Maladie de Chagas : épidémiologie, impact économique, nouveaux champs de recherche

Abstract : Chagas disease, also known as american trypanosomiasis, is a neglected disease with 7 to 8 million people infected. It exists mostly in south and central America, where the disease is endemic in 21 countries, but also in non-endemic areas because of migration. The disease is caused by the protozoan parasite Trypanosoma cruzi. Its transmission is ensured by triatomas. Hundreds of species of triatomas exist but only a few are used with human habitations and can transmit the parasite. The impact of the disease is huge for endemic countries, and WHO estimates the loss of productivity about one billion per year. Programs to fight the disease have allowed some interesting sucess like the vector transmission interruption in a few countries. Disease’s treatment, are the same for 40 years, and includes two trypanocides molecules with several limits (efficacity, side effects…). The fight against Chagas disease targets the vectors insects with insecticids, habitations development, a better access to diagnosis and treatment, and also children’s education. Forgotten during decades, research is on the rise because of new institutions implication and new financial effort. If today, clinical trials have not led to a new drug approval, hope is allowed to discover a new drug soon.
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Master Thesis
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Submitted on : Friday, July 21, 2017 - 9:13:02 AM
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Romain Perrette. Maladie de Chagas : épidémiologie, impact économique, nouveaux champs de recherche. Sciences pharmaceutiques. 2017. ⟨dumas-01566416⟩

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