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Master Thesis

Critères d’évaluation tomodensitométriques et à l’échographie de contraste de la réponse tumorale aux traitements anti-angiogéniques des cancers du rein métastatiques

Abstract : Our objective was to compare DCEUS at one month and the CT-scan at 2 months for the prediction of response in patients treated by tyrosine kinase inhibitors for metastatic renal cell carcinoma. We performed DCE-US in one target at baseline and D30. We selected patients with contrast-enhanced portal phase CT at baseline and after 2 months to calculate PFS. Response assessment using the Response Evaluation Criteria in Solid Tumors and Choi criteria was performed in targets including the DCE-US tumor. Results were correlated to the PFS. 81 patients were analyzed. All had DCEUS at baseline and one month. Thirty nine patients had CT-scan with contrast media injection for the Choi criteria analysis and were finally included. The median of follow-up was 18 months. The difference of PFS between the groups defined by this cut-point was 4 months (bad responders) and 14 months (good responders). Choi criteria has a great predictive value for PFS (p=0.0043). RECIST 1.1 cannot predict PFS in the early evaluation (p=0.1). The decrease of 90% of the AUC is not significant in our sub-group (p=0.14). Choi criteria has a great predictive value to early identify good responders. RECIST is not reliable. Results for DCE-US at one month are not significant probably due to a lack of statistical power.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01429730
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Submitted on : Monday, January 9, 2017 - 10:17:10 AM
Last modification on : Friday, March 27, 2020 - 2:35:51 AM
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  • HAL Id : dumas-01429730, version 1

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Marie-Rose El Bejjani. Critères d’évaluation tomodensitométriques et à l’échographie de contraste de la réponse tumorale aux traitements anti-angiogéniques des cancers du rein métastatiques. Médecine humaine et pathologie. 2016. ⟨dumas-01429730⟩

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