R. Myerson, F. Kong, E. Birnbaum, J. Fleshman, I. Kodner et al., Radiation therapy for epidermoid carcinoma of the anal canal, clinical and treatment factors associated with outcome, Radiotherapy and Oncology, vol.61, issue.1, p.1522, 2001.
DOI : 10.1016/S0167-8140(01)00404-2

A. Ahmed, P. Gibbs, M. Pickles, L. Turnbull, J. Song et al., Texture analysis in assessment and prediction of chemotherapy response in breast cancer):89101. 10 Association between tumor heterogeneity and progression-free survival in non-small cell lung cancer patients with EGFR mutations undergoing tyrosine kinase inhibitors therapy, 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). 2016. p. 126871. 11. Coroller TP al. CT-based radiomic signature predicts distant metastasis in lung adenocarcinoma, 2013.

X. Yang, S. Tridandapani, J. Beitler, D. Yu, E. Yoshida et al., study of late toxicity, 57329. 20. Insight Journal -Computing Textural Feature Maps for N-Dimensional images [Internet]. [cité 26 juin 2017]. Disponible sur, p.985, 2012.
DOI : 10.1016/j.ijrobp.2005.06.042

M. Richard-molard and J. Fayard, Cutoff Finder: a comprehensive and straightforward Web application enabling rapid biomarker cutoff optimization, ):e51862. 23. Gauthé M, 2012.

M. Shali, S. Schmitt, V. Behrendt, F. Winz, O. Heinzel et al., Metabolic tumour volume of anal carcinoma on (18)FDG PET/CT before combined radiochemotherapy is the only independant determinant of recurrence free survival, Eur J Radiol. août, vol.85, issue.8, 2016.

C. Cui, H. Cai, L. Liu, L. Li, H. Tian et al., Quantitative analysis and prediction of regional lymph node status in rectal cancer based on computed tomography imaging, European Radiology, vol.231, issue.11, p.231825, 2011.
DOI : 10.1148/radiol.2311030142

B. Ganeshan, S. Abaleke, R. Young, C. Chatwin, K. Miles et al., tomography: initial evidence for a relationship with tumour glucose metabolism and stage. Cancer Imaging Off Publ Int Cancer Imaging Soc. 6 juill T2- weighted MRI-derived textural features reflect prostate cancer aggressiveness: preliminary results. Eur Radiol. 14 déc 2016 Höckel null, Schlenger null, Mitze null, Schäffer null, Vaupel null. Hypoxia and Radiation Response in Human Tumors Hypoxia imaging and radiotherapy: bridging the resolution gap Tumour heterogeneity in oesophageal cancer assessed by CT texture analysis: preliminary evidence of an association with tumour metabolism, stage, and survival A tumor control probability model for anal squamous cell carcinoma, Semin Radiat Oncol. janv Br J Radiol. Clin Radiol. févr Radiother Oncol J Eur Soc Ther Radiol Oncol. août Lancet Oncol. févr, vol.106671166, issue.3222, pp.13743-283915764192666, 1996.

B. Lelandais, S. Ruan, T. Denoeux, P. Vera, and I. Gardin, Radiation dose escalation based on FDG-PET driven dose painting by numbers in oropharyngeal squamous cell carcinoma: a dosimetric comparison between TomoTherapy- HA and RapidArc. Radiat Oncol Lond Engl. 23 mars 2017 Fusion of multi-tracer PET images for dose painting, Med Image Anal. oct, vol.1218, issue.357, p.59124759, 2014.

R. Glynne-jones, P. Nilsson, C. Aschele, V. Goh, D. Peiffert et al., Anal cancer: ESMO?ESSO?ESTRO clinical practice guidelines for diagnosis, treatment and follow-up, Radiother Oncol. 1 juin, vol.111, issue.3, p.3309, 2014.
DOI : 10.1016/j.ejso.2014.07.030

S. Otto, L. Lee, H. Buhr, B. Frericks, S. Höcht et al., Staging Anal Cancer: Prospective Comparison of Transanal Endoscopic Ultrasound and Magnetic Resonance Imaging, Journal of Gastrointestinal Surgery, vol.242, issue.1
DOI : 10.1148/radiology.175.2.2326475

G. Raghunathan and K. Mortele, Magnetic Resonance Imaging of Anorectal Neoplasms, Clinical Gastroenterology and Hepatology, vol.7, issue.4
DOI : 10.1016/j.cgh.2009.01.014

K. Ciombor, R. Ernst, and G. Brown, Diagnosis and Diagnostic Imaging of Anal Canal Cancer, Surgical Oncology Clinics of North America, vol.26, issue.1, p.4555, 2017.
DOI : 10.1016/j.soc.2016.07.002

J. Kim, G. Beets, M. Kim, A. Kessels, and R. Beets-tan, High-resolution MR imaging for nodal staging in rectal cancer: are there any criteria in addition to the size?):7883. 11. TNCD | SNFGE.org -Société savante médicale française d'hépato-gastroentérologie et d'oncologie digestive, Eur J Radiol. 1 oct, vol.52, issue.1, 2004.

M. Jones, G. Hruby, M. Solomon, N. Rutherford, and J. Martin, The Role of FDG-PET in the Initial Staging and Response Assessment of Anal Cancer: A Systematic Review and Meta-analysis, Annals of Surgical Oncology, vol.71, issue.1, p.357481, 2015.
DOI : 10.1016/j.ijrobp.2007.09.005

M. Krengli, M. Milia, L. Turri, E. Mones, M. Bassi et al., FDG-PET/CT imaging for staging and target volume delineation in conformal radiotherapy of anal carcinoma, Radiation Oncology, vol.5, issue.1, pp.10-14, 2010.
DOI : 10.1186/1748-717X-5-10

R. Oncol, J. Eur-soc-ther-radiol-oncol-bazan, J. Koong, A. Kapp, D. Quon et al., Metabolic tumor volume predicts disease progression and survival in patients with squamous cell carcinoma of the anal canal Anal cancer FDG-PET standard uptake value: correlation with tumor characteristics, treatment response and survival, J Nucl Med Off Publ Soc Nucl Med. janv Radiol Med janv, vol.9554121, issue.311, pp.28891-15549, 2010.

M. Shali, S. Schmitt, V. Behrendt, F. Winz, O. Heinzel et al., Metabolic tumour volume of anal carcinoma on (18)FDG PET/CT before combined radiochemotherapy is the only independant determinant of recurrence free survival, ):13904. 18. Gauthé M, 2016.

M. Mistrangelo, A. Lesca, and . Pet-ct-in, Anal Cancer: Indications and Limits. 2013 [cité 31 août 2017]; Disponible sur: http://www.intechopen.com/books/positron-emission- tomography-recent-developments-in-instrumentation-research-and-clinical-oncological- practice/pet-ct-in-anal-cancer-indications-and-limits 20 Diagnostic performance of positron emission tomography, Caldarella C
DOI : 10.5772/57121

. Al, fluorodeoxyglucose in detecting locoregional nodal involvement in patients with anal canal cancer: a systematic review and meta-analysis, ScientificWorldJournal, vol.2014, issue.21, 2014.

F. Snfge, . Gercor, . Unicancer, . Sfcd, . Sfed et al., Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver Anal carcinoma: prognostic value of endorectal ultrasound (ERUS) Results of a prospective multicenter study, Anal cancer: French Intergroup Clinical Practice Guidelines for diagnosis, p.2316, 2001.

D. Peiffert, Recommandations pour la prise en charge des cancers du canal anal, Cancer/Radioth??rapie, vol.19, issue.6-7
DOI : 10.1016/j.canrad.2015.06.005

R. Graf, P. Wust, B. Hildebrandt, H. Gögler, R. Ullrich et al., Impact of Overall Treatment Time on Local Control of Anal Cancer Treated with Radiochemotherapy, Oncology, vol.65, issue.1
DOI : 10.1159/000071200

D. Weber, J. Kurtz, and A. Allal, The impact of gap duration on local control in anal canal carcinoma treated by split-course radiotherapy and concomitant chemotherapy, International Journal of Radiation Oncology*Biology*Physics, vol.50, issue.3
DOI : 10.1016/S0360-3016(01)01510-3

R. Glynne-jones, D. Sebag-montefiore, R. Adams, A. Mcdonald, S. Gollins et al., Mind the gap »--the impact of variations in the duration of the treatment gap and overall treatment time in the first UK Anal Cancer Trial (ACT I) Induction chemotherapy and dose intensification of the radiation boost in locally advanced anal canal carcinoma: final analysis of the randomized UNICANCER ACCORD 03 trial Epidermoid anal cancer: results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin, UKCCCR Anal Cancer Trial Working Party. UK Co-ordinating Committee on Cancer Research, p.104954, 1996.

M. John, T. Pajak, N. Petrelli, R. Myerson, and S. Doggett, Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study, J Clin Oncol Off J Am Soc Clin Oncol. mai J Clin Oncol Off J Am Soc Clin Oncol. sept, vol.1514, issue.59, p.252739, 1996.

J. Northover, R. Glynne-jones, D. Sebag-montefiore, R. James, H. Meadows et al., Chemoradiation for the treatment of epidermoid anal cancer: 13-year follow-up of the first randomised UKCCCR Anal Cancer Trial (ACT I), British Journal of Cancer, vol.67, issue.7, p.11238, 2010.
DOI : 10.1016/j.ijrobp.2006.09.018

R. James, R. Glynne-jones, H. Meadows, D. Cunningham, A. Myint et al., Mitomycin or cisplatin chemoradiation with or without maintenance chemotherapy for treatment of squamous-cell carcinoma of the anus (ACT II): a randomised, phase 3, open-label, 2??2 factorial trial, The Lancet Oncology, vol.14, issue.6, p.51624, 2013.
DOI : 10.1016/S1470-2045(13)70086-X

S. Gourtsoyianni and V. Goh, MRI of anal cancer: assessing response to definitive chemoradiotherapy, Abdominal Imaging, vol.106, issue.1, p.217, 2014.
DOI : 10.1016/j.ijrobp.2011.10.048

S. Roach, P. Hulse, F. Moulding, R. Wilson, and B. Carrington, Magnetic resonance imaging of anal cancer, Clinical Radiology, vol.60, issue.10, p.11119, 2005.
DOI : 10.1016/j.crad.2005.05.008

P. Robinson, B. Carrington, R. Swindell, J. Shanks, and O. St, Recurrent or Residual Pelvic Bowel Cancer: Accuracy of MRI Local Extent Before Salvage Surgery, Clinical Radiology, vol.57, issue.6, p.51422, 2002.
DOI : 10.1053/crad.2002.0933

L. Vercellino, F. Montravers, V. De-parades, V. Huchet, K. Kerrou et al., Impact of FDG PET/CT in the staging and the follow-up of anal carcinoma, International Journal of Colorectal Disease, vol.12, issue.1, pp.1806-4120110, 2008.
DOI : 10.1007/s00066-009-1944-5

. Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial, JAMA. 23 avr, vol.299, issue.16, p.191421, 2008.

L. Johnson, M. Madeleine, L. Newcomer, S. Schwartz, and J. Daling, Anal cancer incidence and survival: The Surveillance, Epidemiology, and End Results experience, Cancer. 15 juill, vol.101, issue.2, p.2818, 1973.
DOI : 10.1002/cncr.20364

URL : http://onlinelibrary.wiley.com/doi/10.1002/cncr.20364/pdf

S. Salati, A. Kadi, and A. , Anal Cancer : A Review, International Journal of Health Sciences, vol.6, issue.2, pp.20630-20676, 2012.
DOI : 10.12816/0006000

K. Hu, B. Minsky, A. Cohen, D. Kelsen, J. Guillem et al., 30 Gy may be an adequate dose in patients with anal cancer treated with excisional biopsy followed by combined-modality therapy, Journal of Surgical Oncology, vol.35, issue.2, p.717, 1999.
DOI : 10.1016/0360-3016(96)00146-0

P. Hatfield, R. Cooper, and D. Sebag-montefiore, Involved-field, low-dose chemoradiotherapy for early-stage anal carcinoma Analyse de textures en traitement d'images -Free -Recherche Google [Internet]. [cité 10 août 2017]. Disponible sur: https://www.google.fr/search?client=safari&rls=en&q=Analyse+de+textures+en+traitement+ d'images+-+Free&ie=UTF-8&oe=UTF-8&gfe_rd=cr&ei=TFOMWYmdAuP-8AeX2aKAAw 50, Int J Radiat Oncol Biol Phys. 1 févr Texture, vol.70, issue.2, pp.41924-41973, 2008.
DOI : 10.1016/j.ijrobp.2007.06.072

. Disponible-sur, php?title=Texture_(traitement_des_images)&oldid=1370895 56 51. http://haralick.org/journals/TexturalFeatures.pdf -Recherche Google [Internet]. [cité 10 août 2017]. Disponible sur: https://www.google.fr/search?client=safari&rls=en&q=http://haralick.org/journals/TexturalFe atures

R. Google, Disponible sur: https://www.google.fr/search?client=safari&rls=en&q=http://laris.univangers.fr/_resources/logo/MASTERSzpiegaEmmanuel.pdf&ie=UTF-8&oe=UTF- 8&gfe_rd=cr&ei=GleMWc_QMMWT8QfBhoHABQ 56 Association between tumor heterogeneity and progression-free survival in non-small cell lung cancer patients with EGFR mutations undergoing tyrosine kinase inhibitors therapy, al. CT-based radiomic signature predicts distant metastasis in lung adenocarcinoma, pp.126871-57, 2016.

R. Oncol, J. Eur-soc-ther-radiol-oncol, A. Ahmed, P. Gibbs, M. Pickles et al., Texture analysis in assessment and prediction of chemotherapy response in breast cancer Assessment of response to tyrosine kinase inhibitors in metastatic renal cell cancer: CT texture as a predictive biomarker, mars J Magn Reson Imaging JMRI. juill Radiology. oct, vol.11438261, issue.311, pp.34550-5816571, 2011.

C. Yip, D. Landau, R. Kozarski, B. Ganeshan, R. Thomas et al., Primary Esophageal Cancer: Heterogeneity as Potential Prognostic Biomarker in Patients Treated with Definitive Chemotherapy and Radiation Therapy, Radiology, vol.270, issue.1, p.1418, 2014.
DOI : 10.1148/radiol.13122869

D. Cecco, C. Ganeshan, B. Ciolina, M. Rengo, M. Meinel et al., Texture analysis as imaging biomarker of tumoral response to neoadjuvant chemoradiotherapy in rectal cancer patients studied with 3-T magnetic resonance Assessment of primary colorectal cancer heterogeneity by using whole-tumor texture analysis: contrast-enhanced CT texture as a biomarker of 5-year survival Assessment of tumor heterogeneity: an emerging imaging tool for clinical practice? Insights Imaging CT texture analysis using the filtrationhistogram method: what do the measurements mean? Cancer Imaging, Just N. Improving tumour heterogeneity MRI assessment with histograms, pp.23945-6257389, 2012.

-. Bilimoria, K. Bentrem, D. Rock, C. Stewart, A. Ko et al., Disponible sur: https://www.google.fr/search?client=safari&rls=en&q=analyse+multi-echelle+des+textures+- +Laurent+Risser&ie=UTF-8&oe=UTF-8&gfe_rd=cr&ei=hsmMWeK5K-fUXsf7h8gJ 67. Contribution à l'analyse de textures de radiographies osseuses pour ... -Recherche Google [Internet]. [cité 10 août 2017] Disponible sur: https://www.google.fr/search?client=safari&rls=en&q=Contribution+%C3%A0+l'analyse+de +textures+de+radiographies+osseuses+pour+...&ie=UTF-8&oe=UTF- 8&gfe_rd=cr&ei=ZsqMWbmAB-fUXsf7h8gJ 68 Analyse de textures en traitement d'images -Free -Recherche Google [Internet]. [cité 10 août 2017]. Disponible sur: https://www.google.fr/search?client=safari&rls=en&q=Analyse+de+textures+en+traitement+ d'images+-+Free&ie=UTF-8&oe=UTF-8&gfe_rd=cr&ei=TFOMWYmdAuP-8AeX2aKAAw 69 Outcomes and prognostic factors for squamous-cell carcinoma of the anal canal: analysis of patients from the National Cancer Data Base, Quéro L, Duval X, Abramowitz L. [Anal cancer in HIV patients], pp.220513-6662431, 2009.

P. Das, S. Bhatia, C. Eng, J. Ajani, J. Skibber et al., multicentric cohort study of HIV-positive patients receiving highly active antiretroviral therapy Predictors and patterns of recurrence after definitive chemoradiation for anal cancer Prognostic Factors for Squamous Cell Cancer of the Anal Canal, HIV-specific differences in outcome of squamous cell al. FDG-PET metabolic response predicts outcomes in anal cancer managed with chemoradiotherapy, pp.25507-72104, 2007.

D. Koh, A. Dzik-jurasz, B. Tait, D. Husband, J. Brown et al., CT response is predictive of tumor progression and survival in anal carcinoma Pelvic phasedarray MR imaging of anal carcinoma before and after chemoradiation, Pract Radiat Oncol. oct Br J Radiol. 1 févr, vol.681, issue.5962, pp.14954-76918, 2008.

É. Jederán, J. L?vey, Z. Szentirmai, E. Hitre, G. Léránt et al., The Role of MRI in the Assessment of the Local Status of Anal Carcinomas and in Their Management, ):5719. 78. Weiss GJ, 2015.
DOI : 10.1016/j.crad.2005.05.008

. Disponible, A. King, K. Chow, K. Yu, F. Mo et al., Head and neck squamous cell carcinoma: diagnostic performance of diffusion-weighted MR imaging for the prediction of treatment response CT texture analysis: a potential tool for prediction of survival in patients with metastatic clear cell carcinoma treated with sunitinib. Cancer Imaging Off Publ Int Cancer Imaging Soc. 23 janv 2017, ):4. 81. Statistical Texture Classification (Biomedical Image Analysis) [Internet]. [cité 14 juill 2017]. Disponible sur, p.5318, 2013.

X. Yang, S. Tridandapani, J. Beitler, D. Yu, E. Yoshida et al., Ultrasound GLCM texture analysis of radiation-induced parotid-gland injury in head-and-neck cancer radiotherapy: An in vivo study of late toxicity):57329. 83. Entropy of grayscale image -MATLAB entropy -MathWorks France [Internet]. [cité 16 juill 2017]. Disponible sur: https://fr.mathworks.com/help/images/ref/entropy.html 84 T2- weighted MRI-derived textural features reflect prostate cancer aggressiveness: preliminary results, Med Phys. sept Eur Radiol. juill, vol.3927, issue.97, p.30509, 2012.

S. Liu, S. Liu, C. Ji, H. Zheng, X. Pan et al., Application of CT texture analysis in predicting histopathological characteristics of gastric cancers Hypoxia imaging and radiotherapy: bridging the resolution gap Höckel null, Schlenger null, Mitze null, Schäffer null, Vaupel null. Hypoxia and Radiation Response in Human Tumors, Eur Radiol. 22 juin Br J Radiol Semin Radiat Oncol. janv Acta Oncol Stockh Swed. janv, vol.86653, issue.881, p.392532, 1996.

R. Muirhead, M. Partridge, and M. Hawkins, Disponible sur: https://pharmacomedicale.org/medicaments/par-specialites/item/anticancereux-les-points- essentiels 90 A tumor control probability model for anal squamous cell carcinoma, Anticancéreux : Les points essentiels, p.1926, 2015.

F. Liu, X. Xi, H. Wang, Y. Han, X. F. Hu et al., PET/CT-guided dose-painting versus CT-based intensity modulated radiation therapy in locoregional advanced nasopharyngeal carcinoma, Radiation Oncology, vol.24, issue.34, p.15, 2017.
DOI : 10.1200/JCO.2006.07.7982

J. Uzan, A. Nahum, I. Syndikus, N. Meillan, F. Huguet et al., Prostate Dose-painting Radiotherapy and Radiobiological Guided Optimisation Enhances the Therapeutic Ratio [Follow-up after radiotherapy of anal canal carcinoma], Disponible sur, pp.16570-93, 2015.

. Al, Disponible sur: https://fr.wikipedia.org/w/index.php?title=Big_data&oldid=140024248 97

R. Google and ]. Internet, Disponible sur: https://www.google.fr/search?dcr=0&source=hp&q=https%3A%2F%2Fwww.fondation- arc.org%2Factualites%2Fla-radiomique-entre-imagerie-et-big, 2017.