M. Mazoyer and L. Roudart, Agriculture -Histoire des agricultures

). S. Thèse-de-biologie, V. Goscinny, and . Hanot, Le glyphosate dans tous ses états Institut Scientifique de Santé Publique Unité Pesticides Disponible sur : http://www.afsca.be/laboratoires/labinfo/_documents/2012-01_labinfo7fr- p12_fr.pdf (consulté le 12 janvier 2012) (7) H. Deram. Glyphosate : comment s'y retrouver parmi toutes les formulations Chambre d'Agriculture Région Nord Pas de Calais. Le déchaumage, une méthode de désherbage, Disponible sur, pp.149-52, 2002.

). Sb and . Powles, Gene amplification delivers glyphosate-resistant weed evolution, pp.955-956, 2010.

). Y. Heinzlé, Pulvérisation en viticulture durable et choix du matériel et réglages Institut Franc? ais de la Vigne et du Vin Disponible sur : http://www.vignevin.com/fileadmin

J. Butault, C. Dedryver, C. Gary, N. Bruneta, L. Guicharda et al., observatoire-pesticides.gouv.fr (consulté le 23 janvier 2015) (17) Écophyto R&D, Quelles voies pour réduire l'usage des pesticides ? INRA, 2010, n°1 L'indicateur de fréquence de traitements (IFT) : un indicateur pour une utilisation durable des pesticides. Courrier de l'environnement de l'INRA, n°56, ) Observatoire des résidus de Pesticides. Les chiffres du marché. Disponible sur, pp.130-133, 2008.

). G. Miquel, Annexe 45 -Données statistiques sur les pesticides Rapport de l'OPECST (25) Direction de l'information légale et administrative, Certiphyto : un certificat obligatoire pour les professionnels utilisant des produits phytopharmaceutiques, pp.128-131, 2003.

. M. Désherber-en-collectivité-)-g, R. Williams, I. C. Kroes, M. R. Munro, J. Sarason et al., fr (consulté le 27 janvier 2015) (28) National Institute of Environmental Health Sciences Toxicology and Carcinogenesis Studies of Glyphosate. Encyclopedia of Toxicology (29) Krieger. Handbook of Pesticide Toxicology Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for Humans, Regulatory Toxicology and Pharmacology, vol.2, issue.3131, pp.551668-117, 1992.

. Sprague-dawley-rats, tissue distribution, identification, and quantitation of glyphosate-derived materials following a single oral dose, Fundamental and Applied Toxicology, vol.17, pp.43-51, 1991.

M. T. Martínez, M. J. Martin, J. L. Nozal, and . Bernal, Toxicokinetics of glyphosate and its metabolite aminomethyl phosphonic acid in rats, 34) M. Watts. Glyphosate Monograph. Pesticide Action Network Asia & the Pacific, pp.91-95, 2009.

H. L. Lee, K. W. Chen, C. H. Chi, J. J. Huang, C. Tsai-miin et al., Review report for the active subtance glyphosate European Commission Clinical Presentations and Prognostic Factors of a Glyphosate Surfactant Herbicide Intoxication. A Review of 131 Cases NTP Technical Report on Toxicity Studies of Glyphosate Administered in Dosed Feed to F344/N Rats and B6C3F1 Mice, 35) Directorate European Food Safety: plant health38) C. Cox. Glyphosate Fact Sheets: Part 1 Toxicology, pp.906-910, 1992.

A. Grinshpun, M. Adhikari, B. Junguo, L. Yanzhen, and . Xiaoyu, Glyphosate-rich air samples induce IL-33, TSLP and generate IL-13 dependent airway inflammation Immunological and histopathological responses of the kidney of common carp (Cyprinus carpio L.) sublethally exposed to glyphosate, Toxicology Environmental Toxicology and Pharmacology, vol.325, issue.1, pp.42-51, 2014.

L. Buckley, X. F. Xin, S. Wang, A. P. Li, J. M. Chou et al., A Inhibitory effects of pesticides on proteasome activity: Implication in Parkinson's disease Parkinsonism after glycine-derivate exposure, 45) W. Gang, X. Ning-Fan, Y. Tan, Q. Cheng, S. Chen. Parkinsonism after chronic occupational exposure to glyphosate, pp.192-200, 2001.

). Y. Gui, X. Fan-ning, H. Wang, W. Gang, and S. Chen, Glyphosate induced cell death through apoptotic and autophagic mechanisms, Neurotoxicology and Teratology, vol.34, issue.3, pp.344-349, 2012.
DOI : 10.1016/j.ntt.2012.03.005

). R. Negga, J. A. Stuart, M. L. Machen, J. Salva, A. Lizek et al., Exposure to glyphosateand/or Mn/Zn-ethylene-bis-dithiocarbamate-containing pesticides leads to degeneration of ?-aminobutyric acid and dopamine neurons in Caenorhabditis elegans, Neurotox Res, vol.281, issue.47, pp.281-290, 2012.

). D. Cattani, V. Cavalli, C. Rieg, J. Domingues, T. Dal-cim et al., Mechanisms underlying the neurotoxicity induced by glyphosate-based herbicide in immature rat hippocampus: Involvement of glutamate excitotoxicity, Toxicology, vol.320, issue.48, pp.34-45, 2014.
DOI : 10.1016/j.tox.2014.03.001

L. Lima, F. Silva, A. Ritter, J. Bedin, and . Finco, Chronic exposure to the herbicide rather than a concentration sublethal glyphosate Environ, Toxicol. Pharmacol, vol.58, pp.308-313, 2008.

). T. Webster, L. Laing, H. Florance, and E. M. Santos, ), Environmental Science & Technology, vol.48, issue.2, pp.1271-1279, 2014.
DOI : 10.1021/es404258h

. Bertheussen, The toxic effects of carbofuran and glyphosate on semen characteristics in rabbits, J. Environ. Sci. Health, vol.30, issue.52, pp.513-534, 1995.

S. Rosaa, S. Richard, H. Moslemi, N. Sipahutar, G. Benachour et al., Organisation Mondiale de la Santé. Glyphosate. Critères d'hygiène de l'environnement Differential effects of glyphosate and Roundup on human placental cells and aromatase, Aquatic Toxicology Environmental Health Perspectives, vol.155, issue.13 655, pp.322-326, 1994.

). J. Marc, O. Mulner-lorillon, and R. Bell, Glyphosate-based pesticides affect cell cycle regulation, Biology of the Cell, vol.96, issue.3, pp.245-249, 2004.
DOI : 10.1016/j.biolcel.2003.11.010

G. Satayavivad, R. Williams, C. Kroes, and . Munro, Glyphosate induces human breast cancer cells growth via estrogen receptors Safety Evaluation and Risk Assessment of the Herbicide Roundup and Its Active Ingredient, Glyphosate, for Humans, Food and Chemical Toxicology Regulatory Toxicology and Pharmacology, vol.59, issue.31, pp.129-136, 2000.

). C. Heu, C. Elie-caille, V. Mougey, S. Launay, and L. Nicod, A step further toward glyphosate-induced epidermal cell death: Involvement of mitochondrial and oxidative mechanisms, Environmental Toxicology and Pharmacology, vol.34, issue.2, pp.144-153, 2012.
DOI : 10.1016/j.etap.2012.02.010

URL : https://hal.archives-ouvertes.fr/inserm-00723065

). A. Mottier and J. Pini, Effects of a POEA surfactant system (Genamin T-200^|^reg;) on two life stages of the Pacific oyster, Crassostrea gigas, The Journal of Toxicological Sciences, vol.39, issue.2, pp.211-215, 2014.
DOI : 10.2131/jts.39.211

). R. Mesnage, B. Bernay, and G. Séralini, Ethoxylated adjuvants of glyphosate-based herbicides are active principles of human cell toxicity, Disponible sur, pp.122-128, 2013.
DOI : 10.1016/j.tox.2012.09.006

). R. Corbaz and J. Maherou, Principes de Phytopathologie et de lutte contre les maladies des plantes Les pesticdes : quelles conséquences pour la santé ? Disponibles sur : http://www.asef-asso.fr/mon-jardin/nos-syntheses/2124-l- usage-de-pesticides-quelles-consequences-pour-la-sante, Presse polytechniques et universitaires romandes, pp.47-65, 1990.

C. Guha, H. Scoccianti, K. Mattock, and . Straif, Carcinogenicity of tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate. The Lancet Oncology (67) European Food Safety Autority, EFSA explains the carcinogeniity assessment of glyphosate, Disponible, vol.16, pp.490-491, 2015.

). H. Maibach, Roundup formulation. Elimination and dermal penetration in monkeys, p.81, 1983.