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Master Thesis

La sclérose en plaques, perspectives thérapeutiques : étude des signaux calciques intracellulaires de la lignée oligodendrogliale au cours de la remyélinisation chez la souris

Abstract : Multiple sclerosis (MS) is a chronic demyelinating and inflammatory disease of the central nervous system. MS affects about 80 000 people in France and represents the first cause of non-traumatic disability among young adults (20-40 years old). The major disease’s characteristic is the progressive loss of myelin sheath, which is destroyed by the immune system itself, provoking a diminution of the nerve impulse conduction. The current medical therapies are only effective to target inflammatory components. A spontaneous reparation of the damaged myelin sheath in MS is well known, but unfortunately still partial. The main source of remyelination is oligodendrocyte precursor cells (OPCs). Stem cell transplantation is studied to achieve an exogenous remyelination of the lesions without OPCs. Furthermore, antibodies (anti-Lingo and anti-semaphorin 4D) are currently in clinical trials in order to promote an endogen remyelination of lesions with persisting OPCs. Neuronal activity can modulate myelination and cause calcium increases in OPCs. The intracellular calcium of OPCs is known as a secondary messenger capable of regulating the transcription of genes, especially those involved in proliferation, differentiation of OPCs into OLs and in myelination. The main goal of the experimental work carried out in this thesis is to understand whether calcium signals depend on neuronal activity during remyelination with a murin model. The development of remyelination knowledge will result in the discovery of new therapeutic targets and might promote remyelinating and neuroprotective therapeutic strategies in MS.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01601362
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Submitted on : Wednesday, October 4, 2017 - 4:54:26 PM
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Mathilde Richard. La sclérose en plaques, perspectives thérapeutiques : étude des signaux calciques intracellulaires de la lignée oligodendrogliale au cours de la remyélinisation chez la souris. Sciences pharmaceutiques. 2017. ⟨dumas-01601362⟩

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