L. L??-joueraient-un-rôle-dans-la-pathogénicité-de-la-maladie-de-behçet, En effet, il existe une corrélation entre l'activité de cette maladie et l'expansion de ces cellules

L. Lymphocytes and T. Helpers, qui sécrètent respectivement des cytokines de type Th1 (par exemple l'INF ?) et de type Th17 (essentiellement des IL-17). (18) Il y aurait un déséquilibre dans la balance Th17, Th) secrètent des cytokines qui Th1, Th2, Th17, Th22. La réponse immunitaire au cours de la maladie de Behçet ferait appel essentiellement aux Th1 et aux Th17Th1 en faveur des Th17. (38) L'IL-10 fait partie des cytokines de type Th2. Elle pourrait être impliquée dans la pathogénicité de la maladie de Behçet. (25) L'IL-22 pourrait jouer un rôle dans l'oculo-Behçet. (39) L'IL-1

. Diverses-Études-ont-montré-que-la-cytokine-tnf-?-joue-un-rôle-dans-la-pathogénicité-de-la-maladie-de and . Behçet, L'efficacité du traitement par anti-TNF-? conforte cette implication, 18) (34) 2.3. Précautions à prendre au cabinet dentaire pour un patient atteint de la maladie de Behçet 2.3.1. Précautions à l'égard de l'anxiété et des troubles psychiatriques

. Dans-le-cadre-d, un patient atteint de la maladie de Behçet, les patients peuvent être sous AAP et/ou AVK. Il est déconseillé sur un patient à risque hémorragique de faire une anesthésie loco-régionale

. Au-cours-de-son-exercice and . Le-chirurgien, dentiste est amené à prescrire des médicaments Il devra non seulement faire attention aux interactions médicamenteuses mais aussi aux intolérances du patient atteint de la maladie de Behçet vis-à-vis de certains médicaments. (126) 2.3.3.1. Prescription d'antibiotiques L'azithromycine, la clarithromycine et la spiramycine : les interactions médicamenteuses de cette famille d'antibiotiques sont nombreuses

. Le-métronidazole, Flagyl ® ) : il faut prendre des précautions d'emploi notamment quant à son association avec les AVK (risque hémorragique augmenté)

L. Doxycycline, il faut être prudent quant à l'association de cette molécule avec les AVK (augmentation du risque hémorragique) Il est contre-indiqué de prescrire des tétracyclines avec des rétinoïdes

L. Pristinamycine, Pyostacine ® ) : il convient de ne pas en prescrire en association avec la colchicine. Il existe une précaution d'emploi en association avec la ciclosporine et le tacrolimus

. Les-anti-inflammatoires-non-stéroïdiens, ex : ibuprofène, acide tiaprofénique, acide niflumique, kétoprofène, etc? ) sont prescrits, dans l'exercice bucco-dentaire, à visée antalgique.(126) Les anti-inflammatoires non stéroïdiens gardent leurs interactions médicamenteuses et contreindications usuelles Dans le cadre d'un patient atteint de la maladie de Behçet, le praticien devra particulièrement faire attention aux informations

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