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Master Thesis

Les chéloïdes, proposition et évaluation d’une nouvelle classification clinique

Abstract : Keloid is a benign overgrowth resulting from a fibroblastic dysfunction that produces too much collagen fibres. Usually it occurs after a skin injury, even a very insignificant one, but sometimes it can be spontaneous. There is no codified treatment and therapeutical studies have a low level of evidence. We suggest, in this study, a first part focusing on keloids and on what is already known about this subject, followed by a second part where we assess a new clinical classification and last, a third part for discussion. We invited yound and experienced dermatologists and plastic surgeons to participate to an online survey with 32 photos. They had to classify the pictures by choosing among 4 labels : "hypertrophic scar", "keloid with horizontal growth", "keloid with vertical growth" or "small keloid with indefinite growth". Overall, 391 people recieved the survey and 99 answered it (25,3%). Thirty five were residents, 28 were senior dermatologistes and 36 were plastic surgeons. The inter rater agreement was good with a mean Cohen’s kappa of 0,69. Residents answered better than the others groups, with a 18,3% of mistakes whereas experienced dermatologists had 24,4% of mistakes and plastic surgeons 27,5%. This clinical classification that we suggest is repproducible, simple and intuitive. We hope it will help to classify keloids and therefore obtain homogeneous populations for therapeutical studies.
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Master Thesis
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Submitted on : Tuesday, April 19, 2016 - 3:43:52 PM
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  • HAL Id : dumas-01304318, version 1


Gaëlle Hirsch. Les chéloïdes, proposition et évaluation d’une nouvelle classification clinique. Médecine humaine et pathologie. 2015. ⟨dumas-01304318⟩



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