S. Legrain, Consommation médicamenteuse chez le sujet âgé. Consommation, Prescription, Iatrogénie et Observance, 2005.

R. Holland, J. Desborough, L. Goodyer, S. Hall, D. Wright et al., Does pharmacist-led medication review help to reduce hospital admissions and deaths in older people? A systematic review and meta-analysis, British Journal of Clinical Pharmacology, vol.6, issue.3, pp.303-316, 2008.
DOI : 10.1046/j.1365-2125.1997.00629.x

C. Lowe, D. Raynor, J. Purvis, A. Farrin, and J. Hudson, Effects of a medicine review and education programme for older people in general practice, British Journal of Clinical Pharmacology, vol.46, issue.2, pp.172-175, 2000.
DOI : 10.1046/j.1365-2125.2000.00247.x

C. Bond, C. Matheson, S. Williams, P. Williams, and P. Donnan, Repeat prescribing: a role for community pharmacists in controlling and monitoring repeat prescriptions, Br J Gen Pr, vol.50, issue.453, pp.271-275, 2000.

S. Royal, L. Smeaton, A. Avery, B. Hurwitz, and A. Sheikh, Interventions in primary care to reduce medication related adverse events and hospital admissions: systematic review and meta-analysis, Quality and Safety in Health Care, vol.15, issue.1, pp.23-31, 2006.
DOI : 10.1136/qshc.2004.012153

V. Von-gunten, J. Reymond, and J. Beney, Clinical and economic outcomes of pharmaceutical services related to antibiotic use: a literature review, Pharmacy World & Science, vol.37, issue.6, pp.146-163, 2007.
DOI : 10.1007/s11096-006-9042-6

J. Altavela, M. Jones, and M. Ritter, A Prospective Trial of a Clinical Pharmacy Intervention in a Primary Care Practice in a Capitated Payment System, Journal of Managed Care Pharmacy, vol.14, issue.9, pp.831-843, 2008.
DOI : 10.18553/jmcp.2008.14.9.831

A. Spinewine, K. Schmader, N. Barber, C. Hughes, K. Lapane et al., Appropriate prescribing in elderly people: how well can it be measured and optimised?, The Lancet, vol.370, issue.9582, pp.173-184, 2007.
DOI : 10.1016/S0140-6736(07)61091-5

J. Krska and A. Avery, Evaluation of medication reviews conducted by community pharmacists: a quantitative analysis of documented issues and recommendations, British Journal of Clinical Pharmacology, vol.15, issue.3, pp.386-396, 2008.
DOI : 10.1211/ijpp.14.1.0009

A. Zermansky, D. Petty, D. Raynor, N. Freemantle, A. Vail et al., Randomised controlled trial of clinical medication review by a pharmacist of elderly patients receiving repeat prescriptions in general practice, BMJ, vol.323, issue.7325, p.1340, 2001.
DOI : 10.1136/bmj.323.7325.1340

A. Zermansky, D. Alldred, D. Petty, D. Raynor, N. Freemantle et al., Clinical medication review by a pharmacist of elderly people living in care homes--randomised controlled trial, Age and Ageing, vol.35, issue.6, pp.586-591, 2006.
DOI : 10.1093/ageing/afl075

J. Johnson and J. Bootman, Drug-related morbidity and mortality and the economic impact of pharmaceutical care, Am J Health Syst Pharm, vol.54, issue.5, pp.554-558, 1997.

P. Chaffanjon, cours mutimédia d'anatomie rénale -PACES faculté de médecine et de pharmacie de Grenoble, cellule TICE, 2014.

W. Anne and G. Allison, Ross and Wilson Anatomy and Physiology in health and illness, 2004.

G. Diane, cours mutimédia de physiologie rénale -PACES faculté de médecine et de pharmacie de Grenoble, cellule TICE, 2014.

M. Daroux, C. Gaxatte, F. Puisieux, B. Corman, and É. Boulanger, Vieillissement rénal : facteurs de risque et néphroprotection. Presse Médicale, nov, vol.38, issue.11, pp.1667-79, 2009.
DOI : 10.1016/j.lpm.2008.12.027

J. Clèdes, C. Hanrotel-saliou, R. Perrichot, B. Strullu, and T. Tanquerel, Evolution des reins au cours du viellissement, In: Encyclopédie MédChir, 2002.

R. Lindeman, J. Tobin, and N. Shock, Longitudinal Studies on the Rate of Decline in Renal Function with Age, Journal of the American Geriatrics Society, vol.24, issue.4, pp.278-285, 1985.
DOI : 10.1111/j.1532-5415.1985.tb07117.x

B. Lacour and Z. Massy, Diagnostic, suivi biologique de l???insuffisance r??nale chronique et prise en charge de l???insuffisance r??nale chronique terminale, Revue Francophone des Laboratoires, vol.2013, issue.451, pp.59-73, 2013.
DOI : 10.1016/S1773-035X(13)71996-8

M. Moonen, V. Fraipont, L. Radermacher, C. Masset, E. Firre et al., L???insuffisance r??nale aigu????: du concept ?? la pratique, N??phrologie & Th??rapeutique, vol.7, issue.3, pp.172-177, 2011.
DOI : 10.1016/j.nephro.2010.11.005

H. Leriverend, N. Clere, and S. Faure, Insuffisance r??nale et n??phrotoxicit?? m??dicamenteuse, Actualit??s Pharmaceutiques, vol.55, issue.557, pp.23-30, 2016.
DOI : 10.1016/j.actpha.2016.04.005

A. Levey, L. Stevens, and J. Coresh, Conceptual Model of CKD: Applications and Implications, American Journal of Kidney Diseases, vol.53, issue.3, pp.4-16, 2009.
DOI : 10.1053/j.ajkd.2008.07.048

E. Crowe, D. Halpin, and P. Stevens, Guidelines: early identification and management of chronic kidney disease: summary of NICE guidance, BMJ, vol.337, issue.7673, pp.812-815, 2008.

A. Levey, P. De-jong, J. Coresh, E. Nahas, M. Astor et al., The definition, classification, and prognosis of chronic kidney disease: a KDIGO Controversies Conference report, Kidney International, vol.80, issue.1, pp.17-28, 2011.
DOI : 10.1038/ki.2010.483

M. Van-der-velde, K. Matsushita, J. Coresh, B. Astor, M. Woodward et al., Lower estimated glomerular filtration rate and higher albuminuria are associated with all-cause and cardiovascular mortality. A collaborative meta-analysis of high-risk population cohorts, Kidney International, vol.79, issue.12, pp.1341-1352, 2011.
DOI : 10.1038/ki.2010.536

. Groupe-de-travail-de-la-société-de-néphrologie, Évaluation de la fonction rénale et de la protéinurie pour le diagnostic de la maladie rénale chronique chez l'adulte. Recommandations pour la pratique clinique, Néphrologie Thérapeutique, vol.5, issue.4, pp.302-305, 2009.

A. Khwaja, KDIGO Clinical Practice Guidelines for Acute Kidney Injury, Nephron Clinical Practice, vol.120, issue.4, pp.179-184, 2012.
DOI : 10.1159/000339789

A. Akbari, C. Clase, P. Acott, M. Battistella, A. Bello et al., Canadian Society of Nephrology Commentary on the KDIGO Clinical Practice Guideline for CKD Evaluation and Management, American Journal of Kidney Diseases, vol.65, issue.2, pp.177-205, 2015.
DOI : 10.1053/j.ajkd.2014.10.013

B. Stengel, M. Metzger, M. Froissart, M. Rainfray, C. Berr et al., Epidemiology and prognostic significance of chronic kidney disease in the elderly--the Three-City prospective cohort study, Nephrology Dialysis Transplantation, vol.26, issue.10, pp.3286-95, 2011.
DOI : 10.1093/ndt/gfr323

URL : https://hal.archives-ouvertes.fr/inserm-00739525

B. Stengel, L???insuffisance r??nale chronique??: une ??pid??mie???, La Presse M??dicale, vol.40, issue.11, pp.1020-1027, 2011.
DOI : 10.1016/j.lpm.2011.06.020

J. Coresh, E. Selvin, L. Stevens, J. Manzi, J. Kusek et al., Prevalence of Chronic Kidney Disease in the United States, JAMA, vol.298, issue.17, pp.2038-2047, 2007.
DOI : 10.1001/jama.298.17.2038

Q. Zhang and D. Rothenbacher, Prevalence of chronic kidney disease in population-based studies: Systematic review, BMC Public Health, vol.72, issue.Suppl 11, p.1, 2008.
DOI : 10.1038/sj.ki.5002343

C. Simona, Evaluation de la fonction rénale chez la personne âgée selon les formules CG, MDRD, CKD-EPI et son impact sur les prescription médicamenteuses, Thèse de Medecine Génerale, 2015.

A. Levey, J. Bosch, J. Lewis, T. Greene, N. Rogers et al., A More Accurate Method To Estimate Glomerular Filtration Rate from Serum Creatinine: A New Prediction Equation, Annals of Internal Medicine, vol.130, issue.6
DOI : 10.7326/0003-4819-130-6-199903160-00002

A. Levey, L. Stevens, C. Schmid, Y. Zhang, A. Castro et al., A New Equation to Estimate Glomerular Filtration Rate, Annals of Internal Medicine, vol.150, issue.9, pp.604-612, 2009.
DOI : 10.7326/0003-4819-150-9-200905050-00006

M. Flamant, H. Boulanger, H. Azar, and F. Vrtovsnik, Plasma creatinine, Cockcroft and MDRD: validity and limitations for evaluation of renal function in chronic kidney disease]. Presse Medicale Paris Fr, pp.303-311, 1983.

M. Froissart, J. Rossert, C. Jacquot, M. Paillard, and P. Houillier, Predictive Performance of the Modification of Diet in Renal Disease and Cockcroft-Gault Equations for Estimating Renal Function, Journal of the American Society of Nephrology, vol.16, issue.3, pp.763-773, 2005.
DOI : 10.1681/ASN.2004070549

URL : https://hal.archives-ouvertes.fr/inserm-00149221

E. Lamb, M. Webb, D. Simpson, A. Coakley, D. Newman et al., Estimation of Glomerular Filtration Rate in Older Patients with Chronic Renal Insufficiency: Is the Modification of Diet in Renal Disease Formula an Improvement?, Journal of the American Geriatrics Society, vol.39, issue.Suppl. 1, pp.1012-1017, 2003.
DOI : 10.1046/j.1365-2389.2003.51330.x

E. Lamb, M. Webb, O. Riordan, and S. , Using the modification of diet in renal disease (MDRD) and Cockcroft and Gault equations to estimate glomerular filtration rate (GFR) in older people, Age and Ageing, vol.36, issue.6, pp.689-692, 2007.
DOI : 10.1093/ageing/afm121

A. Rule, H. Amer, L. Cornell, S. Taler, F. Cosio et al., The Association Between Age and Nephrosclerosis on Renal Biopsy Among Healthy Adults, Annals of Internal Medicine, vol.152, issue.9, pp.561-567, 2010.
DOI : 10.7326/0003-4819-152-9-201005040-00006

E. Poggio, A. Rule, R. Tanchanco, S. Arrigain, R. Butler et al., Demographic and clinical characteristics associated with glomerular filtration rates in living kidney donors, Kidney International, vol.75, issue.10, pp.1079-1087, 2009.
DOI : 10.1038/ki.2009.11

S. Zimner-rapuch, S. Amet, J. N. Deray, G. Launay-vacher, and V. , Adaptation posologique chez les patients insuffisants r??naux chroniques et ??valuation de la fonction r??nale??: focus sur les patients de cardiologie, Annales de Cardiologie et d'Ang??iologie, vol.64, issue.1, pp.1-8, 2015.
DOI : 10.1016/j.ancard.2014.04.006

T. Nolin, R. Frye, and G. Matzke, Hepatic drug metabolism and transport in patients with kidney disease, American Journal of Kidney Diseases, vol.42, issue.5, pp.906-925, 2003.
DOI : 10.1016/j.ajkd.2003.07.019

D. Hollander, Intestinal permeability, leaky gut, and intestinal disorders, Current Gastroenterology Reports, vol.102, issue.8336, pp.410-416, 1999.
DOI : 10.1007/s11894-999-0023-5

F. Leblond, Downregulation of Intestinal Cytochrome P450 in Chronic Renal Failure, Journal of the American Society of Nephrology, vol.13, issue.6, pp.1579-85, 2002.
DOI : 10.1097/01.ASN.0000017575.50319.77

A. Larroutis and . Victoire, Role du pharmacien dans l'adaptation posologique des médicaments chez l'insuffisant rénal : a propos d'une expérience québécoise à l'hôpital Laval, Thèse de Pharmacie, 2007.

G. Matzke, G. Aronoff, A. Atkinson, W. Bennett, B. Decker et al., Drug dosing consideration in patients with acute and chronic kidney disease???a clinical update from Kidney Disease: Improving Global Outcomes (KDIGO), Kidney International, vol.80, issue.11, pp.1122-1137, 2011.
DOI : 10.1038/ki.2011.322

S. Bagshaw, The long-term outcome after acute renal failure, Current Opinion in Critical Care, vol.12, issue.6, p.561, 2006.
DOI : 10.1097/01.ccx.0000247445.71381.72

S. Karie, V. Launay-vacher, G. Deray, and C. Isnard-bagnis, Toxicit?? r??nale des m??dicaments, N??phrologie & Th??rapeutique, vol.6, issue.1, pp.58-74, 2010.
DOI : 10.1016/j.nephro.2009.02.006

N. Janus, F. Cavagna, F. Beauvais, M. Garenaux, D. Livet et al., Adaptation posologique et fonction r??nale chez la personne ??g??e en officine. R??sultat de l?????tude IPOP, N??phrologie & Th??rapeutique, vol.12, issue.5, p.406, 2016.
DOI : 10.1016/j.nephro.2016.07.127

T. Hoerger, S. Simpson, B. Yarnoff, M. Pavkov, R. Burrows et al., The Future Burden of CKD in the United States: A Simulation Model for the CDC CKD Initiative, American Journal of Kidney Diseases, vol.65, issue.3, pp.403-414, 2015.
DOI : 10.1053/j.ajkd.2014.09.023

X. Pourrat, A. Sipert, P. Gatault, B. Sautenet, N. Hay et al., Community pharmacist intervention in patients with renal impairment, International Journal of Clinical Pharmacy, vol.7, issue.12, pp.1172-1181, 2015.
DOI : 10.1007/s11096-015-0182-4

G. Estrada, L. Martínez, J. Perera, N. Herrera, L. Barroso et al., Prevalencia de insuficiencia renal oculta estimada mediante f??rmulas de c??lculo del grado de funci??n renal en hipertensos mayores de 60 a??os, remitidos para medici??n ambulatoria de la presi??n arterial, Atenci??n Primaria, vol.39, issue.5, pp.247-253, 2007.
DOI : 10.1157/13101799

A. Rule, H. Gussak, G. Pond, E. Bergstralh, M. Stegall et al., Measured and estimated GFR in healthy potential kidney donors, American Journal of Kidney Diseases, vol.43, issue.1, pp.112-121, 2004.
DOI : 10.1053/j.ajkd.2003.09.026

S. Sheen, J. Choi, R. Park, E. Kim, Y. Lee et al., Overdose Rate of Drugs Requiring Renal Dose Adjustment: Data Analysis of 4??Years Prescriptions at a Tertiary Teaching Hospital, Journal of General Internal Medicine, vol.274, issue.4, pp.423-431, 2008.
DOI : 10.1007/s11606-007-0336-8

G. Prudence, Optimisation de la prise en charge médicamenteuse chez la personne agée hospitalisée : diffusion d'un guide local et évaluation de la qualité de la prescription par mesure de la conformité des posologies à la fonction rénale, Thèse de Pharmacie, 2012.

C. Long, Compliance with Dosing Guidelines in Patients with Chronic Kidney Disease, Annals of Pharmacotherapy, vol.48, issue.2
DOI : 10.1159/000180580

X. Pourrat, A. Sipert, B. Sautenet, E. Merieau, J. Grassin et al., Prescriptions m??dicamenteuses ?? la sortie d???hospitalisation de patients insuffisants r??naux??: ??tude de 326??dossiers, La Presse M??dicale, vol.41, issue.4, pp.189-94, 2012.
DOI : 10.1016/j.lpm.2011.09.031

D. Le, Nos missions -Ordre National des Pharmaciens

A. Groleau, M. Nadeau-blouin, and Y. Michiels, ??volution des missions des pharmaciens qu??b??cois avec la ???Loi 41???, Actualit??s Pharmaceutiques, vol.55, issue.557, pp.35-42, 2016.
DOI : 10.1016/j.actpha.2016.04.007