AAT dans les cohortes de tels patients peut être motivé d'un point de vue de la recherche ,
ont décrit pour la première fois l'association du déficit sévère et moyen en AAT avec la vascularite systémique anti-PR3 positif (65), et considéré le rôle pathogénétique du déficit en AAT et l'apparition d'ANCA, avec une spécificité pour la ,
PR3) est une sérine protéase élastase neutrophile-like, localisée dans les granules des polynucléaires neutrophiles, et dont l'AAT est l ,
antigène cible principal des anticorps anticytoplasme des polynucléaires neutrophiles (ANCA) qui sont impliqués dans la pathogénèse des vascularites nécrosantes touchant les petits vaisseaux, particulièrement dans la granulomatose de Wegener (GW) et la polyangéite microscopique (PAM) ,
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