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Master Thesis

Évaluation diagnostique du dosage de la procalcitonine au cordon dans le diagnostic de l’infection néonatale bactérienne précoce, à l’Hôpital Couple Enfants de Grenoble

Abstract : Objectives : The aim of this study was to evaluate the diagnostic value of umbilical cord blood procalcitonin for detecting early onset neontal infection, measurement included since 2015 in the new infectious risk newborns algorithm at Hopital Couple Enfants at Grenoble. Secondary objectives were to compare biological analysis number and to do an economic evaluation. Materials and methods : This was a monocenter retrospective study including, between 1st of may 2015 and october 20th 2015, 773 newborns with a procalcitonin measurement. Infection status was established : infected or not infected. Diagnostic value has been studed by using sensitivity, specificity, positive and negative predictive value. Results : In our population, 12 children were classified as infected : we had an probably infection incidence of 8,2 on 1000 birth. Sensitivity, specifity, positive and negative value likelihood ratio were 75,0% (IC 95% [42,8 ; 94,5]), 98,2% [96,9 ; 99,0], 39,1% [19,7 ; 61,5] and 99,6% [98,8 ; 99,9], respectively. Actual algorithm has shown a decrease in the number of biological analysis ( -84,0 %) and has permitted to make budget savings (-46,9%). Conclusion : The measurement of procalcitonin blood cord seems to be an effective marker in the care of infectious risk newborns.These results have to be confirmed by a multicentric study with more newborn included.
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https://dumas.ccsd.cnrs.fr/dumas-01560878
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Submitted on : Wednesday, July 12, 2017 - 10:06:11 AM
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Marie Duverne. Évaluation diagnostique du dosage de la procalcitonine au cordon dans le diagnostic de l’infection néonatale bactérienne précoce, à l’Hôpital Couple Enfants de Grenoble. Gynécologie et obstétrique. 2017. ⟨dumas-01560878⟩

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