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Master Thesis

Comparaison du taux de rechute locale entre mastectomie totale et mastectomie avec conservation de l'étui cutané dans le traitement des Carcinomes Canalaires In Situ du sein

Abstract : Background: if mastectomy is indicated for pure Ductal Carcinoma In Situ (DCIS) mastectomy with immediate breast reconstruction is routinely proposed to patients. Skin-Sparing Mastectomy (SSM) preserves the breast skin envelope but its oncological safety poses a few concerns. Moreover, no DCIS-specific studies have compared the LR rate following Total Mastectomy (TM) and SSM. Objective: to evaluate the local recurrence (LR) rate in patients with DCIS who underwent TM or SSM. Methods: this is a retrospective study on women who underwent mastectomy with or without immediate breast reconstruction or secondary reconstruction for pure DCIS of the breast. All patients treated at Institut Bergonié by mastectomy for DCIS during the January 1990 and December 2010 have been included. Overall survival (OS) and LR rate were estimated. Results: the study population included 399 patients who were categorized into two groups, 207 in the TM group and 192 in the SSM group. The OS of the entire population at 10 years was 94.7% [95% CI; 91.6 – 96.7]. The 10-year survival for TM group was 92.8% [95% CI, 87.9 – 95.8] and 96.8% [95% CI, 91.6 – 98.8] for the SSM group. The LR rate was 0.97% in the TM group and 1.04% in the SSM group. Conclusions: the LR rate following mastectomy is low, regardless of the surgical technique used, with an excellent OS at 10 years of 94.7% in our study. SSM with Immediate breast reconstruction can therefore be envisaged in case of mastectomy for pure DCIS.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01567092
Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Friday, July 21, 2017 - 4:24:48 PM
Last modification on : Thursday, October 26, 2017 - 1:13:02 AM

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Margaux l'Henaff. Comparaison du taux de rechute locale entre mastectomie totale et mastectomie avec conservation de l'étui cutané dans le traitement des Carcinomes Canalaires In Situ du sein . Médecine humaine et pathologie. 2017. ⟨dumas-01567092⟩

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