R. Lozano, M. Naghavi, K. Foreman, S. Lim, K. Shibuya et al., Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010, The Lancet, vol.380, issue.9859, pp.2095-128, 2010.
DOI : 10.1016/S0140-6736(12)61728-0

URL : https://hal.archives-ouvertes.fr/hal-00827612

N. Terrault, Sexual activity as a risk factor for hepatitis C. Hepatology, 2002.
DOI : 10.1053/jhep.2002.36797

. Brouard, Incidence and routes of transmission of hepatitis B virus in France, J.Hepatol, vol.58, issue.1, pp.2003-2011, 2013.

J. Gournay, Hépatite chronique B : prise en charge, surveillance et traitement. POSTU 2016. 5. World Health Organization, editor. European status report on alcohol and health Copenhagen: World Health Organization, 2010.

F. Imbert--bismut, V. Ratziu, L. Pieroni, F. Charlotte, Y. Benhamou et al., Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study, The Lancet, vol.357, issue.9262, pp.1069-1075, 2001.
DOI : 10.1016/S0140-6736(00)04258-6

P. Calès, F. Oberti, S. Michalak, I. Hubert-fouchard, M. Rousselet et al., A novel panel of blood markers to assess the degree of liver fibrosis, Hepatology, vol.39, issue.6, pp.1373-81, 2005.
DOI : 10.1016/j.hep.2003.09.022

L. Sandrin, B. Fourquet, J. Hasquenoph, Y. S. Fournier, C. Mal et al., Transient elastography: a new noninvasive method for assessment of hepatic fibrosis, Ultrasound in Medicine & Biology, vol.29, issue.12, pp.1705-1718, 2003.
DOI : 10.1016/j.ultrasmedbio.2003.07.001

T. Fest, J. Viel, F. Agis, C. Coffe, J. Dupond et al., Risk factors associated with hepatitis B or C markers or elevated alanine aminotransferase level among blood donors on a tropical island: the Guadeloupe experience, Transfusion, vol.100, issue.8, pp.760-763, 1992.
DOI : 10.7326/0003-4819-100-3-339

R. Demeulemeester, H. Riff, and J. Gabriel, Seroepidemiology of chronic hepatitis B and C in the French Caribbean Island of Guadeloupe L'hépatite B chronique en Guadeloupe : un profil épidémiologique original, BMC Res Notes, vol.755, issue.11, 2013.

M. Gelu-simeon, Facteurs de progression et évolution des hépatopathies chroniques virales et alcooliques en Guadeloupe, 2015.

T. Poynard, V. Ratziu, F. Charlotte, Z. Goodman, J. Mchutchison et al., Rates and risk factors of liver fibrosis progression in patients with chronic hepatitis C, Journal of Hepatology, vol.34, issue.5, pp.730-739, 2001.
DOI : 10.1016/S0168-8278(00)00097-0

T. Poynard, P. Bedossa, and P. Opolon, Natural history of liver fibrosis progression in patients with chronic hepatitis C. The Lancet, pp.825-857, 1997.

H. Matsumura, M. Moriyama, I. Goto, N. Tanaka, H. Okubo et al., Natural course of progression of liver fibrosis in Japanese patients with chronic liver disease type C - a study of 527 patients at one establishment, Journal of Viral Hepatitis, vol.37, issue.4, pp.268-75, 2000.
DOI : 10.1002/hep.510270529

J. Westin, L. Lagging, F. Spak, N. Aires, E. Svensson et al., Moderate alcohol intake increases fibrosis progression in untreated patients with hepatitis C virus infection, Journal of Viral Hepatitis, vol.27, issue.3, pp.235-276, 2002.
DOI : 10.1002/hep.510260707

L. Serfaty, A. Poujol-robert, N. Carbonell, O. Chazouillères, R. Poupon et al., Effect of the interaction between steatosis and alcohol intake on liver fibrosis progression in chronic hepatitis C, The American Journal of Gastroenterology, vol.25, issue.7, pp.1807-1819, 2002.
DOI : 10.1016/S0140-6736(95)91685-7

D. Bissell, Sex and hepatic fibrosis, Hepatology, vol.88, issue.3, pp.988-997, 1999.
DOI : 10.1002/hep.510290351

M. Gelu-simeon, R. Sobesky, S. Haïm-boukobza, M. Ostos, E. Teicher et al., Do the epidemiology, physiological mechanisms and characteristics of hepatocellular carcinoma in HIV-infected patients justify specific screening policies?, AIDS, vol.28, issue.10, pp.1379-91, 2014.
DOI : 10.1097/QAD.0000000000000300

C. Mmath, J. Grebely, J. Raffa, C. Lai, M. Krajden et al., Factors associated with spontaneous clearance of hepatitis C virus among illicit drug users

J. Westin, H. Nordlinder, M. Lagging, and G. Norkrans, Steatosis accelerates fibrosis development over time in hepatitis C virus genotype 3 infected patients, Journal of Hepatology, vol.37, issue.6, pp.837-879, 2002.
DOI : 10.1016/S0168-8278(02)00299-4

L. Serfaty and J. Capeau, Hepatitis C, insulin resistance and diabetes: clinical and pathogenic data, Liver International, vol.29, pp.13-25, 2009.
DOI : 10.1111/j.1478-3231.2008.01952.x

L. Fartoux, Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C. Gut, pp.1003-1011, 2005.

V. Ortiz, M. Berenguer, J. Rayón, D. Carrasco, and J. Berenguer, Contribution of obesity to hepatitis C-related fibrosis progression, The American Journal of Gastroenterology, vol.45, issue.1, pp.2408-2422, 2002.
DOI : 10.1136/gut.48.5.707

L. Hourigan, G. Macdonald, D. Purdie, V. Whitehall, C. Shorthouse et al., Fibrosis in chronic hepatitis C correlates significantly with body mass index and steatosis, Hepatology, vol.29, issue.4, pp.1215-1224, 1999.
DOI : 10.1002/hep.510290401

L. Adinolfi, Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity, Hepatology, vol.33, issue.6, pp.1358-64, 2001.
DOI : 10.1053/jhep.2001.24432

P. Marcellin, T. Asselah, and N. Boyer, Fibrosis and disease progression in hepatitis C. Hepatology, pp.47-56, 2002.
DOI : 10.1002/hep.1840360707

F. Pessione, Cigarette smoking and hepatic lesions in patients with chronic hepatitis C. Hepatology, pp.121-126, 2001.
DOI : 10.1053/jhep.2001.25385

C. Hézode, I. Lonjon, F. Roudot-thoraval, J. Mavier, J. Pawlotsky et al., Impact of smoking on histological liver lesions in chronic hepatitis C. Gut, pp.126-135, 2003.

C. Costentin, F. Roudot-thoraval, E. Zafrani, F. Medkour, J. Pawlotsky et al., Association of caffeine intake and histological features of chronic hepatitis C, Journal of Hepatology, vol.54, issue.6, pp.1123-1132, 2011.
DOI : 10.1016/j.jhep.2010.08.027

M. Alias, Daily Cannabis Use: A Novel Risk Factor of Steatosis Severity in Patients With Chronic Hepatitis C. Gastroenterology, Feb, vol.134, issue.2, pp.432-441, 2008.

R. Kruse, J. Kramer, G. Tyson, Z. Duan, L. Chen et al., Clinical outcomes of hepatitis B virus coinfection in a United States cohort of hepatitis C virus-infected patients, Hepatology, vol.12, issue.Suppl 3, 2014.
DOI : 10.1016/j.cgh.2013.06.006

J. Chen, H. Yang, U. Iloeje, S. You, S. Lu et al., Carriers of Inactive Hepatitis B Virus Are Still at Risk for Hepatocellular Carcinoma and Liver-Related Death, Gastroenterology, vol.138, issue.5, pp.1747-54, 2010.
DOI : 10.1053/j.gastro.2010.01.042

J. Colin, D. Cazals-hatem, M. Loriot, M. Martinot-peignoux, B. Pham et al., Influence of human immunodeficiency virus infection on chronic hepatitis B in homosexual men, Hepatology, vol.84, issue.4, pp.1306-1316, 1999.
DOI : 10.1002/hep.510290447

U. Iloeje, H. Yang, J. Su, C. Jen, S. You et al., Predicting Cirrhosis Risk Based on the Level of Circulating Hepatitis B Viral Load, Gastroenterology, vol.130, issue.3, 2006.
DOI : 10.1053/j.gastro.2005.11.016

E. Baraona, C. Abittan, K. Dohmen, M. Moretti, G. Pozzato et al., Gender Differences in Pharmacokinetics of Alcohol, Alcoholism: Clinical and Experimental Research, vol.112, issue.4, pp.502-509, 2001.
DOI : 10.1300/J251v07n03_21

L. Guldner, L. Multigner, F. Héraud, C. Monfort, P. Thomé et al., Pesticide exposure of pregnant women in Guadeloupe: Ability of a food frequency questionnaire to estimate blood concentration of chlordecone, Environ Res, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00517109

L. Multigner, P. Kadhel, F. Rouget, P. Blanchet, and S. Cordier, Chlordecone exposure and adverse effects in French West Indies populations, Environmental Science and Pollution Research, vol.3, issue.6, pp.3-8, 2016.
DOI : 10.1080/15287398409530582

URL : https://hal.archives-ouvertes.fr/hal-01150382

W. B. Deichmann and W. E. Macdonald, Organochlorine pesticides and liver cancer deaths in the United States, pp.1930-1972, 1977.

S. Cordier, T. B. Le, P. Verger, D. Bard, C. D. Le et al., Viral infections and chemical exposures as risk factors for hepatocellular carcinoma in Vietnam, International Journal of Cancer, vol.51, issue.42, pp.196-201, 1993.
DOI : 10.7326/0003-4819-116-2-97

P. Cocco, N. Kazerouni, and S. Zahm, Cancer Mortality and Environmental Exposure to DDE in the United States, Environmental Health Perspectives, vol.108, issue.1, p.1, 2000.
DOI : 10.1289/ehp.001081

J. Egle, J. Fernandez, P. Guzelian, and J. Borzelleca, Distribution and excretion of chlordecone (Kepone) in the rat, Drug Metab Dispos, vol.6, issue.1, pp.91-96, 1978.

M. D. Reuber, Carcinogenicity of kepone, Journal of Toxicology and Environmental Health, vol.4, issue.5-6, pp.895-911, 1978.
DOI : 10.1016/0048-9697(78)90056-6

M. D. Reuber, Carcinomas and Other Lesions of the Liver in Mice Ingesting Organochlorine Pesticides, Clinical Toxicology, vol.17, issue.2, pp.231-256, 1978.
DOI : 10.1084/jem.80.3.231

R. Althouse, Chemicals and industrial processes associated with cancer in humans: report of an IARC ad hoc working group which met in Lyon to advise the Director, IARC, on chemicals carcinogenic for humans. Lyon: International Agency for Research on Cancer, pp.15-17, 1979.

H. M. Mehendale, Potentiation of halomethane hepatotoxicity: Chlordecone and carbon tetrachloride*1, Fundamental and Applied Toxicology, vol.4, issue.3, pp.295-308, 1984.
DOI : 10.1016/0272-0590(84)90187-8

R. Young and H. Mehendale, Carbon tetrachloride metabolism in partially hepatectomized and sham-operated rats pre-exposed to chlordecone (kepone), Journal of Biochemical Toxicology, vol.9, issue.4, pp.211-220, 1989.
DOI : 10.1080/00039896.1964.10663818

E. Tabet, V. Genet, F. Tiaho, C. Lucas-clerc, M. Gelu-simeon et al., Chlordecone potentiates hepatic fibrosis in chronic liver injury induced by carbon tetrachloride in mice Epidemic kepone poisoning in chemical workers, Toxicol Lett Am.J.Epidemiol, vol.107, pp.529-537, 1978.

L. Castéra, J. Vergniol, J. Foucher, L. Bail, B. Chanteloup et al., Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C, Gastroenterology, vol.128, issue.2, 2005.
DOI : 10.1053/j.gastro.2004.11.018

. Ledinghen, Assessment of cirrhosis and its severity by fibroscan and biochemical markers in alcoholic patients, J Hepatol, 2006.

?. V129café:-oui-????non and . Si-oui, V130nb de tasses/j : de (année)V131????????????? à V132?????????????ou(âge)V133??????? à V134??????? ans V340 Durée : ??????? mois V341??????? années V140Episodes de perte ou gain de poids > 10kg depuis l'âge de 20 ans : oui ????non ???? Si oui, V141poids : ??????? kg, de (année) V142????????????? à V143?????????????ou (âge) V144??????? à V145??????? poids : V146??????? kg, de (année) V147????????????? à V148?????????????ou (âge) V149??????? à V150??????? V163Intervention chirurgicale lourde : oui ??1??non ??0??NSP ??2?? V164date :??/??/??.... V165Spécialité concernée: ?????????????????????????????????

?. V288hémoglobine, . .. ??-/-??-/-??, /. V289plaquettes, and . .. ??-/-??, id ? V290PNN (/mm 3 ) : ?????????.. normes (UI/l): ????.. date :??, ???????? normes id ? V293ASAT (UI/l): ?????????.. V294normes (UI/l): ????.. date :??/??/??.... id ? V295ALAT (UI/l): ?????????.. V296normes (UI/l): ????.. date :??

. V304créatininémie, ?????????? normes (µmol/l):?????? V305Clairance créatinine (ml/min): ???????? date

/. V306ferritine?? and . .. ??-/-??, normes (ng/ml):?????? date, ) : ): ?????????.. normes (mUI/ml):?????? date :??/??/??.... id ?