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Master Thesis

Évaluation du pronostic des nouveau-nés traités par hypothermie thérapeutique

Abstract : The consecutive hypoxic-ischemic encephalopathy causes asphyxia perinatal and present devastating consequences of neo natal death or Cerebral Palsy. Before 2000 the common treatment of new born with hypoxic-ischemic encephalopathy was poor and was essentially based upon homeostasy maintaining body liquid, electrolytic, respiratory functions and treating convulsion. Today hypothermia therapy is the only neuro protecting treatment efficient to treat hypoxic-ischemic encephalopathy. It is now a common therapy to treat new born babies with moderate to severe hypoxic-ischemic encephalopathy. However a considerable percentage of babies are not receptive to this treatment. The answer to the research question which was to identify the different evolution of the new born who received hypothermia therapy could determine the short term unfavourable prognostic. This descriptive and comparative study was carried out on 49 new born babies who received hypothermia therapy treatment between January 2012 and December 2015 at Hôpital Nord de l’AP-HM. The data base of records was made retrospectively using records from the hospital recording forms used during patient hospitalisation. The common result found was abnormal neurological exam with state of coma and abnormal spontaneous motor skills. These were variably poor prognostic. This examination is subjective and difficult to evaluate and it is essential to add para clinic expertise to determine the prognostic and treatment of these new born babies. We can also confirm the benefit of electro physiology prognostic echo magnetic imagery which is a recent imagery technic allowing to study cerebral metabolism Abnormal EEG, IRM and SRM are three variables of evolution determining in the unfavourable prognostic in the short term.
Document type :
Master Thesis
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Contributor : École Universitaire de Maïeutique Marseille Méditerranée (eu3m) <>
Submitted on : Tuesday, January 3, 2017 - 11:22:22 AM
Last modification on : Monday, July 6, 2020 - 4:04:37 PM
Long-term archiving on: : Tuesday, April 4, 2017 - 12:04:52 PM


  • HAL Id : dumas-01370876, version 1


Audrey Begou. Évaluation du pronostic des nouveau-nés traités par hypothermie thérapeutique. Pédiatrie. 2016. ⟨dumas-01370876⟩



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