F. Taglioni, Mayotte s'ancre dans la république française. Un contre-sens de l'histoire? EchoGeo, sur le vif, 2009.

H. Berabrd and A. Kartoibi, Guide d'aide à l'action en éducation pour la santé Agir auprès des publics mahorais

J. Gouvart and . Commandant-de-la-gendarmerie-de-mayotte, Étude sur les infractions à la législation sur les produits stupéfiants à Mayotte, GEND/COMGENDYT/CDT. 2016 février, vol.4, issue.2

A. Daveluy and F. Haramburu, Rapport de mission à la Réunion et à Mayotte

S. Florence, J. Lebas, and S. Lesieur, Migration, santé et recours aux soins à Mayotte en 2007 : enseignements d'une enquête représentative en population générale. Revue d'Epidémiologie et de Santé Publique, pp.237-281, 2010.

O. Sudrie and A. , Quel niveau de développement des départements et collectivités d'outre-mer? Une approche par l'indice de développement humain. Mis à jour en fév 2013. [internet] disponible sur : http://www.afd.fr/jahia/webdav/site

M. Brasset, L. Pabic, and L. , Enquête Budget de famille à Mayotte Entre faiblesse des revenus et hausse de la consommation

M. Martinez and E. Lahaie, Nouveaux produits de synthèse. OFDT, Drogues et addictions, données essentielles, pp.266-272, 2013.

D. M. Wood, S. Davies, and M. Puchnarewicz, Recreational Use of Mephedrone (4-Methylmethcathinone, 4-MMC) with Associated Sympathomimetic Toxicity, Journal of Medical Toxicology, vol.4, issue.3, 2010.
DOI : 10.1007/s13181-010-0018-5

T. Néfau and M. Martinez, Nouveaux produits de synthèse identifiés depuis Note d'information SINTES. OFDT. Actualisé le 1 er juin 2015. [internet] disponible sur http, 2000.

E. Lahaie, M. Martinez, and A. Cadet-taïrou, Nouveaux produits de synthèse et Internet, Tendances, vol.84, 2013.

A. Cadet-taïrou and M. Gandilhon, Marchés, substances, usagers : les tendances récentes, Tendances, vol.86, 2011.

O. Roussel, The emergence of synthetic cannabinoids in Mayotte, Toxicologie Analytique et Clinique, vol.27, issue.1, pp.18-22, 2015.
DOI : 10.1016/j.toxac.2014.12.002

O. Roussel, L. Tensorer, X. Bouvot, C. Balter, and S. Sabini, Le point sur les saisies de nouvelles drogues de synth??se, Toxicologie Analytique et Clinique, vol.27, issue.2, p.23, 2015.
DOI : 10.1016/j.toxac.2015.03.023

M. Gandilhon, A. Cadet-taïrou, E. Lahaie, and M. Chalumeau, Drogues illicites : les observations du dispositif TREND en, Tendances, vol.73, 2009.

S. Fournier and S. Escots, Homosexualité masculine et usages de substances psychoactives en contextes festifs gais. OFDT, 2010.

S. Spilka, L. Nézet, O. Ngantcha, and M. , Les drogues à 17 ans : Analyse de l'enquête ESCAPAD 2014, Tendances, vol.100, 2015.

E. W. Gunderson, H. M. Haughey, and N. Ait-daoud, ???Spice??? and ???K2??? Herbal Highs: A Case Series and Systematic Review of the Clinical Effects and Biopsychosocial Implications of Synthetic Cannabinoid Use in Humans, The American Journal on Addictions, vol.22, issue.4, pp.320-326, 2012.
DOI : 10.1111/j.1521-0391.2012.00240.x

D. Fisher, Revolutionary' legal high law means state regulated drug market. The New Zeland Herald. 2012 jul 28

A. Cadet-taïrou, Profils et pratiques des usagers de Nouveaux produits de synthèse. Tendances, p.8, 2016.

M. Johnson and L. Melvin, The discovery of non-classical cannabinoid analgesics, Cannabinoids as Therapeutic Agents, pp.121-145, 1986.

J. Huffman and D. Dong, Design, Synthesis and Pharmacology of Cannabimimetic Indoles, Bioorganic & Medicinal Chemistry Letters, vol.4, issue.4, pp.563-566, 1994.
DOI : 10.1016/S0960-894X(01)80155-4

V. Auwärter, S. Dresen, and W. Weinmann, ???Spice??? and other herbal blends: harmless incense or cannabinoid designer drugs?, Journal of Mass Spectrometry, vol.5, issue.5, pp.832-837, 2009.
DOI : 10.1002/jms.1558

N. Uchiyama, R. Kikura-hanajiri, and J. Ogata, Chemical analysis of synthetic cannabinoids as designer drugs in herbal products, Forensic Science International, vol.198, issue.1-3, pp.1-331, 2010.
DOI : 10.1016/j.forsciint.2010.01.004

S. More and D. Choi, Promising cannabinoid-based therapies for Parkinson???s disease: motor symptoms to neuroprotection, Molecular Neurodegeneration, vol.160, issue.1074, p.17, 2015.
DOI : 10.1186/s13024-015-0012-0

R. Picone and D. Kendall, Minireview: From the Bench, Toward the Clinic: Therapeutic Opportunities for Cannabinoid Receptor Modulation, Molecular Endocrinology, vol.29, issue.6, pp.801-813, 2015.
DOI : 10.1210/me.2015-1062

A. Wohlfarth, K. Scheidweiler, and M. Castaneto, Abstract, Clinical Chemistry and Laboratory Medicine (CCLM), vol.53, issue.3, pp.423-434, 2015.
DOI : 10.1515/cclm-2014-0612

J. Palamar and P. Acosta, Synthetic cannabinoid use in a nationally representative sample of US high school seniors, Drug and Alcohol Dependence, vol.149, pp.194-202, 2015.
DOI : 10.1016/j.drugalcdep.2015.01.044

B. Kelly, B. Wells, and M. Pawson, Novel psychoactive drug use among younger adults involved in US nightlife scenes, Drug and Alcohol Review, vol.38, issue.Suppl 1, pp.588-593, 2013.
DOI : 10.1111/dar.12058

X. Hu, B. Primack, and T. Barnett, College students and use of K2: an emerging drug of abuse in young persons, Substance Abuse Treatment, Prevention, and Policy, vol.6, issue.1, p.16, 2011.
DOI : 10.1007/BF00991936

K. Egan, C. Suerken, and B. Reboussin, K2 and Spice use among a cohort of college students in southeast region of the USA, The American Journal of Drug and Alcohol Abuse, vol.60, issue.4, pp.317-322, 2015.
DOI : 10.1016/j.drugalcdep.2011.01.018

N. Jaenicke, W. Pogoda, and A. Paulke, Retrospective analysis of synthetic cannabinoids in serum samples ??? epidemiology and consumption patterns, Forensic Science International, vol.242, pp.81-87, 2014.
DOI : 10.1016/j.forsciint.2014.06.010

F. Beck, J. Richard, and R. Guignard, Les niveaux d'usage des drogues en France en 2014, exploitation des données du Baromètre santé 2014, OFDT-INPES Tendances, vol.99, 2015.

D. Debruyne, L. Boisselier, and R. , Emerging drugs of abuse: current perspectives on synthetic cannabinoids, Substance Abuse and Rehabilitation, vol.6, pp.113-129, 2015.
DOI : 10.2147/SAR.S73586

R. Pertwee, -tetrahydrocannabivarin, British Journal of Pharmacology, vol.22, issue.2, pp.199-215, 2008.
DOI : 10.1038/sj.bjp.0707442

P. Pacher, S. Batkai, and G. Kunos, The Endocannabinoid System as an Emerging Target of Pharmacotherapy, Pharmacological Reviews, vol.58, issue.3, pp.389-462, 2006.
DOI : 10.1124/pr.58.3.2

X. Sun and S. Dey, Synthetic cannabinoids and potential reproductive consequences, Life Sciences, vol.97, issue.1, pp.72-77, 2014.
DOI : 10.1016/j.lfs.2013.06.018

H. Cha, K. Lee, and M. Song, Dependence Potential of the Synthetic Cannabinoids JWH-073, JWH-081, and JWH-210: In Vivo and In Vitro Approaches, Biomolecules & Therapeutics, vol.22, issue.4, pp.363-369, 2014.
DOI : 10.4062/biomolther.2014.039

M. Gatch and M. Forster, ??9-Tetrahydrocannabinol-like discriminative stimulus effects of compounds commonly found in K2/Spice, Behavioural Pharmacology, vol.25, issue.8, pp.750-757, 2014.
DOI : 10.1097/FBP.0000000000000093

J. Lapoint, L. James, and C. Moran, Severe Toxicity Following Synthetic Cannabinoid Ingestion, Clinical Toxicology, vol.1, issue.8, pp.760-764, 2011.
DOI : 10.1021/ac201377m

A. Obafemi, K. Kleinschmidt, and C. Goto, Cluster of Acute Toxicity from Ingestion of Synthetic Cannabinoid-Laced Brownies, Journal of Medical Toxicology, vol.35, issue.11, 2015.
DOI : 10.1007/s13181-015-0482-z

R. Marshell, T. Kearney-ramos, and L. Brents, In vivo effects of synthetic cannabinoids JWH-018 and JWH-073 and phytocannabinoid ??9-THC in mice: Inhalation versus intraperitoneal injection, Blulight [forum on the Internet]. Other drugs Forum. Available from, pp.40-47, 2014.
DOI : 10.1016/j.pbb.2014.05.010

V. Auwärter, S. Dresen, and W. Weinmann, ???Spice??? and other herbal blends: harmless incense or cannabinoid designer drugs?, Journal of Mass Spectrometry, vol.5, issue.5, pp.832-837, 2009.
DOI : 10.1002/jms.1558

A. Winstock and M. Barratt, Synthetic cannabis: A comparison of patterns of use and effect profile with natural cannabis in a large global sample, Drug and Alcohol Dependence, vol.131, issue.1-2, pp.1-2106, 2013.
DOI : 10.1016/j.drugalcdep.2012.12.011

R. Tait, D. Caldicott, and D. Mountain, A systematic review of adverse events arising from the use of synthetic cannabinoids and their associated treatment, Clinical Toxicology, vol.22, issue.06, pp.1-13, 2016.
DOI : 10.1016/j.ajem.2011.05.013

M. Forrester, K. Kleinschmidt, and E. Schwarz, Synthetic Cannabinoid Exposures Reported to Texas Poison Centers, Journal of Addictive Diseases, vol.48, issue.4, pp.351-358, 2011.
DOI : 10.3109/15563651003796366

M. Forrester, Adolescent Synthetic Cannabinoid Exposures Reported to Texas Poison Centers, Pediatric Emergency Care, vol.28, issue.10, pp.985-989, 2012.
DOI : 10.1097/PEC.0b013e31826c9a97

A. De-havenon, B. Chin, and K. Thomas, The Secret ???Spice???: An Undetectable Toxic Cause of Seizure, The Neurohospitalist, vol.191, issue.1, pp.182-186, 2011.
DOI : 10.1016/j.beem.2008.10.013

C. Hoyte, J. Jacob, A. Monte, M. Al-jumaan, A. Bronstein et al., A Characterization of Synthetic Cannabinoid Exposures Reported to the National Poison Data System in 2010, Annals of Emergency Medicine, vol.60, issue.4, pp.435-438, 2012.
DOI : 10.1016/j.annemergmed.2012.03.007

A. Winstock, M. Lynskey, and R. Borschmann, Risk of emergency medical treatment following consumption of cannabis or synthetic cannabinoids in a large global sample, Journal of Psychopharmacology, vol.22, issue.6, pp.698-703, 2015.
DOI : 10.1111/j.1464-410X.2012.11028.x

T. Brewer and M. Collins, A review of clinical manifestations in adolescent and young adults after use of synthetic cannabinoids, Journal for Specialists in Pediatric Nursing, vol.106, issue.6, pp.119-126, 2014.
DOI : 10.1111/jspn.12057

A. Celofiga, J. Koprivsek, and J. Klavz, Use of Synthetic Cannabinoids in Patients With Psychotic Disorders: Case Series, Journal of Dual Diagnosis, vol.80, issue.1, pp.168-173, 2014.
DOI : 10.1016/j.toxlet.2010.06.00

J. Van-amsterdam, T. Brunt, and W. Van-den-brink, The adverse health effects of synthetic cannabinoids with emphasis on psychosis-like effects, Journal of Psychopharmacology, vol.106, issue.3, pp.254-263, 2015.
DOI : 10.1007/s00216-011-4743-7

S. Alhadi, A. Tiwari, and R. Vohra, High Times, Low Sats: Diffuse Pulmonary Infiltrates Associated with Chronic Synthetic Cannabinoid Use, Journal of Medical Toxicology, vol.186, issue.4, pp.199-206, 2013.
DOI : 10.1007/s13181-013-0288-9

S. Ibrahim, F. Saffar, and T. Wannenburg, A unique case of cardiac arrest following K2 abuse. Case report Cardiologia, p.120607, 2014.

M. Takematsu, R. Hoffman, and L. Nelson, A case of acute cerebral ischemia following inhalation of a synthetic cannabinoid, Clinical Toxicology, vol.62, issue.9, pp.973-975
DOI : 10.3109/10826080903443628

D. Fergusson, L. Horwood, and K. Northstone, Maternal use of cannabis and pregnancy outcome, BJOG: An International Journal of Obstetrics and Gynaecology, vol.2, issue.1, pp.21-27, 2002.
DOI : 10.1046/j.1360-0443.1997.9211155315.x

Z. Fisar, Inhibition of monoamine oxidase activity by cannabinoids, Naunyn-Schmiedeberg's Archives of Pharmacology, vol.7, issue.Suppl 1, pp.563-572, 2010.
DOI : 10.1007/s00210-010-0517-6

T. Irie, R. Kikura-hanajiri, and M. Usami, MAM-2201, a synthetic cannabinoid drug of abuse, suppresses the synaptic input to cerebellar Purkinje cells via activation of presynaptic CB1 receptors, Neuropharmacology, vol.95, pp.479-491, 2015.
DOI : 10.1016/j.neuropharm.2015.02.025

V. Macfarlane and G. Christie, Synthetic cannabinoid withdrawal: A new demand on detoxification services, Drug and Alcohol Review, vol.376, issue.2, pp.147-153, 2015.
DOI : 10.1111/dar.12225

N. Nacca, D. Vatti, and R. Sullivan, The Synthetic Cannabinoid Withdrawal Syndrome, Journal of Addiction Medicine, vol.7, issue.4, pp.296-298, 2013.
DOI : 10.1097/ADM.0b013e31828e1881

A. Rominger, P. Cumming, and G. Xiong, Effects of acute detoxification of the herbal blend ???Spice Gold??? on dopamine D2/3 receptor availability: A [18F]fallypride PET study, European Neuropsychopharmacology, vol.23, issue.11, pp.1606-1610, 2013.
DOI : 10.1016/j.euroneuro.2013.01.009

M. Weaver, J. Hopper, and E. Gunderson, Designer drugs 2015: assessment and management, Addiction Science & Clinical Practice, vol.10, issue.1, p.8, 2015.
DOI : 10.1081/JA-200066968

T. Health, Z. Burroughs, and A. Thompson, Acute intoxication caused by a synthetic cannabinoid in two adolescents, J Pediatr Pharmacol Ther, vol.17, issue.2, pp.177-181, 2012.

C. Hoyte, J. Jacob, and A. Monte, A Characterization of Synthetic Cannabinoid Exposures Reported to the National Poison Data System in 2010, Annals of Emergency Medicine, vol.60, issue.4, pp.435-438, 2012.
DOI : 10.1016/j.annemergmed.2012.03.007

C. Harris and A. Brown, Synthetic Cannabinoid Intoxication: A Case Series and Review, The Journal of Emergency Medicine, vol.44, issue.2, pp.360-366, 2013.
DOI : 10.1016/j.jemermed.2012.07.061

C. Rodgman, C. Verrico, and R. Worthy, Inpatient Detoxification From a Synthetic Cannabinoid and Control of Postdetoxification Cravings With Naltrexone, The Primary Care Companion For CNS Disorders, vol.16, issue.4, 2014.
DOI : 10.4088/PCC.13l01594

P. Robledo, F. Berrendero, and A. Ozaita, Advances in the field of cannabinoid-opioid cross-talk, Addiction Biology, vol.21, issue.2, pp.213-224, 2008.
DOI : 10.1111/j.1369-1600.2008.00107.x

L. King, Legal controls on cannabimimetics: an international dilemma? Drug Test Anal, pp.80-87, 2014.

S. Boscher and . Un-nouveau-trafic-ouvert-À-mayotte, de la drogue de synthèse suspectée d'être la cause des violences

J. Tyndall, R. Gerona, D. Portu, and G. , An outbreak of acute delirium from exposure to the synthetic cannabinoid AB-CHMINACA. Clinical Toxicology, pp.950-956, 2015.

. Forum-de and . Psychoactif, org, l'espace solidaire entre les consommateurs de substances psychoactives. [internet] disponible sur https://www.psychoactif.org/forum/t12645- p1-Mise-Garde-AB-CHMINACA.html et https

J. Bourgois, Tephrosia vogelii, une plante ichtyotoxique utilisée pour la pêche aux Comores, pp.81-86, 1989.

H. Neuwinger, Plants used for poison fishing in tropical Africa, Toxicon, vol.44, issue.4, pp.417-430, 2004.
DOI : 10.1016/j.toxicon.2004.05.014

K. Melo, R. Oliveira, and C. Grisolia, Short-term exposure to low doses of rotenone induces developmental, biochemical, behavioral, and histological changes in fish, Environmental Science and Pollution Research, vol.31, issue.1, pp.13926-13964, 2015.
DOI : 10.1007/s11356-015-4596-2

R. Betarbet, T. Sherer, and G. Mackenzie, Chronic systemic pesticide exposure reproduces features of Parkinson's disease, Nat Neurosci, vol.3, issue.12, pp.1301-1307, 2000.

. La-drogue-de-synthèse-envahit-les-collèges-de-mayotte, ImazPressReunion. 2014 février 3. [internet] disponible sur : http://www.ipreunion.com/photo-du-jour/reportage, 2014.

R. Week-end-de-noël, trois ans de prison pour une scène d'hyper-violence à Labattoir Le Journal de Mayotte. 2016 janvier 3. [internet] disponible sur : http://lejournaldemayotte.com/une/week-end-de-noel-trois-ans-de-prison-pour-une-scene- dhyper-violence-a-labattoir

O. Loyens, P. Bellusci, G. Dg, and B. , Les Ravages de la chimique. Peur sur l'île. Mayotte Hebdo, pp.10-19, 2015.

A. Zouberi and H. , Affaire Kassim : une mort et une grosse polémique. Habarizacomores. 2015 septembre. [internet] disponible sur

. Trafic, Black Mamba, une nouvelle drogue qui inquiète. Scope. 2013 mai 1er. [internet] disponible sur

. Drogues, Travailleurs sociaux « le profil du consommateur a changé ! ». Le Mauricien. 2013 juin 29. [internet] disponible sur

M. Fridell and M. Nilson, La comorbidité : consommation de drogues et troubles psychiatriques Objectif drogues Briefing de l'Observatoire européen des drogues et des toxicomanies

C. Depecker, Le rôle des influences sociales sur la consommation de cannabis.Stop-cannabis.ch. 2012 octobre. [internet] disponible sur

M. Hermanns-clausen, S. Kneisel, and B. Szabo, Acute toxicity due to the confirmed consumption of synthetic cannabinoids: clinical and laboratory findings, Addiction, vol.4, issue.3, pp.534-544, 2013.
DOI : 10.1111/j.1360-0443.2012.04078.x

A. Zhao and M. Tan, Aung Maung Rhabdomyolysis and Acute Kidney Injury Requiring Dialysis as a Result of Concomitant Use of Atypical Neuroleptics and Synthetic Cannabinoids, Case Rep Nephrol, vol.2015, p.235982, 2015.

R. Mckeever, D. Vearrier, and D. Jacobs, K2???Not the Spice of Life; Synthetic Cannabinoids and ST Elevation Myocardial Infarction: A Case Report, Journal of Medical Toxicology, vol.40, issue.11, pp.129-160
DOI : 10.1007/s13181-014-0424-1

A. Mir, A. Obafemi, and A. Young, Myocardial Infarction Associated With Use of the Synthetic Cannabinoid K2, PEDIATRICS, vol.128, issue.6, pp.1622-1627, 2011.
DOI : 10.1542/peds.2010-3823

S. Ibrahim, F. Saffar, and T. Wannenburg, A unique case of cardiac arrest following K2 abuse. Case report Cardiologia, p.120607, 2014.

D. Gorelick, K. Levin, and M. Copersino, Diagnostic Criteria for Cannabis Withdrawal Syndrome. Drug Alcohol Depend, pp.141-148, 2012.

N. Desjardins and C. Stheneur, Syndrome d'hyperémèse cannabique : revue de la littérature. Arch Pediatr, 2016.

C. Sampson, S. Bedy, and T. Carlisle, Withdrawal Seizures Seen In the Setting of Synthetic Cannabinoid Abuse, The American Journal of Emergency Medicine, vol.33, issue.11, p.1712, 2015.
DOI : 10.1016/j.ajem.2015.03.025

Z. Cooper, Adverse Effects of Synthetic Cannabinoids: Management of Acute Toxicity and Withdrawal. Curr Psychiatry Rep, p.52, 2016.

R. Vandrey, K. Dunn, and J. Fry, A survey study to characterize use of Spice products (synthetic cannabinoids), Drug and Alcohol Dependence, vol.120, issue.1-3, pp.238-241, 2012.
DOI : 10.1016/j.drugalcdep.2011.07.011

M. Castaneto, D. Gorelick, and N. Desrosiers, Synthetic cannabinoids: Epidemiology, pharmacodynamics, and clinical implications, Drug and Alcohol Dependence, vol.144, pp.12-41, 2014.
DOI : 10.1016/j.drugalcdep.2014.08.005