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M. Matériel, Les patients ont été classés par risque d'incident hémorragique :-risque intermédiaire : Temps de prothrombine (TP) >1.2 fois le témoin ou Temps de céphaline activée (TCA) >1.2 fois le témoin et/ou taux de plaquettes <150*109/l.-risque majeur : TP ou TCA >2.2 fois le témoin et/ou taux de plaquettes <50*109/l. Les effets secondaires hémorragiques pris en compte dans notre étude sont :Saignement péri-cathéter, Hématome mineur, Hémorragie majeure. Le rapport entre l'incidence des effets secondaires et les facteurs de risque relatifs à l'hémostase a été étudié à l'aide d'une régression logistique et a été exprimé par un Odds-ratio avec un intervalle de confiance à 95%, La relation avec le nombre de pose de PICCs a été calculée par la méthode de Fisher avec tables de contingence Les résultats ont été considérés significatifs si p < 0.05