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Master Thesis

Prokinéticine 1 : nouveau biomarqueur de l’implantation embryonnaire en fécondation in vitro

Abstract : Infertility affects 15% of couples worldwide. Despite many advances in in vitro fertilization (IVF) techniques, the clinical validation of new prognostic biomarkers of embryo implantation is mandatory to significantly improve the IVF outcome. My project was to evaluate the interest of PROK1 measurement in IVF biological samples to predict the reproductive outcome in patients who received a first conventional IVF-embryo transfer (cIVF-ET). We conducted a prospective study between January 2013 and June 2015 at the University Hospital of Grenoble, and enrolled 135 infertile IVF patients in the CRB GERMETHEQUE. Our results show: (1) PROK1 expression in the human follicles, (2) PROK1 secretion by follicular ovarian cells, with a significantly higher secretion by primary mural granulosa cell cultures as compared to cumulus cultures, and (3) that follicular PROK1 levels were significantly higher in the embryo implantation group and were predictive of subsequent embryo implantation. PROK1 levels in IVF biological samples could constitute new predictive non-invasive markers of successful embryo implantation in cIVF-ET.
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Master Thesis
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Submitted on : Friday, January 13, 2017 - 6:26:47 PM
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  • HAL Id : dumas-01432593, version 1


Sophie Brouillet. Prokinéticine 1 : nouveau biomarqueur de l’implantation embryonnaire en fécondation in vitro. Sciences pharmaceutiques. 2015. ⟨dumas-01432593⟩



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