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M. Et-methodes, Les pts avec un CCRm dMMR et/ou MSI ont été identifiés rétrospectivement. Le statut dMMR et MSI a été confirmé de manière centralisée. Les critères d'exclusion étaient : absence de matériel tumoral disponible, tumeur pMMR (proficient MMR) et MSS (MS stables) Les statuts RAS, BRAF et l

L. 'atteinte-métastatique-Était-Été-moins-fréquemment-résécable, La médiane de survie globale des SP à partir du stade métastatique était inférieure à celle des LS (18.5 vs 40.7 mois, P=.004) La survie sans progression médiane en 1 e ligne métastatique (N=89) était de 6, et 9.2 mois (P=.65). La survie sans maladie des cas métastatiques réséqués