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En oncologie, la cachexie reste une cause importante de mortalité pour laquelle les ressources thérapeutiques sont limitées et le rôle de la dépense énergétique de repos (DER) mal défini. L'objectif de cette étude est d'étudier le lien entre la DER et les marqueurs clinico-biologiques de cachexie en oncologie. Patients et méthodes. Nous avons mesuré la DER par calorimétrie indirecte chez des patients atteints de cancer. Nous avons défini selon l'équation de Harris et Benedict des patients hypermétaboliques (Hm) (DER mesurée >110% de la calculée, normométaboliques (Nm) (90%-110%) et hypométaboliques (Hom) (<90%). Nous avons étudié la perte de poids, le performance status (PS), l'albuminémie, le Nutritional Risk Index (NRI), les apports caloriques journaliers et calculé la balance énergétique ,
Les Hm étaient plus dénutris que les Nm: perte de poids était de 5,9% vs 3,94 % (p=0,02) et la perte de poids > 5% de 67% vs 50% OR=4 p=0,014. L'albuminémie était plus basse : 39,01 g ,
hypermétabolisme induit la cachexie par le biais d'une balance énergétique négative chez les patients atteints de cancer ,