C. P. Simopoulos-«the-rodriguez-leyva, R. Bassett, G. N. Pierce, B. D. Mccullough, B. Oomah et al., «The cardiovascular effects of flaxseed and its omega-3 fatty acid, alpha-linolenic acid «Variation in the Composition of Water-Soluble Polysaccharides in Flaxseed, Biomedicine & Pharmacotherapy» Canadian Journal of Cardiology» Journal of Agriculture and Food Chemistry Chromatographia, vol.56, issue.58, pp.365-379, 1995.

J. Attoumbré, C. Hano, F. Mesnard, F. Lamblin, L. Bensaddek et al., Identification by NMR and accumulation of a neolignan, the dehydrodiconiferyl alcohol-4-??-d-glucoside, in Linum usitatissimum cell cultures, Comptes Rendus Chimie, vol.9, issue.3-4, pp.420-425, 2006.
DOI : 10.1016/j.crci.2005.06.012

U. Bayindir, A. Alfermann, and E. Fuss, Hinokinin biosynthesis in Linum corymbulosum Reichenb, Planta Medica, vol.74, issue.09, pp.810-830, 2008.
DOI : 10.1055/s-0028-1084838

V. Beejmohun, O. Fliniaux, C. Hano, S. Pilard, E. Grand et al., Coniferin dimerisation in lignan biosynthesis in flax cells, Phytochemistry, vol.68, issue.22-24, pp.2744-52, 2007.
DOI : 10.1016/j.phytochem.2007.09.016

C. Corbin, C. Renouard, C. Lopez, C. Lamblin, E. Lainé et al., Identification and characterization of cis-acting elements involved in the regulation of ABA- and/or GA-mediated LuPLR1 gene expression and lignan biosynthesis in flax (Linum usitatissimum L.) cell cultures, Journal of Plant Physiology, vol.170, issue.5, pp.516-538, 2013.
DOI : 10.1016/j.jplph.2012.11.003

J. Doyle and J. Doyle, Isolation of plant DNA from fresh tissue, BRL Focus, vol.12, pp.13-18, 1990.

E. Babahadi, S. Sharifia, M. Behmaneshb, M. Safaiec, N. Muratad et al., Time-course changes in fungal elicitor-induced lignan synthesis and expression of the relevant genes in cell cultures of Linum album, Journal of Plant Physiology, vol.169, issue.5, pp.487-91, 2012.
DOI : 10.1016/j.jplph.2011.12.006

S. Fenart, Y. Ndong, J. Duarte, N. Rivière, W. J. Van-wuytswinkel et al., Development and validation of a flax (Linum usitatissimum L.) gene expression oligo microarray, BMC Genomics, vol.11, issue.1, pp.592-605, 2010.
DOI : 10.1186/1471-2164-11-592

URL : https://hal.archives-ouvertes.fr/hal-00535989

J. Ford, K. Huang, H. Wang, and N. Lewis, ) Seed., Journal of Natural Products, vol.65, issue.5, pp.1388-97, 2001.
DOI : 10.1021/np020006x

C. Hano, I. Martin, O. Fliniaux, B. Legrand, L. Gutierrez et al., Pinoresinol???lariciresinol reductase gene expression and secoisolariciresinol diglucoside accumulation in developing flax (Linum usitatissimum) seeds, Planta, vol.7, issue.6, pp.1291-301, 2006.
DOI : 10.1007/s00425-006-0308-y

C. Hano, M. Addi, L. Bensaddek, D. Crônier, S. Baltora-rosset et al., Differential accumulation of monolignol-derived compounds in elicited flax (Linum usitatissimum) cell suspension cultures, Planta, vol.209, issue.5, pp.975-89, 2006.
DOI : 10.1007/s00425-005-0156-1

J. Harmatha and L. Dinan, Biological activities of lignans and stilbenoids associated with plant-insect chemical interactions, Phytochemistry Reviews, vol.56, issue.2, pp.321-351, 2003.
DOI : 10.1023/B:PHYT.0000045494.98645.a3

J. Harmatha and J. Nawrot, Insect feeding deterrent activity of lignans and related phenylpropanoids with a methylenedioxyphenyl (piperonyl) structure moiety, Entomologia Experimentalis et Applicata, vol.104, issue.1, pp.51-60, 2002.
DOI : 10.1046/j.1570-7458.2002.00990.x

C. Helliwell and P. Waterhouse, Constructs and methods for high-throughput gene silencing in plants, Methods, vol.30, issue.4, pp.289-95, 2003.
DOI : 10.1016/S1046-2023(03)00036-7

S. Hemmati, T. Schmidt, and E. Fuss, Himmelszelt involved in the biosynthesis of justicidin B, FEBS Letters, vol.13, issue.4, pp.603-613, 2007.
DOI : 10.1016/j.febslet.2007.01.018

S. Hemmati, V. Heimendahl, C. Klaes, M. Alfermann, A. Schmidt et al., L., Planta Medica, vol.76, issue.09, pp.928-962, 2010.
DOI : 10.1055/s-0030-1250036

URL : https://hal.archives-ouvertes.fr/pastel-00005609

A. Kamal-eldin, N. Peerlkamp, P. Johnsson, R. Andersson, R. Andersson et al., An oligomer from flaxseed composed of secoisolariciresinoldiglucoside and 3-hydroxy-3-methyl glutaric acid residues, Phytochemistry, vol.58, issue.4, pp.587-90, 2001.
DOI : 10.1016/S0031-9422(01)00279-5

H. Kim, E. Ono, K. Morimoto, T. Yamagaki, A. Okazawa et al., Metabolic Engineering of Lignan Biosynthesis in Forsythia Cell Culture, Plant and Cell Physiology, vol.50, issue.12, pp.2200-2209, 2009.
DOI : 10.1093/pcp/pcp156

D. Kitts, Y. Yaun, A. Wijewickreme, and L. Thompson, Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone, Molecular and Cellular Biochemistry, vol.202, issue.1/2, pp.91-100, 1999.
DOI : 10.1023/A:1007022329660

J. Lacoux, D. Klein, J. Domon, H. Dauchel, F. Lamblin et al., Study of a pectin methylesterase using transgenesis with antisens construct and promoter?reporter fusion, Pectins and pectinases, pp.183-200, 2003.

E. Lainé, C. Hano, L. Lignans, S. Knasmüller, D. Demarini et al., Chemoprevention of cancer and DNA damage by dietary factors, pp.555-68, 2009.

K. Mcginnis, RNAi for functional genomics in plants, Briefings in Functional Genomics, vol.9, issue.2, pp.111-118, 2010.
DOI : 10.1093/bfgp/elp052

L. Mlynarova, M. Bauer, J. Nap, and A. Pretova, High efficiency Agrobacterium-mediated gene transfer to flax, Plant Cell Reports, vol.11, issue.5, pp.282-287, 1994.
DOI : 10.1007/BF00233320

M. Roach, N. Mokshina, A. Badhan, A. Snegireva, N. Hobson et al., Development of Cellulosic Secondary Walls in Flax Fibers Requires ??-Galactosidase, PLANT PHYSIOLOGY, vol.156, issue.3, pp.1351-63, 2011.
DOI : 10.1104/pp.111.172676

G. Morel and R. Wetmore, Fern Callus Tissue Culture, American Journal of Botany, vol.38, issue.2, pp.141-144, 1951.
DOI : 10.2307/2437837

T. Murashige and F. Skoog, A Revised Medium for Rapid Growth and Bio Assays with Tobacco Tissue Cultures, Physiologia Plantarum, vol.7, issue.3, pp.473-97, 1962.
DOI : 10.1146/annurev.pp.02.060151.001311

S. Renouard, C. Hano, C. Corbin, O. Fliniaux, T. Lopez et al., Cellulase-assisted release of secoisolariciresinol from extracts of flax (Linum usitatissimum) hulls and whole seeds, Food Chemistry, vol.122, issue.3, pp.679-87, 2010.
DOI : 10.1016/j.foodchem.2010.03.036

S. Renouard, C. Corbin, T. Lopez, J. Montquillon, L. Gutierrez et al., Abscisic acid regulates pinoresinol???lariciresinol reductase gene expression and secoisolariciresinol accumulation in developing flax (Linum usitatissimum L.) seeds, Planta, vol.231, issue.1, pp.85-98, 2012.
DOI : 10.1007/s00425-011-1492-y

I. Rieu and S. Powers, Real-Time Quantitative RT-PCR: Design, Calculations, and Statistics, THE PLANT CELL ONLINE, vol.21, issue.4, pp.1031-1034, 2009.
DOI : 10.1105/tpc.109.066001

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685626

F. Schroeder, M. Del-campo, J. Grant, D. Weibel, S. Smedley et al., Pinoresinol: A lignol of plant origin serving for defense in a caterpillar, Proceedings of the National Academy of Sciences, vol.103, issue.42, pp.15497-501, 2006.
DOI : 10.1073/pnas.0605921103

K. Struijs, J. Vincken, R. Verhoef, W. Van-oostveen-van-casteren, A. Voragen et al., The flavonoid herbacetin diglucoside as a constituent of the lignan macromolecule from flaxseed hulls, Phytochemistry, vol.68, issue.8, pp.1227-1262, 2007.
DOI : 10.1016/j.phytochem.2006.10.022

K. Struijs, J. Vincken, R. Verhoef, A. Voragen, and H. Gruppen, Hydroxycinnamic acids are ester-linked directly to glucosyl moieties within the lignan macromolecule from flaxseed hulls, Phytochemistry, vol.69, issue.5, pp.1250-60, 2008.
DOI : 10.1016/j.phytochem.2007.11.010

V. Heimendahl, C. Schäfer, K. Eklund, P. Sjöholm, R. Schmidt et al., Pinoresinol???lariciresinol reductases with different stereospecificity from Linum album and Linum usitatissimum, Phytochemistry, vol.66, issue.11, pp.1254-63, 2005.
DOI : 10.1016/j.phytochem.2005.04.026

N. Westcott and A. Muir, Flax seed lignan in disease prevention and health promotion, Phytochemistry Reviews, vol.124, issue.2, pp.401-418, 2003.
DOI : 10.1023/B:PHYT.0000046174.97809.b6

S. Wesley, C. Helliwell, N. Smith, M. Wang, D. Rouse et al., Construct design for efficient, effective and high-throughput gene silencing in plants, The Plant Journal, vol.101, issue.6, pp.581-90, 2001.
DOI : 10.1046/j.1365-313X.2001.01105.x