal of Circumpolar Health, vol.42, issue.1, 2013.
DOI : 10.3402/ijch.v72i0.21159

B. Woitsch, D. Carr, D. Stachel, I. Schmid, S. Weiland et al., A Comprehensive Analysis of Interleukin-4 Receptor Polymorphisms and Their Association with Atopy and IgE Regulation in Childhood, International Archives of Allergy and Immunology, vol.135, issue.4, pp.319-343, 2004.
DOI : 10.1159/000082326

B. Beghé, S. Barton, S. Rorke, Q. Peng, I. Sayers et al., Polymorphisms in the interleukin-4 and interleukin-4 receptor alpha chain genes confer susceptibility to asthma and atopy in a Caucasian population, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.156, issue.2, pp.1111-1118, 2003.
DOI : 10.1007/s002510100324

H. Xue, K. Sun, W. Xie, and H. Wang, [Meta-analysis on interleukin-4 receptor ? chain Q576R gene polymorphisms and bronchial asthma susceptibility], Zhonghua Jie He He Hu Xi Za Zhi Zhonghua Jiehe He Huxi Zazhi Chin J Tuberc Respir Dis. nov, vol.33, issue.11, pp.831-837, 2010.

R. Gouvis-echraghi, P. Saint-pierre, A. Besharaty, A. Bernard, and J. Just, Exhaled nitric oxide measurement confirms 2 severe wheeze phenotypes in young children from the Trousseau Asthma Program, Journal of Allergy and Clinical Immunology, vol.130, issue.4, pp.1005-1012, 2012.
DOI : 10.1016/j.jaci.2012.07.007