M. Levy and J. Feingold, Estimating prevalence in single-gene kidney diseases progressing to renal failure, Kidney International, vol.58, issue.3, pp.925-943, 2000.
DOI : 10.1046/j.1523-1755.2000.00250.x

O. Dalgaard, Bilateral polycystic disease of the kidneys; a follow-up of two hundred and eighty-four patients and their families, Acta Med. Scand, vol.328, pp.1-255, 1957.

C. G. Iglesias, Epidemiology of adult polycystic kidney disease

E. M. Spithoven, Renal replacement therapy for autosomal dominant polycystic kidney disease (ADPKD) in Europe: prevalence and survival--an analysis of data from the ERA-EDTA Registry, Nephrology Dialysis Transplantation, vol.29, issue.suppl 4
DOI : 10.1093/ndt/gfu017

T. Mochizuki, PKD2, a Gene for Polycystic Kidney Disease That Encodes an Integral Membrane Protein, Science, vol.272, issue.5266, pp.1339-1342, 1996.
DOI : 10.1126/science.272.5266.1339

N. Hateboer, Comparison of phenotypes of polycystic kidney disease types 1 and 2, The Lancet, vol.353, issue.9147
DOI : 10.1016/S0140-6736(98)03495-3

S. Rossetti, The Position of the Polycystic Kidney Disease 1 (PKD1) Gene Mutation Correlates with the Severity of Renal Disease, Journal of the American Society of Nephrology, vol.13, issue.5, pp.1230-1237, 2002.
DOI : 10.1097/01.ASN.0000013300.11876.37

C. Gall, E. Audrézet, M. Meur, Y. L. Chen, J. Férec et al., Genetics and Pathogenesis of Autosomal Dominant Polycystic Kidney Disease: 20 Years On, Human Mutation, vol.30, issue.12, pp.1393-1406, 2014.
DOI : 10.1111/cge.12383

J. Hughes, The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains, Nature Genetics, vol.10, issue.2, pp.151-160, 1995.
DOI : 10.1016/0014-5793(92)80506-C

T. Hayashi, Characterization of the Exon Structure of the Polycystic Kidney Disease 2 Gene (PKD2), Genomics, vol.44, issue.1, pp.131-136, 1997.
DOI : 10.1006/geno.1997.4851

V. E. Torres, P. C. Harris, and Y. Pirson, Autosomal dominant polycystic kidney disease, The Lancet, vol.369, issue.9569, pp.1287-1301, 2007.
DOI : 10.1016/S0140-6736(07)60601-1

URL : https://hal.archives-ouvertes.fr/hal-01328055

V. E. Torres and P. Harris, Strategies Targeting cAMP Signaling in the Treatment of Polycystic Kidney Disease, Journal of the American Society of Nephrology, vol.25, issue.1, pp.18-32, 2014.
DOI : 10.1681/ASN.2013040398

S. V. Fedeles, A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation, Nature Genetics, vol.94, issue.7
DOI : 10.1074/jbc.274.40.28557

V. H. Gattone, X. Wang, P. C. Harris, and V. E. Torres, Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist, Nature Medicine, vol.9, issue.10, pp.1323-1326, 2003.
DOI : 10.1038/nm935

T. V. Masyuk, A. I. Masyuk, V. E. Torres, P. C. Harris, and N. Larusso, Octreotide Inhibits Hepatic Cystogenesis in a Rodent Model of Polycystic Liver Disease by Reducing Cholangiocyte Adenosine 3???,5???-Cyclic Monophosphate, Gastroenterology, vol.132, issue.3, pp.1104-1116, 2007.
DOI : 10.1053/j.gastro.2006.12.039

S. N. Kip, [Ca2+]i Reduction Increases Cellular Proliferation and Apoptosis in Vascular Smooth Muscle Cells: Relevance to the ADPKD Phenotype, Circulation Research, vol.96, issue.8, pp.873-880, 2005.
DOI : 10.1161/01.RES.0000163278.68142.8a

B. Banizs, Altered pHi regulation and Na+/HCO3- transporter activity in choroid plexus of cilia-defective Tg737orpk mutant mouse, AJP: Cell Physiology, vol.292, issue.4, pp.1409-1416, 2007.
DOI : 10.1152/ajpcell.00408.2006

T. Yamaguchi, cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway11See Editorial by Grande, p. 1770, Kidney International, vol.57, issue.4, pp.1460-1471, 2000.
DOI : 10.1046/j.1523-1755.2000.00991.x

M. Ye and J. J. Grantham, The Secretion of Fluid by Renal Cysts from Patients with Autosomal Dominant Polycystic Kidney Disease, New England Journal of Medicine, vol.329, issue.5, pp.310-313, 1993.
DOI : 10.1056/NEJM199307293290503

V. E. Torres, Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease, Nature Medicine, vol.10, issue.4, pp.363-364, 2004.
DOI : 10.1038/nm1004

V. E. Torres, Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease, New England Journal of Medicine, vol.367, issue.25, pp.2407-2418, 2012.
DOI : 10.1056/NEJMoa1205511

J. J. Grantham, Volume Progression in Polycystic Kidney Disease, New England Journal of Medicine, vol.354, issue.20
DOI : 10.1056/NEJMoa054341

A. Lacquaniti, Apelin and copeptin: Two opposite biomarkers associated with kidney function decline and cyst growth in autosomal dominant polycystic kidney disease, Peptides, vol.49, pp.1-8, 2013.
DOI : 10.1016/j.peptides.2013.08.007

S. Nagao, Increased Water Intake Decreases Progression of Polycystic Kidney Disease in the PCK Rat, Journal of the American Society of Nephrology, vol.17, issue.8, pp.2220-2227, 2006.
DOI : 10.1681/ASN.2006030251

C. L. Kelleher, K. K. Mcfann, A. M. Johnson, and R. W. Schrier, Characteristics of hypertension in young adults with autosomal dominant polycystic kidney disease compared with the general U.S. population, American Journal of Hypertension, vol.17, issue.11, pp.1029-1034, 2004.
DOI : 10.1016/j.amjhyper.2004.06.020

P. A. Gabow, Factors affecting the progression of renal disease in autosomal-dominant polycystic kidney disease, Kidney International, vol.41, issue.5, pp.1311-1319, 1992.
DOI : 10.1038/ki.1992.195

B. Orskov, V. R. Sørensen, B. Feldt-rasmussen, and S. Strandgaard, Changes in causes of death and risk of cancer in Danish patients with autosomal dominant polycystic kidney disease and end-stage renal disease, Nephrology Dialysis Transplantation, vol.27, issue.4
DOI : 10.1093/ndt/gfr467

V. E. Torres, Angiotensin Blockade in Late Autosomal Dominant Polycystic Kidney Disease, New England Journal of Medicine, vol.371, issue.24, pp.2267-2276, 2014.
DOI : 10.1056/NEJMoa1402686

R. W. Schrier, Blood Pressure in Early Autosomal Dominant Polycystic Kidney Disease, New England Journal of Medicine, vol.371, issue.24, pp.2255-2266, 2014.
DOI : 10.1056/NEJMoa1402685

S. Klahr, Dietary protein restriction, blood pressure control, and the progression of polycystic kidney disease. Modification of Diet in Renal Disease Study Group

C. Gall and E. , Type of PKD1 Mutation Influences Renal Outcome in ADPKD, Journal of the American Society of Nephrology, vol.24, issue.6, pp.1006-1013, 2013.
DOI : 10.1681/ASN.2012070650

A. M. Johnson and P. A. Gabow, Identification of patients with autosomal dominant polycystic kidney disease at highest risk for end-stage renal disease, J. Am. Soc. Nephrol

M. V. Irazabal, Extended Follow-Up of Unruptured Intracranial Aneurysms Detected by Presymptomatic Screening in Patients with Autosomal Dominant Polycystic Kidney Disease, Clinical Journal of the American Society of Nephrology, vol.6, issue.6, pp.1274-1285, 2011.
DOI : 10.2215/CJN.09731110

H. W. Xu, S. Q. Yu, C. L. Mei, and M. H. Li, Screening for Intracranial Aneurysm in 355 Patients With Autosomal-Dominant Polycystic Kidney Disease, Stroke, vol.42, issue.1, pp.204-206, 2011.
DOI : 10.1161/STROKEAHA.110.578740

S. Rossetti, Association of mutation position in polycystic kidney disease 1

D. Chauveau, Intracranial aneurysms in autosomal dominant polycystic kidney disease, Kidney International, vol.45, issue.4, pp.1140-1146, 1994.
DOI : 10.1038/ki.1994.151

W. I. Schievink, V. E. Torres, D. G. Piepgras, and D. O. Wiebers, Saccular intracranial aneurysms in autosomal dominant polycystic kidney disease, J. Am. Soc. Nephrol. JASN, vol.3, pp.88-95, 1992.

D. O. Wiebers, Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment, The Lancet, vol.362, issue.9378, pp.103-110, 2003.
DOI : 10.1016/S0140-6736(03)13860-3

M. D. Griffin, V. E. Torres, J. P. Grande, and R. Kumar, Vascular expression of polycystin, J. Am. Soc. Nephrol. JASN, vol.8, pp.616-626, 1997.

O. Ibraghimov-beskrovnaya, Polycystin: In vitro synthesis, in vivo tissue expression, and subcellular localization identifies a large membrane-associated protein, Proceedings of the National Academy of Sciences, vol.94, issue.12
DOI : 10.1073/pnas.94.12.6397

A. Lumiaho, Mitral valve prolapse and mitral regurgitation are common in patients with polycystic kidney disease type 1, American Journal of Kidney Diseases, vol.38, issue.6, pp.1208-1216, 2001.
DOI : 10.1053/ajkd.2001.29216

C. V. Leier, P. B. Baker, J. W. Kilman, and C. Wooley, Cardiovascular Abnormalities Associated with Adult Polycystic Kidney Disease, Annals of Internal Medicine, vol.100, issue.5, pp.683-688, 1984.
DOI : 10.7326/0003-4819-100-5-683

D. Alvaro, Estrogens and the pathophysiology of the biliary tree, World Journal of Gastroenterology, vol.12, issue.22
DOI : 10.3748/wjg.v12.i22.3537

R. Sherstha, Postmenopausal estrogen therapy selectively stimulates hepatic enlargement in women with autosomal dominant polycystic kidney disease

V. E. Torres, Hepatic venous outflow obstruction in autosomal dominant polycystic kidney disease, J. Am. Soc. Nephrol. JASN, vol.5, pp.1186-1192, 1994.

M. H. Vlak, A. Algra, R. Brandenburg, and G. J. Rinkel, Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis, The Lancet Neurology, vol.10, issue.7, pp.626-636, 2011.
DOI : 10.1016/S1474-4422(11)70109-0

M. W. Vernooij, Incidental Findings on Brain MRI in the General Population, New England Journal of Medicine, vol.357, issue.18
DOI : 10.1056/NEJMoa070972

N. F. Kassell, The International Cooperative Studyon the Timing of Aneurysm Surgery, Journal of Neurosurgery, vol.73, issue.1, pp.18-36, 1990.
DOI : 10.3171/jns.1990.73.1.0018

J. Rinne, J. Hernesniemi, M. Puranen, and T. Saari, Multiple Intracranial Aneurysms in a Defined Population, Neurosurgery, vol.35, issue.5, pp.803-808, 1994.
DOI : 10.1227/00006123-199411000-00001

R. D. Brown-jr and J. P. Broderick, Unruptured intracranial aneurysms: epidemiology, natural history, management options, and familial screening, The Lancet Neurology, vol.13, issue.4, pp.393-404, 2014.
DOI : 10.1016/S1474-4422(14)70015-8

B. M. Kissela, Subarachnoid Hemorrhage: A Preventable Disease With a Heritable Component, Stroke, vol.33, issue.5, pp.1321-1326, 2002.
DOI : 10.1161/01.STR.0000014773.57733.3E

S. Hemorrhage and . Group, Risks and benefits of screening for intracranial aneurysms in firstdegree relatives of patients with sporadic subarachnoid hemorrhage, N. Engl. J. Med, vol.341, pp.1344-1350, 1999.

A. Ronkainen, Familial intracranial aneurysms, The Lancet, vol.349, issue.9049, pp.380-384, 1997.
DOI : 10.1016/S0140-6736(97)80009-8

V. S. Alg, R. Sofat, H. Houlden, and D. J. Werring, Genetic risk factors for intracranial aneurysms: A meta-analysis in more than 116,000 individuals, Neurology, vol.80, issue.23, pp.2154-2165, 2013.
DOI : 10.1212/WNL.0b013e318295d751

E. W. Gieteling and G. J. Rinkel, Characteristics of intracranial aneurysms and subarachnoid haemorrhage in patients with polycystic kidney disease, Journal of Neurology, vol.250, issue.4, pp.418-423, 2003.
DOI : 10.1007/s00415-003-0997-0

M. Sonobe, T. Yamazaki, M. Yonekura, and H. Kikuchi, Small Unruptured Intracranial Aneurysm Verification Study: SUAVe Study, Japan, Stroke, vol.41, issue.9, pp.1969-1977, 2010.
DOI : 10.1161/STROKEAHA.110.585059

S. Juvela, M. Porras, and K. Poussa, Natural history of unruptured intracranial aneurysms: probability of and risk factors for aneurysm rupture, Journal of Neurosurgery, vol.108, issue.5, pp.379-387, 2000.
DOI : 10.3171/JNS/2008/108/5/1052

S. Juvela, M. Porras, and K. Poussa, Natural history of unruptured intracranial aneurysms: probability of and risk factors for aneurysm rupture, Journal of Neurosurgery, vol.108, issue.5, pp.1052-1060, 2008.
DOI : 10.3171/JNS/2008/108/5/1052

I. Ucas-japan, The natural course of unruptured cerebral aneurysms in a Japanese cohort, N. Engl. J. Med, vol.366, pp.2474-2482, 2012.

E. J. Lee, Rupture rate for patients with untreated unruptured intracranial aneurysms in South Korea during 2006???2009, Journal of Neurosurgery, vol.117, issue.1, pp.53-59, 2012.
DOI : 10.3171/2012.3.JNS111221

L. H. Phillips, J. P. Whisnant, W. M. O-'fallon, and T. M. Sundt, The unchanging pattern of subarachnoid hemorrhage in a community, Neurology, vol.30, issue.10, pp.1034-1040, 1980.
DOI : 10.1212/WNL.30.10.1034

Y. Pirson, D. Chauveau, and V. Torres, Management of cerebral aneurysms in autosomal dominant polycystic kidney disease, J. Am. Soc. Nephrol. JASN, vol.13, pp.269-276, 2002.

F. Rincon, R. H. Rossenwasser, and A. Dumont, The Epidemiology of Admissions of Nontraumatic Subarachnoid Hemorrhage in the United States, Neurosurgery, vol.73, issue.2, pp.217-222, 2013.
DOI : 10.1227/01.neu.0000430290.93304.33

G. J. Rinkel, Intracranial aneurysm screening: indications and advice for practice, The Lancet Neurology, vol.4, issue.2
DOI : 10.1016/S1474-4422(05)00993-2

R. B. Schwartz, H. M. Tice, S. M. Hooten, L. Hsu, and P. Stieg, Evaluation of cerebral aneurysms with helical CT: correlation with conventional angiography and MR angiography., Radiology, vol.192, issue.3, pp.717-722, 1994.
DOI : 10.1148/radiology.192.3.8058939

T. Grobner, Gadolinium - a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis?, Nephrology Dialysis Transplantation, vol.21, issue.4, pp.1104-1108, 2006.
DOI : 10.1093/ndt/gfk062

P. Marckmann, Nephrogenic Systemic Fibrosis: Suspected Causative Role of Gadodiamide Used for Contrast-Enhanced Magnetic Resonance Imaging, Journal of the American Society of Nephrology, vol.17, issue.9, pp.2359-2362, 2006.
DOI : 10.1681/ASN.2006060601

S. Amet, Incidence of Nephrogenic Systemic Fibrosis in Patients Undergoing Dialysis After Contrast-Enhanced Magnetic Resonance Imaging With Gadolinium-Based Contrast Agents, Investigative Radiology, vol.49, issue.2, pp.109-115, 2014.
DOI : 10.1097/RLI.0000000000000000

URL : https://hal.archives-ouvertes.fr/inserm-01102645

G. F. Gibbs, J. Huston, M. A. Bernstein, S. J. Riederer, and R. D. Brown, 3.0-Tesla MR angiography of intracranial aneurysms: Comparison of time-of-flight and contrast-enhanced techniques, Journal of Magnetic Resonance Imaging, vol.216, issue.2, pp.97-102, 2005.
DOI : 10.1002/jmri.20247

URL : https://hal.archives-ouvertes.fr/hal-00461660

G. F. Gibbs, J. Huston, M. A. Bernstein, S. J. Riederer, and R. D. Brown, Improved image quality of intracranial aneurysms: 3.0-T versus 1.5-T time-of-flight MR angiography

W. Brinjikji, Better Outcomes with Treatment by Coiling Relative to Clipping of Unruptured Intracranial Aneurysms in the United States, 2001-2008, American Journal of Neuroradiology, vol.32, issue.6, pp.1071-1075, 2001.
DOI : 10.3174/ajnr.A2453

A. B. Chapman, Autosomal-dominant polycystic kidney disease
URL : https://hal.archives-ouvertes.fr/hal-01328055

N. Kanaan, O. Devuyst, and Y. Pirson, Renal transplantation in autosomal dominant polycystic kidney disease, Nature Reviews Nephrology, vol.16, issue.8, pp.455-465, 2014.
DOI : 10.1038/nrneph.2014.104

R. D. Perrone, R. Ruthazer, and N. C. Terrin, Survival after end-stage renal disease in autosomal dominant polycystic kidney disease: Contribution of extrarenal complications to mortality, American Journal of Kidney Diseases, vol.38, issue.4, pp.777-784, 2001.
DOI : 10.1053/ajkd.2001.27720

D. J. Yoo, L. Agodoa, C. M. Yuan, K. C. Abbott, and R. Nee, Risk of intracranial hemorrhage associated with autosomal dominant polycystic kidney disease in patients with end stage renal disease, BMC Nephrology, vol.7, issue.10, p.39, 2014.
DOI : 10.1016/j.semnephrol.2010.06.002

. Aucune, car il est inutile de l'inquiéter J'évoque tout de même systématiquement cette complication et la conduite à tenir en cas de signes évocateurs de rupture J'évoque cette complication au cas par cas, en fonction de la demande du patient Pour terminer