.. Traitement-de-substitution-aux-opiacés, 48 3.3.9 Association entre l'évolution des traitements psychotropes et l'issue du traitement par baclofène, p.48

.. Tolérance-du-baclofène-À-haute-dose, 49 3.4.1 Description des effets indésirables 49 3.4.2 Association entre les effets indésirables au cours de la 1ère année de suivi et l'issue du traitement à 1 an, p.51

.. Forces-et-limites-de-l-'étude, 55 4.2.1 Limites de l'étude, p.56

F. Beck, J. Richard, R. Guignard, L. Nézet, O. Spilka et al., Les niveaux d'usage des drogues en France en 2014, Tend OFDT. mars, issue.99, p.8, 2015.

J. Saunders, O. Aasland, T. Babor, J. De-la-fuente, and M. Grant, Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption-II, Addiction, vol.i, issue.6
DOI : 10.1111/j.1360-0443.1993.tb02093.x

F. Beck, R. Guignard, I. Obradovic, A. Gautier, and L. Karila, Increasing trends in screening for addictives behaviors among general practitioners in France]. Rev Dépidémiologie Santé Publique, oct, vol.59, issue.5, pp.285-94, 2011.

M. Mouquet and H. Villet, Les risques d'alcoolisation excessive chez les patients ayant recours aux soins un jour donné, Etudes Résultats Dress. sept, 0192.

. Société-française-d-'alcoologie, Mésusage de l'alcool : dépistage, diagnostic et traitement Recommandation de bonne pratique, 5?84. 8. International guide for monitoring alcohol consumption and related Harm, 2015.

J. Ewing, . Detecting-alcoholism-v, P. Michaud, S. Arfaoui, P. Gache et al., The CAGE questionnaire Fast alcohol consumption evaluation: a screening instrument adapted for French general practitioners, ):1905?7. 11. Dewost A, pp.1889-95, 1984.

L. Amato, S. Minozzi, S. Vecchi, and M. Davoli, Benzodiazepines for alcohol withdrawal, CD005063. 15. Rösner S, 2010.
DOI : 10.1002/14651858.CD005063.pub3

M. Skinner, P. Lahmek, H. Pham, and H. Aubin, Disulfiram Efficacy in the Treatment of Alcohol Dependence: A Meta-Analysis, PLoS ONE, vol.74, issue.2, p.87366, 2014.
DOI : 10.1371/journal.pone.0087366.s002

G. Haute-autorité-de-santé, G. Gessa, and G. Gasbarrini, Disponible sur: http://www.hassante.fr/portail/upload/docs/application/pdf/2014- 02/selincro_04122013_synthese_ct12945_2014-02-28_12-00-18_162.pdf 20, 2013.

O. Ameisen, COMPLETE AND PROLONGED SUPPRESSION OF SYMPTOMS AND CONSEQUENCES OF ALCOHOL-DEPENDENCE USING HIGH-DOSE BACLOFEN: A SELF-CASE REPORT OF A PHYSICIAN, Alcohol and Alcoholism, vol.40, issue.2, pp.147-50, 2005.
DOI : 10.1093/alcalc/agh130

O. Ameisen and . Le-dernier-verre, Paris: Denoël, 2008.

«. Abstinence, S. Low-risk-cardone, L. Vonghia, and A. Mirijello, consumption 1 year after the initiation of high-dose baclofen: a retrospective study among « high-risk » drinkers Suppression of alcohol dependence using baclofen: a 2- year observational study of 100 patients. Front Psychiatry Recommandation relative à la prise en charge à titre dérogatoire du Baclofène dans le cadre d'une recommandation temporaire d'utilisation [Internet]. Haute autorité de santé -Direction de l'évaluation médicale, économique et de santé publique, 439?42. 26. de Beaurepaire R Disponible sur, pp.103-272014, 2012.

P. Rosca, E. Aronovich, A. Weizman, and A. Grinshpoon, Efficacy and safety of baclofen for alcohol dependence: a randomized, double-blind, placebo-controlled trial Baclofen as add-on to standard psychosocial treatment for alcohol dependence: a randomized, double-blind, placebo-controlled trial with 1 year follow-up, Alcohol Clin Exp Res. nov J Subst Abuse Treat. mai, vol.3452, issue.11, pp.24-30, 2010.

C. Müller, O. Geisel, P. Pelz, V. Higl, J. Krüger et al., High-dose baclofen for the treatment of alcohol dependence (BACLAD study): A randomized, placebo-controlled trial Antidepressant-like effects of baclofen and LY367385 in the forced swim test in rats Effects of GABAB receptor ligands in animal tests of depression and anxiety, Eur Neuropsychopharmacol J Eur Coll Neuropsychopharmacol. août Pharmacol Rep PR. oct Pharmacol Rep PR. déc Krupitsky EM, Burakov AM, vol.255859, issue.346, pp.645-55, 2006.

. Aja-null, Baclofen administration for the treatment of affective disorders in alcoholic patients, Drug Alcohol Depend. sept, vol.33, issue.2, pp.157-63, 1993.

L. Cuny, . Joussaume, and . Bastien, Baclofen in the treatment of alcohol withdrawal syndrome: a comparative study vs diazepam Indifférence, recueil de témoignage sur le traitement par le baclofène de l'alcoolisme et autres addictions Le Publieur; 2012. 198 p. 38. de Beaurepaire R. The use of very high-doses of baclofen for the treatment of alcohol-dependence: a case series, Am J Med. mars Front Psychiatry, vol.1195, issue.3, pp.276-289, 2006.