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Master Thesis

Pré éclampsie : apport prédictif des marqueurs sériques du premier trimestre de grossesse

Abstract : Objectives. First trimester serum markers screening for detection of Down's Syndrome arouses interest in the early prediction of pregnancy diseases. The main purpose of this study was to determine whether a difference exists in the PAPP-A and ß-HCG levels between patients who suffered from preeclampsia and a controlled group. We also looked for associations between low levels of serum markers (≤ 0.5 MoM) and the preeclampsia's precocity, severity, and severity criteria. Material and methods. We conducted a case-controlled study at the Hôpital Couple-Enfant (Grenoble). Cases were patients who received a preeclampsia diagnosis between January first 2015 and December 31st 2016. Each case was paired with a patient from the controlled group following four criteria: age, parity, tobacco consumption, and BMI. The main outcome measure was the PAPP-A and β-HCG’s values in MoM. Results. 90 subjects were included in our study. There was no statistically-significant difference in the PAPP-A and ß-HCG levels between the two samples. No significant association was found between low serum markers levels (≤ 0.5MoM) and preeclampsia, neither with its precocity, or severity. In the case population, a PAPP-A level of less than 0.5MoM was found to be significantly associated with foetal growth restriction (FGR, p=0.0141). Conclusion. Unlike previous study, ours did not find any significant association between low levels of serum markers and preeclampsia, neither with its precocity, or severity. However, low PAPP-A levels are associated with FGR.
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https://dumas.ccsd.cnrs.fr/dumas-01560872
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Submitted on : Wednesday, July 12, 2017 - 10:01:14 AM
Last modification on : Wednesday, July 15, 2020 - 9:38:04 AM
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  • HAL Id : dumas-01560872, version 1

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Laurie Dossena. Pré éclampsie : apport prédictif des marqueurs sériques du premier trimestre de grossesse. Gynécologie et obstétrique. 2017. ⟨dumas-01560872⟩

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