I. Tableau, Part des différentes modalités de diagnostics de cancers broncho-pulmonaires primitifs à La Réunion Endoscopie sous anesthésie locale, pp.316-362

J. Lortet-tieulent, I. Soerjomataram, J. Ferlay, M. Rutherford, E. Weiderpass et al., International trends in lung cancer incidence by histological subtype: Adenocarcinoma stabilizing in men but still increasing in women, Lung Cancer, vol.84, issue.1, pp.13-22, 2014.
DOI : 10.1016/j.lungcan.2014.01.009

G. Marshall, C. Ferreccio, Y. Yuan, M. Bates, C. Steinmaus et al., Fifty-Year Study of Lung and Bladder Cancer Mortality in Chile Related to Arsenic in Drinking Water, JNCI Journal of the National Cancer Institute, vol.99, issue.12, pp.920-928, 2007.
DOI : 10.1093/jnci/djm004

S. Khuder, Effect of cigarette smoking on major histological types of lung cancer: a meta-analysis, Lung Cancer, vol.31, issue.2-3, pp.2-3139, 2001.
DOI : 10.1016/S0169-5002(00)00181-1

W. Travis, E. Brambilla, M. Noguchi, A. Nicholson, K. Geisinger et al., International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma, Journal of Thoracic Oncology, vol.6, issue.2, pp.244-85, 2011.
DOI : 10.1097/JTO.0b013e318206a221

URL : https://hal.archives-ouvertes.fr/inserm-00561753

J. Yim, L. Zhu, L. Chiriboga, H. Watson, J. Goldberg et al., Histologic features are important prognostic indicators in early stages lung adenocarcinomas, Modern Pathology, vol.67, issue.2, pp.233-274, 2007.
DOI : 10.1038/modpathol.3800734

I. Weinstein and . Cancer, CANCER: Enhanced: Addiction to Oncogenes--the Achilles Heal of Cancer, Science, vol.297, issue.5578, pp.63-67, 2002.
DOI : 10.1126/science.1073096

D. Hanahan and R. Weinberg, The Hallmarks of Cancer, Cell, vol.100, issue.1, pp.57-70, 2000.
DOI : 10.1016/S0092-8674(00)81683-9

D. Hanahan and R. Weinberg, Hallmarks of Cancer: The Next Generation, Cell, vol.144, issue.5, pp.646-74, 2011.
DOI : 10.1016/j.cell.2011.02.013

W. Kaelin, The Concept of Synthetic Lethality in the Context of Anticancer Therapy, Nature Reviews Cancer, vol.269, issue.9, pp.689-98, 2005.
DOI : 10.1073/pnas.0403672101

J. Baselga and S. Swain, Novel anticancer targets: revisiting ERBB2 and discovering ERBB3, Nature Reviews Cancer, vol.25, issue.7, pp.463-75, 2009.
DOI : 10.1038/nrc2656

C. Hortet, A. Gilgenkrantz, H. Guidotti, J. , C. Hortet et al., EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration, EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration, International Journal of Hepatology, International Journal of Hepatology, vol.2012, p.476910, 2012.

S. Sharma, D. Bell, J. Settleman, and D. Haber, Epidermal growth factor receptor mutations in lung cancer, Nature Reviews Cancer, vol.64, issue.3, pp.169-81, 2007.
DOI : 10.1038/nrc2088

H. Yu, M. Arcila, N. Rekhtman, C. Sima, M. Zakowski et al., Analysis of Tumor Specimens at the Time of Acquired Resistance to EGFR-TKI Therapy in 155 Patients with EGFR-Mutant Lung Cancers, Clinical Cancer Research, vol.19, issue.8, pp.2240-2247, 2013.
DOI : 10.1158/1078-0432.CCR-12-2246

C. Mascaux, N. Iannino, B. Martin, M. Paesmans, T. Berghmans et al., The role of RAS oncogene in survival of patients with lung cancer: a systematic review of the literature with meta-analysis, British Journal of Cancer, vol.27, issue.1, pp.131-140, 2005.
DOI : 10.1007/s004320050208

M. Soda, Y. Choi, M. Enomoto, S. Takada, Y. Yamashita et al., Identification of the transforming EML4???ALK fusion gene in non-small-cell lung cancer, Nature, vol.276, issue.7153, pp.561-567, 2007.
DOI : 10.1038/nature05945

P. Groome, V. Bolejack, J. Crowley, C. Kennedy, M. Krasnik et al., The IASLC Lung Cancer Staging Project: Validation of the Proposals for Revision of the T, N, and M Descriptors and Consequent Stage Groupings in the Forthcoming (Seventh) Edition of the TNM Classification of Malignant Tumours, Journal of Thoracic Oncology, vol.2, issue.8, pp.694-705, 2007.
DOI : 10.1097/JTO.0b013e31812d05d5

E. Wynder and E. Graham, TOBACCO SMOKING AS A POSSIBLE ETIOLOGIC FACTOR IN BRONCHIOGENIC CARCINOMA, Journal of the American Medical Association, vol.143, issue.4, pp.329-365, 1950.
DOI : 10.1001/jama.1950.02910390001001

R. Doll and A. Hill, Smoking and carcinoma of the lung. Preliminary report, Bull World Health Organ, vol.77, issue.1, pp.84-93, 1950.

B. Pesch, B. Kendzia, P. Gustavsson, K. Jöckel, G. Johnen et al., Cigarette smoking and lung cancer-relative risk estimates for the major histological types from a pooled analysis of case-control studies, International Journal of Cancer, vol.293, issue.1 Part 1, pp.1210-1219, 2012.
DOI : 10.1002/ijc.27339

URL : https://hal.archives-ouvertes.fr/pasteur-00722977

R. Doll and R. Peto, Cigarette smoking and bronchial carcinoma: dose and time relationships among regular smokers and lifelong non-smokers., Journal of Epidemiology & Community Health, vol.32, issue.4, pp.303-316, 1978.
DOI : 10.1136/jech.32.4.303

R. Peto, S. Darby, H. Deo, P. Silcocks, E. Whitley et al., Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies, BMJ, vol.321, issue.7257, pp.323-332, 2000.
DOI : 10.1136/bmj.321.7257.323

A. Ferketich, J. Niland, R. Mamet, C. Zornosa, D. Amico et al., Smoking status and survival in the national comprehensive cancer network non-small cell lung cancer cohort, Cancer, vol.8, issue.suppl 3, pp.847-53, 2013.
DOI : 10.1002/cncr.27824

K. Weaver, J. Rowland, E. Augustson, and A. Atienza, Smoking Concordance in Lung and Colorectal Cancer Patient-Caregiver Dyads and Quality of Life, Cancer Epidemiology Biomarkers & Prevention, vol.20, issue.2, pp.239-287, 2011.
DOI : 10.1158/1055-9965.EPI-10-0666

J. Harris, M. Thun, A. Mondul, and E. Calle, Cigarette tar yields in relation to mortality from lung cancer in the cancer prevention study II prospective cohort, 1982-8, BMJ, vol.328, issue.7431, p.72, 1982.
DOI : 10.1136/bmj.37936.585382.44

A. Hackshaw, M. Law, and N. Wald, The accumulated evidence on lung cancer and environmental tobacco smoke, BMJ, vol.315, issue.7114, pp.980-988, 1997.
DOI : 10.1136/bmj.315.7114.980

P. Boffetta, P. Autier, M. Boniol, P. Boyle, C. Hill et al., An Estimate of Cancers Attributable to Occupational Exposures in France, Journal of Occupational and Environmental Medicine, vol.52, issue.4, pp.399-406, 2010.
DOI : 10.1097/JOM.0b013e3181d5e355

URL : https://hal.archives-ouvertes.fr/hal-01260430

D. Luce, I. Stücker, . Icare-study, and . Group, Investigation of occupational and environmental causes of respiratory cancers (ICARE): a multicenter, population-based case-control study in France, BMC Public Health, vol.127, issue.1, p.928, 2011.
DOI : 10.1002/ijc.25064

URL : https://hal.archives-ouvertes.fr/inserm-00667291

N. Bruce, M. Dherani, R. Liu, H. Hosgood, A. Sapkota et al., Does household use of biomass fuel cause lung cancer? A systematic review and evaluation of the evidence for the GBD 2010 study, Thorax, vol.40, issue.(6), pp.433-474, 2015.
DOI : 10.1136/thoraxjnl-2014-206625

D. Cruz, C. Tanoue, L. Matthay, and R. , Lung Cancer: Epidemiology, Etiology, and Prevention, Clinics in Chest Medicine, vol.32, issue.4, pp.605-649, 2011.
DOI : 10.1016/j.ccm.2011.09.001

Y. Yang, J. Dong, K. Sun, L. Zhao, F. Zhao et al., Obesity and incidence of lung cancer: A meta-analysis, International Journal of Cancer, vol.115, issue.5, pp.1162-1171, 2013.
DOI : 10.1002/ijc.27719

H. Sox, Screening for Lung Cancer With Chest Radiographs, JAMA, vol.306, issue.17, pp.1916-1924, 2011.
DOI : 10.1001/jama.2011.1609

M. Oken, W. Hocking, P. Kvale, G. Andriole, S. Buys et al., Screening by Chest Radiograph and Lung Cancer Mortality, JAMA, vol.306, issue.17, pp.1865-73, 2011.
DOI : 10.1001/jama.2011.1591

D. Aberle, A. Adams, C. Berg, W. Black, and J. Clapp, Reduced lung-cancer mortality with low-dose computed tomographic screening, N Engl J Med, vol.365, issue.5, pp.395-409, 2011.

F. Delva, M. J. Brochard, P. Laurent, F. Petitprez, K. Pairon et al., Recommandations de bonne pratique??: surveillance m??dico-professionnelle des travailleurs expos??s ou ayant ??t?? expos??s ?? des agents canc??rog??nes pulmonaires, Archives des Maladies Professionnelles et de l'Environnement, vol.77, issue.3, 2016.
DOI : 10.1016/j.admp.2016.03.001

B. Besse, A. Adjei, P. Baas, P. Meldgaard, M. Nicolson et al., 2nd ESMO Consensus Conference on Lung Cancer: non-small-cell lung cancer first-line/second and further lines of treatment in advanced disease, Annals of Oncology, vol.25, issue.8, pp.1475-84, 2014.
DOI : 10.1093/annonc/mdu123

W. Eberhardt, D. Ruysscher, D. Weder, W. , L. Péchoux et al., 2nd ESMO Consensus Conference in Lung Cancer: locally advanced stage III non-small-cell lung cancer, ESMO Consensus Conference in Lung Cancer: locally advanced stage III nonsmall-cell lung cancer, pp.1573-88, 2015.
DOI : 10.1093/annonc/mdv187

URL : http://www.zora.uzh.ch/112749/1/Eberhartd%20et%20al_AoO_2015.pdf

M. Fruh, D. Ruysscher, D. Popat, S. Crino, L. Peters et al., Small-cell lung cancer (SCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up, Annals of Oncology, vol.24, issue.suppl 6, pp.99-105, 2013.
DOI : 10.1093/annonc/mdt178

K. Kerr, L. Bubendorf, M. Edelman, A. Marchetti, T. Mok et al., Second ESMO consensus conference on lung cancer: pathology and molecular biomarkers for non-small-cell lung cancer, Annals of Oncology, vol.25, issue.9, pp.1681-90, 2014.
DOI : 10.1093/annonc/mdu145

M. Reck, S. Popat, N. Reinmuth, D. Ruysscher, D. Kerr et al., Metastatic non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up, Annals of Oncology, vol.25, issue.suppl 3, pp.27-39, 2014.
DOI : 10.1093/annonc/mdu199

J. Vansteenkiste, L. Crino, C. Dooms, J. Douillard, C. Faivre-finn et al., 2nd ESMO Consensus Conference on Lung Cancer: early-stage non-small-cell lung cancer consensus on diagnosis, treatment and follow-up, Annals of Oncology, vol.25, issue.8, pp.1462-74, 2014.
DOI : 10.1093/annonc/mdu089

J. Vansteenkiste, D. Ruysscher, D. Eberhardt, W. Lim, E. Senan et al., Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up, Annals of Oncology, vol.24, issue.suppl 6, pp.89-98, 2013.
DOI : 10.1093/annonc/mdt241

C. Rudin, N. Ismaila, C. Hann, N. Malhotra, B. Movsas et al., Treatment of Small-Cell Lung Cancer: American Society of Clinical Oncology Endorsement of the American College of Chest Physicians Guideline, Journal of Clinical Oncology, vol.33, issue.34, pp.4106-4117, 2015.
DOI : 10.1200/JCO.2015.63.7918

G. Masters, S. Temin, C. Azzoli, G. Giaccone, S. Baker et al., Systemic Therapy for Stage IV Non???Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update, Journal of Clinical Oncology, vol.33, issue.30, pp.3488-515, 2015.
DOI : 10.1200/JCO.2015.62.1342

A. Bezjak, S. Temin, G. Franklin, G. Giaccone, R. Govindan et al., Definitive and Adjuvant Radiotherapy in Locally Advanced Non???Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the American Society for Radiation Oncology Evidence-Based Clinical Practice Guideline, Journal of Clinical Oncology, vol.33, issue.18, pp.2100-2105, 2015.
DOI : 10.1200/JCO.2014.59.2360

N. Leighl, N. Rekhtman, W. Biermann, J. Huang, M. Mino-kenudson et al., Molecular Testing for Selection of Patients With Lung Cancer for Epidermal Growth Factor Receptor and Anaplastic Lymphoma Kinase Tyrosine Kinase Inhibitors: American Society of Clinical Oncology Endorsement of the College of American Pathologists/International Association for the Study of Lung Cancer/Association for Molecular Pathology Guideline, Journal of Clinical Oncology, vol.32, issue.32, pp.3673-3682, 2014.
DOI : 10.1200/JCO.2014.57.3055

W. Evans, D. Osoba, R. Feld, F. Shepherd, M. Bazos et al., Etoposide (VP-16) and cisplatin: an effective treatment for relapse in small-cell lung cancer., Journal of Clinical Oncology, vol.3, issue.1, pp.65-71, 1985.
DOI : 10.1200/JCO.1985.3.1.65

M. Oken, R. Creech, D. Tormey, J. Horton, T. Davis et al., Toxicity and response criteria of the Eastern Cooperative Oncology Group, AMERICAN JOURNAL OF CLINICAL ONCOLOGY, vol.5, issue.6, pp.649-55, 1982.
DOI : 10.1097/00000421-198212000-00014

L. Paz-ares, F. De-marinis, M. Dediu, M. Thomas, J. Pujol et al., PARAMOUNT: Final Overall Survival Results of the Phase III Study of Maintenance Pemetrexed Versus Placebo Immediately After Induction Treatment With Pemetrexed Plus Cisplatin for Advanced Nonsquamous Non???Small-Cell Lung Cancer, Journal of Clinical Oncology, vol.31, issue.23, pp.2895-902, 2013.
DOI : 10.1200/JCO.2012.47.1102

N. Meta and C. Group, Preoperative chemotherapy for non-smallcell lung cancer: a systematic review and meta-analysis of individual participant data, Lancet, vol.383, issue.9928, pp.1561-71, 2014.

J. Pignon, H. Tribodet, G. Scagliotti, J. Douillard, F. Shepherd et al., Lung Adjuvant Cisplatin Evaluation: A Pooled Analysis by the LACE Collaborative Group, Journal of Clinical Oncology, vol.26, issue.21
DOI : 10.1200/JCO.2007.13.9030

A. Cortot, Traitements cibl??s et immunoth??rapie : quel apport en pratique ?, Revue des Maladies Respiratoires Actualit??s, vol.7, issue.1, pp.51-62, 2015.
DOI : 10.1016/S1877-1203(15)30015-X

J. Wolchok, A. Hoos, O. Day, S. Weber, J. Hamid et al., Guidelines for the Evaluation of Immune Therapy Activity in Solid Tumors: Immune-Related Response Criteria, Clinical Cancer Research, vol.15, issue.23, pp.7412-7432, 2009.
DOI : 10.1158/1078-0432.CCR-09-1624

B. Roswit, M. Patno, R. Rapp, A. Veinbergs, B. Feder et al., The Survival of Patients with Inoperable Lung Cancer: A Large-Scale Randomized Study of Radiation Therapy Versus Placebo, Radiology, vol.90, issue.4, pp.688-97, 1968.
DOI : 10.1148/90.4.688

. Globocan-2012, Lung cancer incidence and mortality worldwide in 2012, 2012.

C. Fitzmaurice, D. Dicker, A. Pain, H. Hamavid, and M. Moradi-lakeh, The Global Burden of Cancer 2013, JAMA Oncology, vol.1, issue.4, pp.505-532, 2015.
DOI : 10.1001/jamaoncol.2015.0735

C. Allemani, H. Weir, H. Carreira, R. Harewood, D. Spika et al., Global surveillance of cancer survival 1995???2009: analysis of individual data for 25???676???887 patients from 279 population-based registries in 67 countries (CONCORD-2), The Lancet, vol.385, issue.9972, pp.977-1010, 2015.
DOI : 10.1016/S0140-6736(14)62038-9

F. Binder-foucard, A. Belot, P. Delafosse, L. Remontet, A. Woronoff et al., Estimation nationale de l'incidence et de la mortalité par cancer en France entre 1980 et 2012, 2013.

C. Locher, D. Debieuvre, D. Coëtmeur, F. Goupil, O. Molinier et al., Major changes in lung cancer over the last ten years in France: The KBP-CPHG studies, Lung Cancer, vol.81, issue.1, pp.32-40, 2013.
DOI : 10.1016/j.lungcan.2013.03.001

M. Bardot, Le Cancer à La Réunion, ORS Océan, 2015.

F. Caliez, E. Chirpaz, and M. Ravault, Etude sur le cancer, évolution jusqu'à 2011, ARS OI, 2013.

F. Blanchon, M. Grivaux, T. Collon, M. Zureik, H. Barbieux et al., Epidemiologic of primary bronchial carcinoma management in the general French hospital centers], Rev Mal Respir, vol.19, issue.6, pp.727-761, 2002.

D. Debieuvre, C. Locher, A. Neidhardt, F. Goupil, B. Lemaire et al., ??volution en 10ans du cancer bronchique non ?? petites cellules en fonction du sexe. R??sultats de l?????tude KBP-2010-CPHG du Coll??ge des pneumologues des h??pitaux g??n??raux, Revue des Maladies Respiratoires, vol.31, issue.9, pp.805-821, 2014.
DOI : 10.1016/j.rmr.2013.10.644

F. Barlesi, J. Mazieres, J. Merlio, D. Debieuvre, J. Mosser et al., Routine molecular profiling of patients with advanced non-small-cell lung cancer: results of a 1-year nationwide programme of the French Cooperative Thoracic Intergroup (IFCT), The Lancet, vol.387, issue.10026, 2016.
DOI : 10.1016/S0140-6736(16)00004-0

L. Ribassin-majed and C. Hill, Trends in tobacco-attributable mortality in France, The European Journal of Public Health, vol.25, issue.5, pp.824-832, 2015.
DOI : 10.1093/eurpub/ckv078

D. Coëtmeur, G. Leveiller, V. Frappat, M. Martin, M. Peureux et al., Relation entre cancer bronchique primitif et consommation tabagique. R??sultats de l?????tude KBP-2010-CPHG du Coll??ge des pneumologues des h??pitaux g??n??raux, Revue des Maladies Respiratoires, vol.33, issue.7, 2016.
DOI : 10.1016/j.rmr.2015.09.008

M. Oberg, M. Jaakkola, A. Woodward, A. Peruga, and A. Prüss-ustün, Worldwide burden of disease from exposure to second-hand smoke: a retrospective analysis of data from 192 countries, The Lancet, vol.377, issue.9760, pp.139-185, 2011.
DOI : 10.1016/S0140-6736(10)61388-8

E. Imbernon, Estimation du nombre de cas de certains cancers attribuables à des facteurs professionnels en France. INVS, 2003.

G. Soit-ilg, A. Houot, M. , A. Durand, S. Brochard et al., Estimation des parts attribuables de cancers aux expositions professionnelles à l'amiante en France, 2015.

F. Caliez, La population de la Réunion, 2012.

M. Segi, T. Daigaku, . Nippon-taigan, and . Kyokai, Cancer mortality for selected sites in 24 countries (1950-57). Department of Public Health, 1960.

R. Doll and J. Waterhouse, Cancer in Five Continents Vol I, Geneva: UICC, 1966.

H. Shigematsu and A. Gazdar, Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers, International Journal of Cancer, vol.4, issue.2, pp.257-62, 2006.
DOI : 10.1002/ijc.21496

R. Jones, F. Barone-adesi, S. Koutros, C. Lerro, A. Blair et al., Incidence of solid tumours among pesticide applicators exposed to the organophosphate insecticide diazinon in the Agricultural Health Study: an updated analysis, Occupational and Environmental Medicine, vol.131, issue.7, pp.496-503, 2015.
DOI : 10.1136/oemed-2014-102728

E. Quoix, I. Monnet, P. Scheid, A. Hamadouche, C. Chouaid et al., IFCT 02-02??: la prise en charge du cancer bronchique chez les patients ??g??s de 70??ans et plus en France, Revue des Maladies Respiratoires, vol.27, issue.5, pp.421-451, 2010.
DOI : 10.1016/j.rmr.2010.02.013

H. Wakelee, E. Chang, S. Gomez, T. Keegan, D. Feskanich et al., Lung Cancer Incidence in Never Smokers, Journal of Clinical Oncology, vol.25, issue.5, pp.472-480, 2007.
DOI : 10.1200/JCO.2006.07.2983